Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase - 32P-postlabeling analysis of DNA adduct formation

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 493, Issue 1-2, 2001, Pages 149-160

  Stiborová, Marie ^a   Frei, Eva ^b   Breuer, Andrea ^b   Wiessler, Manfred ^b   Schmeiser, Heinz H ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

32P postlabeling; Aristolochic acid; Chinese herbs nephropathy; DNA adducts; Prostaglandin H synthase; Reductive activation

Indexed keywords

7 (DEOXYADENOSIN 6 N YL)ARISTOLACTAM I; 7 (DEOXYADENOSIN 6 N YL)ARISTOLACTAM II; 7 (DEOXYGUANOSIN 2 N YL)ARISTOLACTAM I; 7 (DEOXYGUANOSIN 2 N YL)ARISTOLACTAM II; ARACHIDONIC ACID; ARISTOLOCHIC ACID; ARISTOLOLACTAM; AROMATIC NITRO COMPOUND; BUTANOL; CYTOCHROME P450 1A1; CYTOCHROME P450 INHIBITOR; DNA; ENZYME INHIBITOR; HYDROGEN PEROXIDE; INDOMETACIN; KIDNEY ENZYME; NUCLEASE; PHOSPHORUS 32; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; THIOCTIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHINESE HERB; CONTROLLED STUDY; DNA ADDUCT; DNA STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PURIFICATION; KIDNEY DISEASE; KIDNEY PARENCHYMA; MALE; METABOLIC ACTIVATION; METABOLITE; NONHUMAN; PRIORITY JOURNAL; REDUCTION; SEMINAL VESICLE;

ANIMALS; ARISTOLOCHIC ACIDS; BIOTRANSFORMATION; CARCINOGENS; CYCLOOXYGENASE INHIBITORS; DNA ADDUCTS; INDOMETHACIN; MALE; OXIDATION-REDUCTION; PHENANTHRENES; PHOSPHORUS RADIOISOTOPES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SEMINAL VESICLES; SHEEP;

OVIS; RICE STRIPE VIRUS;

EID: 0035958272     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00171-1     Document Type: Article

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