Hepatic fatty acid synthesis is suppressed in mice with fatty livers due to targeted apolipoprotein B38.9 Mutation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 3, 2002, Pages 476-482

  Lin, Xiaobo ^a   Schonfeld, Gustav ^a   Yue, Pin ^a   Chen, Zhouji ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apolipoprotein B; Familial hypobetalipoproteinemia; Fatty acid synthesis; Fatty liver; Sterol regulatory element binding protein 1c

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACYL COENZYME A DESATURASE; APOLIPOPROTEIN B; CARNITINE PALMITOYLTRANSFERASE; FATTY ACID; FATTY ACID SYNTHASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIET RESTRICTION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY LIVER; GENE MUTATION; GENETIC ENGINEERING; HYPOBETALIPOPROTEINEMIA; LIPID METABOLISM; LIVER METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; REFEEDING;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; APOLIPOPROTEINS B; CCAAT-ENHANCER-BINDING PROTEINS; DNA-BINDING PROTEINS; FASTING; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FEMALE; GENE TARGETING; HYPOBETALIPOPROTEINEMIAS; KINETICS; LIVER; MALE; MICE; MUTATION; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 0036124635     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/hq0302.105271     Document Type: Article

References (48)

1. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
2. Studies on the biosynthesis of hepatic pyruvate kinase and its correlation with enhanced hepatic lipogenesis in mealtrained rats
3. Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL
4. Carbohydrate-induced changes in very low density lipoprotein composition and structure
5. Carbohydrate-induced hypertriacylglycerolemia: Historical perspective and review of biological mechanisms
6. Liver pathology in diabetes mellitus and morbid obesity: Clinical, pathological, and biochemical considerations
7. Fatty liver in heterozygous hypobetalipoproteinemia caused by a novel truncated form of apolipoprotein B
8. Diffuse fatty liver in familial heterozygous hypobetalipoproteinemia
9. Fatty liver in familial hypobetalipoproteinemia (FHBL)
10. The hypobetalipoproteinemias
11. Familial hypobetalipoproteinemia
12. Apoprotein B-100 production is decreased in subjects heterozygous for truncations of apoprotein B
13. Decreased production rates of VLDL triglycerides and apoB-100 in subjects heterozygous for familial hypobetali-poproteinemias
14. Decreased production and increased catabolism of apoli-poprotein B-100 in apolipoprotein B-67/B-100 heterozygotes
15. Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells
16. A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglycerides
17. Regulation of mammalian acetyl-coenzyme A carboxylase
18. Fatty acid synthesis and its regulation
19. The regulation of stearoyl-CoA desaturase (SCD)
20. Biosynthesis of triacylglycerols
21. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
22. Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol
23. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
24. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
25. Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
26. Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver
27. The mitochondrial carnitine palmitoyltransferase system: From concept to molecular analysis
28. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
29. General procedures for separating lipid components of tissue
30. Overproduction of cholesterol and fatty, acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
31. Differential expression of exon 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
32. Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway: Involvement of protein kinase B/Akt
33. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
34. Comparison of three actincoding sequences in the mouse: Evolutionary relationships between the actin genes of warm-blooded vertebrates
35. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia
36. A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion
37. Regulation of fatty acid synthase (FAS)
38. Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription
39. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
40. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
41. Despite hypersecretion of apoli-poprotein B-27.6, fatty livers occur in hypobetalipoproteinemic mice with a targeted apolipoprotein B-27.6 allele
42. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
43. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
44. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis
45. Mechanisms of nutritional and hormonal regulation of lipogenesis
46. Fatty acid-induced β-cell apoptosis: A link between obesity and diabetes
47. Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells: A potential link between insulin resistance and beta-cell dysfunction
48. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance