Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells

Journal of Cancer Research and Clinical Oncology

Volumn 123, Issue 3, 1997, Pages 152-160

  Zimra, Yael ^a,b   Wasserman, Lina ^b   Maron, Lea ^b   Shaklai, Mati ^a,b   Nudelman, Abraham ^c   Rephaeli, Ada ^b  

^a RABIN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c BAR ILAN UNIVERSITY   (Israel)

Author keywords

apoptosis; butyric acid derivative; differentiation; HL 60

Indexed keywords

BUTYRIC ACID; PIVALOYLOXYMETHYL BUTYRATE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

EID: 0030957625     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01214667     Document Type: Article

References (38)

1. Benito A, Grillot D, Nunez G, Fernandez-Luna JL (1995) Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells. Am J Pathol 146:481-490
2. Bundgaard H, Nielsen NM (1987) Esters of N, N-disubstituted 2-hydroxyacetamides as novel highly biolabile prodrug type for carboxylic acid agents. J Med Chem 30:451-455
3. Calabresse C, Venturini L, Ronco G, Villa P, Chomienne C, Belpomme D (1993) Butyric acid and its monosaccharide ester induce apoptosis in the HL-60 cell line. Biochem Biophy Res Commun 195:31-38
4. Calabresse C, Venturini L, Ronco G, Villa P, Degos L, Belpomme D, Chomienne C (1994) Selective induction of apoptosis in myeloid leukemic cell lines by monoacetone glucose-3 butyrate. Biochem Biophy Res Commun 201:266-283
5. Delina D, Aiello A, Formelli F, Fontanella E, Costa A, Miyashita T, Reed JC, Pierotti MA (1995) Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2. Blood 85:359-367
6. Dive C, Hickman JA (1991) Drug-target interactions: only the first step in the commitment to a programmed cell death? Br J Cancer 64:192-196
7. Filippovich I, Sorokina N, Khanna KK, Lavin MF (1994) Butyrate induced apoptosis in lymphoid cells preceded by transient overexpression of HSP70 mRNA. Biochem Biophys Res Commun 198:257-265
8. Fischkoff SA, Hoessly MC, Rossi RM (1990) Characterization of sublines of HL-60 human leukemia cells resistant to induction of differentiation by butyric acid. Leukemia 4:302-306
9. Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiewicz Z (1993) The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 53:3186-3192
10. Hague A, Manning AM, Hanlon KA, Huschtscha LI, Hart D, Paraskeva C (1993) Sodium butyrate induces apoptosis in human colonic tumor cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int J Cancer 55:498-505
11. Hare JD, Bahler DW (1986) Analysis of plasmodium falciparum growth in culture using acridine orange and flow cytometry. J Histochem Cytochem 34:215-220
12. Hockenbery D, Nunez G, Milliman C, Schreber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336
13. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251
14. Itoha N, Yonehara S, Ishii A, Yonehara M, Mizushima SI, Sameshima M, Hase A, Seto Y, Nagata S (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233-243
15. Jacobson MD, Burne JF, King MP, Miyashita T, Reed JC, Raff MC (1993) Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA. Nature 361:365-369
16. Koeffler HP (1983) Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 62:709-721
17. Lotem J, Sachs L (1993) Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiative myeloid leukemic cells. Cell Growth Differ 4:41-47
18. Martin SJ, Bradley JG, Cotter TG (1990) HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis. Clin Exp Immunol 79:448-453
19. Martin SJ, Lennon SV, Bonham AM, Cotter TG (1990) Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis. J Immunol 145:1859-1867
20. McCarthy JV, Fernandes RS, Gotter TG (1994) Increased resistance to apoptosis associated with HL-60 myeloid differentiation status. Anticancer Res 14:2063-2072
21. Miller AA, Kurschel E, Osieka R, Schmidt C (1987) Clinical pharmacology of sodium butyrate in patients with acute leukemia. Eur J Cancer Clin Oncol 23:1283-1287
22. Miyashita and Reed (1993) Bcl-2 Oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell lne. Blood 81:151-157
23. Naumovski L, Cleary ML (1994) Bcl2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood 83:2261-2267
24. Nudelman A, Ruse M, Aviram A, Rabizadeh E, Shaklai M, Zimra Y, Rephaeli A (1992) Novel anticancer prodrugs of butyric acid. J Med Chem 35:687-694
25. Park JR, Robertson K, Hickstein DD, Tsai S, Hockenbery DM, Collins SJ (1994) Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid induced HL-60 granulocytes. Blood 84:440-445
26. Prasad KN (1980) Butyric acid: a small fatty acid with diverse biological functions. Life Sci. 27:1351-1358
27. Prasad KN, Cohrs RJ, Sharma OK (1990) Decreased expression of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture. Biochem Cell Biol 68:1250-1255
28. Rabizadeh E, Shaklai M, Nudelman A, Eisenbach L, Rephaeli A (1993) Rapid alteration of c-myc and c-jun expression in leukemic cells induced to differentiate by a butyric acid prodrug. Febs Lett 328:225-229
29. Ratan RR, Murphy TH, Baraban JM (1994) Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem 62:376-379
30. Rephaeli A, Rabizadeh E, Aviram A, Shaklai M, Ruse M, Nudelman A (1991) Derivatives of butyric acid as potential anti-neoplastic agents. Int J Cancer 49:66-72
31. Rephaeli A, Nordenberg J, Aviram A, Rabizadeh E, Nudelman A, Novogrodsky A, Shaklai M (1994) Butyrate induced differentiation in leukemic myeloid cells: in vitro and in vivo studies. Int J Oncol: 4:1-5
32. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y (1995) Prevention of hypoxia induced cell death by Bcl-2 and Bcl-xl. Nature 374:811-813
33. Solary E, Bertrand R, Kohn KW, Pommier Y (1993) Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors. Blood 81:1359-1368
34. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462
35. Toscani A, Sporano DR, Sporano KJ (1988) Molecular analysis of sodium butyrate induced growth arrest. Oncogene Res 3:223-238
36. Vidali G, Boffa LC, Bradbury EM, Allfrey FG (1978) Butyrate suppression of histone deacetylation leads to accumulation of polyacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences. Proc Natl Acad Sci USA 75:2239-2243
37. Wolf D, Rotter V (1985) Major deletion in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. Proc Natl Acad Sci USA 82:790-794
38. Xu HM, Tepper CG, Jones JB, Fernandez CE, Studzinski GP (1993) 1,25-Dihydroxyvitamin D3 protects HL-60 cells against apoptosis but down regulates the expression of the bcl-2 gene. Exp Cell Res 209:367-374