Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with chinese herbs nephropathy

Experimental and Toxicologic Pathology

Volumn 51, Issue 4-5, 1999, Pages 421-427

  Stiborova M ^a   Frei, E ^b   Breuer, A ^b   Bieler, C A ^b   Schmeiser, H H ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Aristolactams; Aristolochic acids; Carcinogens; Chinese herbs nephropathy; Cytochrome P450; DNA adducts; Nephropathy; Peroxidase

Indexed keywords

ARISTOLOCHIC ACID; ARISTOLOLACTAM; CYTOCHROME P450; DEOXYADENOSINE DERIVATIVE; DEOXYGUANOSINE DERIVATIVE; DRUG METABOLITE; PEROXIDASE;

CARCINOGENICITY; CHINESE HERB; CONFERENCE PAPER; DETOXIFICATION; DNA ADDUCT; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; KIDNEY FIBROSIS; NEPHROTOXICITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY;

ANIMALIA; ARISTOLOCHIA;

EID: 0032780946     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(99)80033-5     Document Type: Conference Paper

References (24)

1. BIELER CA, STIBOROVÁ M, WIESSLER M, et al.: 32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy. Carcinogenesis 1997; 18: 1063-1067.
2. 3H]-1,6-dinitropyrene. Cancer Res 1987; 47: 6272-6277.
3. 32P-postlabeling in target and non-target organs in rats treated with aristolochic acid I. In: PHILLIPS DH, CASTEGNARO M, BARTSCH H (eds.): Postlabelling methods for detection of DNA adducts. Lyon International Agency for Research on Cancer, IARC Sci Publ 1993; 124: pp. 167-171.
4. JACKSON L, KOFMAN S, WEISS A, BRODOVSKY H: Aristolochic acid (NSC-50413): Phase I clinical study. Cancer Chemother Rep 1964; 42: 35-37.
5. 32P-adduct assay: comparative recoveries of structurally diverse DNA adducts in the various enhancement procedures. Carcinogenesis 1988; 9: 1687-1693.
6. KIMURA T, KODAMA M, NAGATA C; N-hydroxylation enzymes of carcinogenic aminoazo dyes: possible involvement of cytochrome P-448. Jpn J Cancer Gann 1982; 73: 455-462.
7. KRUMBIEGEL G, HALLENSLEBEN J, MEUNICKE W, et al.: Studies on the metabolism of aristolochic acid I and I. Xenobiotica 1987; 17: 981-991.
8. KUPCHAN SM, MERIANOS JJ: The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indiga. J Org Chem 1968; 33: 3735-3738.
9. MENGS U, LANG W, POCH JA: The carcinogenic action of aristolochic acid. Arch Toxicol 1982; 51: 107-119.
10. MENGS U: Tumour induction in mice following exposure to aristolochic acid. Arch Toxicol 1988; 61: 504-505.
11. PRIESTAP SM: Seven aristolactams from Aristolochia argentina. Phytochemistry 1985; 24: 849-852.
12. 32P-post-labelling test for structurally diverse DNA adducts. Carcinogenesis 1986; 7: 1543-1551.
13. SCHMEISER HH, POOL BL, WIESSLER M: Mutagenicity of the two main components of commercially available carcinogenic aristolochic acids in Salmonella typhimurium. Cancer Lett. 1984; 23: 97-101.
14. SCHMEISER HH, POOL BL, WIESSLER M: Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver. Carcinogenesis 1986; 7: 59-63.
15. 32P-postlabelling and high pressure liquid chromatographic analyses for 7,12-dimethylbez(a)anthracene-DNA adducts. Carcinogenesis 1988; 9: 633-638.
16. SCHMEISER HH, BIELER CA, WIESSLER M, et al.: Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 1996; 56: 2025-2028.
17. 32P-post-labelling: evidence for reductive activation by peroxidases. Carcinogenesis 1997; 18: 1055-1061.
18. STIBOROVÁ M, ASFAW B, ANZENBACHER P, et al.: The first identification of the benzenediazonium ion formation from a non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) by microsomes of rat livers. Cancer Lett 1988; 40: 319-326.
19. 32P-postlabelling of DNA adducts derived from peroxidase activation of carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I), Carcinogenesis 1990; 11: 1843-1848.
20. 32P-postlabelling analysis using different chromatographic procedure. Carcinogenesis 1994; 15: 1187-1192.
21. STIBOROVÁ M, FREI E, SCHMEISER HH, WIESSLER M: Cytochrome P-450 and peroxidase oxidize detoxication products of carcinogenic aristolochic acids (aristolactams) to reactive metabolites binding to DNA in vitro. Collect Czech Chem Commun 1995; 60: 2189-2199.
22. VAN HERWEGHEM JL, DEPIERREUX M, TIELEMANS C, et al.: Rapidly progressive instestitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993; 341: 387-391.
23. WOO Y-T, LAI DY, ARCOS JC, ARGUS MF: Chemical induction of cancer IIIc, Academic Press, San Diego, CA, 1988.
24. YAMAZOE Y, ZENSER TV, MILLER DW, KADLUBAR FF: Mechanism of formation and structural characterization of DNA adducts derived from peroxidative activation of benzidine. Carcinogenesis 1988; 8: 1635-1641.