Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence

Experimental Cell Research

Volumn 273, Issue 2, 2002, Pages 127-137

  Barradas, Marta ^a   Gonos, Efstathios S ^b   Zebedee, Zoë ^c   Kolettas, Evangelos ^d   Petropoulou, Charikleia ^b   Delgado, M Dolores ^e   León, Javier ^e   Hara, Eiji ^c   Serrano, Manuel ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b INSTITUTE OF BIOLOGY   (Greece)

^c CHRISTIE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF IOANNINA   (Greece)

^e UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

3p21; Ras; Senescence; Stress; Tumor suppressors

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; HYDROGEN PEROXIDE; ONCOPROTEIN; PROTEIN P21; RAS PROTEIN; TRANSCRIPTION FACTOR ETS 2; VIRUS PROTEIN;

AGING; ARTICLE; BIOFILTER; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; SCREENING; SENESCENCE; TUMOR SUPPRESSOR GENE;

EID: 0036059249     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5434     Document Type: Article

References (54)

1. The cat and mouse games that genes, viruses, and cells play
2. Tumor suppressors and oncogenes in cellular senescence
3. INK4a
4. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
5. Senescence of human fibroblasts induced by oncogenic Raf
6. Genetic and epigenetic changes in human epithelial cells immortalized by telomerase
7. Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells
8. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
9. Cellular senescence as a tumor-protection mechanism: The essential role of counting
10. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
11. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
12. The ARF/p53 pathway
13. Genes involved in senescence and immortalization
14. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
15. Creation of human tumour cells with defined genetic elements
16. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
17. Role of the INK4a locus in tumor suppression and cell mortality
18. Cooperating oncogenes converge to regulate cyclin/cdk complexes
19. ARF
20. ARF links the tumour suppressor p53 to Ras
21. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
22. The INK4a/ARF locus in murine tumorigenesis
23. Telomere length in fibroblasts and blood cells from healthy centenarians
24. INK4a expression during cellular senescence
25. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
26. Increased expression of glycolysis-associated genes in oncogene-transformed and growth-accelerated states
27. From cells to organisms: Can we learn about aging from cells in culture?
28. Genetic pathways that regulate ageing in model organisms
29. 1, arrest but not cell replication
30. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblasts
31. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
32. Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts
33. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
34. The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle
35. A genome-wide survey of RAS transformation targets
36. Mechanism of TGFβ receptor inhibition by FKBP12
37. FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle
38. How cells read TGF-β signals
39. Metallothionein expression and stress responses in aging human diploid fibroblasts
40. Downregulation of metallothionein-IIA expression occurs at immortalization
41. Microarray analysis of replicative senescence
42. Mitotic misregulation and human aging
43. Gene expression profile of aging and its retardation by caloric restriction
44. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
45. The functional significance of brain metallothioneins
46. Regulation of metallothionein gene expression by TNF-α and IFN-β in human fibroblasts
47. Metallothionein induction in human CNS in vitro: Neuroprotection from ionizing radiation
48. Signal transduction and the Ets family of transcription factors
49. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes
50. A 1-Mb PAC contig spanning the Common Eliminated Region 1 (CER1) in microcell hybrid-derived SCID tumors
51. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the Common Eliminated Region 1 (C3CER1) in 3p21.3
52. Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice
53. Isolation of cDNA clones and tissue expression of rat RalA and Ral B GTP-binding proteins