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Volumn 34, Issue 1, 1999, Pages 169-180

Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; CANDIDA ANTIGEN; GENE PRODUCT; PEPSTATIN; POLYCLONAL ANTIBODY;

EID: 0001421998     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01590.x     Document Type: Article
Times cited : (199)

References (45)
  • 1
    • 0031971193 scopus 로고    scopus 로고
    • The expression of secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages
    • Borg-von Zepelin, M., Beggah, S., Boggian, K., Sanglard, D., and Monod, M. (1998) The expression of secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages. Mol Microbiol 28: 543-554.
    • (1998) Mol Microbiol , vol.28 , pp. 543-554
    • Borg-Von Zepelin, M.1    Beggah, S.2    Boggian, K.3    Sanglard, D.4    Monod, M.5
  • 2
    • 0023874209 scopus 로고
    • Expression of extracellular acid proteinase by proteolytic Candida spp. During experimental infection of oral mucosa
    • Borg-von Zepelin, M., and Rüchel, R. (1988) Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa. Infect Immun 56: 626-631.
    • (1988) Infect Immun , vol.56 , pp. 626-631
    • Borg-von Zepelin, M.1    Rüchel, R.2
  • 3
    • 0029961316 scopus 로고    scopus 로고
    • Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase
    • Colina, A.R., Aumont, F., Deslauriers, N., Belhumeur, P., and de Repentigny, L. (1996) Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase. Infect Immun 64: 4514-4519.
    • (1996) Infect Immun , vol.64 , pp. 4514-4519
    • Colina, A.R.1    Aumont, F.2    Deslauriers, N.3    Belhumeur, P.4    De Repentigny, L.5
  • 4
    • 0025989934 scopus 로고
    • Putative virulence factors of Candida albicans
    • Cutler, J.E. (1991) Putative virulence factors of Candida albicans. Annu Rev Microbiol 45: 187-218.
    • (1991) Annu Rev Microbiol , vol.45 , pp. 187-218
    • Cutler, J.E.1
  • 5
    • 0001066006 scopus 로고
    • A chrome-osmium fixative for electron microscopy
    • Dalton, A.J. (1955) A chrome-osmium fixative for electron microscopy. Anat Rec 121: 281.
    • (1955) Anat Rec , vol.121 , pp. 281
    • Dalton, A.J.1
  • 6
    • 0028952695 scopus 로고
    • Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis
    • De Bernardis, F., Cassone, A., Sturtevant, J., and Calderone, R. (1995) Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis. Infect Immun 63: 1887-1892.
    • (1995) Infect Immun , vol.63 , pp. 1887-1892
    • De Bernardis, F.1    Cassone, A.2    Sturtevant, J.3    Calderone, R.4
  • 7
    • 0030749898 scopus 로고    scopus 로고
    • Protective role of anti-mannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats
    • De Bernardis, F., Boccanera, M., Adriani, D., Spreghini, E., Santoni, G., and Cassone, A. (1997) Protective role of anti-mannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats. Infect Immun 65: 3399-3405.
    • (1997) Infect Immun , vol.65 , pp. 3399-3405
    • De Bernardis, F.1    Boccanera, M.2    Adriani, D.3    Spreghini, E.4    Santoni, G.5    Cassone, A.6
  • 8
    • 0004790502 scopus 로고    scopus 로고
    • Evidence that members of secretory aspartyl proteinases gene family, in particular SAP2, are virulence factor for Candida vaginitis
    • De Bernardis, F., Arancia, S., Morelli, L., Hube, B., Sanglard, D., Schäfer, W., and Cassone, A. (1999) Evidence that members of secretory aspartyl proteinases gene family, in particular SAP2, are virulence factor for Candida vaginitis. J Infect Dis 179: 201-208.
    • (1999) J Infect Dis , vol.179 , pp. 201-208
    • De Bernardis, F.1    Arancia, S.2    Morelli, L.3    Hube, B.4    Sanglard, D.5    Schäfer, W.6    Cassone, A.7
  • 9
    • 0031719293 scopus 로고    scopus 로고
    • Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice
    • Dubois, N., Colina, A.R., Aumont, F., Belhumeur, P., and de Repentigny, L. (1998) Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice. Microbiology 144: 2299-2310.
    • (1998) Microbiology , vol.144 , pp. 2299-2310
    • Dubois, N.1    Colina, A.R.2    Aumont, F.3    Belhumeur, P.4    De Repentigny, L.5
  • 10
    • 0031037510 scopus 로고    scopus 로고
    • Role of aspartic proteases in disseminated Candida albicans infection in mice
    • Fallon, K., Bausch, K., Noonan, B., Huguenel, E., and Tamburini, P. (1997) Role of aspartic proteases in disseminated Candida albicans infection in mice. Infect Immun 65: 551-556.
