Cartilage-derived morphogenetic proteins and cartilage morphogenesis

Microscopy Research and Technique

Volumn 43, Issue 2, 1998, Pages 131-136

  Reddi, A H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Research Bldg i   (United States)

Author keywords

Bone morphogenetic proteins; Cartilage derived morphogenetic proteins; Insulin like growth factors; Platelet derived growth factor; Transforming growth factor

Indexed keywords

BONE; GLYCOPROTEINS; JOINTS (ANATOMY); MORPHOLOGY; PROTEINS;

ARTICULAR CARTILAGES; BONE MORPHOGENETIC PROTEINS; CARTILAGE-DERIVED MORPHOGENETIC PROTEIN; INSULIN-LIKE GROWTH FACTOR; MORPHOGENETIC PROTEINS; MULTISTEPS; PLATELET-DERIVED GROWTH FACTORS; SKELETAL DEVELOPMENT; TRANSFORMING GROWTH FACTOR Β; TRANSFORMING GROWTH FACTORS;

CARTILAGE;

BONE MORPHOGENETIC PROTEIN; MORPHOGEN; TRANSFORMING GROWTH FACTOR BETA;

ARTICULAR CARTILAGE; BONE DEVELOPMENT; BONE MATRIX; CHONDROGENESIS; EMBRYO DEVELOPMENT; EXTRACELLULAR MATRIX; HUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0032532261     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0029(19981015)43:2<131::AID-JEMT6>3.0.CO;2-C     Document Type: Review

References (73)

