Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats

Archives of Toxicology

Volumn 72, Issue 11, 1998, Pages 738-743

  Cosyns, Jean Pierre ^a   Goebbels, Rose Marie ^a   Liberton, Vinciane ^a   Schmeiser, Heinz H ^b   Bieler, Christian A ^b   Bernard, Alfred M ^c  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

Author keywords

Aristolochic acid; Carcinogenicity; Chinese herbs; Toxicology

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CHINESE HERB; CHINESE MEDICINE; FEMALE; FORESTOMACH; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH TUMOR; TOXICITY TESTING; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; ARISTOLOCHIC ACIDS; CARCINOGENS; DRUGS, CHINESE HERBAL; FEMALE; FIBRIN; MALE; NEPHRITIS, INTERSTITIAL; PHENANTHRENES; RATS; RATS, WISTAR; STOMACH NEOPLASMS;

ANIMALIA;

EID: 0032422056     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050568     Document Type: Article

References (24)

1. 32P-postlabeling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy. Carcinogenesis 18: 1063-1067
2. But PPH (1993) Need for correct identification of herbs in herbal poisoning. Lancet 341: 637
3. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV (1997) Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 337: 581-588
4. Cosyns JP, Jadoul M, Squifflet JP, De Plaen JF, Ferluga D, van Ypersele de Strihou C (1994a) Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int 45: 1680-1688
5. Cosyns JP, Jadoul M, Squifflet JP, Van Cangh PJ, van Ypersele de Strihou C (1994b) Urothelial malignancy in nephropathy due to Chinese herbs. Lancet 344: 188
6. Depierreux M, Van Damme B, Vanden Houte K, Vanherweghem JL (1994) Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs. Am J Kidney Dis 24: 172-180
7. Farthing MJG, Clark ML, Pendry A, Sloane J, Alexander P (1981) Nature of the toxicity of cyclosporin A in the rat. Biochem Pharmacol 30: 3311-3316
8. Gillum DM, Truong L, Tasby J, Migliore P, Suki WN (1988) Chronic cyclosporine nephrotoxicity. Transplantation 46: 285-292
9. Johnston CJ, Piedboeuf B, Baggs R, Rubin P, Finkelstein JN (1995) Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis. Radiat Res 142: 197-203
10. Mengs U (1988) Tumour induction in mice following exposure to aristolochic acid. Arch Toxicol 61: 504-505
11. Mengs U, Stotzem CD (1993) Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Arch Toxicol 67: 307-311
12. Mengs U, Lang W, Poch JA (1982) The carcinogenic action of aristolochic acid in rats. Arch Toxicol 51: 107-119
13. Ohtsuka Y, Munakata M, Ukita H, Takahashi T, Satoh A, Homma Y, Kawakami Y (1995) Increased susceptibility to silicosis and TNF-alpha production in C57BL/6J mice. Am J Respir Crit Care Med 152: 2144-2149
14. Reginster F, Jadoul M, van Ypersele de Strihou C (1997) Chinese herbs nephropathy presentation, natural history and fate after transplatation. Nephrol Dial Transplant 12: 81-86
15. Schmeiser HH, Pool BL, Wiessler M (1986) Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver. Carcinogenesis 7: 59-63
16. Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C, Cosyns JP (1996) Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 56: 2025-2028
17. Schrier DJ, Kunkel RG, Phan SH (1983) The role of strain variation in murine bleomycin-induced pulmonary fibrosis. Am Rev Respir Dis 127: 63-66
18. 32P-postlabelling analysis using different chromatographic procedures. Carcinogenesis 15: 1187-1192
19. Vanhaelen M, Vanhaelen-Fastre R, But P, Vanherweghem JL (1994) Identification of aristolochic acid in Chinese herbs. Lancet 343: 174
20. Vanherweghem JL (1997) Association of valvular heart disease with Chinese-herb nephropathy. Lancet 350: 1858
21. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R, Vanhaelen M (1993) Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 341: 387-391
22. Vanherweghem JL, Tielemans C, Simon J, Depierreux M (1995) Chinese herbs nephropathy and renal pelvic carcinoma. Nephrol Dial Transplant 10: 270-273
23. van Ypersele de Strihou C (1998) Valvular heart disease and Chinese-herb nephropathy. Lancet 351: 991
24. van Ypersele de Strihou C, Vanherweghem JL (1995) The tragic paradigm of Chinese herbs nephropathy. Nephrol Dial Transplant 10: 157-160