    • (1997) Infect Immun , vol.65 , pp. 551-556
    • Fallon, K.1    Bausch, K.2    Noonan, B.3    Huguenel, E.4    Tamburini, P.5
  • 11
    • 0020961272 scopus 로고
    • Scanning electron microscope study of Candida albicans invasion of cultured human cervical epithelial cells
    • Farrell, S.M., Hawkins, D.F., and Ryder, T.A. (1983) Scanning electron microscope study of Candida albicans invasion of cultured human cervical epithelial cells. Sabourodia 21: 251-254.
    • (1983) Sabourodia , vol.21 , pp. 251-254
    • Farrell, S.M.1    Hawkins, D.F.2    Ryder, T.A.3
  • 12
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi, W.A., and Irwin, M.Y. (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728.
    • (1993) Genetics , vol.134 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 13
    • 84907135425 scopus 로고
    • Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans
    • Ghannoum, M., and Abu Elteen, K. (1986) Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans. J Med Vet Mycol 24: 407-413.
    • (1986) J Med Vet Mycol , vol.24 , pp. 407-413
    • Ghannoum, M.1    Abu Elteen, K.2
  • 14
    • 0021742042 scopus 로고
    • Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
    • Gillum, A.M., Tsay, E.Y.H., and Kirsch, D.R. (1984) Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet 198: 179-182.
    • (1984) Mol Gen Genet , vol.198 , pp. 179-182
    • Gillum, A.M.1    Tsay, E.Y.H.2    Kirsch, D.R.3
  • 17
    • 0029998914 scopus 로고    scopus 로고
    • The role of Candida albicans secreted aspartic proteinase in the development of candidoses
    • Hoegl, L., Ollert, M., and Korting, H.C. (1996) The role of Candida albicans secreted aspartic proteinase in the development of candidoses. J Mol Med 74: 135-142.
    • (1996) J Mol Med , vol.74 , pp. 135-142
    • Hoegl, L.1    Ollert, M.2    Korting, H.C.3
  • 18
    • 0027295767 scopus 로고
    • Induction of extracellular proteinase in Candida albicans
    • Homma, M., Chibana, H., and Tanaka, K. (1991) Induction of extracellular proteinase in Candida albicans. J Gen Microbiol 139: 1187-1193.
    • (1991) J Gen Microbiol , vol.139 , pp. 1187-1193
    • Homma, M.1    Chibana, H.2    Tanaka, K.3
  • 19
    • 0030310227 scopus 로고    scopus 로고
    • Candida albicans secreted aspartyl proteinases
    • Hube, B. (1996) Candida albicans secreted aspartyl proteinases. Curr Top Med Mycol 7: 55-69.
    • (1996) Curr Top Med Mycol , vol.7 , pp. 55-69
    • Hube, B.1
  • 20
    • 0002740711 scopus 로고    scopus 로고
    • Possible role of proteinases in Candida infections
    • Hube, B. (1998) Possible role of proteinases in Candida infections. Revista Iberoamericana Micologia 15: 68-71.
    • (1998) Revista Iberoamericana Micologia , vol.15 , pp. 68-71
    • Hube, B.1
  • 21
    • 0027940569 scopus 로고
    • Expression of seven members of the gene family encoding secretory aspartyl proteinase in Candida albicans
    • Hube, B., Monod, M., Schofield, D.A., Brown, A.J.P., and Gow, N.A.R. (1994) Expression of seven members of the gene family encoding secretory aspartyl proteinase in Candida albicans. Mol Microbiol 14: 87-99.
    • (1994) Mol Microbiol , vol.14 , pp. 87-99
    • Hube, B.1    Monod, M.2    Schofield, D.A.3    Brown, A.J.P.4    Gow, N.A.R.5
  • 22
    • 0030884478 scopus 로고    scopus 로고
    • Gene disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2 and SAP3 in Candida albicans attenuates virulence
    • Hube, B., Sanglard, D., Odds, F.C., Hess, D., Monod, M., Schäfer, W., et al. (1997) Gene disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2 and SAP3 in Candida albicans attenuates virulence. Infect Immun 65: 3529-3538.
    • (1997) Infect Immun , vol.65 , pp. 3529-3538
    • Hube, B.1    Sanglard, D.2    Odds, F.C.3    Hess, D.4    Monod, M.5    Schäfer, W.6
  • 23
    • 0031865886 scopus 로고    scopus 로고
    • Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells
    • Ibrahim, A.S., Scott, G.F., Sanglard, D., Edwards, J.E., and Hube, B. (1998) Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells. Infect Immun 66: 3003-3005.
