Secreted lipases of Candida albicans: Cloning, characterisation and expression analysis of a new gene family with at least ten members

Archives of Microbiology

Volumn 174, Issue 5, 2000, Pages 362-374

  Hube, Bernhard ^a   Stehr, Frank ^b   Bossenz, Michael ^b   Mazur, Anna ^b   Kretschmar, Marianne ^c   Schäfer, Wilhelm ^b  

^a ROBERT KOCH INSTITUTE   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c Klin Dermatol Venerol/Allergol   (Germany)

Author keywords

Candida albicans; Gene family; Human pathogen; Lipases

Indexed keywords

CARBON; LIPID; TRIACYLGLYCEROL LIPASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CANDIDA ALBICANS; ENZYME ANALYSIS; GENE EXPRESSION; GLYCOSYLATION; HYDROPHOBICITY; LIPOLYSIS; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; VIRULENCE;

AMINO ACID SEQUENCE; CANDIDA ALBICANS; CANDIDIASIS; CLONING, MOLECULAR; CULTURE MEDIA; GENES, FUNGAL; HUMANS; LIPASE; LIPID METABOLISM; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; OPEN READING FRAMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

CANDIDA ALBICANS;

EID: 0033696811     PISSN: 03028933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002030000218     Document Type: Article

References (56)

1. Molecular cloning and physical analysis of an 8.2 kb segment of chromosome XI of Saccharomyces cerevisiae reveals five tightly linked genes
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Lipases and esterases: A review of their sequences, structure and evolution
4. The Swiss-Prot protein sequence data bank and its new supplement TREMBL
5. Localization of lipase genes on Candida rugosa chromosomes
6. A characterization of pH-regulated dimorphism in Candida albicans
7. Molecular analysis of CaMnt1p, a mannosyl transferase important for adhesion and virulence of Candida albicans
8. Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis
9. Host-pathogen interactions: Re-defining the basic concepts of virulence and pathogenicity
10. Learning from the genome sequence of Mycobacterium tuberculosis H37Rv
11. Elongation factor 3 (EF-3) from Candida albicans shows both structural and functional similarity to EF-3 from Saccharomyces cerevisiae
12. Putative virulence factors of Candida albicans
13. News from the interface: The molecular structures of triacylglyceride lipases
14. Conformational lability of lipases observed in the absence of an oil-water interface: Crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar
15. Cloning and characterisation of a gene (LIP1) which encodes a lipase from the pathogenic yeast Candida albicans
16. Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
17. Cell-surface hydrophobicity and lipolysis as essential factors in human tinea nigra
18. Vacuolation, branch production and linear growth of germ tubes in Candida albicans
19. Interaction of Propionibacterium aches with skin lipids in vitro
20. Lipid mediators in inflammatory disorders
21. CLUSTAL: A package for performing multiple sequence alignments on microcomputer
22. Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene
23. Candida albicans ALS3 and insights into the nature of the ALS gene family
24. Candida albicans secreted aspartyl proteinases
25. Expression of seven members of the gene family encoding secretory aspartyl proteinase in Candida albicans
26. Evidence implicating phospholipase as a virulence factor of Candida albicans
27. Extracellular enzymes of Pseudomonas aeruginosa as virulence factors
28. Extracellular lipase of Pseudomonas aeruginosa: Biochemical characterization and effect on human neutrophil and monocyte function in vitro
29. Extracellular lipase of Pseudomonas aeruginosa: Biochemistry and potential role as virulence factor
30. Induction of inflammatory mediator release (12-hydroxyeicosatetraenoic acid) from human platelets by Pseudomonas aeruginosa
31. Specific and sensitive plate assay for bacterial lipases
32. Germ tubes and proteinase activity contribute to virulence of Candida albicans in munne peritonitis
33. Cloning and disruption of caPLB1, a phospholipase B gene involved in the pathogenicity of Candida albicans
34. Genome mapping and gene discovery in Candida albicans
35. Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1β
36. Purification and characterization of lysophospholipase-transacylase (h-LPTA) from a highly virulent strain of Candida albicans
37. Differential regulation of SAP8 and SAP9, which encode two new members of secreted aspartic proteinase family in Candida albicans
38. Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans
39. In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis
40. Candida species and virulence
41. Lipase of Malassezia furfur: Some properties and their relationship to cell growth
42. Interference of Staphylococcus aureus lipase with human granulocyte function
43. Non-standard translational events in Candida albicans mediated by an unusual seryltRNA with a 5'-CAG-3' (leucine) anticodon
44. Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity
45. Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis
46. Changes in cell morphology and carnitine acetyltransferase activity in Candida albicans following growth on lipids and serum and after in vivo incubation in mice
47. Analysis of secreted aspartic proteinases from Candida albicans: Purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes
48. The entomopathogenic fungus Metarhizium anisopliae alters ambient pH, allowing extracellular protease Production and activity
49. Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans
50. Induction of an extracellular esterase from Candida albicans and some of its properties
51. Antifungal drug resistance in pathogenic fungi
52. Pathogenesis, host resistance, and predisposing factors
53. A new method for predicting signal sequence cleavage sites
54. Untersuchungen uber die Lipaseaktivitat bei Hefen und hefeahnlichen Pilzen
55. Candida albicans secreted aspartyl proteinases: Isoenzyme pattern is determined by cell type, and levels are determined by environmental factors