Phosphorylation in transcription: The CTD and more

Gene Expression

Volumn 9, Issue 1-2, 2000, Pages 3-13

  Riedl, T ^a   Egly, J M ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

CTD; GTFs; Phosphorylation; Transcription activators; Transcription regulation

Indexed keywords

MESSENGER RNA; PHOSPHOTRANSFERASE; RNA POLYMERASE II; TRANSCRIPTION FACTOR;

CARBOXY TERMINAL SEQUENCE; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; NONHUMAN; PHOSPHORYLATION; REVIEW; RNA SYNTHESIS; TRANSCRIPTION REGULATION;

EID: 0033678601     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000001783992704     Document Type: Review

References (103)

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10. Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD)
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12. Purification and characterization of a phosphatase from HeLa cells which dephosphorylates the C-terminal domain of RNA polymerase II
13. The activity of COOH-terminal domain phosphatase is regulated by a docking site on RNA polymerase II and by the general transcription factors IIF and IIB
14. Activation of estrogen receptor α by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7
15. The interaction of RNA polymerase II with the adenovirus-2 major late promoter is precluded by phosphorylation of the C-terminal domain of subunit IIa
16. Phosphorylation of human general transcription factors TATA-binding protein and transcription factor IIB by DNA-dependent protein kinase. Synergistic stimulation of RNA polymerase II basal transcription in vitro
17. mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain
18. A protein phosphatase functions to recycle RNA polymerase II
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20. Promoter-proximal pausing by RNA polymerase II in vitro: Transcripts shorter than 20 nucleotides are not capped
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24. Enhanced phosphorylation of the C-terminal domain of polymerase II upon serum stimulation of quiescent cells: Possible involvement of MAP kinases
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31. RNA polymerase II is an essential mRNA polyadenylation factor
32. Phosphorylated RNA polymerase II stimulate pre-mRNA splicing
33. RNA polymerase II and the integration of nuclear events
34. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8
35. Distinct effector roles for Ser2 and Ser5 phosphorylation of the RNA polymerase II CTD in the recruitment and allosteric activation of mammalian capping enzyme
36. The regulation of transcription by phosphorylation
37. The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT 1, targets and enhances CAK activity on the POU domains of octamer transcription factors
38. Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation
39. Tackling tat
40. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
41. The major late promoter of adenovirus-2 is accurately transcribed by RNA polymerases IIO, IIA, and IIB
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43. Splicing factors associate with hyperphosphorylated RNA polymerase II in the absence of pre-messenger RNA
44. Regulation of the human general transcription initiation factor TFIIF by phosphorylation
45. p53 is phosphorylated by cdk7-cyclin H in a p36MAT1-dependent manner
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47. The RNA polymerase II holoenzyme responsive to activators
48. The RNA polymerase II holoenzyme and its implications for gene regulation
49. Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-I, and transcriptional corepressors Ssn6-Tup1
50. Transcription-dependent structural changes in the C-terminal domain of mammalian RNA polymerase subunit IIa/o
51. From androgen receptor to the general transcription factor TFIIH
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54. RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro
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56. Three distinct signalling responses by murine fibroblasts to genotoxic stress
57. Repression of TFIIH transcriptional activity and TFIIH-associated cdk 7 kinase activity at mitosis
58. Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
59. The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
60. A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription
61. Phosphorylation of yeast TBP by protein kinase CK2 reduces its specific binding to DNA
62. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro
63. Purification of P-TEFb, a transcription factor required for the transition into productive elongation
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66. The C-terminal domain RNA polymerase II couples messenger RNA processing to transcription
67. Amgen EST Program: Shuman, S.; Bentley, D. 5'-capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II
68. Mechanisms of switching on p53: A role for covalent modification?
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70. The TAFII250 subunit of TFIID has histone acetyl-transferase activity
71. Regulation of TFIIH ATPase and kinase activities by TFIIE during active initiation complex formation
72. The general transcription factors of RNA polymerase II
73. A mammalian RNA polymerase II holoenzyme containing all components required for promoter specific transcription initiation
74. Enhanced processivity of RNA polymerase II triggered by by Tat-induced phosphorylation of its carboxy-terminal domain
75. Identification of a cyclin subunit required for the function of Drosophila P-TEFb
76. Identification of multiple cyclin subunits of human P-TEFb
77. How RNA polymerase II terminates transcription in higher eukaryotes
78. Stimulation of RARα activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7
79. Kin 28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II
80. Kinase activity and phosphorylation of the largest subunit of TFIIF transcription factor
81. The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
82. RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals
83. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity
84. Mitotic regulation of TFIID: Inhibition of activator-dependent transcription and changes in subcellular localization
85. Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription
86. Factors regulating the transcriptional elongation activity of RNA polymerase II
87. The DNA-dependent protein kinase
88. Phosphorylation of TFIIA stimulates TATA binding protein-TATA interaction and contributes to maximal transcription and viability in yeast
89. The yeast carboxyl-terminal repeat domain kinase CTDKI is a divergent cyclin-cyclin-dependent kinase complex
90. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
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92. A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast
93. Characterization of the residues phosphorylated in vitro by different C-terminal domain kinases
94. Specific Interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein
95. Residues phosphorylated byt TFIIH are required for E2F-1 degradation during S-phase
96. DSIF, a novel transcription elongation factor that regulates Pol II processivity, is composed of human Spt4 and Spt5 homologs
97. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional diferrences between PTEFb and TFIIH
98. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation
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100. The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro
101. Phosphorylation causes a conformational change in the carboxy-terminal domain of the mouse RNA polymerase II largest subunit
102. Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages