Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans

Microbiology

Volumn 144, Issue 10, 1998, Pages 2731-2737

  Monod, Michel ^a   Hube, Bernhard ^c   Hess, Daniela ^c   Sanglard, Dominique ^b  

^a Service de Dermatologie (DHURDV)   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Candida albicans; Gene family; Secreted aspartic proteinases

Indexed keywords

ASPARTIC PROTEINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; FUNGAL GENETICS; GENE CONTROL; GENE ISOLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRULENCE;

ANIMALIA; CANDIDA ALBICANS;

EID: 0031765521     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-144-10-2731     Document Type: Article

References (26)

1. Ash, J., Dominguez, M., Bergeron, J. J. M., Thomas, D. Y. & Bourbonnais, Y. (1995). The yeast proprotein convertase encoded by YAP3 is a glycophosphatidylinositol-anchored protein that localizes to the plasma membrane. J Biol Chem 270, 20847-20854.
2. - -cloning vectors. 1. Improved polylinker region to facilitate the use of sonicated DNA for nucleotide sequencing. Gene 68, 139-149.
3. Colthurst, D. R., Schauer, B. S., Hates, M. V. & Tuite, M. F. (1992). Elongation factor 3 (EF-3) from Candida albicans shows both structural and functional similarity to EF-3 from Saccharomyces cerevisiae. Mol Microbiol 6, 1025-1033.
4. Crandall, M. & Edwards, J. E. (1987). Segregation of proteinase-negative mutants from heterozygous Candida albicans. J Gen Microbiol 133, 2817-2824.
5. Egel-Mitani, M., Flygenring, H. P. & Hansen, M. T. (1990). A novel aspartyl protease allowing KEX2-independent MFα propheromone processing in yeast. Yeast 6, 127-137.
6. Gerber, L. D., Kodukula, K. & Udenfriend, S. (1992). Phosphatidylinositol glycan (PI-G) anchored membrane proteins. J Biol Chem 267, 12168-12173.
7. Grossberger, D. (1987). Minipreps of DNA from bacteriophage lambda. Nucleic Acids Res 15, 6737.
8. von Heijne, G. (1986). A new method for predicting signal sequence cleavage sites. Nucleic Acids Res 14, 4683-4690.
9. Higgins, D. G. & Sharp, P. M. (1989). Fast and sensitive multiple sequence alignments on a microcomputer. CABIOS 5, 151-153.
10. Hube, B., Monod, M., Schofield, A., Brown, A. J. P. & Gow, N. A. R. (1994). Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol 14, 87-99.
11. Hube, B., Sanglard, D., Monod, M., Brown, A. J. P. & Gow, N. A. R. (1997a). Extracellular proteolytic activity of Candida species. In Host-Fungus Interplay. Proceedings of the 5th Symposium on Topics in Mycology 1995, pp. 109-122. Edited by H. Vanden Bossche, D. A. Stevens & F. C. Odds. Bethesda, MD : National Foundation for Infectious Diseases.
12. Hube, B., Sanglard, D., Odds, F. C., Hess, D., Monod, M., Schäfer, W., Brown, A. J. P. & Gow, N. A. R. (1997b). Disruption of each of the aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect Immun 65, 3529-3538.
13. Julius, D., Brake, A., Blair, L., Kunisawa, R. & Thorner, J. (1984). Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor. Cell 37, 1075-1089.
14. Monod, M., Togni, G., Hube, B. & Sanglard, D. (1994). Multiplicity of genes encoding secreted aspartic proteases in Candida species. Mol Microbiol 13, 357-368.
15. Morrison, C. J., Hurst, S. F., Bragg, S. L., Kuykendall, R. J., Diaz, H., Pohl, J. & Reiss, E. (1993). Heterogeneity of the purified extracellular aspartyl proteinase from Candida albicans: characterization with monoclonal antibodies and N-terminal amino acid sequence analysis. Infect Immun 61, 2030-2036.
16. Morrow, B., Srikantha, T. & Soll, D. R. (1992). Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans. Mol Cell Biol 12, 2997-3005.
17. Morrow, B., Ramsey, H. & Soll, D. R. (1994). Regulation of phasespecific genes in the more general switching system of Candida albicans strain 3153A. J Med Vet Mycol 32, 287-294.
18. Newport, G. & Agabian, N. (1997). KEX2 influences Candida albicans proteinase secretion and hyphal formation. J Biol Chem 272, 28954-28961.
19. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
20. Sanglard, D., Hube, B., Monod, M., Odds, F. C. & Gow, N. A. R. (1997). A triple deletion of the aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence. Infect Immun 65, 3539-3546.
21. Soll, D. R. (1992). High-frequency switching in Candida albicans. Clin Microbiol Rev 5, 183-185.
22. Swoboda, R. K., Bertram, G., Colthurst, D. R., Tuite, M. F., Gow, N. A. R., Gooday, G. W. & Brown, A. J. P. (1994). Regulation of the gene encoding translation elongation factor 3 during growth and morphogenesis in Candida albicans. Microbiology 140, 2611-2616.
23. Togni, G., Sanglard, D., Falchetto, R. & Monod, M. (1991). Isolation and nucleotide sequence of the extracellular acid protease gene (ACP) from the yeast Candida tropicalis. FEBS Lett 286, 181-185.
24. de Viragh, P. A., Sanglard, D., Togni, G., Falchetto, R. & Monod, M. (1993). Cloning and sequencing of two Candida parapsilosis genes encoding acid proteases. J Gen Microbiol 139, 335-342.
25. White, T. C. & Agabian, N. (1995). Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors. J Bacteriol 177, 5215-5221.
26. White, T. C., Miyasaki, S. H. & Agabian, N. (1993). Three distinct secreted aspartyl proteinases in Candida albicans. J Bacteriol 175, 6126-6133.