Thapsigargin stimulates increased NO activity in hypoxic hypertensive rat lungs and pulmonary arteries

Journal of Applied Physiology

Volumn 80, Issue 4, 1996, Pages 1336-1344

  Muramatsu, Masashi ^a,b   Tyler, Robert C ^a   Rodman, David M ^a   McMurtry, Ivan F ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

calcium; endothelium derived relaxing factor; nitric oxide; pulmonary hypertension; vasoregulation

Indexed keywords

CALCIUM CHANNEL STIMULATING AGENT; CALCIUM ION; N(G) NITROARGININE; NITRIC OXIDE; RYANODINE; THAPSIGARGIN;

ALTITUDE ACCLIMATIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0029986837     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.4.1336     Document Type: Article

References (33)

1. Adnot, S., B. Raffestin, S. Eddahibi, P. Braquet, and P. E. Chabrier. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest. 87: 155-162, 1991.
2. Archer, S. L., K. Rist, D. P. Nelson, E. G. Demaster, N. Cowan, and E. K. Weir. Comparison of the hemodynamic effects of nitric oxide and endothelium-dependent vasodilators in intact lungs. J. Appl. Physiol. 68: 735-747, 1990.
3. Barer, G. R., Y. Cai, P. C. Russel, and C. J. Emery. Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. Am. Rev. Respir. Dis. 140: 1483-1485, 1989.
4. Barer, G. R., C. Emery, A. Stewart, D. Bee, and P. Howard. Endothelial control of the pulmonary circulation in normal and chronically hypoxic rats. J. Physiol. Lond. 463: 1-16, 1993.
5. Carville, C., B. Raffestin, S. Eddahibi, Y. Blouquit, and S. Adnot. Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. J. Cardiovasc. Pharmacol. 22: 889-896, 1993.
6. Crawley, D. E., L. Zhao, M. A. Giembycz, S. Liu, P. J. Barnes, R. J. D. Winter, and T. W. Evans. Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary artery relaxation in the rat. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L325-L332, 1992.
7. Dolor, R. J., L. M. Hurwitz, Z. Mirza, H. C. Strauss, and A. R. Whorton. Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool. Am. J. Physiol. 262 (Cell Physiol. 31): C171-C181, 1992.
8. Eddahibi, S., S. Adnot, C. Carville, Y. Blouquit, and B. Raffestin. L- arginine restores endothelium-dependent relaxation in pulmonary circulation of chronically hypoxic rats. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L194-L200, 1992.
9. Ignarro, L. J., J. M. Fukuto, J. M. Griscavage, N. E. Rogers, and R. E. Byrns. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc. Natl. Acad. Sci. USA 90: 8103-8107, 1993.
10. Isaacson, T. C., V. Hampl, E. K. Weir, D. P. Nelson, and S. L. Archer. Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J. Appl. Physiol. 76: 933-940, 1994.
11. Kim, Y., and J. R. Lancaster, Jr. Tetrahydrobiopterin-dependent nitrite oxidation to nitrate in isolated rat hepatocytes. FASEB J 332: 255-259, 1993.
12. -, pH, and membrane potential. J. Physiol. Lond. 464: 1-13, 1993.
13. Le Cras, T. D., G. C. Dailey, and R. A. Johns. Endothelial NO synthase m-RNA and protein, and inducible NO synthase m-RNA are upregulated in the rat lung following chronic hypoxia (Abstract). Am. J. Respir. Crit. CareMed. 151: A729, 1995.
14. MacArthur, H., M. Hecker, R. Busse, and J. R. Vane. Selective inhibition of agonist-induced but not shear stress-dependent release of endothelial autacoids by thapsigargin. Br. J. Pharmacol. 108: 100-105, 1993.
