Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation

Toxicological Sciences

Volumn 55, Issue 1, 2000, Pages 143-151

  Mylchreest, Eve ^a,c   Wallace, Duncan G ^c   Cattley, Russell C ^b,c   Foster, Paul M D ^c  

^a DUPONT COMPANY   (United States)

^b AMGEN INC   (United States)

^c CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Ale reproductive development; Androgen; Di(n butyl); In utero exposure; Leydig cell hyperplasia; Phthalate; Reproductive tract malformations; Testicular toxicity

Indexed keywords

PHTHALIC ACID DIBUTYL ESTER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FETUS; FETUS MALFORMATION; GESTATIONAL AGE; HYPOSPADIAS; LEYDIG CELL; MALE; MALE GENITAL TRACT MALFORMATION; NONHUMAN; PREGNANCY; RAT; REPRODUCTIVE TOXICITY; TESTIS CELL;

EID: 0034021024     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/55.1.143     Document Type: Article

References (37)

1. Arcadi, F. A., Costa, C., Imperatore, C., Marchese, A., Rapisarda, A., Salemi, M., Trimarchi, G. R., and Costa, G. (1998). Oral toxicity of bis(2-ethylhexyl) phthalate during pregnancy and suckling in the Long-Evans rat. Food Chem. Toxicol. 36, 963-970.
2. Boorman, G. A., Hamlin, M. H., and Eustis, S. L. (1987). Focal Interstitial cell hyperplasia, testes, rat. In Monographs on the Pathology of Laboratory Animals. Genital System (T. C. Jones, U. Mohr, and R. D. Hunt, Eds.), pp. 200-204. Springer-Verlag, Berlin.
3. Cater, B. R., Cook, M. W., Gangolli, S. D., and Grasso, P. (1977). Studies on dihutyl phthalate-induced testicular atrophy in the rat: Effect on zinc metabolism. Toxicol. Appl. Pharmacol. 41, 609-618.
4. Cattley, R. C., DeLuca, J., Elcombe, C., Fenner-Crisp, P., Lake, B. G., Marsman, D. S., Pastoor, T. A., Popp, J. A., Robinson, D. E., Schwetz, B., Tugwood, J., and Wahli, W. (1998). Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? Regul. Toxicol. Pharmacol. 27, 47-60.
5. Dostal, L. A., Chapin, R. E., Stefanski, S. A., Harris, M. W., and Schwetz, B. A. (1988). Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults. Toxicol. Appl. Pharmacol. 95, 104-121.
6. Ema, M., Amano, H., Itami, T., and Kawasaki, H. (1993). Teratogenic evaluation of di-n-butyl phthalate in rats. Toxicol. Lett. 69, 197-203.
7. Foster, P. M. D., Foster, J. R., Cook, M. W., Thomas, L. V., and Gangolli, S. D. (1982). Changes in ultrastructure and cytochemical localization of zinc in rat testis following the administration of di-n-pentyl phthalate. Toxicol. Appl. Pharmacol. 63, 120-132.
8. Foster, P. M. D., Thomas, L. V., Cook, M. W., and Gangolli, S. D. (1980). Study of the testicular effects and changes in zinc excretion produced by some n-alkyl phthalates in the rat. Toxicol. Appl. Pharmacol. 54, 392-398.
9. Gray, L. E., Jr., Ostby, J., Monosson, E., and Kelce, W. R. (1999a). Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat. Toxicol. Ind. Health 15, 48-64.
10. Gray, L. E., Jr., Wolf, C., Lambright, C., Mann, P., Price, M., Cooper, R. L., and Ostby, J. (1999b). Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl-and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol. Ind. Health 15, 94-118.
11. Gray, T. J. B., and Beamand, J. A. (1984). Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells. Food Chem. Toxicol. 22, 123-131.
12. Gray, T. J. B., Butterworth, K. R., Gaunt, I. F., Grasso, G. P., and Gangolli, S. D. (1977). Short-term toxicity study of di-(2-ethylhexyl) phthalate in rats. Food Cosmet. Toxicol. 15, 389-399.
13. Hess, R. A., Bunick, D., Lee, K. H., Bahr, J., Taylor, J. A., Korach, K. S., and Lubahn, D. B. (1997). A role for estrogens in the male reproductive system. Nature 390, 509-512.
14. Imperato-McGinley, J., Binienda, Z., Gedney, J., and Vaughan, E. D., Jr. (1986). Nipple differentiation in fetal male rats treated with an inhibitor of the enzyme 5 alpha-reductase: Definition of a selective role for dihydrotestosterone. Endocrinology 118, 132-137.
15. IPCS (International Programme on Chemical Safety). (1997). Environmental Health Criteria 189. Di-n-Butyl Phthalate. World Health Organization, Geneva.
16. Jost, A., Vigier, B., Prépin, J., and Perchellet, J.-P. (1973). Studies on sex differentiation in mammals. Recent Prog. Horm. Res. 29, 1-41.
