Microinjection of morphine in the A7 catecholamine cell group produces opposing effects on nociception that are mediated by α1- and α2- adrenoceptors

Neuroscience

Volumn 91, Issue 3, 1999, Pages 979-990

  Holden, J E ^a   Schwartz, E J ^a   Proudfit, H K ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

1 adrenoceptor antagonist; 2 adrenoceptor antagonist; Naltrexone; Opioid; WB4101; Yohimbine

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; MORPHINE; NALTREXONE; YOHIMBINE;

ADRENERGIC NERVE; ALPHA ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CELL POPULATION; CONTROLLED STUDY; DOSE RESPONSE; FACILITATION; FEMALE; HYPERALGESIA; INTRATHECAL DRUG ADMINISTRATION; LATENT PERIOD; MEDULLA OBLONGATA; MICROINJECTION; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; CATECHOLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICROINJECTIONS; MORPHINE; NARCOTIC ANTAGONISTS; NEURONS; NOCICEPTORS; PONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA; TEGMENTUM MESENCEPHALI;

EID: 0032946742     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00673-3     Document Type: Article

References (52)

1. Akil H., Watson S.J, Young E., Lewis M.E, Khachaturian H., Walker J.M Endogenous opioids: biology and functions. A. Rev. Neurosci. 7:1984;223-255.
2. Aran S., Proudfit H.K Antinociceptive interactions between intrathecally administered alpha noradrenergic agonists and 5′-N-ethylcarboxamide adenosine. Brain Res. 519:1990;287-293.
3. Bajic D., Proudfit H.K Projections from the ventrolateral periaqueductal gray to noradrenergic cells in the brainstem that are involved in modulating nociception. Soc. Neurosci. Abstr. 23:1997;158.
4. Baraban S.C, Stornetta R.L, Guyenet P.G Effects of morphine and morphine withdrawal on adrenergic neurons of the rat rostral ventrolateral medulla. Brain Res. 676:1995;245-257.
5. Belcher G., Ryall R.W, Schaffner R. The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat. Brain Res. 151:1978;307-321.
6. Brodie M.S, Proudfit H.K Antinociception induced by local injection of carbachol into the nucleus raphe magnus: alteration by intrathecal injection of noradrenergic antagonists. Brain Res. 371:1986;70-79.
7. Clark F.M, Proudfit H.K The projection of noradrenergic neurons in the A7 catecholamine cell group to the spinal cord in the rat demonstrated by anterograde tracing combined with immunocytochemistry. Brain Res. 547:1991;279-288.
8. Clark F.M, Proudfit H.K Projections of neurons in the ventromedial medulla to pontine catecholamine cell groups involved in the modulation of nociception. Brain Res. 540:1991;105-115.
9. Crain S.M, Shen K.F Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons. Trends pharmac. Sci. 11:1990;77-81.
10. 2-adrenoceptors. Neuroscience. 16:1985;673-682.
11. Doyle C.A, Maxwell D.J Catecholaminergic innervation of the spinal dorsal horn: a correlated light and electron microscopic analysis of tyrosine hydroxylase-immunoreactive fibres in the cat. Neuroscience. 45:1991;161-176.
12. Doyle C.A, Maxwell D.J Ultrastructural analysis of noradrenergic nerve terminals in the cat lumbosacral spinal dorsal horn: a dopamine-β-hydroxylase immunocytochemical study. Brain Res. 563:1991;329-333.
13. Duggan A.W, North R.A Electrophysiology of opioids. Pharmac. Rev. 35:1984;219-281.
14. Fang F., Marczynski T.J, Proudfit H.K Projections from neurons in the ventrolateral periaqueductal gray to spinally-projecting noradrenergic neurons in the A7 catecholamine cell group. Soc. Neurosci. Abstr. 21:1995;386.
15. Fang F., Proudfit H.K Spinal cholinergic and monoamine receptors mediate the antinociceptive effect of morphine microinjected in the periaqueductal gray on the rat tail, but not the feet. Brain Res. 722:1996;95-108.
16. Fang F., Proudfit H.K Antinociception produced by microinjection of morphine in the periaqueductal gray is enhanced in the rat foot, but not the tail, by intrathecal injection of alpha1-adrenoceptor antagonists. Brain Res. 790:1998;14-24.
17. 2 receptor mediates the selective inhibition by noradrenaline of nociceptive responses of identified dorsal horn neurones. Brain Res. 334:1985;243-254.
18. Hagihira S., Senba E., Yoshida S., Tohyama M., Yoshiya I. Fine structure of noradrenergic terminals and their synapses in the rat spinal dorsal horn: an immunohistochemical study. Brain Res. 526:1990;73-80.
19. Hammond D.L, Tyce G.M, Yaksh T.L Efflux of 5-hydroxytryptamine and noradrenaline into spinal cord superfusates during stimulation of the rat medulla. J. Physiol. 359:1985;151-162.
20. Herkenham M., Pert C.B Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality. J. Neurosci. 2:1982;1129-1149.
21. Holden J.E, Proudfit H.K Projection of substance P and met-enkephalin neurons to the dorsolateral pontine tegmentum: a possible role in the modulation of nociception. Soc. Neurosci. Abstr. 20:1994;757.
22. Holden J.E, Proudfit H.K Microinjection of morphine in the A7 catecholamine cell group produces hyperalgesia. Soc. Neurosci. Abstr. 22:1996;1363.
23. Holden J.E, Proudfit H.K Enkephalin neurons that project to the A7 catecholamine cell group are located in brainstem nuclei that modulate nociception: ventromedial medulla. Neuroscience. 83:1998;929-947.
