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Volumn 3, Issue 3, 2002, Pages 234-243

Electrophysiologic characterization of the antinociceptive actions of S18616, a novel and potent alpha2-adrenoceptor agonist, after acute and persistent pain states

Author keywords

Formalin; Inflammation; Nerve injury; Neuropathic pain; Rat; Spinal cord; 2 adrenoceptors

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ATIPAMEZOLE; FORMALDEHYDE; IDAZOXAN; S 18616; UNCLASSIFIED DRUG;

EID: 0036087228     PISSN: 15265900     EISSN: None     Source Type: Journal    
DOI: 10.1054/jpai.2002.123651     Document Type: Article
Times cited : (12)

References (90)
  • 5
    • 0033105552 scopus 로고    scopus 로고
    • Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation
    • (1999) J Physiol , vol.515 , pp. 533-542
    • Birder, L.A.1    Perl, E.R.2
  • 12
    • 0022634250 scopus 로고
    • Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn
    • (1986) Pain , vol.24 , pp. 211-222
    • Dickenson, A.H.1    Sullivan, A.F.2
  • 16
  • 19
    • 0029873885 scopus 로고
    • A double-blind randomised comparison of the effects of epidural clonidine, lignocaine and the combination of clonidine and lignocaine in patients with chronic pain
    • (1995) Pain , vol.64 , pp. 337-343
    • Glynn, C.1    O'Sullivan, K.2
  • 20
    • 0033955367 scopus 로고    scopus 로고
    • Synergistic interactions between two α2-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats
    • (2000) Pain , vol.85 , pp. 135-143
    • Graham, B.1    Hammond, D.2    Proudfit, H.3
  • 25
    • 0032946742 scopus 로고    scopus 로고
    • Microinjection of morphine in the A7 catecholamine cell group produces opposing effects on nociception that are mediated by α1- and α2-adrenoceptors
    • (1999) Neuroscience , vol.91 , pp. 979-990
    • Holden, J.1    Schwartz, E.2    Proudfit, H.3
  • 29
    • 0026646670 scopus 로고
    • Noradrenergic modulation of noxious heatevoked fos-like immunoreactivity in the dorsal horn of the rat sacral spinal cord
    • (1992) J Comp Neurol , vol.325 , pp. 435-445
    • Jones, S.L.1
  • 31
    • 0028945541 scopus 로고
    • Systemic clonidine differentially modulates the abnormal reactions to mechanical and thermal stimuli in rats with peripheral mononeuropathy
    • (1995) Pain , vol.60 , pp. 275-285
    • Kayser, V.1    Desmeules, J.2    Guilbaud, G.3
  • 32
    • 0026730401 scopus 로고
    • Potent antinociceptive effects of clonidine systemically administered in an experimental model of clinical pain, the arthritic rat
    • (1992) Brain Res , vol.593 , pp. 7-13
    • Kayser, V.1    Guilbaud, G.2    Besson, J.3
  • 35
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • (1992) Pain , vol.50 , pp. 355-363
    • Kim, S.H.1    Chung, J.M.2
  • 43
    • 0028954690 scopus 로고
    • Analysis of drug interaction between intrathecal clonidine and MK-801 in peripheral neuropathic pain rat model
    • (1995) Anesthesiology , vol.82 , pp. 741-748
    • Lee, Y.W.1    Yaksh, T.L.2
  • 45
    • 0027753819 scopus 로고
    • Influence of an experimental peripheral mononeuropathy on the responses of medial bulboreticular neurons to noxious skin stimulation and the modulation of the responses by an alpha 2-adrenoceptor agonist in the rat
    • (1993) Exp Neurol , vol.124 , pp. 390-394
    • Luukko, M.1    Pertovaara, A.2
  • 48
    • 77956765460 scopus 로고    scopus 로고
    • Alpha 2-adrenergic mechanisms of analgesia: Strategies for improving their therapeutic window and identification of the novel, potent alpha 2A-adrenergic receptor agonist, S 18616
    • (1998) Adv Pharmacol (New York) , vol.42 , pp. 575-579
    • Millan, M.1
  • 56
    • 0025672652 scopus 로고
    • Pharmacology of intrathecal adrenergic agonists: Cardiovascular and nociceptive reflexes in halothane-anesthetized rats
    • (1990) Anesthesiology , vol.73 , pp. 1198-1207
    • Nagasaka, H.1    Yaksh, T.L.2
  • 62
    • 0029862244 scopus 로고    scopus 로고
    • Enhanced descending modulation of nociception in rats with persistent hindpaw inflammation
    • (1996) J Neurophysiol , vol.76 , pp. 3025-3037
    • Ren, K.1    Dubner, R.2
  • 63
    • 0028171675 scopus 로고
    • Multiple alpha2 adrenergic receptor subtypes. I. Comparison of [3H]RX821002-labeled rat R alpha-2A adrenergic receptors in cerebral cortex to human H alpha2A adrenergic receptor and other populations of alpha-2 adrenergic subtypes
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 946-957
    • Renouard, A.1    Widdowson, P.S.2    Millan, M.J.3
  • 64
    • 0030597993 scopus 로고    scopus 로고
    • Roles of monoaminergic, glycinergic and GABAergic inhibitory systems in the spinal cord in rats with peripheral mononeuropathy
    • (1996) Brain Res , vol.728 , pp. 27-36
    • Satoh, O.1    Omote, K.2
  • 67
    • 0033981479 scopus 로고    scopus 로고
    • Effects of the I (1) imidazoline/α2-adrenergic receptor agonist moxonidine in comparison with clonidine is the formalin test in rats
    • (2000) Pain , vol.85 , pp. 161-167
    • Shannon, H.1    Lutz, E.2
  • 74
    • 0033889656 scopus 로고    scopus 로고
    • The inhibitory effects of the A1 adenosine receptor agonist, N6-cyclopentyladenosine on the electrical and natural evoked responses of spinal dorsal horn neurones in a rat model of mononeuropathy
    • (2000) J Pain , vol.1 , pp. 99-110
    • Suzuki, R.1    Gale, A.2    Dickenson, A.3
  • 76
    • 0026041943 scopus 로고
    • Relative efficacy of spinal alpha-2 agonists, dexmedetomidine, clonidine and ST-91, determined in vivo by using N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline, an irreversible antagonist
    • (1991) J Pharmacol Exp Ther , vol.258 , pp. 438-446
    • Takano, Y.1    Yaksh, T.L.2
  • 77
    • 0030459419 scopus 로고    scopus 로고
    • Descending modulation from the region of the locus coeruleus on nociceptive sensitivity in a rat model of inflammatory hyperalgesia
    • (1996) Brain Res , vol.743 , pp. 86-92
    • Tsuruoka, M.1    Willis, W.2
  • 78
    • 0033519545 scopus 로고    scopus 로고
    • Laminar-selective noradrenergic and serotoninergic modulation includes spinoparabrachial cells after inflammation
    • (1999) Neuroreport , vol.10 , pp. 1757-1761
    • Wei, F.1    Dubner, R.2    Ren, K.3
  • 79
    • 0030611941 scopus 로고    scopus 로고
    • Peripherally administered alpha2-adrenoceptor agonist in the modulation of chronic allodynia induced by spinal nerve ligation in the rat
    • (1997) Anesth Analg , vol.85 , pp. 1122-1127
    • Wei, H.1    Pertovaara, A.2
  • 88
    • 0025993546 scopus 로고
    • Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors
    • (1991) Anesthesiology , vol.75 , pp. 817-826
    • Yamamoto, T.1    Yaksh, T.L.2
  • 90
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.