17. Kendall, R. J., Dickerson, R. L., Giesy, J. P., and Suk, W. P. (1998). Principles and Processes for Evalulating Endocrine Disruption in Wildlife. SETAC Press, Pensacola, FL.
18. Keys, D. A., Wallace, D. G., Kepler, T. B., and Conolly, R. B. (1999). Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats. Toxicol. Sci. 49, 172-185.
19. Korenbrot, C. C., Huhtaniemi, I. T., and Weiner, R. I. (1977). Preputial separation as an external sign of pubertal development in the male rat. Biol. Reprod. 17, 298-303.
20. Mylchreest, E., Cattley, R. C., and Foster, P. M. D. (1998). Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism? Toxicol. Sci. 43, 47-60.
21. Mylchreest, E., Sar, M., Cattley, R. C., and Foster, P. M. D. (1999). Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol. Appl. Pharmacol. 156, 81-95.
22. Neumann, F., Berswordt-Wallrabe, R. V., Elger, W., Steinbeck, H., Hahn, J. D., and Kramer, M. (1970). Aspects of androgen-dependent events as studied by antiandrogens. Recent Prog. Horm. Res. 26, 337-410.
23. Neumann, F., and Goldman, A. S. (1970). Prevention of mammary gland defects in experimental congenital adrenal hyperplasia due to inhibition to 3 beta-hydroxysteroid dehydrogenase in rats. Endocrinology 86, 1169-1171.
24. NRC (National Research Council). (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.
25. NTP (National Toxicology Program). (1991). Final Report on the Reproductive Toxicity of Di-n-butyl Phthalate (CAS No. 84-74-2) in Sprague-Dawley Rats. NTIS Publication No. PB92-111996, National Technical Information Service (NTIS), U.S. Department of Commerce. Springfield, VA.
26. NTP (National Toxicology Program). (1995). Toxicity studies of dibutyl phthalate (CAS No. 84-74-2) administered in feed to F344/N rats and B6C3F1 mice. NTIS Publication No. PB95-232427, National Technical Information Service (NTIS), U.S. Department of Commerce. Springfield, VA.
27. Ostby, J., Kelce, W. R., Lambright, C., Wolf, C. J., Mann, P., and Gray, L. E., Jr. (1999). The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro. Toxicol. Ind. Health 15, 80-93.
28. Poon, R., LeCavalier, P., Mueller, R., Valli, V. E., Procter, B. G., and Chu, I. (1997). Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl) phthalate in the rat. Food Chem. Toxicol. 35, 225-239.
29. Rhodes, C., Orton, T. C., Pratt, I. S., Batten, P. L., Bratt, H., Jackson, S. J., and Elcombe, C. R. (1986). Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP) in rats and marmosets: Extrapolation of effects in rodents to man. Environ. Health Perspect. 65, 299-308.
30. Saillenfait, A. M., Payan, J. P., Fabry, J. P., Beydon, D., Langonne, I., Gallissot, F., and Sabate, J. P. (1998). Assessment of the developmental toxicity, metabolism, and placental transfer of di-n-butyl phthalate administered to pregnant rats. Toxicol. Sci. 45, 212-224.
31. Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L. J., Jr., Jégou, B., Jensen, T. K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J. A., Meyer, O., Müller, J., Rajpert-De Meyts, E., Scheike, T., Sharpe, R., Sumpter, J., and Skakkebæk, N. E. (1996). Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104(Suppl. 4), 741-803.
32. UK MAFF (United Kingdom Ministry of Agriculture, Fisheries, and Food). (1998). Phthalates in Food and Infant Formulae: Follow-up Survey. Food Surveillance Information Sheet No. 168. MAFF. London, UK.
33. UK MAFF (United Kingdom Ministry of Agriculture, Fisheries, and Food). (1996a). Phthalates in Food. Food Surveillance Information Sheet No. 82. MAFF. London, UK.
34. UK MAFF (United Kingdom Ministry of Agriculture, Fisheries, and Food). (1996b). Phthalates in Infant Formulae. Food Surveillance Information Sheet No. 83. MAFF. London, UK.
35. UK MAFF (United Kingdom Ministry of Agriculture, Fisheries, and Food). (1990). Plasticizers: Continuing Surveillance. Food Surveillance Paper No. 30. HMSO Publications. London, UK.
36. Warren, D. W., Huhtaniemi, I. T., Tapanainen, J., Dufau, M. L., and Catt, K. J. (1984). Ontogeny of gonadotrophin receptors in the fetal and neonatal rat testis. Endocrinology 114, 470-176.
37. You, L., Casanova, M., Archibeque-Engle, S., Sar, M., Fan, L. Q., and Heck, H. A. (1998). Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p′-DDE. Toxicol. Sci. 45, 162-173.