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Volumn 65, Issue 9, 1997, Pages 3539-3546

A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; FUNGAL PROTEIN;

EID: 0030884697     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.9.3539-3546.1997     Document Type: Article
Times cited : (246)

References (40)
  • 1
    • 0025108055 scopus 로고
    • Demonstration of fungal proteinase during phagocytosis of Candida albicans and Candida tropicalis
    • Borg, M., and R. Rüchel. 1990. Demonstration of fungal proteinase during phagocytosis of Candida albicans and Candida tropicalis. J. Med. Vet. Mycol. 28:3-14.
    • (1990) J. Med. Vet. Mycol. , vol.28 , pp. 3-14
    • Borg, M.1    Rüchel, R.2
  • 2
    • 0029645880 scopus 로고
    • The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors
    • Cutfield, S. M., E. J. Dodson, B. F. Anderson, P. Moody, C. J. Marshall, P. A. Sullivan, and J. F. Cutfield. 1995. The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors. Structure 3:1261-1271.
    • (1995) Structure , vol.3 , pp. 1261-1271
    • Cutfield, S.M.1    Dodson, E.J.2    Anderson, B.F.3    Moody, P.4    Marshall, C.J.5    Sullivan, P.A.6    Cutfield, J.F.7
  • 3
    • 0025989934 scopus 로고
    • Putative virulence factors of Candida albicans
    • Cutler, J. E. 1991. Putative virulence factors of Candida albicans. Annu. Rev. Microbiol. 45:187-218.
    • (1991) Annu. Rev. Microbiol. , vol.45 , pp. 187-218
    • Cutler, J.E.1
  • 4
    • 0028952695 scopus 로고
    • Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis
    • DeBernardis, F., A. Cassone, J. Sturtevant, and R. Calderone. 1995. Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis. Infect. Immun. 63:1887-1892.
    • (1995) Infect. Immun. , vol.63 , pp. 1887-1892
    • Debernardis, F.1    Cassone, A.2    Sturtevant, J.3    Calderone, R.4
  • 5
    • 0030031314 scopus 로고    scopus 로고
    • Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus
    • DeBernardis, F., P. Chiani, M. Ciccozzi, G. Pellegrini, T. Ceddia, G. D'Offizzi, I. Quinti, P. A. Sullivan, and A. Cassone. 1996. Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus. Infect. Immun. 64:466-471.
    • (1996) Infect. Immun. , vol.64 , pp. 466-471
    • DeBernardis, F.1    Chiani, P.2    Ciccozzi, M.3    Pellegrini, G.4    Ceddia, T.5    D'Offizzi, G.6    Quinti, I.7    Sullivan, P.A.8    Cassone, A.9
  • 6
    • 0021381028 scopus 로고
    • A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
    • Feinberg, A., and B. Vogelstein. 1984. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 137:266-267.
    • (1984) Anal. Biochem. , vol.137 , pp. 266-267
    • Feinberg, A.1    Vogelstein, B.2
  • 7
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
    • (1993) Genetics , vol.134 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 8
    • 0027978324 scopus 로고
    • Extracellular aspartic proteinases from Candida albicans, Candida tropicalis, and Candida parapsilosis yeasts differ substantially in their specificities
    • Fusek, M., E. A. Smith, M. Monod, B. M. Dunn, and S. I. Foundling. 1994. Extracellular aspartic proteinases from Candida albicans, Candida tropicalis, and Candida parapsilosis yeasts differ substantially in their specificities. Biochemistry 33:9791-9799.
    • (1994) Biochemistry , vol.33 , pp. 9791-9799
    • Fusek, M.1    Smith, E.A.2    Monod, M.3    Dunn, B.M.4    Foundling, S.I.5
  • 9
    • 0000075317 scopus 로고
    • Techniques for transformation of E. coli
    • D. M. Glover (ed.), IRL Press, Oxford, United Kingdom
    • Hanahan, D. 1985. Techniques for transformation of E. coli, p. 109-135. In D. M. Glover (ed.), DNA cloning. A practical approach. IRL Press, Oxford, United Kingdom.