    • (1998) Infect Immun , vol.66 , pp. 3003-3005
    • Ibrahim, A.S.1    Scott, G.F.2    Sanglard, D.3    Edwards, J.E.4    Hube, B.5
  • 24
    • 0001166951 scopus 로고
    • A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy
    • Karnovsky, M.J. (1965) A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J Cell Biol 27: 137-138.
    • (1965) J Cell Biol , vol.27 , pp. 137-138
    • Karnovsky, M.J.1
  • 25
    • 0032873005 scopus 로고    scopus 로고
    • Influence of the HIV-proteinase inhibitors saquinavir and indinavir on the in vitro activity of secreted aspartyl proteinases from Candida albicans isolates of HIV-infected patients
    • Korting, H.C., Schaller, M., Eder, G., Hamm, G., Böhmer, U., and Hube, B. (1999) Influence of the HIV-proteinase inhibitors saquinavir and indinavir on the in vitro activity of secreted aspartyl proteinases from Candida albicans isolates of HIV-infected patients. Antimicrob Agents Chemother 43: 2038-2042.
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 2038-2042
    • Korting, H.C.1    Schaller, M.2    Eder, G.3    Hamm, G.4    Böhmer, U.5    Hube, B.6
  • 26
    • 0021796963 scopus 로고
    • Genetic evidence for role of extracellular proteinase in virulence of Candida albicans
    • Kwon-Chung, K.J., Lehman, D., Good, C., and Magee, P.T. (1985) Genetic evidence for role of extracellular proteinase in virulence of Candida albicans. Infect Immun 49: 571-575.
    • (1985) Infect Immun , vol.49 , pp. 571-575
    • Kwon-Chung, K.J.1    Lehman, D.2    Good, C.3    Magee, P.T.4
  • 27
    • 0020663680 scopus 로고
    • Virulence for mice of a proteinase-secreting strain of Candida albicans and a proteinase-deficient mutant
    • MacDonald, F., and Odds, F.C. (1983) Virulence for mice of a proteinase-secreting strain of Candida albicans and a proteinase-deficient mutant. J Gen Microbiol 129: 431-438.
    • (1983) J Gen Microbiol , vol.129 , pp. 431-438
    • Macdonald, F.1    Odds, F.C.2
  • 28
    • 0009696612 scopus 로고
    • Formation of Candida spheroplasts
    • Maresca, B., and Kobayashi, G.S. (eds). New York: Telos Press
    • Magee, B.B. (1994) Formation of Candida spheroplasts. In Molecular Biology of Pathogenic Fungi. Maresca, B., and Kobayashi, G.S. (eds). New York: Telos Press, pp. 113-115.
    • (1994) Molecular Biology of Pathogenic Fungi , pp. 113-115
    • Magee, B.B.1
  • 29
    • 0030561299 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1β
    • Maneu, V., Cervera, A.M., Martinez, J.P., and Gozalbo, D. (1996) Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1β. FEMS Microbiol Lett 145: 157-162.
    • (1996) FEMS Microbiol Lett , vol.145 , pp. 157-162
    • Maneu, V.1    Cervera, A.M.2    Martinez, J.P.3    Gozalbo, D.4
  • 30
    • 0028233073 scopus 로고
    • Multiplicity of genes encoding secreted aspartic proteinases in Candida species
    • Monod, M., Togni, G., Hube, B., and Sanglard, D. (1994) Multiplicity of genes encoding secreted aspartic proteinases in Candida species. Mol Microbiol 13: 357-368.
    • (1994) Mol Microbiol , vol.13 , pp. 357-368
    • Monod, M.1    Togni, G.2    Hube, B.3    Sanglard, D.4
  • 31
    • 0031765521 scopus 로고    scopus 로고
    • Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida Albicans
    • Monod, M., Hube, B., Hess, D., and Sanglard, D. (1998) Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida Albicans. Microbiology 144: 2731-2737.
    • (1998) Microbiology , vol.144 , pp. 2731-2737
    • Monod, M.1    Hube, B.2    Hess, D.3    Sanglard, D.4
  • 32
    • 0026749939 scopus 로고
    • Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans
    • Morrow, B., Srikantha, T., and Soll, D.R. (1992) Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans. Mol Cell Biol 12: 2997-3005.
    • (1992) Mol Cell Biol , vol.12 , pp. 2997-3005
    • Morrow, B.1    Srikantha, T.2    Soll, D.R.3
  • 34
    • 0028002452 scopus 로고
    • Candida species and virulence
    • Odds, F.C. (1994) Candida species and virulence. Am Soc Microbiol News 60: 313-318.
