Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity

Human Molecular Genetics

Volumn 10, Issue 8, 2001, Pages 807-814

  Jones, B K ^a   Levorse, J ^a   Tilghman, S M ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

H 19 PROTEIN; NUCLEASE; SOMATOMEDIN B; STRUCTURAL PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CHOROID PLEXUS; CHROMATIN; CHROMOSOME 7; CONTROLLED STUDY; ENZYME DEGRADATION; FEEDING BEHAVIOR; FEMALE; GENE ACTIVITY; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENOME IMPRINTING; HYPOPHAGIA; LEPTOMENINX; LIPID METABOLISM; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REGULATOR GENE; SKELETAL MUSCLE; TONGUE;

ANIMALIA;

EID: 0035311042     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.8.807     Document Type: Article

References (47)

1. Disruption of imprinting caused by deletion of the H19 gene region in mice
2. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
3. H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19
4. Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
5. Parental-origin-specific epigenetic modifications of the mouse H19 gene
6. A paternal-specific methylation imprint marks the alleles of the mouse H19 gene
7. A 5′ two kilobase pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development
8. Chromatin conformation of the H19 epigenetic mark
9. Characterization of novel parent-specific epigenetic modifications upstream of the imprinted mouse H19 gene
10. Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene
11. Modulation of an CTCF-dependent enhancer boundary by DNA methylation control imprinting of the Igf2 gene
12. CTCF mediates methylation-sensitive enhancer blocking activity at the H19/Igf2 locus
13. A transcriptional insulator at the imprinted H19/Igf2 locus
14. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
15. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
16. A position-effect assay for boundaries of higher order chromosomal domains
17. A group of scs elements function as domain boundaries in an enhancer-blocking assay
18. Chromatin boundaries: Punctuating the genome
19. Two regulatory domains flank the mouse H19 gene
20. Appropriate expression of the mouse H19 gene utilises three or more distinct enhancer regions spread over more than 130 kb
21. Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting
22. Parental imprinting of the mouse insulin-like growth factor II gene
23. H19 is imprinted in the choroid plexus and leptomeninges of the mouse foetus
24. Comparative analysis of Igf-2/H19 imprinted domain: Identification of a highly conserved intergenic DNase I hypersensitive region
25. Genomic regions regulating imprinting and insulin-like growth factor-II promoter 3 activity in transgenics: Novel enhancer and silencer elements
26. A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene
27. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
28. Insulin-like growth factors cross the blood-brain barrier
29. Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting
30. The structural H19 gene is required for its own imprinting
31. Location of enhancers is essential for imprinting of H19 and Igf2
32. Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element
33. Enhancer competition between H19 and Igf2 does not mediate their imprinting
34. Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
35. Promoter-specific imprinting of the human insulin-like growth factor-II gene
36. High plasma insulin-like growth factor-II and low lipid content in transgenic mice: Measurements of lipid metabolism
37. Apa1 polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males
38. An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs
39. Evidence for the role of insulin-like growth factor II (IGF-II) in the control of food intake
40. Insulin-like growth factors: A role in growth hormone negative feedback and body weight regulation via brain
41. Intracerebroventricular injection of insulin or glucose alters insulin-like growth factor II (IGF-II) concentrations in specific hypothalamic nuclei
42. Divergent effects of insulin on insulin-like growth factor-II gene expression in the rat hypothalamus
43. Effects of insulin and 2-deoxy-D-glucose administration on CNS IGF-II content
44. Role of brain insulin receptor in control of body weight and reproduction
45. Igf2 imprinting does not require its own DNA methylation or H19 RNA
46. Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells
47. An enhancer deletion affects both H19 and Igf2 expression