-
1
-
-
0027742184
-
Distinct roles for cyclin-dependent kinases in cell cycle control
-
Van den Heuvel S, Harlow E: Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993, 262:2050-2054.
-
(1993)
Science
, vol.262
, pp. 2050-2054
-
-
Van Den Heuvel, S.1
Harlow, E.2
-
2
-
-
0028171292
-
G1 phase progression: Cycling on cue
-
Sherr CJ: G1 phase progression: cycling on cue. Cell 1994, 79:551-555.
-
(1994)
Cell
, vol.79
, pp. 551-555
-
-
Sherr, C.J.1
-
3
-
-
0028931265
-
Principles of CDK regulation
-
Morgan DO: Principles of CDK regulation. Nature 1995, 374:131-134. A thorough review of the principles of COK regulation.
-
(1995)
Nature
, vol.374
, pp. 131-134
-
-
Morgan, D.O.1
-
4
-
-
0029317904
-
Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle
-
Nigg EA: Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 1995, 17:471-480. A recent review of both the regulation and the substrates of CDK-cyclin complexes.
-
(1995)
Bioessays
, vol.17
, pp. 471-480
-
-
Nigg, E.A.1
-
6
-
-
0029029617
-
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
-
Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massagué J, Pavletich NP: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature 1995, 376:313-320. The crystal structure of a human CDK2-cyclin A complex is determined at 2.3 Ȧ resolution. This work provides the basis for a detailed understanding of the regulation and substrate specificity of CDK-cyclin complexes. The reported structure concerns unphosphorylated CDK2; it will be interesting to see how phosphorylation of Thr160 alters the conformation of the T-loop of CDK2.
-
(1995)
Nature
, vol.376
, pp. 313-320
-
-
Jeffrey, P.D.1
Russo, A.A.2
Polyak, K.3
Gibbs, E.4
Hurwitz, J.5
Massagué, J.6
Pavletich, N.P.7
-
7
-
-
0027532449
-
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin a in vitro
-
Connell-Cowley L, Solomon MJ, Wei N, Harper JW: Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro. Mol Biol Cell 1993, 4:79-92.
-
(1993)
Mol Biol Cell
, vol.4
, pp. 79-92
-
-
Connell-Cowley, L.1
Solomon, M.J.2
Wei, N.3
Harper, J.W.4
-
8
-
-
0027943714
-
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase
-
Matsuoka M, Kato JY, Fisher RP, Morgan DO, Sherr C: Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. Mol Cell Biol 1994, 14:7265-7275.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 7265-7275
-
-
Matsuoka, M.1
Kato, J.Y.2
Fisher, R.P.3
Morgan, D.O.4
Sherr, C.5
-
9
-
-
0028970682
-
160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin
-
160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science 1995, 270:90-93. The phosphatase CDK-associated phosphatase (KAP) was originally identified in yeast two-hybrid screens as a protein which interacts with CDKs. Structurally, it resembles dual-specificity phosphatases such as Cdc25. As shown here, however, it specifically dephosphorylates Thr160 (but not Tyr15) in monomeric Cdk2, at least when assayed in vitro. Binding to cyclin A protects Cdk2 from dephosphorylation. Thus, if KAP acts on Cdk2 in vivo, it is likely to do so only after cyclin degradation.
-
(1995)
Science
, vol.270
, pp. 90-93
-
-
Ryc, P.1
Hunter, T.2
-
10
-
-
0029020282
-
The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks SK, Hunter T: The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 1995, 9:576-596. A comprehensive review of the primary structures of protein kinases. Besides containing other useful information, this compilation illustrates that many protein kinases have phosphorylatable residues in positions corresponding roughly to the T-loop-phosphorylation sites of CDKs.
-
(1995)
FASEB J
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
11
-
-
0026727119
-
Structural framework for the protein kinase family
-
Taylor SS, Knighton DR, Zheng J, Lynn F, Eyck TF, Sowadski JM: Structural framework for the protein kinase family. Annu Rev Cell Biol 1992, 8:429-462.
