The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

Genes and Development

Volumn 14, Issue 16, 2000, Pages 1997-2002

  Schmidt, Jennifer V ^a,b   Matteson, Paul G ^a   Jones, Beverly K ^a   Guan, Xiao Juan ^a   Tilghman, Shirley M ^a  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Dlk1; Genomic imprinting; Gtl2

Indexed keywords

CELL DNA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRICETIDAE; DNA METHYLATION; EMBRYO; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION; GENE LOCATION; GENE MAPPING; GENE SEQUENCE; GENETIC LINKAGE; GENOME IMPRINTING; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; DNA METHYLATION; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOMIC IMPRINTING; LINKAGE (GENETICS); MURIDAE; PEROMYSCUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0034663920     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

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2. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus
3. Competition - A common motif for the imprinting mechanism?
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5. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
6. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
7. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis
8. Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/ delta-like protein in pancreatic islets: Molecular cloning and expression pattern during development and growth of the endocrine pancreas
9. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster
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14. CTCF mediates methylation-sensitive enhancer blocking activity at the H19/Igf2 locus
15. Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of Dlk1 and pG2
16. Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2
17. Dlk1, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line
18. Disruption of imprinting caused by deletion of the H19 gene region in mice
19. An enhancer deletion affects both H19 and Igf2 expression
20. The role of DNA methylation in genomic imprinting
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23. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs
24. The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA
25. Gtl2lacZ, an insertional mutation on mouse chromosome 12 with parental origin-dependent phenotype
26. Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern
27. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
28. Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation
29. Maternal uniparental disomy for chromosome 14
30. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
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32. Genomic imprinting is disrupted in interspecific Peromyscus hybrids
33. Uniparental heterodisomy for chromosome 14 in a phenotypically abnormal familial balanced 13/14 Robertsonian translocation carrier
34. Imprinted expression of the Igf2r gene depends on an intronic CpG island