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Volumn 151, Issue 1, 1998, Pages 135-142

Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; CHLORPHENOTANE; ESTRADIOL; FLUTAMIDE; HYDROXYFLUTAMIDE; METHOXYCHLOR; PROGESTERONE; TESTOSTERONE;

EID: 0031752451     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8431     Document Type: Article
Times cited : (178)

References (43)
  • 1
    • 0020964670 scopus 로고
    • Estrogenic action of DDT analogs
    • Bulger, W. H., and Kupfer, D. (1983). Estrogenic action of DDT analogs. Am. J. Ind. Med. 4, 163-173.
    • (1983) Am. J. Ind. Med. , vol.4 , pp. 163-173
    • Bulger, W.H.1    Kupfer, D.2
  • 2
    • 0018078757 scopus 로고
    • Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation
    • Bulger, W. H., Muccitelli, R. M., and Kupper, D. (1978). Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem. Pharmacol. 27, 2417-2423.
    • (1978) Biochem. Pharmacol. , vol.27 , pp. 2417-2423
    • Bulger, W.H.1    Muccitelli, R.M.2    Kupper, D.3
  • 3
    • 0030907094 scopus 로고    scopus 로고
    • Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells
    • Chen, C. W., Hurd, C., Vorojeikina, D. P., Arnold, S. F., and Notides, A. C. (1997). Transcriptional activation of the human estrogen receptor by DDT isomers and metabolites in yeast and MCF-7 cells. Biochem. Pharmacol. 53, 1161-1172.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 1161-1172
    • Chen, C.W.1    Hurd, C.2    Vorojeikina, D.P.3    Arnold, S.F.4    Notides, A.C.5
  • 4
    • 0027428381 scopus 로고
    • Developmental effects of endocrine-disrupting chemicals in wildlife and humans
    • Colburn, T., vom Saal, F. S., and Soto, A. M. (1993). Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 101, 378-384.
    • (1993) Environ. Health Perspect. , vol.101 , pp. 378-384
    • Colburn, T.1    Vom Saal, F.S.2    Soto, A.M.3
  • 5
    • 0031039480 scopus 로고    scopus 로고
    • Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor
    • Doesburg, P., Kuil, C. W., Berrevoets, C. A., Steketee, K., Faber, P. W., Mulder, E., Brinkmann, A. O., and Trapman, J. (1997). Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor. Biochemistry 36, 1052-1064.
    • (1997) Biochemistry , vol.36 , pp. 1052-1064
    • Doesburg, P.1    Kuil, C.W.2    Berrevoets, C.A.3    Steketee, K.4    Faber, P.W.5    Mulder, E.6    Brinkmann, A.O.7    Trapman, J.8
  • 7
    • 0025321496 scopus 로고
    • The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin
    • Eil, C., and Nisula, B. C. (1990). The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin. J. Steroid Biochem. 35, 409-414.
    • (1990) J. Steroid Biochem. , vol.35 , pp. 409-414
    • Eil, C.1    Nisula, B.C.2
  • 8
    • 0016801085 scopus 로고
    • Estrogenic behavior of 2(o-chlorophenyl)-2-(p-chlorophenyl)-1,1,1-trichloroethane and its homologues
    • Forster, M. S., Wilder, E. L., and Heinrichs, W. L. (1975). Estrogenic behavior of 2(o-chlorophenyl)-2-(p-chlorophenyl)-1,1,1-trichloroethane and its homologues. Biochem. Pharmacol. 24, 1777-1780.
    • (1975) Biochem. Pharmacol. , vol.24 , pp. 1777-1780
    • Forster, M.S.1    Wilder, E.L.2    Heinrichs, W.L.3
  • 9
    • 0031105822 scopus 로고    scopus 로고
    • Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay
    • Gaido, K. W., Leonard, L. S., Lovell, S., Gould, J. C., Babai, D., Portier, C. J., and McDonnell, D. P. (1997). Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene transcription assay. Toxicol. Appl. Pharmacol. 143, 205-212.
