Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver

Trends in Cardiovascular Medicine

Volumn 10, Issue 7, 2000, Pages 275-278

  Shimano, Hitoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; FISH OIL; POLYUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; DIET; GENE CONTROL; GENE EXPRESSION; KNOCKOUT MOUSE; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY;

EID: 0034445548     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(00)00079-7     Document Type: Review

References (27)

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4. Regulated intramembrane proteolysis; a control mechanism conserved from bacteria to humans
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6. Dietary regulation of gene expression; enzymes involved in carbohydrate and lipid metabolism
7. Sterol regulatory element-binding-1 protein is regulated by glucose at the transcriptional level
8. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis
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10. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
11. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
12. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mrnas
13. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
14. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
15. Peroxisome proliferator-activated receptor alpha inhibits hepatic S14 gene transcription. Evidence against the peroxisome proliferator-activated receptor alpha as the mediator of polyunsaturated fatty acid regulation of s14 gene transcription
16. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
17. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
18. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
19. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
20. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
21. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
22. Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins
23. ADD1; a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
24. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization
25. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein
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27. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene