메뉴 건너뛰기




Volumn 19, Issue 11, 1999, Pages 2714-2721

Decreased production rates of VLDL triglycerides and ApoB-100 in subjects heterozygous for familial hypobetalipoproteinemia

Author keywords

Apolipoprotein B; Familial hypobetalipoproteinemia; Stable isotopes; Triglycerides

Indexed keywords

APOLIPOPROTEIN B100; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 0032698343     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.11.2714     Document Type: Article
Times cited : (60)

References (42)
  • 1
    • 0029096553 scopus 로고
    • The hypobetalipoproteinemias
    • Schonfeld G. The hypobetalipoproteinemias. Annu Rev Nutr. 1995;15:23-34.
    • (1995) Annu Rev Nutr , vol.15 , pp. 23-34
    • Schonfeld, G.1
  • 4
    • 0024410226 scopus 로고
    • Hypobetalipoproteinemia due to an apolipoprotein B gene exon 21 deletion derived by Alu-Alu recombination
    • Huang LS, Ripps ME, Korman SH, Deckelbaum RJ, Breslow JL. Hypobetalipoproteinemia due to an apolipoprotein B gene exon 21 deletion derived by Alu-Alu recombination. J Biol Chem. 1989;264:11394-11400.
    • (1989) J Biol Chem , vol.264 , pp. 11394-11400
    • Huang, L.S.1    Ripps, M.E.2    Korman, S.H.3    Deckelbaum, R.J.4    Breslow, J.L.5
  • 5
    • 0025885015 scopus 로고
    • ApoB gene nonsense and splicing mutations in a compound heterozygote for familial hypobetalipoproteinemia
    • Huang LS, Kayden H, Sokol RJ, Breslow JL. ApoB gene nonsense and splicing mutations in a compound heterozygote for familial hypobetalipoproteinemia. J Lipid Res. 1991;32:1341-1348.
    • (1991) J Lipid Res , vol.32 , pp. 1341-1348
    • Huang, L.S.1    Kayden, H.2    Sokol, R.J.3    Breslow, J.L.4
  • 6
    • 0029971275 scopus 로고    scopus 로고
    • Positive linear correlation between the length of truncated apolipoprotein B and its secretion rate (in vivo studies in apoB-89, apoB-75, apoB-54.8, and apoB-31 heterozygotes)
    • Parhofer KG, Barrett PHR, Bier DM, Schonfeld G. Positive linear correlation between the length of truncated apolipoprotein B and its secretion rate (in vivo studies in apoB-89, apoB-75, apoB-54.8, and apoB-31 heterozygotes). J Lipid Res. 1996;37:844-852.
    • (1996) J Lipid Res , vol.37 , pp. 844-852
    • Parhofer, K.G.1    Barrett, P.H.R.2    Bier, D.M.3    Schonfeld, G.4
  • 8
    • 0026749611 scopus 로고
    • Lipoproteins containing the truncated apolipoprotein, apoB-89, are cleared from human plasma more rapidly than apoB-100 containing lipoproteins in vivo
    • Parhofer KG, Barrett PHR, Bier DM, Schonfeld G. Lipoproteins containing the truncated apolipoprotein, apoB-89, are cleared from human plasma more rapidly than apoB-100 containing lipoproteins in vivo. J Clin Invest. 1992;89:1931-1937.
    • (1992) J Clin Invest , vol.89 , pp. 1931-1937
    • Parhofer, K.G.1    Barrett, P.H.R.2    Bier, D.M.3    Schonfeld, G.4
  • 9
    • 0026697215 scopus 로고
    • ApoB-75, a truncation of apolipoprotein B associated with familial hypobetalipoproteinemia: Genetic and kinetic studies
    • Krul ES, Parhofer KG, Barrett PHR, Wagner RD, Schonfeld G. ApoB-75, a truncation of apolipoprotein B associated with familial hypobetalipoproteinemia: genetic and kinetic studies. J Lipid Res. 1992;33:1037-1050.
    • (1992) J Lipid Res , vol.33 , pp. 1037-1050
    • Krul, E.S.1    Parhofer, K.G.2    Barrett, P.H.R.3    Wagner, R.D.4    Schonfeld, G.5
  • 12
    • 0030798890 scopus 로고    scopus 로고
    • Fatty acid regulation of very low density lipoprotein production