-
(1992)
Annu Rev Cell Biol
, vol.8
, pp. 429-462
-
-
Taylor, S.S.1
Knighton, D.R.2
Zheng, J.3
Lynn, F.4
Eyck, T.F.5
Sowadski, J.M.6
-
12
-
-
0028271690
-
Protein kinase regulation: Insights from crystal structure analysis
-
Morgan DO, De Bondt HL: Protein kinase regulation: insights from crystal structure analysis. Curr Opin Cell Biol 1994, 6:239-246.
-
(1994)
Curr Opin Cell Biol
, vol.6
, pp. 239-246
-
-
Morgan, D.O.1
De Bondt, H.L.2
-
13
-
-
0027296041
-
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
-
Fesquet D: The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. EMBO J 1993, 12:3111-3121.
-
(1993)
EMBO J
, vol.12
, pp. 3111-3121
-
-
Fesquet, D.1
-
16
-
-
0025035855
-
40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus laevis oocytes
-
40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus laevis oocytes. EMBO J 1990, 9:3233-3240.
-
(1990)
EMBO J
, vol.9
, pp. 3233-3240
-
-
Shuttleworth, J.1
Godfrey, R.2
Colman, A.3
-
17
-
-
0027994603
-
A novel cyclin associates with MO15/cdk7 to form the CDK-activating kinase
-
Fisher RP, Morgan DO: A novel cyclin associates with MO15/cdk7 to form the CDK-activating kinase. Cell 1994, 78:713-724.
-
(1994)
Cell
, vol.78
, pp. 713-724
-
-
Fisher, R.P.1
Morgan, D.O.2
-
18
-
-
0028070243
-
A cyclin associated with the CDK-activating kinase MO15
-
Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA: A cyclin associated with the CDK-activating kinase MO15. Nature 1994, 371:254-257.
-
(1994)
Nature
, vol.371
, pp. 254-257
-
-
Mäkelä, T.P.1
Tassan, J.P.2
Nigg, E.A.3
Frutiger, S.4
Hughes, G.J.5
Weinberg, R.A.6
-
19
-
-
0028168543
-
Expression and activity of p40MO15, the catalytic subunit of cdk-activating kinase, during Xenopus oogenesis and embryogenesis
-
Brown AJ, Jones T, Shuttleworth J: Expression and activity of p40MO15, the catalytic subunit of cdk-activating kinase, during Xenopus oogenesis and embryogenesis. Mol Biol Cell 1994, 5:921-932.
-
(1994)
Mol Biol Cell
, vol.5
, pp. 921-932
-
-
Brown, A.J.1
Jones, T.2
Shuttleworth, J.3
-
21
-
-
0028089946
-
Cell cycle analysis of the activity, subcellular localisation, and subunit composition of human CAK (CDK-activating kinase)
-
Tassan JP, Schultz SJ, Bartek J, Nigg EA: Cell cycle analysis of the activity, subcellular localisation, and subunit composition of human CAK (CDK-activating kinase). J Cell Biol 1994, 127:467-478.
-
(1994)
J Cell Biol
, vol.127
, pp. 467-478
-
-
Tassan, J.P.1
Schultz, S.J.2
Bartek, J.3
Nigg, E.A.4
-
24
-
-
0028856425
-
MAT1, a new RING-finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK
-
••].
-
(1995)
EMBO J
, vol.14
, pp. 5027-5036
-
-
Devault, A.1
Martinez, A.M.2
Fesquet, D.3
Labbé, J.C.4
Tassan, J.P.5
Nigg, E.A.6
Cavadore, J.C.7
Dorée, M.8
-
25
-
-
0027239790
-
The RING finger-a novel protein sequence motif related to the zinc finger
-
Freemont PS: The RING finger-a novel protein sequence motif related to the zinc finger. Annu NY Acad Sci 1993, 684:174-192.