1. Alini, M., Carey, D., Hirata, S., Grynpas, M.D., Pidoux, I., and Poole, A.R. (1994) Cellular and matrix changes before and at the time of calcification in the growth plate studied in vitro: Arrest of type X collagen synthesis and net loss of collagen when calcification is initiated. J. Bone Mineral Res., 9:1077-1087.
2. Amizuka, N., Warshawsky, J., Henderson, J.E., Goltzman, D., and Karaplis, A.C. (1994) Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J. Cell Biol., 126:1611-1623.
3. Ballock, R.T., and Reddi, A.H. (1994) Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. J. Cell Biol., 126:1311-1318.
4. Bohme, K., Winterhalter, K.K., and Bruckner, P. (1995) Terminal differentiation of chondrocytes in culture is a spontaneous process and is arrested by transforming growth factor-β2 and basic fibroblast growth factor in synergy. Exp. Cell Res., 216:191-198.
5. Bruckner, P., and van der Rest, M. (1994) Structure and function of cartilage collagens. Microsc.Res.Tech., 28:378-384.
6. Brunet, L.J., McMahon, J.A., McMahon, A.P., and Harland, R.M. (1998) Noggin, cartilage morphogenesis and joint formation in the mammalian skeleton. Science, 280:1455-1457.
7. Cancedda, R., Descolzi-Cancedda, F., and Castagnola, P. (1995) Chondrocyte differentiation. Int. Rev. Cytol., 159:265-358.
8. Carrington, J.L., Chen, P., Yanagishita, M., and Reddi, A.H. (1991) Osteogenin (bone morphogenetic protein-3 stimulates cartilage formation by chick limb bud cells in vitro. Dev. Biol., 146:406-415.
9. Chan, D., Cole, W.G., Chow, C.W., Mundlos, S., and Bateman, J.F. (1995) A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagens in cartilage. J. Biol. Chem., 270:1747-1753.
10. Chang, S.C., Hoang, B., Thomas, J.T., Vukicevic, S., Luyten, F.P., Ryba, N.J.P., Kozak, C.A., Reddi, A.H., and Moos, M. (1994) Cartilage-derived morphogenetic proteins. J. Biol. Chem., 269:28227-28234.
11. Cheah, K.S.E., Levy, A., Trainor, P.A., Wai, A.W.K., Kuffner, T., So, C.L., Leung, K.K.H., Lovell-Badge, R.H., and Tam, P.P.L. (1995) Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development. J. Cell Biol., 128:223-237.
12. Chen, P., Carrington, J.L., Hammonds, R.G., and Reddi, A.H. (1991) Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein-2B (BMP-2B) and modulation by transforming growth factor β1 and β2. Exp. Cell Res., 195:509-515.
13. Chen, P., Carrington, J.L., Paralkar, V.M., Pierce, G.F., and Reddi, A.H. (1992) Chick limb bud mesodermal cell chondrogenesis: Inhibition by isoforms of platelet-derived growth factor and reversal by recombinant bone morphogenetic protein. Exp. Cell Res., 200:110-117.
14. Cohn, M.J., Izpisua-Belmonte, J.C., Aloud, H., Heath, J. K., and Tickle, C. (1995) Fibroblast growth factors induce additional limb development from the flank of chicken embryos. Cell, 80:739-746.
15. Cunningham, N.S., Paralkar, V.M., and Reddi, A.H. (1992) Osteogenin and recombinant bone morphogenetic protein-2B are chemotactic for human monocytes and stimulate transforming growth factor β1 mRNA expression. Proc. Natl. Acad. Sci. U.S.A., 89:11740-11744.
16. Cunningham, N.S., Jenkins, N.A., Gilbert, D.J., Copeland, N.B., Reddi, A.H., and Lee, S.J. (1995) Growth/differentiation factor-10: A new member of the transforming growth factor-β superfamily related to bone morphogenetic protein-3. Growth Factors, 12:99-109.
17. Dolle, P., Dierich, A., Le Meur, M., Schimmang, T., Schuhbaur, B., Chambon, P., and Duboule, D. (1993) Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell, 75:431-441.
18. Erlacher, L., McCartney, J., Piek, E., ten Dijke, P., Yanagishita, M., Oppermann, H., and Luyten, F.P. (1998) Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. J. Bone Min. Res., 13:383-392.
19. Fallon, J.F., Lopez, N., Ros, M.A. Savage, M.P., Olwin, B.B., and Simandal, B.K. (1994) FGF-2: Apical ectodermal ridge growth signal for chick development. Science, 264:104-107.
20. Farnum, C.E. (1994) Differential growth rates of long bones. In: Bone, Vol. 8, B.K. Hall, ed. CRC Press, Boca Raton, pp. 193-222.
21. Fassler, R., Schnegelsberg, P.N.J., Dausmann, J., Shinya, T., Muragaki, Y., McCarthy, M.T., Olsen, B.R., and Jaenisch, R. (1994) Mice lacking an α1(IX) collagen develop noninflammatory degenerative joint disease. Proc. Natl. Acad. Sci. U.S.A., 91:5070-5074.
22. Francis, P.H., Richardson, M.K., Brickell, P.M., and Tickle, C. (1994) Bone morphogenetic proteins and a signaling pathway that controls patterning in the developing chick limb. Development, 120:209-218.
23. Freisinger, P., Ala-Kokko, L., Le Guellec, D., Franc, S., Bouvier, R., Ritvaniemi, P., Prockop, D.J., and Bonaventure, J. (1994) Mutation in the COL2A1 gene in a patient with hypochondrogenesis. J. Biol. Chem., 269:13663-13669.
24. Hotten, G.C., Matsumoto, T., Kimura, M., Bechtold, R.F., Kron, R., O'Hara, T., Tanaka, H., Satoh, Y., Okazoki, M., Shitai, T., Pan, H., Kawai, S., Pohl, J.S., and Kudo, A. (1996) Recombinant human growth/differentiation factor 5 stimulates mesenchyme aggregation and chondrogenesis responsible for skeletal development of limbs. Growth Factors. 13:65-74.
