Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control

Journal of Cellular Physiology

Volumn 190, Issue 2, 2002, Pages 160-169

  Oelgeschlager T ^a  

^a MARIE CURIE RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; HEPTAPEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; PROTEIN TYROSINE KINASE; RNA POLYMERASE II;

CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CYTOSTASIS; DEPHOSPHORYLATION; DNA DAMAGE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HUMAN; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION INITIATION;

ANIMALS; CELL CYCLE; CYCLIN-DEPENDENT KINASES; HUMANS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RNA POLYMERASE II; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 0036136668     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10058     Document Type: Review

References (174)

1. MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH
2. Requirement for TFIIH kinase activity in transcription by RNA polymerase II
3. The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7
4. TFIIH is negatively regulated by cdk8-containing mediator complexes
5. Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases
6. The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: A conserved structure with an essential function
7. Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II
8. Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain
9. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
10. Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: Possible role in transcription elongation
11. Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos
12. Phosphorylation of the RNA polymerase II largest subunit during Xenopus laevis oocyte maturation
13. Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD)
14. Coupling RNA polymerase II transcription with pre-mRNA processing
15. Transcription-independent phosphorylation of the RNA polymerase II C- terminal domain (CTD) involves ERK kinases (MEK1/2)
16. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
17. Cytostellin distributes to nuclear regions enriched with splicing factors
18. Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains
19. UV-induced ubiquitination of RNA polymerase II: A novel modification deficient in Cockayne syndrome cells
20. Cell cycle regulation and RNA polymerase II
21. The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II
22. Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II
23. The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts
24. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
25. Mammalian MAP kinase signalling cascades
26. Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7
27. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity
28. Ten years of TFIIH
29. Promoter-proximal pausing by RNA polymerase II in vitro: Transcripts shorter than 20 nucleotides are not capped
30. A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II
31. Phosphorylation of eukaryotic DNA-dependent RNA polymerase. Identification of calf thymus RNA polymerase subunits phosphorylated by two purified protein kinases, correlation with in vivo sites of phosphorylation in HeLa cell RNA polymerase II
32. The role of multisite phosphorylation in the regulation of RNA polymerase II activity
33. Reversible phosphorylation of the C-terminal domain of RNA polymerase II
34. CDK9 (PITALRE): A multifunctional cdc2-related kinase
35. MAT1 ('menage a trois') a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK
36. Human cyclin-dependent kinase-activating kinase exists in three distinct complexes
37. Enhanced phosphorylation of the C-terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: Possible involvement of MAP kinases
38. Heat-shock inactivation of the TFIIH-associated kinase and change in the phosphorylation sites on the C-terminal domain of RNA polymerase II
39. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxyterminal domain kinase and Cdk-activating kinase activity
40. Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
41. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
42. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
43. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
44. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase
45. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription
46. HIV-1 Tat: Coping with negative elongation factors
47. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop
48. Upregulation of cyclin T1/CDK9 complexes during T cell activation
49. Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription
50. RNA polymerase II C-terminal domain required for enhancer-driven transcription
51. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro
52. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
53. Growth suppression by p18, a p161NK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
54. RAD25 is a DNA helicase required for DNA repair and RNA polymerase II transcription
55. RNA polymerase II as a control panel for multiple coactivator complexes
56. p15INK4B is a potential effector of TGF-βinduced cell cycle arrest
57. The role of Cdk7 in CAK function, a retro-retrospective
58. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin- dependent kinases
59. Fission yeast Cskl is a CAK-activating kinase (CAKAK)
60. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
61. RNA polymerase II and the integration of nuclear events
62. Distinct roles for CTD Ser-2 and Ser-5 phosphorylation in the recruitment and allosteric activation of mammalian mRNA capping enzyme
63. Three transitions in the RNA polymerase II transcription complex during initiation
64. The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase
65. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors
66. The cdk-activating kinase (CAK): From yeast to mammals
67. Analysis of CAK activities from human cells
68. A cell cycle regulator potentially involved in genesis of many tumor types
69. RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter
70. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner
71. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
72. An RNA polymerase II holoenzyme responsive to activators
73. A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID
74. Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription
75. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity
76. T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity
77. Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo
78. Transcription of eukaryotic protein-coding genes
79. Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs)
80. Cyclin dependent kinase regulation
81. A kinase-cyclin pair in the RNA polymerase II holoenzyme
82. Growth retardation and neonatal lethality in mice with a homozygous deletion in the C-terminal domain of RNA polymerase II