-
(1993)
Annu NY Acad Sci
, vol.684
, pp. 174-192
-
-
Freemont, P.S.1
-
26
-
-
0029987031
-
MAT1, cdk7 and cyclin H form a kinase complex which is UV light sensitive upon association with TFIIH
-
in press
-
Adamczewski JP, Rossignol M, Tassan JP, Nigg EA, Moncollin V, Egly JM: MAT1, cdk7 and cyclin H form a kinase complex which is UV light sensitive upon association with TFIIH. EMBO J 1996, in press. MAT1 is shown to be present in those CDK7-cyclin H complexes that associate with TFIIH. Furthermore, evidence is presented that TFIIH-associated (but not bulk!) CDK7 activity drops in response to UV irradiation of cells. These observations raise the possibility that CDK7 might participate in a checkpoint signalling pathway that relays the presence of DNA damage to the transcriptional apparatus.
-
(1996)
EMBO J
-
-
Adamczewski, J.P.1
Rossignol, M.2
Tassan, J.P.3
Nigg, E.A.4
Moncollin, V.5
Egly, J.M.6
-
27
-
-
0028270189
-
Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase
-
Kato JY, Matsuoka M, Strom DK, Sherr CJ: Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol Cell Biol 1994, 14:2713-2721.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 2713-2721
-
-
Kato, J.Y.1
Matsuoka, M.2
Strom, D.K.3
Sherr, C.J.4
-
28
-
-
0029017132
-
1 and mitotic cyclins
-
1 phase of the cell cycle. A strain harboring a mutation in Cdc37p is now reported to contain reduced levels of Cdc28-cyclin complexes. These results suggest that Cdc37p is somehow required for the formation of CDK-cyclin complexes in budding yeast. However, the Cdc37 gene product is not stably associated with Cdc28-cyclin complexes, suggesting that its mode of action is different from that of vertebrate MAT1.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 4651-4655
-
-
Gerber, M.R.1
Farrell, A.2
Raymond, J.D.3
Herskowitz, I.4
Morgan, D.O.5
-
29
-
-
0028173587
-
M015 associates with p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating activity in Xenopus oocytes
-
M015 associates with p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating activity in Xenopus oocytes. EMBO J 1994, 13:5155-5164.
-
(1994)
EMBO J
, vol.13
, pp. 5155-5164
-
-
Labbé, J.C.1
Martinez, A.M.2
Fesquet, D.3
Capony, J.P.4
Darbon, J.M.5
Derancourt, J.6
Devault, A.7
Morin, N.8
Cavadore, J.C.9
Dorée, M.10
-
30
-
-
0028600051
-
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
-
••]).
-
(1994)
Cell
, vol.79
, pp. 1093-1101
-
-
Roy, R.1
Adamczewski, J.P.2
Seroz, T.3
Vermeulen, W.4
Tassan, J.P.5
Schaeffer, L.6
Nigg, E.A.7
Hoejimakers, J.H.J.8
Egly, J.M.9
-
31
-
-
0028904925
-
TFIIH: A link between transcription, DNa repair and cell cycle regulation
-
Seroz T, Hwang JR, Moncollin V, Egly JM: TFIIH: a link between transcription, DNA repair and cell cycle regulation. Curr Opin Genet Dev 1995, 5:217-221.
-
(1995)
Curr Opin Genet Dev
, vol.5
, pp. 217-221
-
-
Seroz, T.1
Hwang, J.R.2
Moncollin, V.3
Egly, J.M.4
-
32
-
-
85030205280
-
-
A recent review on TFIIH subunits and their involvement in transcription, DNA repair, and cell cycle regulation. See also [32•]
-
A recent review on TFIIH subunits and their involvement in transcription, DNA repair, and cell cycle regulation. See also [32•].
-
-
-
-
34
-
-
0028139742
-
The role of multisite phosphorylation in the regulation of RNA polymerase II activity
-
Dahmus ME: The role of multisite phosphorylation in the regulation of RNA polymerase II activity. Prog Nucleic Acid Res Mol Biol 1994, 48:143-179.
-
(1994)
Prog Nucleic Acid Res Mol Biol
, vol.48
, pp. 143-179
-
-
Dahmus, M.E.1
-
36
-
-
0028954227
-
Cdk-activating kinase complex is a component of human transcription factor TFIIH
-
••].