    • (1985) DNA Cloning. A Practical Approach , pp. 109-135
    • Hanahan, D.1
  • 10
    • 0027940569 scopus 로고
    • Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans
    • Hube, B., M. Monod, D. A. Schofield, A. J. P. Brown, and N. A. R. Gow. 1994. Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol. Microbiol. 14:87-99.
    • (1994) Mol. Microbiol. , vol.14 , pp. 87-99
    • Hube, B.1    Monod, M.2    Schofield, D.A.3    Brown, A.J.P.4    Gow, N.A.R.5
  • 11
    • 0141623936 scopus 로고    scopus 로고
    • Extracellular proteolytic activity of Candida species
    • H. Vanden Bossche, D. A. Stevens, and F. C. Odds (ed.), Host-fungus interplay. National Foundation for Infectious Diseases, Bethesda, Md.
    • Hube, B., D. Sanglard, M. Monod, A. J. P. Brown, and N. A. R. Gow. 1997. Extracellular proteolytic activity of Candida species, p. 109-122. In H. Vanden Bossche, D. A. Stevens, and F. C. Odds (ed.), Host-fungus interplay. Proceedings of the Fifth Symposium on Topics in Mycology 1995. National Foundation for Infectious Diseases, Bethesda, Md.
    • (1997) Proceedings of the Fifth Symposium on Topics in Mycology 1995 , pp. 109-122
    • Hube, B.1    Sanglard, D.2    Monod, M.3    Brown, A.J.P.4    Gow, N.A.R.5
  • 12
    • 0030884478 scopus 로고    scopus 로고
    • Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence
    • Hube, B., D. Sanglard, F. C. Odds, D. Hess, M. Monod, W. Schäfer, A. J. P. Brown, and N. A. R. Gow. 1997. Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect. Immun. 65:3529-3538.
    • (1997) Infect. Immun. , vol.65 , pp. 3529-3538
    • Hube, B.1    Sanglard, D.2    Odds, F.C.3    Hess, D.4    Monod, M.5    Schäfer, W.6    Brown, A.J.P.7    Gow, N.A.R.8
  • 15
    • 33845382806 scopus 로고
    • Non-parametric estimation from incomplete observations
    • Kaplan, E. L., and P. Meier. 1958. Non-parametric estimation from incomplete observations. J. Am. Statist. Assoc. 53:457-481.
    • (1958) J. Am. Statist. Assoc. , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 16
    • 0025851152 scopus 로고
    • Pathogenicity of Candida albicans auxotrophic mutants in experimental infections
    • Kirsch, D. R., and R. R. Whitney. 1991. Pathogenicity of Candida albicans auxotrophic mutants in experimental infections. Infect. Immun. 59:3297-3300.
    • (1991) Infect. Immun. , vol.59 , pp. 3297-3300
    • Kirsch, D.R.1    Whitney, R.R.2
  • 17
    • 0021796963 scopus 로고
    • Genetic evidence tor role of extracellular proteinase in virulence of Candida albicans
    • Kwon-Chung, K. J., D. Lehman, C. Good, and P. T. Magee. 1985. Genetic evidence tor role of extracellular proteinase in virulence of Candida albicans. Infect. Immun. 49:571-575.
    • (1985) Infect. Immun. , vol.49 , pp. 571-575
    • Kwon-Chung, K.J.1    Lehman, D.2    Good, C.3    Magee, P.T.4
  • 18
    • 0018854347 scopus 로고
    • Inducible proteinase of Candida albicans in diagnostic serology and in the pathogenesis of systemic candidosis
    • MacDonald, F., and F. C. Odds. 1980. Inducible proteinase of Candida albicans in diagnostic serology and in the pathogenesis of systemic candidosis. J. Med. Microbiol. 13:423-435.
    • (1980) J. Med. Microbiol. , vol.13 , pp. 423-435
    • MacDonald, F.1    Odds, F.C.2
  • 19
    • 0020663680 scopus 로고
    • Virulence for mice of a proteinase-secreting strain of Candida albicans and a proteinase-deficient mutant
    • MacDonald, F., and F. C. Odds. 1983. Virulence for mice of a proteinase-secreting strain of Candida albicans and a proteinase-deficient mutant. J. Gen. Microbiol. 129:431-438.