    • Lewis GF. Fatty acid regulation of very low density lipoprotein production. Curr Opin Lipidol. 1997;8:146-153.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 146-153
    • Lewis, G.F.1
  • 13
    • 0019506499 scopus 로고
    • Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: Normolipidemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia
    • Kissebah AH, Alfarsi S, Adams PW. Integrated regulation of very low density lipoprotein triglyceride and apolipoprotein-B kinetics in man: normolipidemic subjects, familial hypertriglyceridemia and familial combined hyperlipidemia. Metabolism. 1981;30:856-868.
    • (1981) Metabolism , vol.30 , pp. 856-868
    • Kissebah, A.H.1    Alfarsi, S.2    Adams, P.W.3
  • 14
    • 0019086594 scopus 로고
    • Dissociation of apoprotein B and triglyceride production in very low density lipoproteins
    • Melish G, Le NA, Ginsberg H, Steinberg D, Brown WV. Dissociation of apoprotein B and triglyceride production in very low density lipoproteins. Am J Physiol. 1980;239:E354-E362.
    • (1980) Am J Physiol , vol.239
    • Melish, G.1    Le, N.A.2    Ginsberg, H.3    Steinberg, D.4    Brown, W.V.5
  • 15
    • 0020615761 scopus 로고
    • A new model of human VLDL metabolism based on simultaneous studies of its apoB and triglyceride
    • Steiner G, Reardon MF. A new model of human VLDL metabolism based on simultaneous studies of its apoB and triglyceride. Metabolism. 1983;32:342-347.
    • (1983) Metabolism , vol.32 , pp. 342-347
    • Steiner, G.1    Reardon, M.F.2
  • 17
    • 0031725165 scopus 로고    scopus 로고
    • Donor splice mutation (665+1 G-T) in familial hypobetalipoproteinemia with no detectable apoB truncation
    • Pulai JI, Hamideh Z, Kwok PY, Kim JH, Wu J, Schonfeld G. Donor splice mutation (665+1 G-T) in familial hypobetalipoproteinemia with no detectable apoB truncation. Am J Med Genet. 1998;80:218-220.
    • (1998) Am J Med Genet , vol.80 , pp. 218-220
    • Pulai, J.I.1    Hamideh, Z.2    Kwok, P.Y.3    Kim, J.H.4    Wu, J.5    Schonfeld, G.6
  • 18
    • 0021672477 scopus 로고
    • Direct determination of human and rabbit apolipoprotein B selectively precipitated with butanol-isopropyl ether
    • Klein RL, Zilversmit DB. Direct determination of human and rabbit apolipoprotein B selectively precipitated with butanol-isopropyl ether. J Lipid Res. 1984;25:1380-1386.
    • (1984) J Lipid Res , vol.25 , pp. 1380-1386
    • Klein, R.L.1    Zilversmit, D.B.2
  • 19
    • 0016391907 scopus 로고
    • Determination of amino acid profiles in biological samples by gas chromatography
    • Adams RF. Determination of amino acid profiles in biological samples by gas chromatography. J Chromatogr. 1974;95:189-212.
    • (1974) J Chromatogr , vol.95 , pp. 189-212
    • Adams, R.F.1
  • 20
    • 0025913070 scopus 로고
    • Incorporation of a stable isotopically labeled amino acid into multiple human apolipoproteins
    • Patterson BW, Hachey DL, Cook GL, Amann JM, Klein PD. Incorporation of a stable isotopically labeled amino acid into multiple human apolipoproteins. J Lipid Res. 1991;32:1063-1072.
    • (1991) J Lipid Res , vol.32 , pp. 1063-1072
    • Patterson, B.W.1    Hachey, D.L.2    Cook, G.L.3    Amann, J.M.4    Klein, P.D.5
  • 21
    • 0031801379 scopus 로고    scopus 로고
    • Improved accuracy and precision of gas chromatography/mass spectrometry measurements for metabolic tracers
    • Patterson BW, Zhao G, Klein S. Improved accuracy and precision of gas chromatography/mass spectrometry measurements for metabolic tracers. Metabolism. 1998;47:706-712.