-
(1995)
Nature
, vol.374
, pp. 283-287
-
-
Shiekhattar, R.1
Mermelstein, F.2
Fisher, R.3
Drapkin, R.4
Dynlacht, B.5
Wessling, H.C.6
Morgan, D.O.7
Reinberg, D.8
-
37
-
-
0028832869
-
A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation
-
Ossipow V, Tassan JP, Nigg EA, Schibler U: A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Cell 1995, 83:137-146. This study shows that a monoclonal anti-CDK7 antibody can be used for the rapid purification of a RNAPII holoenzyme from a highly concentrated rat liver nuclear extract. The anti-CDK7 immunoprecipitate contains all components required for transcription initiation at both viral and cellular promoters. This is the first description of a mammalian RNAPII holoenzyme.
-
(1995)
Cell
, vol.83
, pp. 137-146
-
-
Ossipow, V.1
Tassan, J.P.2
Nigg, E.A.3
Schibler, U.4
-
38
-
-
0029091310
-
The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin dependent kinase complex
-
Sterner DE, Lee JM, Hardin SE, Greenleaf AL: The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin dependent kinase complex. Mol Cell Biol 1995, 15:5716-5724. The budding yeast CTD kinase 1 is shown to contain a CDK-cyclin pair (CTK1-CTK2), in addition to a third subunit (CTK3). CTK2 is structurally related to mammalian cyclin C. CTK3 shares no obvious sequence similarity with MAT1, but it is noteworthy that two distinct CDKs with CTD-kinase activity (CDK7 in metazoans and CTK1 in S. cerevisiae) both exist in heterotrimeric complexes.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 5716-5724
-
-
De Sterner1
Lee, J.M.2
Hardin, S.E.3
Greenleaf, A.L.4
-
39
-
-
0028937199
-
A kinase-cyclin pair in the RNA polymerase II holoenzyme
-
•].
-
(1995)
Nature
, vol.374
, pp. 193-196
-
-
Liao, S.M.1
Zhang, J.2
Jeffery, D.A.3
Koleske, A.J.4
Thompson, C.M.5
Chao, D.M.6
Viljoen, M.7
Van Vuuren, J.J.8
Young, R.A.9
-
44
-
-
0029558989
-
Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK
-
•], but in this paper it is referred to as Mop1. Evidence is presented that fission yeast Mop1 and Mcs2 can associate with the heterologous mammalian partners cyclin H and CDK7, respectively.
-
(1995)
EMBO J
, vol.14
, pp. 6164-6172
-
-
Damagnez, V.1
Mäkelä, T.P.2
Cottarel, G.3
-
45
-
-
0027503605
-
Characterisation of the fission yeast mcs2 cyclin and its associated protein kinase activity
-
Molz L, Beach D: Characterisation of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J 1993, 12:1723-1732.
-
(1993)
EMBO J
, vol.12
, pp. 1723-1732
-
-
Molz, L.1
Beach, D.2
-
46
-
-
0022799517
-
KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28
-
Simon M, Séraphin B, Faye G: KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28. EMBO J 1986, 5:2697-2701.
-
(1986)
EMBO J
, vol.5
, pp. 2697-2701
-
-
Simon, M.1
Séraphin, B.2
Faye, G.3
-
47
-
-
0027377670
-
The Kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae
-
Valay JG, Simon M, Faye G: The Kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae. J Mol Biol 1993, 234:307-310.
-
(1993)
J Mol Biol
, vol.234
, pp. 307-310
-
-
Valay, J.G.1
Simon, M.2
Faye, G.3
-
51
-
-
0024709822
-
cdc2 and the regulation of mitosis: Six interacting mes genes
-
Molz L, Booher R, Young P, Beach D: cdc2 and the regulation of mitosis: six interacting mes genes. Genetics 1989, 122:773-782.
-
(1989)
Genetics
, vol.122
, pp. 773-782
-
-
Molz, L.1
Booher, R.2
Young, P.3
Beach, D.4
|