    • (1983) J. Gen. Microbiol. , vol.129 , pp. 431-438
    • MacDonald, F.1    Odds, F.C.2
  • 22
    • 0028233073 scopus 로고
    • Multiplicity of genes encoding secreted aspartic proteinases in Candida species
    • Monod, M., G. Togni, B. Hube, and D. Sanglard. 1994. Multiplicity of genes encoding secreted aspartic proteinases in Candida species. Mol. Microbiol. 13:357-368.
    • (1994) Mol. Microbiol. , vol.13 , pp. 357-368
    • Monod, M.1    Togni, G.2    Hube, B.3    Sanglard, D.4
  • 24
    • 0026659739 scopus 로고
    • Antifungal susceptibility testing Candida spp. by relative growth measurement at single concentrations of antifungal agents
    • Odds, F. C. 1992. Antifungal susceptibility testing Candida spp. by relative growth measurement at single concentrations of antifungal agents. Antimicrob. Agent Chemother. 36:1727-1737.
    • (1992) Antimicrob. Agent Chemother. , vol.36 , pp. 1727-1737
    • Odds, F.C.1
  • 25
    • 0028002452 scopus 로고
    • Candida species and virulence
    • Odds, F. C. 1994. Candida species and virulence. ASM News 60:313-318.
    • (1994) ASM News , vol.60 , pp. 313-318
    • Odds, F.C.1
  • 27
    • 0004120289 scopus 로고
    • Detection of Candida acid proteinase (CAP) antibodies in systemic candidiasis by enzyme immunoassay
    • Ray, T. L., and C. D. Payne. 1987. Detection of Candida acid proteinase (CAP) antibodies in systemic candidiasis by enzyme immunoassay. Clin. Res. 35:711A.
    • (1987) Clin. Res. , vol.35
    • Ray, T.L.1    Payne, C.D.2
  • 28
    • 0023706676 scopus 로고
    • Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: A role for Candida acid proteinase
    • Ray, T. L., and C. D. Payne. 1988. Scanning electron microscopy of epidermal adherence and cavitation in murine candidiasis: a role for Candida acid proteinase. Infect. Immun. 56:1942-1949.
    • (1988) Infect. Immun. , vol.56 , pp. 1942-1949
    • Ray, T.L.1    Payne, C.D.2
  • 29
    • 79961220619 scopus 로고    scopus 로고
    • Virulence of an aspergillopepsin-deficient mutant of Aspergillus fumigatus and evidence for another uspartic proteinase linked to fungal cell wall
    • Reichard, U., M. Monod, F. Odds, and R. Rüchel. 1997. Virulence of an aspergillopepsin-deficient mutant of Aspergillus fumigatus and evidence for another uspartic proteinase linked to fungal cell wall. J. Med. Vet. Mycol. 35:189-196.
    • (1997) J. Med. Vet. Mycol. , vol.35 , pp. 189-196
    • Reichard, U.1    Monod, M.2    Odds, F.3    Rüchel, R.4
  • 30
    • 0025240749 scopus 로고
    • The secreted aspartate proteinase of Candida albicans: Physiology of secretion and virulence of a proteinase-deficient mutant
    • Ross, I. K., F. DeBernardis, G. W. Emerson, A. Cassone, and P. A. Sullivan. 1990. The secreted aspartate proteinase of Candida albicans: physiology of secretion and virulence of a proteinase-deficient mutant. J. Gen. Microbiol. 136:687-694.
    • (1990) J. Gen. Microbiol. , vol.136 , pp. 687-694
    • Ross, I.K.1    Debernardis, F.2    Emerson, G.W.3    Cassone, A.4    Sullivan, P.A.5
  • 31
    • 0023937005 scopus 로고
    • A synoptical approach to the diagnosis of candidosis, relying on serological antigen and antibodidy tests, on culture, and on evaluation of clinical data
    • Rüchel, R., B. Böning-Stutzer, and A. Mari. 1988. A synoptical approach to the diagnosis of candidosis, relying on serological antigen and antibodidy tests, on culture, and on evaluation of clinical data. Mycoses 31:87-106.