24. Howe J.R, Wang J.-Y., Yaksh T.L Selective antagonism of the antinociceptive effect of intrathecally applied α-adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. J. Pharmac. exp. Ther. 224:1983;552-558.
25. Howe J.R, Zieglgänsberger W. Responses of rat dorsal horn neurons to natural stimulation and to iontophoretically applied norepinephrine. J. comp. Neurol. 255:1987;1-17.
26. Iwamoto E.T, Marion L. Adrenergic, serotonergic and cholinergic components of nicotinic antinociception in rats. J. Pharmac. exp. Ther. 265:1993;777-789.
27. Jensen T.S, Yaksh T.L II. Examination of spinal monoamine receptors through which brainstem opiate-sensitive systems act in the rat. Brain Res. 363:1986;114-127.
28. 2-adrenoceptors. Brain Res. 364:1986;315-330.
29. Keppel G. (1973) Design and Analysis: A Researcher's Handbook. Prentice-Hall, Englewood Cliffs, NJ.
30. Light A. R. (1992) The initial processing of pain and its descending control: spinal and trigeminal systems. In Pain and Headache (ed. Gildenberg P. L.), Vol. 12, pp. 1-306. Karger, Basel.
31. Loomis C.W, Arunachalam K.D Intrathecal St-587: effects on nociceptive reflexes and blood pressure in the rat. J. Pharmac. exp. Ther. 263:1992;428-435.
32. Mansour A., Khatchaturian H., Lewis M.E, Akil H., Watson S.J Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain. J. Neurosci. 7:1987;2445-2464.
33. Millar J., Williams G.V Effects of iontophoresis of noradrenaline and stimulation of the periaqueductal gray on single-unit activity in the rat superficial dorsal horn. J. comp. Neurol. 287:1989;119-133.
34. Miller J.F, Proudfit H.K Antagonism of stimulation-produced antinociception from ventrolateral pontine sites by intrathecal administration of α-adrenergic antagonists and naloxone. Brain Res. 530:1990;20-34.
35. Mugnaini E. and Oertel W. H. (1985) An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunohistochemistry. In Handbook of Chemical Neuroanatomy (eds Björklund A. and Hökfelt T.), Vol. 4, pp. 436-608. Elsevier, Amsterdam.
36. North R.A Cellular actions of opiates and cocaine. Ann. N. Y. Acad. Sci. 654:1992;1-6.
37. North R.A, Yoshimura M. The actions of noradrenaline on neurones of the rat substantia gelatinosa in vitro. J. Physiol. 349:1984;43-55.
38. Nuseir K., Heidenreich B.A, Proudfit H.K Evidence that the antinociception produced by carbachol in the nucleus raphe magnus is mediated by noradrenergic neurons in the A7 catecholamine cell group. Soc. Neurosci. Abstr. 22:1996;114.
39. A antagonist bicuculline in the A7 catecholamine cell group produces antinociception. Soc. Neurosci. Abstr. 23:1997;1814.
40. Proudfit H. K. (1992) The behavioural pharmacology of the noradrenergic descending system. In Toward the Use of Noradrenergic Agonists for the Treatment of Pain (ed. Besson J.-M.), pp. 119-136. Elsevier, Amsterdam.
41. Proudfit H.K, Monsen M. Ultrastructural evidence that substance P neurons make synaptic contacts on noradrenergic neurons in the A7 cell group that modulate nociception. Soc. Neurosci. Abstr. 19:1993;1409.
42. Proudfit H. K. and Yeomans D. C. (1995) The modulation of nociception by enkephalin-containing neurons in the brainstem. In The Pharmacology of Opioid Peptides (ed. Tseng L. F.), pp. 197-217. Harwood Academic, Amsterdam.
43. Reddy S.V.R., Maderdrut J.L, Yaksh T.L Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J. Pharmac. exp. Ther. 213:1980;525-533.
44. Sagen J., Proudfit H.K Release of endogenous monoamines into spinal cord superfusates following local injection of phentolamine into the nucleus raphe magnus. Brain Res. 406:1987;246-254.
45. Takano Y., Yaksh T.L Relative efficacy of spinal alpha-2 agonists, dexmedetomidine, clonidine and ST-91, determined in vivo by using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, an irreversible antagonist. J. Pharmac. exp. Ther. 258:1991;438-446.
46. Todd A.J, Millar J. Receptive fields and responses to iontophoretically applied noradrenaline and 5-hydroxytryptamine of units recorded in laminae I-III of cat dorsal horn. Brain Res. 288:1983;159-167.
47. Weight F.F, Salmoiraghi G.C Responses of spinal cord interneurons to acetylcholine, norepinephrine and serotonin administered by microelectrophoresis. J. Pharmac. exp. Ther. 153:1966;420-427.
48. West W.L, Yeomans D.C, Proudfit H.K The function of noradrenergic neurons in mediating antinociception induced by electrical stimulation of the locus coeruleus in two different sources of Sprague-Dawley rats. Brain Res. 626:1993;127-135.
49. Westlund K.N, Carlton S.M, Zhang D., Willis W.D Direct catecholaminergic innervation of primate spinothalamic tract neurons. J. comp. Neurol. 299:1990;178-186.
50. Yeomans D.C, Clark F.M, Paice J.A, Proudfit H.K Antinociception induced by electrical stimulation of spinally-projecting noradrenergic neurons in the A7 catecholamine cell group of the rat. Pain. 48:1992;449-461.
51. Yeomans D.C, Proudfit H.K Projections of substance P-immunoreactive neurons located in the ventromedial medulla to the A7 noradrenergic nucleus of the rat demonstrated using retrograde tracing combined with immunocytochemistry. Brain Res. 532:1990;329-332.
52. Yeomans D.C, Proudfit H.K Antinociception induced by microinjection of substance P into the A7 catecholamine cell group in the rat. Neuroscience. 49:1992;681-691.