15. Maruyama, J., and K. Maruyama. Impaired nitric oxide-dependent responses and their recovery in hypertensive pulmonary arteries of rats. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H2476-H2488, 1994.
16. Matsuyama, S., H. Shuntoh, S. Katayama, and C. Tanaka. Thapsigargin induces an endothelium-dependent, intracellular calcium ion-dependent vasodilation in vitro. Life Sci. 53: 681-688, 1993.
17. 2+-ATPase inhibitor, relaxes rat aorta via nitric oxide formation. Life Sci. 54: 153-158, 1994.
18. Oka, M., K. Hasunuma, S. A. Webb, T. J. Stelzner, D. M. Rodman, and I. F. McMurtry. EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am. J. Physiol. 264 (Lung Cell. Mol. Physiol. 8): L587-L597, 1993.
19. Porcelli, R. J., and M. J. Bergman. Effects of chronic hypoxia on pulmonary vascular responses to biogenic amines. J. Appl. Physiol. 55: 534-540, 1983.
20. Resta, T. C., and B. R. Walker. Orally administered L-arginine does not alter right ventricular hypertrophy in chronically hypoxic rats. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R559-R563, 1994.
21. Resta, T. C., and B. R. Walker. Augmented endothelium-dependent vasodilation in isolated lungs from chronically hypoxic rats (Abstract). FASEB J. 9: A600, 1995.
22. + channel-mediated relaxation. Am. J. Physiol. 263 (Lung Cell. Mol. Physiol. 7): L88-L94, 1992.
23. Rodman, D. M., T. Yamaguchi, K. Hasunuma, R. F. O'Brien, and I. F. McMurtry. Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery. Am. J. Physiol. 258 (Lung Cell. Mol. Physiol. 2): L207-L214, 1990.
24. Rosier, M. F., C. P. Python, M. M. Burnay, W. Schlegel, M. B. Vallotton, and A. M. Capponi. Thapsigargin inhibits voltage-activated calcium channels in adrenal glomerulosa cells. Biochem. J. 296: 309-312, 1993.
25. Russ, R. D., and B. R. Walker. Maintained endothelium-dependent pulmonary vasodilation following chronic hypoxia in the rat. J. Appl. Physiol. 74: 339-344, 1993.
26. Shaul, P. W., L. B. Wells, and K. M. Horning. Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms. J. Cardiovase. Pharmacol. 22: 819-827, 1993.
27. Spriestersbach, R., F. Grimminger, N. Weissmann, D. Walmrath, and W. Seeger. On-line measurement of nitric oxide generation in buffer-perfused rabbit lungs. J. Appl. Physiol. 78: 1502-1508, 1995.
28. Tyler, R. C., T. J. Stelzner, D. M. Rodman, K. D. Bloch, and I. F. McMurtry. Hypoxic and monocrotaline but not fawn-fooded hypertensive rat lungs express increased mRNA for endothelial nitric oxide synthase (Abstract). FASEB J. 9: A131, 1995.
29. Wanstall, J. C., I. E. Hughes, and S. R. O'Donnell. Reduced relaxant potency of nitroprusside on pulmonary artery preparations taken from rats during the development of hypoxic pulmonary hypertension. Br. J. Pharmacol. 107: 407-413, 1992.
30. 2+ entry in vascular smooth muscle cells: nicardipine-sensitive and -insensitive pathways Am. J. Physiol. 262 (Cell Physiol. 31): C1258-C1265, 1992.
31. Xue, C., A. Rengasamy, T. D. Lecras, P. A. Koberna, G. C. Dailey, and R. A. Jones. Distribution of NOS in normoxic vs hypoxic rat lungs: upregulation of NOS by chronic hypoxia Am. J. Physiol. 267 (Lung Cell. Mol. Physiol. 11): L667-L678, 1994.
32. Yamaguchi, T., R. F. O'Brien, W. L. Hanson, W. W. Wagner, Jr., and I. F. McMurtry. Prostacyclin contributes to inhibition of hypoxic pulmonary vasoconstriction by alkalosis. Prostaglandins 38: 53-63, 1989.
33. 2+ store is present in vascular endothelial cells. Circ. Res. 74: 151-156, 1994.