Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats

British Journal of Pharmacology

Volumn 125, Issue 4, 1998, Pages 681-688

  Eddahibi, Saadia ^a   Raffestin, Bernadette ^b   Le Monnier De Gouville, Anne Charlotte ^c   Adnot, Serge ^a  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Laboratoire GlaxoWellcome   (France)

Author keywords

Cyclic GMP; Nitric oxide; Phosphodiesterase 5 inhibitors; Pulmonary hypertension

Indexed keywords

1,3 DIMETHYL 6 (2 PROPOXY 5 METHANESULFONYLAMIDOPHENYL)PYRAZOLO[3,4 D]PYRIMIDIN 4 (5H) ONE; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; ISOPRENALINE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; HEART OUTPUT; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; INTRAVENOUS DRUG ADMINISTRATION; ISOLATED LUNG; LUNG ALVEOLUS WALL; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SECOND MESSENGER; VASODILATATION;

ALLOPURINOL; ANIMALS; ANOXIA; ATRIAL NATRIURETIC FACTOR; CYCLIC GMP; DRUG INTERACTIONS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; NITROPRUSSIDE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; TIME FACTORS; VASODILATION;

EID: 0031758015     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702124     Document Type: Article

References (25)

1. ADNOT, S., RAFFESTIN, B., EDDAHIBI, S., BRAQUET, P. & CHABRIER, P.E. (1991). Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest., 87, 155-162.
2. BEAVO, J.A. (1995). Cyclic nucleotide phosphodiesterase: functional implications of multiple isoforms. Physiol. Rev., 75, 725-748.
3. CARVILLE, C., ADNOT, S., EDDAHIBI, S., TEIGER, E., RIDEAU, D. & RAFFESTIN, B. (1997). Induction of nitric oxide synthase activity in pulmonary arteries from normoxic and chronically hypoxic rats. Eur. Respir. J., 10, 437-445.
4. CARVILLE, C., RAFFESTIN, B., EDDAHIBI, S., BLOUQUIT, Y. & ADNOT, S. (1993) Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. J. Cardiovasc. Pharmacol., 22, 889-896.
5. COHEN, A.H., HANSON, K., MORRIS, K., FOUTY, B., MCMURTRY, J.F., CLARKE, W. & RODMAN, D.M. (1996). Inhibition of cyclic 3′ 5′-guanosine monophosphate-specific selectively vasodilates the pulmonary circulation in chronically hypoxic rats. J. Clin. Invest., 97, 172-179.
6. COSTE, H. & GRONDIN, P. (1995). Characterization of a novel potent and specific inhibitor of type V phosphodiesterase. Biochem. Pharmacology, 50, 1577-1585.
7. DENT, G., MAGNESSEN, H. & RABE, K.F. (1994). Cyclic nucleotide phosphodiesterases in the human lung. Lung, 172, 129-146.
8. DEPLY, E., COSTE, H. & LE MONNIER DE GOUVILLE, A.C. (1996). Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase. Br. J. Pharmacol., 119, 471-478.
9. DEPLY, E. & LE MONNIER DE GOUVILLE, A.-C. (1996). Cardiovascular effects of a novel, potent and selective phosphodieterase 5 inhibitor. DMPPO: in vitro and in vivo characterization. Br. J. Pharmacol., 118, 1377-1384.
10. FURUYA, M., TAKEHISA, M., MINAMITAKE, Y., KITAJIMA, Y., MAYASHI, Y., OHNUMA, N., ISHIHARA, T., MINAMINO, N., KANGAWA, K. & MATSUO, H. (1990). Novel natriuretic peptide, CNP, potently stimulates cyclic GMP production in rat cultured vascular smooth muscle cells. Biochem. Biophys. Res. Commun., 170, 201-208.