    • (1997) Toxicol. Appl. Pharmacol. , vol.143 , pp. 205-212
    • Gaido, K.W.1    Leonard, L.S.2    Lovell, S.3    Gould, J.C.4    Babai, D.5    Portier, C.J.6    McDonnell, D.P.7
  • 10
    • 0343957442 scopus 로고
    • Estrogenic activity of the insecticide chlordecone (kepone) and interaction with uterine estrogen receptors
    • Hammond, B., Katzenellenbogen, B. S., Krauthammer, N., and McConnell, J. (1979). Estrogenic activity of the insecticide chlordecone (kepone) and interaction with uterine estrogen receptors. Proc. Natl. Acad. Sci. USA 76, 6641-6645.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 6641-6645
    • Hammond, B.1    Katzenellenbogen, B.S.2    Krauthammer, N.3    McConnell, J.4
  • 12
    • 0002488167 scopus 로고
    • The steroid hormone receptor superfamily - Molecular mechanisms of action
    • (B. Weintraub, Ed.), Raven Press, New York
    • Ing, N. H., and O'Malley, B. W. (1995). The steroid hormone receptor superfamily - molecular mechanisms of action. In Molecular Endocrinology: Basic Concepts and Clinical Correlations, (B. Weintraub, Ed.), pp. 195-215. Raven Press, New York.
    • (1995) Molecular Endocrinology: Basic Concepts and Clinical Correlations , pp. 195-215
    • Ing, N.H.1    O'Malley, B.W.2
  • 13
    • 0028860636 scopus 로고
    • Do environmental estrogens contribute to the decline in male reproductive health?
    • Jensen, T. K., Toppari, J., Keiding, N., and Skakkebaek, N. E. (1995). Do environmental estrogens contribute to the decline in male reproductive health? Clin. Chem. 41, 1896-1901.
    • (1995) Clin. Chem. , vol.41 , pp. 1896-1901
    • Jensen, T.K.1    Toppari, J.2    Keiding, N.3    Skakkebaek, N.E.4
  • 14
    • 0030071445 scopus 로고    scopus 로고
    • Tripartite steroid hormone receptor pharmacology: Interaction with multiple effector sites as a basis for the cell- And promoter-specific action of these hormones
    • Katzenellenbogen, J. A., O'Malley, B. W., and Katzenellenbogen, B. S. (1996). Tripartite steroid hormone receptor pharmacology: Interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones. Mol. Endocrinol. 10, 119-131.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 119-131
    • Katzenellenbogen, J.A.1    O'Malley, B.W.2    Katzenellenbogen, B.S.3
  • 15
    • 0031019418 scopus 로고    scopus 로고
    • Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism
    • Kelce, W. R. (1997). Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism. Toxicol. Appl. Pharmacol. 142, 192-200.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 192-200
    • Kelce, W.R.1
  • 16
    • 0029047149 scopus 로고
    • Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist
    • Kelce, W. R., Stone, C. R., Laws, S. C., Gray, L. E., Kemppainen, J. A., and Wilson, E. M. (1995). Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist. Nature 375, 581-585.
    • (1995) Nature , vol.375 , pp. 581-585
    • Kelce, W.R.1    Stone, C.R.2    Laws, S.C.3    Gray, L.E.4    Kemppainen, J.A.5    Wilson, E.M.6
  • 17
    • 0030981923 scopus 로고    scopus 로고
    • Environmental antiandrogens: Developmental effects, molecular mechanisms, and clinical implications
    • Kelce, W. R., and Wilson, E. M. (1997). Environmental antiandrogens: Developmental effects, molecular mechanisms, and clinical implications. J. Mol. Med. Immunol. 75, 198-207.
    • (1997) J. Mol. Med. Immunol. , vol.75 , pp. 198-207
    • Kelce, W.R.1    Wilson, E.M.2
  • 18
    • 0026595896 scopus 로고
    • Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones
    • Kemppainen, J. A., Lane, M. V., Sar, M., and Wilson, E. M. (1992). Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones. J. Biol. Chem. 267, 968-974.