25. Hunziker, E.B. (1994) Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc. Res. Tech., 28:505-519.
26. Johnson, R.L., and Tabin, C. (1995) The long and short of hedgehog signaling. Cell, 81:313-316.
27. Karaplis, A.C., Luz, A., Glowacki, J., Bronson, R.T., Tybulewicz, V.L.J., Kronenberg, H.M., and Mulligan, R.C. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev., 8:277-289.
28. Kato, Y., and Iwamoto, M. (1990) Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation. J. Biol. Chem., 265:5903-5909.
29. Kato, Y. Iwamoto, M., Koike, T., Suzuki, F., and Takono, Y. (1988) Terminal differentiation and calcification in rabbit chondrocyte cutures in centrifuge tubes. Proc. Natl. Acad. Sci. U.S.A., 85:9552-9556.
30. Kawakami, Y., Ishikawa, T., Shimabara, M., Tanda, N., Enomoto-Iwamoto, M., Iwamoto, M., Kuwana, T., Ueki, A., Noj, S., and Nohno, T. (1996) BMP signaling during bone pattern determination in the developing limb. Development, 122:3557-3566.
31. Kawashima-Ohya, Y., Satakeda, H., Kuruta, Y., Kawamoto, T., Yan, W., Akagawa, Y., Hayakawa, T., Noshiro, M., Okada, Y., Nakamura, S., and Kato, Y. (1998) Effects of parathyroid hormone (PTH) and PTH-related peptide (PTH-rp) on expression of matrix-metalloproteinase-2, -3, and -9 in growth plate chondrocyte cultures. Endocrinology, 139:2120-2127.
32. Kingsley, D.M., Bland, A.E., Grubber, J.M., Marker, P.C., Russell, L.B., Copeland, N.G., and Jenkins, N.A. (1992) The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF-β superfamily. Cell, 71:399-410.
33. Krumlauf, R. (1994) Hox genes in vertebrate development. Cell, 78:191-201.
34. Li, Y., Lacerda, D.A., Warman, M.L., Beier, D.R., Yoshioka, H., Ninomiya, Y., Osfor, J.T., Morris, N. P., Andrikopoulos, K., Ramirez, F., Wardell, B.B., Lifferth, G.D., Teuscher, C., Woodward, S.R., Taylor, B.A., Seegmiller, R.E., and Olsen, B.R. (1995) A fibrillar collagen gene Col11α1, is essential for skeletal morphogenesis. Cell, 80:423-430.
35. Lietman, S.A., Yanagishita, M., Sampath, T.K., and Reddi, A.H. (1997) Stimulation of proteoglycan synthesis in explants of porcine articular cartilage by recombinant osteogenic protein-1. J. Bone Joint Surg., 79A:1132-1137.
36. Luyten, F.P., Yu, Y.M., Yanagishita, M., Vukicevic, S., Hammonds, R.G., and Reddi, A.H. (1992) Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant cultures. J. Biol. Chem., 267:3691-3695.
37. Luyten, F.P., Chen, P., Paralkar, V.M., and Reddi, A.H. (1994) Recombinant bone morphogenetic protein-4, transforming growth factor β and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. Exp. Cell Res., 210:224-229.
38. Lyons, K.M., Pelton, R.W., and Hogan, B.L.K. (1990) Organogenesis and pattern formation in the mouse. RNA distribution patterns suggest a role for BMP-2A. Development, 109:833-844.
39. Nakanishi, T., Kimura, Y., Tamura, T., Ichikawa, H., Yamagi, Y., Sigimoto, T., Takigawa, M. (1997) Cloning of a mRNA preferentially expressed in chondrocytes by differential display: PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA. Biochem. Biophy. Res. Commun., 234:206-210.
40. Nakata, K., Ono, K., Miyasaki, J., Olsen, B.R., Murajaki, Y., Adachi, E., Yamamura, K., and Kimura, T. (1993) Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing α1(IX) collagen chains with a central deletion. Proc. Natl. Acad. Sci. U.S.A., 90:2870-2874.
41. Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S., and Miyazono, K. (1996) Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J. Biol. Chem., 271:21345-21352.
42. Niswander, L., Tickle, C., Vogel, A., Booth, I., and Martin, G.R. (1993) FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell, 75:579-587.
43. Ozkaynak, E., Schnegelsberg, P.N.J., Jin, D.F., Clifford, G.M., Warren, F.D., Drier, E.A., and Opperman, H. (1992) Osteogenic protein-2. A new member of the TGF-β superfamily expressed in early embryogenesis. J. Biol. Chem., 267:25220-25227.
44. Pacifici, M., Golden, E.B., Oshima, O., Sharpiro., I.M., Leboy, P.S., and Adams, S.L. (1990) Hypertrophic chondrocytes: The terminal stage of differentiation in the chondrogenic cell lineage? Ann. N.Y. Acad. Sci., 599:45-57.
45. Peters, K., Ornitz, D., Werner, S., and Williams, L. (1993) Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev. Biol., 155:423-430.
46. Quarto, R., Campanile, G., Cancedda, R., and Dozin, B. (1992) Thyroid hormone, insulin and glucocorticoids are sufficient to support chondrocyte differentiation to hypertrophy: A serum-free analysis. J. Cell Biol., 119:989-995.
47. Reddi, A.H. (1981) Cell biology and biochemistry of endochondral bone development. Coll. Rel. Res., 1:209-226.
48. Reddi, A.H. (1984) Extracellular matrix and development. In: Extracellular Matrix Biochemistry. K.A. Piez and A.H. Reddi, eds. Elsevier, New York, pp. 375-412.