    • (1988) Mycoses , vol.31 , pp. 87-106
    • Rüchel, R.1    Böning-Stutzer, B.2    Mari, A.3
  • 32
    • 0025032294 scopus 로고
    • Modulation of experimental systemic murine candidosis by intravenous pepstatin
    • Rüchel, R., B. Ritter, and M. Schaffrinski. 1990. Modulation of experimental systemic murine candidosis by intravenous pepstatin. Zentralbl. Bakteriol. Microbiol. Hyg. 273:391-403.
    • (1990) Zentralbl. Bakteriol. Microbiol. Hyg. , vol.273 , pp. 391-403
    • Rüchel, R.1    Ritter, B.2    Schaffrinski, M.3
  • 34
    • 0027050034 scopus 로고
    • DNA transformations of Candida tropicalis with replicative and integrative vectors
    • Sanglard, D., and A. Fiechter. 1992. DNA transformations of Candida tropicalis with replicative and integrative vectors. Yeast 8:1065-1075.
    • (1992) Yeast , vol.8 , pp. 1065-1075
    • Sanglard, D.1    Fiechter, A.2
  • 35
    • 0029820482 scopus 로고    scopus 로고
    • Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    • Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1996. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 40:2300-2305.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 2300-2305
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 36
    • 0027120764 scopus 로고
    • Disruption of the gene encoding the secreted acid protease (ACP) in the yeast Candida tropicalis
    • Sanglard, D., G. Togni, P. A. de Viragh, and M. Monod. 1992. Disruption of the gene encoding the secreted acid protease (ACP) in the yeast Candida tropicalis. FEMS Microbiol. Lett. 95:149-156.
    • (1992) FEMS Microbiol. Lett. , vol.95 , pp. 149-156
    • Sanglard, D.1    Togni, G.2    De Viragh, P.A.3    Monod, M.4
  • 37
    • 0022386562 scopus 로고
    • Pathogenicity of morphological and auxotrophic mutants of Candida albicans in experimental infections
    • Shepherd, M. G. 1985. Pathogenicity of morphological and auxotrophic mutants of Candida albicans in experimental infections. Infect. Immun. 50: 541-544.
    • (1985) Infect. Immun. , vol.50 , pp. 541-544
    • Shepherd, M.G.1
  • 38
    • 0025784503 scopus 로고
    • Isolation and nucleotide sequence of the extracellular acid protease gene (ACP) from the yeast Candida tropicalis
    • Togni, G., D. Sanglard, R. Falchetto, and M. Monod. 1991. Isolation and nucleotide sequence of the extracellular acid protease gene (ACP) from the yeast Candida tropicalis. FEBS Lett. 286:181-185.
    • (1991) FEBS Lett. , vol.286 , pp. 181-185
    • Togni, G.1    Sanglard, D.2    Falchetto, R.3    Monod, M.4
  • 39
    • 84907127188 scopus 로고
    • Acid proteinase secreted by Candida tropicalis: Virulence in mice of a proteinase-negative mutant
    • Togni, G., D. Sanglard, and M. Monod. 1994. Acid proteinase secreted by Candida tropicalis: virulence in mice of a proteinase-negative mutant. J. Med. Vet. Mycol. 32:257-265.
    • (1994) J. Med. Vet. Mycol. , vol.32 , pp. 257-265
    • Togni, G.1    Sanglard, D.2    Monod, M.3
  • 40
    • 0029128928 scopus 로고
    • Candida albicans secreted aspartyl proteinases: Isoenzyme pattern is determined by cell type, and levels are determined by environmental factors
    • White, T. C., and N. Agabian. 1995. Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors. J. Bacteriol. 177:5215-5221.
    • (1995) J. Bacteriol. , vol.177 , pp. 5215-5221
    • White, T.C.1    Agabian, N.2


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