    • (1992) J. Biol. Chem. , vol.267 , pp. 968-974
    • Kemppainen, J.A.1    Lane, M.V.2    Sar, M.3    Wilson, E.M.4
  • 19
    • 0030200951 scopus 로고    scopus 로고
    • Agonist and antagonist activities of hydroxyflutamide and Casodex relate to androgen receptor stabilization
    • Kemppainen, J. A., and Wilson, E. M. (1996). Agonist and antagonist activities of hydroxyflutamide and Casodex relate to androgen receptor stabilization. Urology 48, 157-163.
    • (1996) Urology , vol.48 , pp. 157-163
    • Kemppainen, J.A.1    Wilson, E.M.2
  • 20
    • 0023839436 scopus 로고
    • Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes
    • Korach, K. S., Sarver, P., Chae, K., McLachlan, J. A., and McKinney, J. D. (1988). Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes. Mol. Pharmacol. 33, 120-126.
    • (1988) Mol. Pharmacol. , vol.33 , pp. 120-126
    • Korach, K.S.1    Sarver, P.2    Chae, K.3    McLachlan, J.A.4    McKinney, J.D.5
  • 21
    • 0027222826 scopus 로고
    • Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving
    • Krishnan, A. V., Stathis, P., Permuth, S. F., Tokes, L., and Feldman, D. (1993). Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132, 2279-2286.
    • (1993) Endocrinology , vol.132 , pp. 2279-2286
    • Krishnan, A.V.1    Stathis, P.2    Permuth, S.F.3    Tokes, L.4    Feldman, D.5
  • 22
    • 0028891989 scopus 로고
    • Ligand-induced conformational alterations of the androgen receptor analyzed by limited trypsinization - Studies on the mechanism of antiandrogen action
    • Kuil, C. W., Berrevoets, C. A., and Mulder, E. (1995). Ligand-induced conformational alterations of the androgen receptor analyzed by limited trypsinization - studies on the mechanism of antiandrogen action. J. Biol. Chem. 270, 27569-27576.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27569-27576
    • Kuil, C.W.1    Berrevoets, C.A.2    Mulder, E.3
  • 23
    • 0028237201 scopus 로고
    • Mechanism of antiandrogen action: Conformational changes of the receptor
    • Kuil, C. W., and Mulder, E. (1994). Mechanism of antiandrogen action: Conformational changes of the receptor. Mol. Cell. Endocrinol. 102, R1-5.
    • (1994) Mol. Cell. Endocrinol. , vol.102
    • Kuil, C.W.1    Mulder, E.2
  • 24
    • 0029124028 scopus 로고
    • Effects of androgens and antiandrogens on the conformation of the androgen receptor
    • Kuil, C. W., and Mulder, E. (1995). Effects of androgens and antiandrogens on the conformation of the androgen receptor. Ann. NY Acad. Sci. 761, 351-354.
    • (1995) Ann. NY Acad. Sci. , vol.761 , pp. 351-354
    • Kuil, C.W.1    Mulder, E.2
  • 25
    • 0029560494 scopus 로고
    • Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer
    • Langley, E., Zhou, Z. X., and Wilson, E. M. (1995). Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer. J. Biol. Chem. 270, 29983-29990.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29983-29990
    • Langley, E.1    Zhou, Z.X.2    Wilson, E.M.3
  • 26
    • 0029038986 scopus 로고
    • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens
    • McDonnell, D. P., Clemm, D. L., Herman, T., Goldman, M. E., and Pike, J. W. (1995). Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol. Endocrinol. 9, 659-669.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 659-669
    • McDonnell, D.P.1    Clemm, D.L.2    Herman, T.3    Goldman, M.E.4    Pike, J.W.5
  • 28
    • 0030893546 scopus 로고    scopus 로고
    • Relative binding affinity serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol a and octylphenol
    • Nagel, S. C., vom Saal, F. S., Thayer, K. A., Dhar, M. G., Boechler, M., and Welshons, W. V. (1997). Relative binding affinity serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ. Health Perspect. 105, 70-76.
