α2-Adrenergic Mechanisms of Analgesia: Strategies for Improving Their Therapeutic Window and Identification of the Novel, Potent α2-Adrenergic Receptor Agonist, S 18616

Advances in Pharmacology

Volumn 42, Issue C, 1997, Pages 575-579

  Millan, Mark J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956765460     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60816-9     Document Type: Article

References (6)

1. Hayashi Y., and Maze M. Alpha 2 adrenoceptor agonists and anaesthesia. Br. J. Anaesth 71 (1993) 108-118
2. Millan M.J., Bervoets K., Rivet J.M., Widdowson P., Renouard A., Le Marouille-Girardon S., and Gobert A. Multiple alpha 2-adrenergic receptor subtypes. II. Evidence for a role of rat Rα 2A-ARS in the control of nociception, motor behaviour and hippocampal synthesis of noradrenaline. J. Pharmacol. Exp. Ther 270 (1994) 958-972
3. In: Besson J.M., and Guilbaud G. (Eds). Towards the Use of Noradrenergic Agonists for the Treatment of Pain (1992), Elsevier, Amsterdam 233
4. Nicholas A.P., Pieribone V.A., and Hökfelt T. The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends Pharmacol. Sci 17 (1996) 245-255
5. 3H]RX821002-labelled rat Rα 2A-adrenergic receptors in cerebral cortex to human Hα 2A-adrenergic receptors and other populations of α 2A-adrenergic subtypes. J. Pharmacol. Exp. Ther 270 (1994) 946-957
6. Eisenach J.C. Alpha-2 agonists and analgesia. Exp. Opin. Invest. Drugs 3 (1994) 1005-1010