Growth factors and cartilage repair

Clinical Orthopaedics and Related Research

Volumn 391, Issue SUPPL., 2001, Pages

  Van den Berg, W B ^a   Van der Kraan, P M ^a   Scharstuhl, A ^a   Van Beuningen, H M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; GROWTH FACTOR; INTERLEUKIN 1; NITRIC OXIDE; PROTEOGLYCAN; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ARTHRITIS; CARTILAGE; CELL PROLIFERATION; CHONDROPATHY; CONFERENCE PAPER; DRUG EFFECT; MOUSE; NONHUMAN; OSTEOPHYTE; PRIORITY JOURNAL; SAFETY; TISSUE REPAIR;

EID: 0034797743     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-200110001-00023     Document Type: Conference Paper

References (29)

1. Over expression of active TGFβ1 in the murine knee joint: Evidence for synovial-layer dependent chondro-osteophyte formation
2. TGF-β in disease: The dark side of tissue repair
3. Outside-in signaling in the chondrocyte: Nitric oxide disrupts fibronectin-induced assembly of subplasmalemmal actin/rho a focal adhesion kinase signaling complex
4. Human osteoarthritic chondrocytes possess an increased number of IGF-1 binding proteins but are unresponsive to its stimulation
5. Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro
6. Bone morphogenetic protein-2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract IL-1β effects on proteoglycan synthesis and content
7. Stimulation of articular cartilage repair in established arthritis by local administration of TGFβ into murine knee joints
8. Correlation of the size of type II transforming growth factor β (TGF-β) receptor with TGF-β responses of isolated bovine articular chondrocytes
9. Effects of recombinant human osteogenic protein I on the production of proteoglycan, prostaglandin E2, and IL1ra by human articular chondrocytes cultured in the presence of IL-1β
10. Glucose regulation of the IGF-1 response system in chondrocytes: Induction of an IGF-1 resistant state
11. TGF-β signaling by Smad proteins
12. Collagenase-3 (MMP-13) is preferentially localized in the deep layer of human arthritic cartilage in situ. In vitro mimicking effect by TGFβ
13. Cartilage-derived morphogenetic proteins and cartilage morphogenesis
14. Chondrocyte nonresponsiveness to insulin-like growth factor 1 in experimental arthritis
15. Insulin-like growth factor stimulation of chondrocyte proteoglycan synthesis by human synovial fluid
16. Expression of a truncated kinase-defcetive TGFβ tpe II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
17. Differential patterns of response to doxycycline and TGFβ in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes
18. Nitric oxide and proteoglycan turnover in rabbit articular cartilage
19. The role of nitric oxide in proteoglycan turnover by bovine articular cartilage organ culture
20. Osteoarthritis-like changes in the murine knee joint resulting from intra-articular TGFβ injections
21. Differential effects of local application of BMP-2 or TGF-β1 on both articular cartilage composition and osteophyte formation
22. Transforming growth factor-β1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint
23. Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-IL-1 treated wild-type mice with unabated joint inflammation
24. Pathogenesis of joint damage in RA: Evidence of a dominant role for IL-1
25. Role of growth factors and cartilage repair
26. Role of nitric oxide in the inhibition of BMP2-mediated stimulation of proteoglycan synthesis in articular cartilage
27. Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally-induced arthritis
28. Localization and quantification of the insulin-like growth factor-1 receptor in mouse articular cartilage by confocal laser scanning microscopy
29. The Smad pathway