49. Reddi, A.H. (1992) Regulation of cartilage and bone differentiation by bone morphogenetic proteins. Curr. Opin. Cell Biol., 4:850-855.
50. Reddi, A.H. (1994) Bone and cartilage differentiation. Curr. Opin. Genet. Dev., 4:737-744.
51. Reddi, A.H. (1997) Bone morphogenetic proteins: An unconventional approach to isolation of first mammalian morphogens. Cytokine Growth Factor Rev., 8:11-20.
52. Reddi, A.H. (1998) Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nature Biotechnol., 16:247-252.
53. Reddi, A.H., and Huggins, C.B. (1972) Biochemical sequences in the transformation of normal fibroblasts in adolescent rat. Proc. Natl. Acad. Sci. U.S.A., 69:1601-1605.
54. Riddle, R.D., Johnson, R.L., Laufer, E., and Tabin, C. (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell, 75:1401.
55. Rosati, R., Horan, G.S.B., Pinero, G.J., Garofalo, S., Keene, D.R., Horton, W.A., Vuorio, E., de Crombrugghe, B., and Behringer, R.R. (1994) Normal long bone growth and development in type X collagen-null mice. Nature Genet., 8:129-134.
56. Rousseau, F., Bonaventure, J., Legeal-Mallet, L., Pelet, A., Rozet, J.M., Maroteaux, P., Le Merrer, M., and Munnich, A. (1994) Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature, 371:252-254.
57. Sampath, T.K., and Reddi, A.H. (1981) Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc. Natl. Acad. Sci. U.S.A., 78:7599-7603.
58. Shiang, R., Thompson, L.M., Zhu, Y.Z., Church, D.M., Fielder, T.J., Bocian, M., Winokur, S.T., and Wasmuth, J.J. (1994) Mutations in the transmembrane domain of FGFR-3 cause the most common genetic form of dwarfism, achondroplasia. Cell, 78:335-342.
59. Storm, E.E., Huynh, T.V., Copeland, N.G., Jenkins, N.A., Kingsley, D.M., and Lee, S.J. (1994) Limb alterations in brachypodism mice due to mutations in a new member of the TGF-β superfamily. Nature, 368:639-642.
60. Takigawa, M., Okawa, T., Pan, H., Aoki, C., Takahashi, K., Zue, J., Suzuki, F., and Kinoshita, A. (1997) Insulin-like growth factors I and II are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondroctyes, acting through their respective receptors on a clonal human chondrosarcoma-derived chondrocyte cell line HCS-2/8. Endocrinology, 138:4390-4400.
61. ten Dijke, P., Yamashita, H., Sampath, T.K., Reddi, A.H., Estevez, M., Riddle, D.L., Ichijo, H., Heldin, C.H., and Miyazono, K. (1994) Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J. Biol. Chem., 269:16985-16988.
62. Thomas, J.T., Lin, K., Nandedkar, M., Camargo, M., Cervenka, J., and Luyten, F.P. (1996) A human chondrodysplasia due to a mutation in a TGF β superfamily member. Nature Genet., 12:315-317.
63. Urist, M.R. (1965) Bone formation by autoinduction. Science, 150:893-899.
64. Vikkula, M., Metsaranta, M., and Ala-Kokko, L. (1994) Type II collagen mutations in rare and common cartilage disease. Ann. Med., 26:107-114.
65. Vikkula, M., Mariman, E.C.M., Lui, V.C.H., Zhidova, N.I., Tiller, G.E., Goldring, M.B., van Beersun, S.E.C., de waal Malefijt, M.C., van deen Hoogen, F.H.J., Ropers, H.H., Mayne, R., Cheah, K.S.E., Olsen, B.R., Warman, M.L., and Brunner, H.G. (1995) Autosomal dominant and recessive osteochondrodysplasias associated with COL11A2 locus. Cell, 80:431-437.
66. Vukicevic, S., Luyten, F.P., and Reddi, A.H. (1989) Stimulation of osteogenic and chondrogenic phenotypes in vitro by osteogenin Proc. Natl. Acad. Sci. U.S.A., 86:8793-8797.
67. Vukicevic, S. Latin, V., Chen, P., Batorsky, R., Reddi, A.H., and Sampath, T.K. (1994) Localization of osteogenic protein-1 (Bone Morphogenetic Protein-7) during human embryonic development: High affinity binding to basement membranes. Biochem. Biophys. I Res. Commun., 198:693-700.
68. Warman, M.L., Abbott, M., Apte, S.S., Hefferon, T., McIntosh, I., Cohn, D.H., Hecht, J.T., Olsen, B.R., and Francomano, C.A. (1993) A type X collagen mutation causes Schmid metaphyseal chondroplasia. Nature Genet., 5:79-82.
69. Wolfman, N.M., Hattersley, G., Cox, K., Celeste, A.J., Nelson, R., Yamaji, N., Dube, J.L., DiBlasio-Smith, E., Nove, J., Wozney, J.M., and Rosen, V. (1997) Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6 and 7, members of the TGF β gene family. J. Clin. Invest., 100:321-330.
70. Wright, E., Hargrave, M.R., Christianses, J., Cooper, L., Kun, J., Evans, T., Gangadharan, U., Greenfield, A., and Koopman, P. (1995) The Sry-related gene Sox 9 is expressed during chondrogenesis in mouse embryos. Nature Genet., 9:15-20.
71. Zhao, G.Q., Zhou, X., Eberspaecher, H., Solursh, M., and de Crombrugghe, B. (1993) Cartilage homeoprotein-1, a homeoprotein selectively expressed in chondrocytes. Proc. Natl. Acad. Sci. U.S.A., 90:8633-8637.
72. Zhao, G.Q., Eberspaecher, H., Seldin, M.F., and de Crombrugghe, B. (1994) The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech. Dev., 48:245-254.
73. Zhou, X., Sasaki, H., Lowe, L., Hogan, B.L.M., and Kuehn, M.R. (1993) Nodal is a novel TGF-β-like gene expressed in the mouse node duringgastrulation. Nature, 361:543-547.