Thrombocytes ave the major source for soluble vascular endothelial growth factor in peripheral blood

Oncology

Volumn 58, Issue 2, 2000, Pages 169-174

  Gunsilius, Eberhard ^a,b   Petzer, Andreas ^a   Stockhammer, Günther ^a   Nussbaumer, Walter ^a   Schumacher, Petra ^a   Clausen, Johannes ^a   Gastl, Günther ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Peripheral blood; Platelet count; Prognosis; Tumor stage; Vascular endothelial growth factor plasma levels; Vascular endothelial growth factor serum levels

Indexed keywords

MYELOABLATIVE AGENT; VASCULOTROPIN; ENDOTHELIAL CELL GROWTH FACTOR; LYMPHOKINE; VASCULOTROPIN A;

ADULT; AGED; ARTICLE; BLOOD; BLOOD CLOTTING; CANCER; CANCER REGRESSION; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOLYSIS; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL; SUPERNATANT; THROMBOCYTE; THROMBOCYTE VOLUME; METABOLISM; MIDDLE AGED; NEOPLASM; PATHOLOGY; THROMBOCYTOPHERESIS;

ADULT; AGED; BLOOD PLATELETS; ENDOTHELIAL GROWTH FACTORS; HUMANS; LYMPHOKINES; MIDDLE AGED; NEOPLASMS; PLATELETPHERESIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033621896     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000012095     Document Type: Article

References (29)

1. Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other diseuse. Nat Med 1995; 1:27-31.
2. Kolch W, Martiny Baron G, Kieser A, Marme D: Regulation of the expression of the VEGF/ VPS and its receptors: Role in tumor angiogenesis. Breast Cancer Res Treat 1995;36:139-155.
3. Salven P, Ruotsalainen T, Mattson K, Joensuu H: High pro-treatment serum level of vascular endotholial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer, Int J Cancer 1998;79:144-146.
4. Salven P, Teerenhovi L, Joensuu H: A high pre-treatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkins' lymphoma. Blood 1997;90:3167-3171
5. Mohle R, Green D, Moore MA, Nachman RL, Rafii S: Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proe Natl Acad Sci USA 1997;94: 663-668.
6. Bessman D: Prediction of platelet production during chemotherapy of acute leukemia. Am J Hematol 1982;13:219-227.
7. Banks RE, Forbes MA, Kinsey SH, Stanley A, Ingham E, Walters C, Selby PJ: Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: Significance for VHGF measurements and cancer biology. Br J Cancer 1998;77:956-964.
8. Nissen NN, Polverini P, Koch AE, Volin MV, Gamelli RL, DiPietro LA: Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am J Pathol 1998;152:1445-1452.
9. Shweiki D, Itin A, Soffer D, Keshet E: Vascular cndothclial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-845.
10. Webb NJ, Myers CR, Watson CJ, Bottomley MJ, Brenchley PE: Activated human neutrophils express vascular endothelial growth factor (VEGF). Cytokine 1998;10:254-257.
11. Harmey JH, Dimitriadis E, Kay E, Redmond HP, Bouchier Hayes D: Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor beta-1. Ann Surg Oncol 1998;5:271-278.
12. Grutzkau A, Kruger Krasagakes S, Baumeister H,. Schwarz C, Kogel H, Welker P, Lippert U, Henz BM, Moller A: Synthesis, storage, and release of vascular endothelial growth factor/ vascular permeability factor (VEGF/VPF) by human mast cells: Implications for the biological significance of VEGF206. Mol Biol Cell 1998;9:875-884.
13. Freeman MR, Schneck FX, Gagnon ML, Corless C, Soker S, Niknejad K, Peoples GE, Klagsbrun M: Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis. Cancer Res 1995;55:4140-4145.
14. Stockhammer G, Schumacher P, Deisenhammer F, Muigg A, Unterberger I, Seiwald M, Pfausler H, Gunsilius E, Gastl G: VEGF as tumor marker for leptomeningeal metastases (abstract). J Neurooncol 1998;39:183.
15. Kraft A, Weindel K, Ochs A, Marth C, Zmija J, Schumacher P, Unger C, Marme D, Gastl G: Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease. Cancer 1999;85:178-187.
16. Tschmelitsch J, Eberwein M, Schwelberger H, Gastl G, Gunsilius E: Vascular endothelial growth factor levels in mesenteric and peripheral blood from patients with colorectal cancer: Correlation with tumor stage and histological grading (abstract). Acta Med Austria 1999;26 (suppl 48):20.
17. Nand S, Messmore H: Hemostasis in malignancy. Am J Hematol 1990;35:45-55.
18. Griga T, Tromm A, Spranger J, May B: Increased serum levels of vascular endothelial growth factor in patients with inflammatory bowel disease. Scand J Gastroenterol 1998;33: 504-508.
19. Ameglio F, D'Auria L, Cordiali Fei P, Mussi A, Valenzano L, D'Agosto G, Ferraro C, Bonifati C, Giacalone B: Bullous pemphigoid and pemphigus vulgaris: Correlated behaviour of serum VEGF, sE-selectin and TNF-alpha levels. J Biol Regul Homeost Agents 1997;11:148-153.
20. Linder C, Linder S, Munck Wikland E, Strander H: Independent expression of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with carcinoma and sarcoma. Anticancer Res 1998;18:2063-2068.
21. Kumar H, Heer K, Lee PW, Duthie GS, MacDonald AW, Greenman J, Kerin MJ, Monson JR: Preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer. Clin Cancer Res 1998;4:1279-1285.
22. Fujisaki K, Mitsuyama K, Toyonaga A, Matsuo K, Tanikawa K: Circulating vascular endothelial growth factor in patients with colorectal cancer. Am J Gastroentcrol 1998;93:249-252.
23. Donovan D, Harmey JH, Toomey D, Osborne DH, Redmond HP, Bouchier Hayes DJ: TGF beta-1 regulation of VEGF production by breast cancer cells. Ann Surg Oncol 1997;4: 621-627.
24. Dirix LY, Vermeulen PB, Pawinski A, Prove A, Benoy I, De Pooter C, Martin M, Van Oosterom AT: Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br J Cancer 1997;76:238-243.
25. Salven P, Manpaa H, Orpana A, Alitalo K, Joensuu H: Serum vascular endothelial growth factor is often elevated in disseminated cancer. Clin Cancer Res 1997;3:647-651.
26. Pedersen LM, Milman N: Prognostic significance of thromhocytosis in patients with primary lung cancer. Eur Respir J 1996;9:1826-1830.
27. Hernandez E, Lavine M, Dunton CJ, Gracely E, Parker J: Poor prognosis associated with thrombocytosis in patients with cervical cancer. Cancer 1992;69:2975-2977.
28. Kantarjian HM, McLaughlin P, Fuller LM, Dixon DO, Osborne BM, Cabanillas FF: Follicular large cell lymphoma: Analysis and prognostic factors in 62 patients. J Clin Oncol 1984; 2:811-819.
29. Menczer J, Schejter E, Geva D, Ginath S, Zakut H: Ovarian carcinoma associated thrombocytosis. Correlation with prognostic factors and with survival. Eur J Gynaecol Oncol 1998; 19:82-84.