    • (1998) Metabolism , vol.47 , pp. 706-712
    • Patterson, B.W.1    Zhao, G.2    Klein, S.3
  • 23
    • 0025739878 scopus 로고
    • Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes
    • Parhofer KG, Barrett PHR, Bier DM, Schonfeld G. Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes. J Lipid Res. 1991;32:1311-1323.
    • (1991) J Lipid Res , vol.32 , pp. 1311-1323
    • Parhofer, K.G.1    Barrett, P.H.R.2    Bier, D.M.3    Schonfeld, G.4
  • 24
    • 0018418362 scopus 로고
    • Kinetic model for production and metabolism of very low density lipoprotein triglycerides: Evidence for a slow production pathway and results for normolipidemic subjects
    • Zech LA, Grundy SM, Steinberg D, Berman M. Kinetic model for production and metabolism of very low density lipoprotein triglycerides: evidence for a slow production pathway and results for normolipidemic subjects. J Clin Invest. 1979;63:1262-1273.
    • (1979) J Clin Invest , vol.63 , pp. 1262-1273
    • Zech, L.A.1    Grundy, S.M.2    Steinberg, D.3    Berman, M.4
  • 25
    • 0025264443 scopus 로고
    • Measurement of very low density and low density lipoprotein apolipoprotein (apo) B-100 and high density lipoprotein apo A-I production in human subjects using deuterated leucine: Effect of fasting and feeding
    • Cohn JS, Wagner DA, Cohn SD, Millar JS, Schaefer EJ. Measurement of very low density and low density lipoprotein apolipoprotein (apo) B-100 and high density lipoprotein apo A-I production in human subjects using deuterated leucine: effect of fasting and feeding. J Clin Invest. 1990;85:804-811.
    • (1990) J Clin Invest , vol.85 , pp. 804-811
    • Cohn, J.S.1    Wagner, D.A.2    Cohn, S.D.3    Millar, J.S.4    Schaefer, E.J.5
  • 27
    • 0014906080 scopus 로고
    • Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets
    • Quarfordt SH, Frank A, Shames DM, Berman M, Steinberg D. Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets. J Clin Invest. 1970;49:2281-2297.
    • (1970) J Clin Invest , vol.49 , pp. 2281-2297
    • Quarfordt, S.H.1    Frank, A.2    Shames, D.M.3    Berman, M.4    Steinberg, D.5
  • 28
    • 0018364379 scopus 로고
    • Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia
    • Grundy SM, Mok HYI, Zech L, Steinberg D, Berman M. Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J Clin Invest. 1979;63:1274-1283.
    • (1979) J Clin Invest , vol.63 , pp. 1274-1283
    • Grundy, S.M.1    Mok, H.Y.I.2    Zech, L.3    Steinberg, D.4    Berman, M.5
  • 29
    • 0023884149 scopus 로고
    • Triglyceride-rich lipoprotein metabolism during acute hyperinsulinemia in hypertriglyceridemic humans
    • Shumak SL, Zinman B, Zuniga-Guarjardo S, Poapst M, Steiner G. Triglyceride-rich lipoprotein metabolism during acute hyperinsulinemia in hypertriglyceridemic humans. Metabolism. 1988;37:461-466.
    • (1988) Metabolism , vol.37 , pp. 461-466
    • Shumak, S.L.1    Zinman, B.2    Zuniga-Guarjardo, S.3    Poapst, M.4    Steiner, G.5
  • 30
    • 0029964729 scopus 로고    scopus 로고
    • Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man
    • Aarsland A, Chinkes D, Wolfe RR. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest. 1996;98:2008-2017.
    • (1996) J Clin Invest , vol.98 , pp. 2008-2017
    • Aarsland, A.1    Chinkes, D.2    Wolfe, R.R.3
  • 32
    • 0025283305 scopus 로고
    • Assembly and secretion of hepatic very low density lipoprotein
    • Gibbons GF. Assembly and secretion of hepatic very low density lipoprotein. Biochem J. 1990;268:1-13.
    • (1990) Biochem J , vol.268 , pp. 1-13