11. GARY, U.C. & HASSID, A. (1989). Nitric oxide generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibits mitogenesis and proliferation of cultured rat smooth muscle cells. J. Clin. Invest., 83, 1774-1777.
12. ICHINOSE, F., ADRIE, C., HURFORD, W.E. & ZAPOL, W.R. (1995). Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs. J. Appl. Physiol., 78, 1288-1295.
13. KOUYOUMDJIAN, C., ADNOT, S., LEVAME, M., EDDAHIBI, S., BOUSBAA, H. & RAFFESTIN, B. (1994). Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats. J. Clin. Invest., 94, 578-584.
14. LAFFERTY, H.M., GUNNING, M.E., SYLVA, P., ZIMMERMAN, M.B., BRENNER, B.M. & ANDERSON, S. (1989). Enkephalinase inhibition increases plasma atrial natriuretic peptide levels, glomerular filtration rate and urinary sodium excretion in rats with reduced renal mass. Circ. Res., 65, 640-646.
15. MACLEAN, M.R., SWEENEY, G., BAIRD, M., MCCULLOCH, K.M., HOUSLAY, M. & MORECROFT, I. (1996). 5-hydroxytryptamine receptors mediating vasoconstriction of pulmonary arteries from control and pulmonary hypertensive rats. Br. J. Pharmacol., 119, 917-930.
16. MACLEAN, R.M., JOHNSON, E.D., MCCULLOCH, K.M., POOLEY, L., HOUSLAY, M.D. & SWEENEY, G. (1997). Phosphodiesterase isoforms in the pulmonary circulation arterial of the rat: changes in pulmonary hypertension. J. Pharmacol. Exper. Ther., 283, 619-624.
17. MURAD, F. (1986). Cyclic guanosine monophosphate as a mediator of vasodilation. J. Clin. Invest., 78, 1-5.
18. MURAMATSU, M., TYLER, R.C., GUTKOWSKA, J., KLINGER, J.R., HILL, N.S., RODMAN, D.M. & MCMURTRY, L.F. (1997). Atrial natriuretic peptide accounts for increased cGMP in hypoxia-induced hypertensive rat lungs. Am. J. Physiol., 272, L1126-L1132.
19. POLSON, J.B. & STRADA, S.J. (1996). Cyclic nucleotide phosphodiesterases and vascular smooth muscle. Ann. Rev. Pharmacol. Toxicol., 36, 403-427.
20. RABE, K.F., TENOR, H., DENT, G., SCHUDT, C., NAKASHIMA, M. & MAGNUSSEN, H. (1994). Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors. Am. J. Physiol., 266, L536-L543.
21. RAFFESTIN, B., LEVAME, M., EDDAHIBI, S., VIOSSAT, I., BRAQUET, P., CHABRIER, P.E., CANTIN, M. & ADNOT, S. (1992). Pulmonary vasodilator action of endogenous atrial natriuretic factor in rats with hypoxic pulmonary hypertension: effects of monoclonal atrial natriuretic factor antibody. Circ. Res., 70, 184-192.
22. SUGA, S.-L. NAKAO, K., ITOH, H., KOMATSU, Y., OGAWA, Y., HAMA, N. & IMURA, H. (1992). Endothelial production of C-type natriuretics peptide and its marked augmentation by transforming growth factor-β. J. Clin. Invest., 90, 1145-1149.
23. WINTER, R.J.D., MELEAGROS, L., PERVEZ, S., JAMAL, H., KRAUSZ, T., POLAK, J.M. & BLOOM, S.R. (1989). Atrial natriuretic peptide levels in plasma and cardiac tissues after chronic hypoxia in rats. Clin. Sci., 76, 95-101.
24. XUE, C., RENGASAMY, A., LE CRAS, T.D., KOBERNA, P.A., DAILEY, G.C. & JOHNS, R.A. (1994). Distribution of NOS in normoxic vs hypoxic rat lung: upregulation of NOS by chronic hypoxia. Am. J. Physiol., 267, L667-L678.
25. ZAR, J.H. (1974). Biostatical analysis. Englewood Cliffs, NJ: Prentice Hall.