83. Three distinct signalling responses by murine fibroblasts to genotoxic stress
84. Repression of TFIIH transcriptional activity and TFIIH-associated cdk7 kinase activity at mitosis
85. Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
86. Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb
87. A human RNA polymerase II complex associated with SRB and DNA-repair proteins
88. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
89. Purification of P-TEFb, a transcription factor required for the transition into productive elongation
90. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase
91. Dual phosphorylation of the T-loop in cdk7: Its role in controlling cyclin H binding and CAK activity
92. Displacement of sequence-specific transcription factors from mitotic chromatin
93. Role of RNA polymerase II carboxy-terminal domain in coordinating transcription with RNA processing
94. Conditional expression of RNA polymerase II in mammalian cells. Deletion of the carboxyl-terminal domain of the large subunit affects early steps in transcription
95. Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain
96. Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity
97. Principles of CDK regulation
98. Cyclin-dependent kinases: Engines, clocks, and microprocessors
99. A cyclin associated with the CDK-activating kinase MO15
100. A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription
101. Cyclin-dependent kinase 7: At the cross-roads of transcription, DNA repair and cell cycle control?
102. Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation
103. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
104. Composite co-activator ARC mediates chromatin-directed transcriptional activation
105. Regulation of TFIIH ATPase and kinase activities by TFIEE during active initiation complex formation
106. The general transcription factors of RNA polymerase II
107. A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation
108. Mitotic repression of RNA polymerase II transcription is accompanied by release of transcription elongation complexes
109. Growth-related changes in phosphorylation of yeast RNA polymerase II
110. Identification of a cyclin subunit required for the function of Drosophila P-TEFb
111. Identification of multiple cyclin subunits of human P-TEFb
112. The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2
113. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II
114. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
115. Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences
116. Poliovirus-induced modification of host cell RNA polymerase IIO is prevented by cycloheximide and zinc
117. Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. Implications for transcription-coupled DNA repair
118. Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH
119. RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection
120. Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II
121. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases
122. Phosphorylation in transcription: The CTD and more
123. Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7
124. UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II
125. The role of general initiation factors in transcription by RNA polymerase II
126. Role of general and gene-specific cofactors in the regulation of eukaryotic transcription
127. Integrating the MAP kinase signal into the G1 phase cell cycle machinery
128. Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1
129. Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH
130. The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
131. The transcriptional cofactor complex CRSP is required for activity of the enhancerbinding protein Spl
132. Dynamic association of capping enzymes with transcribing RNA polymerase II
133. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity
134. Mitotic regulation of TFIID: Inhibition of activator-dependent transcription and changes in subcellular localization
135. Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH
136. Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription
137. Association of Cdk-activating kinase subunits with transcription factor TFIIH
138. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
139. Cancer cell cycles
140. Cdk-activating kinase complex is a component of human transcription factor TFIIH
141. CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15
142. Prevalence of p16 and CDK4 germline mutations in 48 melanomaprone families in France
143. TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA
144. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
145. Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome
146. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)
147. In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein
148. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C
149. Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II
150. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
151. Reconstitution of the transcription factor TFIIH: Assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7
152. Characterization of the residues phosphorylated in vitro by different C-terminal domain kinases
153. The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpblp CTD
154. Cycling, stressed-out and nervous: Cellular functions of c-Abl
155. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro
156. Abl tyrosine kinase in signal transduction and cell-cycle regulation
157. Polymerase II promoter activation: Closed complex formation and ATP-driven start site opening
158. Cytostellin: A novel, highly conserved protein that undergoes continuous redistribution during the cell cycle
159. Modulation of TFIIH-associated kinase activity by complex formation and its relationship with CTD phosphorylation of RNA polymerase II
160. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
161. The retinoblastoma protein and cell cycle control
162. MAT1-modulated CAK activity regulates cell cycle G(1) exit
163. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation
164. Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation
165. TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines
166. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase
167. Regulation of CDK7 substrate specificity by MAT1 and TFIIH
168. RNA polymerase II
169. The cycling of RNA polymerase II during transcription
170. Recycling of the general transcription factors during RNA polymerase II transcription
171. The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro
172. Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit
173. Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription
174. Transcription elongation: The 'Foggy' is lifting