Cysteine mutagenesis and computer modeling of the S6 region of an intermediate conductance IKCa channel

Journal of General Physiology

Volumn 120, Issue 1, 2002, Pages 99-116

  Simoes, Manuel ^a   Garneau, Line ^a   Klein, Hélène ^b   Banderali, Umberto ^b   Hobeila, Fadi ^a   Roux, Benoit ^a   Parent, Lucie ^a   Sauvé, Rémy ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Calcium activated potassium channel; Channel pore; Cysteine; HeLa cells; Thiol reagents

Indexed keywords

ALANINE; CALCIUM ION; CYSTEINE; MUTANT PROTEIN; POTASSIUM CHANNEL; THIOL REAGENT; THREONINE; TRIMETHYLAMMONIUM SALT DERIVATIVE; VALINE; WATER; (2 (TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; (2 SULFONATOETHYL)METHANETHIOSULFONATE; (2-(TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; (2-SULFONATOETHYL)METHANETHIOSULFONATE; CALCIUM ACTIVATED POTASSIUM CHANNEL; MESYLIC ACID DERIVATIVE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CURRENT; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; ANIMAL; BIOLOGICAL MODEL; COMPUTER; ELECTRIC CONDUCTIVITY; GENETICS; OOCYTE; PHYSIOLOGY; XENOPUS LAEVIS;

ANIMAL; COMPUTERS; CYSTEINE; ELECTRIC CONDUCTIVITY; FEMALE; HELA CELLS; HUMAN; MESYLATES; MODELS, BIOLOGICAL; MODELS, GENETIC; MUTAGENESIS; OOCYTES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; SEQUENCE HOMOLOGY; SULFHYDRYL REAGENTS; SUPPORT, NON-U.S. GOV'T; XENOPUS LAEVIS; ANIMALS; HUMANS;

EID: 0036020150     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028586     Document Type: Article

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