    • (1994) Am Soc Microbiol News , vol.60 , pp. 313-318
    • Odds, F.C.1
  • 36
    • 0023706676 scopus 로고
    • Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: A role for Candida acid proteinase
    • Ray, T.L., and Payne, C.D. (1988) Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: a role for Candida acid proteinase. Infect Immun 56: 1942-1949.
    • (1988) Infect Immun , vol.56 , pp. 1942-1949
    • Ray, T.L.1    Payne, C.D.2
  • 38
    • 0002152853 scopus 로고
    • Proteinase
    • Bennett, J.E., Hay, R.J., and Peterson, P.K. (eds). Edinburgh: Churchill Livingstone
    • Rüchel, R. (1992) Proteinase. In New Strategies in Fungal Disease. Bennett, J.E., Hay, R.J., and Peterson, P.K. (eds). Edinburgh: Churchill Livingstone, pp. 17-31.
    • (1992) New Strategies in Fungal Disease , pp. 17-31
    • Rüchel, R.1
  • 39
    • 0022374087 scopus 로고
    • Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck
    • Rupniak, H.T., Rowlatt, C., Lane, E.B., Steele, J.G., Trejdosiewicz, L.K., Laskiewicz, B., et al. (1985) Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck. J Natl Cancer Inst 75: 621-635.
    • (1985) J Natl Cancer Inst , vol.75 , pp. 621-635
    • Rupniak, H.T.1    Rowlatt, C.2    Lane, E.B.3    Steele, J.G.4    Trejdosiewicz, L.K.5    Laskiewicz, B.6
  • 40
    • 0030884697 scopus 로고    scopus 로고
    • A triple deletion in SAP4, SAP5 and SAP6 secretory aspartyl proteinase genes of Candida albicans causes attenuated virulence
    • Sanglard, D., Hube, B., Monod, M., Odds, F.C., and Gow, N.A.R. (1997) A triple deletion in SAP4, SAP5 and SAP6 secretory aspartyl proteinase genes of Candida albicans causes attenuated virulence. Infect Immun 65: 3539-3546.
    • (1997) Infect Immun , vol.65 , pp. 3539-3546
    • Sanglard, D.1    Hube, B.2    Monod, M.3    Odds, F.C.4    Gow, N.A.R.5
  • 41
    • 0031875677 scopus 로고    scopus 로고
    • Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity
    • Schaller, M., Schäfer, W., Korting, H.C., and Hube, B. (1998) Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol Microbiol 29: 605-615.
    • (1998) Mol Microbiol , vol.29 , pp. 605-615
    • Schaller, M.1    Schäfer, W.2    Korting, H.C.3    Hube, B.4
  • 42
    • 0033018944 scopus 로고    scopus 로고
    • In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients
    • Schaller, M., Hube, B., Ollert, M.W., Schäfer, W., Borgvon Zepelin, M., Thoma-Greber, E., and Korting, H.C. (1999) In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients. J Invest Dermatol 112: 383-386.
    • (1999) J Invest Dermatol , vol.112 , pp. 383-386
    • Schaller, M.1    Hube, B.2    Ollert, M.W.3    Schäfer, W.4    Borgvon Zepelin, M.5    Thoma-Greber, E.6    Korting, H.C.7
  • 43
    • 0030924566 scopus 로고    scopus 로고
    • Ultrastructural localization of the secretory aspartyl proteinase in Candida albicans cell wall in vitro and in experimentally infected rat vagina
    • Stringaro, A., Crateri, P., Pellegrini, G., Arancia;, G., Cassone, A., and De Bernardis, F. (1997) Ultrastructural localization of the secretory aspartyl proteinase in Candida albicans cell wall in vitro and in experimentally infected rat vagina. Mycopathologia 137: 95-105.
    • (1997) Mycopathologia , vol.137 , pp. 95-105
    • Stringaro, A.1    Crateri, P.2    Pellegrini, G.3    Arancia, G.4    Cassone, A.5    De Bernardis, F.6
  • 44
    • 0032007999 scopus 로고    scopus 로고
    • Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes
    • Watts, H.J., Cheah, F.S., Hube, B., Sanglard, D., and Gow, N.A.R. (1998) Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes. FEMS Microbiol Lett 159: 129-135.
    • (1998) FEMS Microbiol Lett , vol.159 , pp. 129-135
    • Watts, H.J.1    Cheah, F.S.2    Hube, B.3    Sanglard, D.4    Gow, N.A.R.5
  • 45
    • 0029128928 scopus 로고
    • Candida albicans secreted aspartyl proteinases: Isoenzyme pattern is determined by cell type, levels are determined by environmental factors
    • White, T.C., and Agabian, N. (1995) Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, levels are determined by environmental factors. J Bacteriol 177: 5215-5221.
    • (1995) J Bacteriol , vol.177 , pp. 5215-5221
    • White, T.C.1    Agabian, N.2


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