    • (1997) Environ. Health Perspect. , vol.105 , pp. 70-76
    • Nagel, S.C.1    Vom Saal, F.S.2    Thayer, K.A.3    Dhar, M.G.4    Boechler, M.5    Welshons, W.V.6
  • 29
    • 0029856633 scopus 로고    scopus 로고
    • Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity
    • Norris, J. D., Fan, D. J., Wagner, B. L., and McDonnell, D. P. (1996). Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. Mol. Endocrinol. 10, 1605-1616.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1605-1616
    • Norris, J.D.1    Fan, D.J.2    Wagner, B.L.3    McDonnell, D.P.4
  • 30
    • 0029810140 scopus 로고    scopus 로고
    • Subcellular distribution of glucocorticoid receptor in cultured rat and human liver-derived cells and cell lines: Influence of dexamethasone
    • Raddatz, D., Henneken, M., Armbrust, T., and Ramadori, G. (1996). Subcellular distribution of glucocorticoid receptor in cultured rat and human liver-derived cells and cell lines: Influence of dexamethasone. Hepatology 24, 928-933.
    • (1996) Hepatology , vol.24 , pp. 928-933
    • Raddatz, D.1    Henneken, M.2    Armbrust, T.3    Ramadori, G.4
  • 31
    • 0030704659 scopus 로고    scopus 로고
    • Additive estrogenic activities of a binary mixture of 2′,4′,6′-trichloro- And 2′,3′,4′,5′-tetrachloro-4- biphenylol
    • Ramamoorthy, K., Vyhlidal, C., Wang, F., Chen, I. C., Safe, S., McDonnell, D. P., Leonard, L. S., and Gaido, K. W. (1997). Additive estrogenic activities of a binary mixture of 2′,4′,6′-trichloro- and 2′,3′,4′,5′-tetrachloro-4- biphenylol. Toxicol. Appl. Pharmacol. 147, 93-100.
    • (1997) Toxicol. Appl. Pharmacol. , vol.147 , pp. 93-100
    • Ramamoorthy, K.1    Vyhlidal, C.2    Wang, F.3    Chen, I.C.4    Safe, S.5    McDonnell, D.P.6    Leonard, L.S.7    Gaido, K.W.8
  • 32
    • 0022320032 scopus 로고
    • Estrogenic activity of DDT: Estrogen-receptor profiles and the responses of individual uterine cell types following o,p′-DDT administration
    • Robison, A. K., Schmidt, W. A., and Stancel, G. M. (1985). Estrogenic activity of DDT: Estrogen-receptor profiles and the responses of individual uterine cell types following o,p′-DDT administration. J. Toxicol. Environ. Health 16, 493-508.
    • (1985) J. Toxicol. Environ. Health , vol.16 , pp. 493-508
    • Robison, A.K.1    Schmidt, W.A.2    Stancel, G.M.3
  • 33
    • 0027232797 scopus 로고
    • Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract
    • Sharpe, R. M., and Skakkebaek, N. F. (1993). Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract. Lancet 341, 1392-1395.
    • (1993) Lancet , vol.341 , pp. 1392-1395
    • Sharpe, R.M.1    Skakkebaek, N.F.2
  • 34
    • 0026042049 scopus 로고
    • Nonylphenol: An estrogenic xenobiotic released from "modified" polystyrene
    • Soto, A. M., Honorato, J., Wray, J. W., and Sonnenschein, C. (1991). Nonylphenol: An estrogenic xenobiotic released from "modified" polystyrene. Environ. Health Perspect. 92, 167-173.