    • Gibbons, G.F.1
  • 33
    • 0029033102 scopus 로고
    • Synthesis and secretion of apolipoprotein B from cultured liver cells
    • Ginsberg HN. Synthesis and secretion of apolipoprotein B from cultured liver cells. Curr Opin Lipidol. 1995;6:275-280.
    • (1995) Curr Opin Lipidol , vol.6 , pp. 275-280
    • Ginsberg, H.N.1
  • 34
    • 0032897496 scopus 로고    scopus 로고
    • Molecular bases of low production rates of apolipoprotein B-100 and truncated apoB-82 in a mutant HepG2 cell line generated by targeted modification of the apolipoprotein B gene
    • Srivastava RAK, Srivastava N, Averna M, Cefalu AB, Schonfeld G. Molecular bases of low production rates of apolipoprotein B-100 and truncated apoB-82 in a mutant HepG2 cell line generated by targeted modification of the apolipoprotein B gene. J Lipid Res. 1999;40:901-912.
    • (1999) J Lipid Res , vol.40 , pp. 901-912
    • Srivastava, R.A.K.1    Srivastava, N.2    Averna, M.3    Cefalu, A.B.4    Schonfeld, G.5
  • 35
    • 0027200040 scopus 로고
    • Substrate delivery as a determinant of hepatic apoB secretion
    • Sniderman AD, Cianflone K. Substrate delivery as a determinant of hepatic apoB secretion. Arterioscler Thromb. 1993;13:629-636.
    • (1993) Arterioscler Thromb , vol.13 , pp. 629-636
    • Sniderman, A.D.1    Cianflone, K.2
  • 36
    • 0028036640 scopus 로고
    • Studies on the assembly of apolipoprotein B100 and apoB48-containing very low density lipoprotein in McARH7777 cells
    • Boren J, Rustaeus S, Olofsson SO. Studies on the assembly of apolipoprotein B100 and apoB48-containing very low density lipoprotein in McARH7777 cells. J Biol Chem. 1994;269:25879-25888.
    • (1994) J Biol Chem , vol.269 , pp. 25879-25888
    • Boren, J.1    Rustaeus, S.2    Olofsson, S.O.3
  • 37
    • 12644303527 scopus 로고    scopus 로고
    • Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step
    • Gordon DA, Jamil H, Gregg RE, Olofsson S-O, Boren J. Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J Biol Chem. 1996;271:33047-33053.
    • (1996) J Biol Chem , vol.271 , pp. 33047-33053
    • Gordon, D.A.1    Jamil, H.2    Gregg, R.E.3    Olofsson, S.-O.4    Boren, J.5
  • 38
    • 0001558236 scopus 로고
    • Nascent VLDL assembly occurs in two steps in the endoplasmic reticulum (ER) of hepatocytes
    • Woodford XFP, Davignon J, Sniderman A, eds. Amsterdam, Netherlands. Elsevier Science
    • Hamilton RL, Erickson SK, Havel RJ. Nascent VLDL assembly occurs in two steps in the endoplasmic reticulum (ER) of hepatocytes. In: Woodford XFP, Davignon J, Sniderman A, eds. Atherosclerosis. Amsterdam, Netherlands. Elsevier Science; 1995:414-418.
    • (1995) Atherosclerosis , pp. 414-418
    • Hamilton, R.L.1    Erickson, S.K.2    Havel, R.J.3
  • 39
    • 0031846319 scopus 로고    scopus 로고
    • Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency
    • Hamilton RL, Wong JS, Cham CM, Nielsen LB, Young SG. Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency. J Lipid Res. 1998;39:1543-1557.
    • (1998) J Lipid Res , vol.39 , pp. 1543-1557
    • Hamilton, R.L.1    Wong, J.S.2    Cham, C.M.3    Nielsen, L.B.4    Young, S.G.5
  • 42
    • 0028217791 scopus 로고
    • Fatty liver due to heterozygous hypobetalipoproteinemia
    • Wishingrad M, Paaso B, Garcia G. Fatty liver due to heterozygous hypobetalipoproteinemia. Am J Gastroenterol. 1994;89:1106-1107.
    • (1994) Am J Gastroenterol , vol.89 , pp. 1106-1107
    • Wishingrad, M.1    Paaso, B.2    Garcia, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.