The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells

Journal of Membrane Biology

Volumn 157, Issue 2, 1997, Pages 177-191

  Rittenhouse, A R ^a,d   Vandorpe, D H ^a,d   Brugnara, C ^b,c   Alper, S L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Charybdotoxin; Clotrimazole; Cytochrome P 450; Gardos channel; Iberiotoxin; MEL cells; Murine erythroleukemia cells; PC12; Pheochromocytoma cells; Potassium channels

Indexed keywords

ANTIFUNGAL AGENT; CALCIMYCIN; CHARYBDOTOXIN; CLOTRIMAZOLE; CYTOCHROME P450; DRUG METABOLITE; IBERIOTOXIN; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; ERYTHROLEUKEMIA CELL; ION CURRENT; NONHUMAN; PATCH CLAMP; PHEOCHROMOCYTOMA CELL; POTASSIUM CURRENT;

ANIMALS; ANIMALS, NEWBORN; ANTIFUNGAL AGENTS; CALCIMYCIN; CALCIUM; CLOTRIMAZOLE; IONOPHORES; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; PATCH-CLAMP TECHNIQUES; PC12 CELLS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SUPERIOR CERVICAL GANGLION; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0030916620     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002329900227     Document Type: Article

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