    • (1991) Environ. Health Perspect. , vol.92 , pp. 167-173
    • Soto, A.M.1    Honorato, J.2    Wray, J.W.3    Sonnenschein, C.4
  • 35
    • 84995870933 scopus 로고
    • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions
    • Tzukerman, M. T., Esty, A., Santiso-Mere, D., Danielian, P., Parker, M. G., Stein, R. B., Pike, J. W., and McDonnell, D. P. (1994). Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol. Endocrinol. 8, 21-30.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 21-30
    • Tzukerman, M.T.1    Esty, A.2    Santiso-Mere, D.3    Danielian, P.4    Parker, M.G.5    Stein, R.B.6    Pike, J.W.7    McDonnell, D.P.8
  • 36
    • 0027427216 scopus 로고
    • Human progesterone receptor a form is a cell- And promoter-specific repressor of human progesterone receptor B function
    • Vegeto, E., Shahbaz, M. M., Wen, D. X., Goldman, M. E., O'Malley, B. W., and McDonnell, D. P. (1993). Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol. Endocrinol. 7, 1244-1255.
    • (1993) Mol. Endocrinol. , vol.7 , pp. 1244-1255
    • Vegeto, E.1    Shahbaz, M.M.2    Wen, D.X.3    Goldman, M.E.4    O'Malley, B.W.5    McDonnell, D.P.6
  • 38
    • 0028233813 scopus 로고
    • Environmentally persistent alkylphenolic compounds are estrogenic
    • White, R., Jobling, S., Hoare, S. A., Sumpter, J. P., and Parker, M. G. (1994). Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-181.
    • (1994) Endocrinology , vol.135 , pp. 175-181
    • White, R.1    Jobling, S.2    Hoare, S.A.3    Sumpter, J.P.4    Parker, M.G.5
  • 39
    • 0028801268 scopus 로고
    • Environmental organochlorine exposure as a potential etiologic factor in breast cancer
    • Wolff, M. S., and Toniolo, P. G. (1995). Environmental organochlorine exposure as a potential etiologic factor in breast cancer. Environ. Health Perspect. 103, 141-145.
    • (1995) Environ. Health Perspect. , vol.103 , pp. 141-145
    • Wolff, M.S.1    Toniolo, P.G.2
  • 40
    • 0029123855 scopus 로고
    • Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide
    • Wong, C. I., Kelce, W. R., Sar, M., and Wilson, E. M. (1995). Androgen receptor antagonist versus agonist activities of the fungicide vinclozolin relative to hydroxyflutamide. J. Biol. Chem. 270, 19998-20003.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19998-20003
    • Wong, C.I.1    Kelce, W.R.2    Sar, M.3    Wilson, E.M.4
  • 41
    • 0030889734 scopus 로고    scopus 로고
    • Hydroxyflutamide may not always be a pure antiandrogen
    • Yeh, S., Miyamoto, H., and Chang, C. (1997). Hydroxyflutamide may not always be a pure antiandrogen [letter]. Lancet 349, 852-853.
    • (1997) Lancet , vol.349 , pp. 852-853
    • Yeh, S.1    Miyamoto, H.2    Chang, C.3
  • 42
    • 0029951486 scopus 로고    scopus 로고
    • Cloning and characterization of a specific coactivator, ARA(70), for the androgen receptor in human prostate cells
    • Yeh, S. Y., and Chang, C. S. (1996). Cloning and characterization of a specific coactivator, ARA(70), for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. USA 93, 5517-5521.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5517-5521
    • Yeh, S.Y.1    Chang, C.S.2
  • 43
    • 0028809317 scopus 로고
    • Specificity of ligand-dependent androgen receptor stabilization: Receptor domain interactions influence ligand dissociation and receptor stability
    • Zhou, Z. X., Lane, M. V., Kemppainen, J. A., French, F. S., and Wilson, E. M. (1995). Specificity of ligand-dependent androgen receptor stabilization: Receptor domain interactions influence ligand dissociation and receptor stability. Mol. Endocrinol. 9, 208-218.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 208-218
    • Zhou, Z.X.1    Lane, M.V.2    Kemppainen, J.A.3    French, F.S.4    Wilson, E.M.5


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