Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 282, Issue 6 26-6, 2002, Pages

  Jernigan, Nikki L ^a   Resta, Thomas C ^a,b  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^b Pulmonary Research

Author keywords

Isolated rat lung; Nitric oxide; Phosphodiesterase; Pulmonary hypertension; Soluble guanylate cyclase

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 8 BROMO CYCLIC GMP; CYCLIC GMP; DIPYRIDAMOLE; GUANYLATE CYCLASE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V; SODIUM CHLORIDE; SPERMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RADIOIMMUNOASSAY; RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION; WESTERN BLOTTING;

EID: 0036084399     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00273.2001     Document Type: Article

References (41)

1. Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension
2. sGC and PDE 5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension
3. Ca channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis
4. Molecular mechanism of cGMP-mediated smooth muscle relaxation
5. The type III phosphodiesterase inhibitor milrinone and type V PDE inhibitor dipyridamole individually and synergistically reduce elevated pulmonary vascular resistance
6. Inhibition of cyclic 3′-5′-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats
7. Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat
8. Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats
9. Arachidonic acid causes cyclooxygenase-dependent and -independent pulmonary vasodilation
10. Selective inhibition of cGMP-inhibitable cAMP phosphodiesterase decreases pulmonary vasoreactivity
11. Role of cAMP-dependent protein kinase in cAMP-mediated vasodilation
12. Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats
13. Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: Differences between early and established pulmonary hypertension
14. Characterization and effects of methyl-2-(4-aminophenyl)-1,2-dihydro-1-oxo-7- (2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-3-isoquinoline carboxylate sulfate (T-1032), a novel potent inhibitor of cGMP-binding cGMP-specific phosphodiesterase (PDE5)
15. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung
16. Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia
17. Guanylyl cyclases and signaling by cyclic GMP
18. Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: Changes in pulmonary hypertension
19. Impaired nitric oxide-dependent responses and their recovery in hypertensive pulmonary arteries of rats
20. Thapsigargin stimulates increased NO activity in hypoxic hypertensive rat lungs and pulmonary arteries
21. Phosphodiesterase 5 inhibition restores impaired ACh relaxation in hypertensive conduit pulmonary arteries
22. EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs
23. Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia
24. Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression
25. Segmental vasodilatory effectiveness of inhaled NO in lungs from chronically hypoxic rats
26. Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation
27. Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery
28. Chronic inhaled nitric oxide: Effects on pulmonary vascular endothelial function and pathology in rats
29. Enhanced reactivity to bradykinin, angiotensin I and the effect of captopril in the pulmonary vasculature of chronically hypoxic rats
30. ATP channel
31. Mechanisms of NO/cGMP-dependent vasorelaxation
32. Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung
33. + currents in pulmonary arterial myocytes
34. + current in rat pulmonary artery muscle cells
35. Membrane properties of smooth muscle cells in pulmonary arteries of the rat
36. Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension
37. Phosphodiesterase inhibition improves agonist-induced relaxation of hypertensive pulmonary arteries
38. Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats
39. Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodeling in the hypoxic rat
40. Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus
41. Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments