The induction of transplantation tolerance by intrathymic (i.t.) delivery of alloantigen: A critical relationship between i.t. deletion, thymic export of new T cells and the timing of transplantation

International Immunology

Volumn 10, Issue 11, 1998, Pages 1637-1646

  Jones, Nick D ^a   Fluck, Nick C ^a   Mellor, Andrew L ^b   Morris, Peter J ^a   Wood, Kathryn J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Cardiac allograft; TCR transgenic mice

Indexed keywords

ALLOANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DONOR; HEART TRANSPLANTATION; HISTOCOMPATIBILITY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GRAFT SURVIVAL; H-2 ANTIGENS; HEART TRANSPLANTATION; IMMUNE TOLERANCE; IMMUNOSUPPRESSION; INJECTIONS, INTRALYMPHATIC; ISOANTIGENS; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SPLEEN; T-LYMPHOCYTES; THYMECTOMY; THYMUS GLAND; TIME FACTORS; TRANSPLANTATION, HETEROTOPIC;

EID: 0031725432     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.11.1637     Document Type: Article

References (40)

1. Miller, J. F. A. P. 1961. Immunological functions of the thymus. Lancet ii:748
2. Zinkernagel, R. M., Althage, A., Waterfield, E., Kindred, B., Welsh, R. M., Callahan, G. and Pincett, P. 1980. Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts. J. Exp. Med. 151:376
3. Nossal, G. J. V. and Pike, B. L. 1981. Functional clonal deletion in immunological tolerance to major histocompatibility complex antigens. Proc. Natl Acad. Sci. USA 78:3844
4. Good, M. F., Pyke, K. W. and Nossal, G. J. V. 1983. Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic anlagen. Proc. Natl Acad. Sci. USA 80:3045.
5. Kappler, J., Rohm, N. and Marrack, P. 1987. T cell tolerance by clonal elimination in the thymus Cell 49:273.
6. a-encoded antigens. Nature 332:40.
7. + thymocytes. Nature 333:742.
8. Pircher, H., Burki, K., Lang, R., Hengartner, H. and Zinkernagel, R. M. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559.
9. Ramsdell, F., Lantz, T. and Fowlkes, B. J. 1989. A non-deletional mechanism of thymic self tolerance. Science 246:1038.
10. Roberts, J. L., Sharrow, S. O. and Singer, A. 1990. Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. J. Exp. Med. 171:935.
11. Blackman, M. A., Gerhard-Burgert, H., Woodland, D. L., Palmer, E., Kappler, J. W. and Marrack, P. 1990. A role for clonal inactivation in T cell tolerance to MIs-1a. Nature 345:540
12. Grossman, Z. 1993. Cellular tolerance as a dynamic state of the adaptable lymphocyte. Immunol. Rev 133:45.
13. Kawai, K. and Ohashi, P. S. 1995. Immunological function of a defined T cell population tolerized to low-affinity self antigens. Nature 374:68.
14. Sebzda, E., Kundig, T. M., Thomson, C. T., Aoki, K., Mak, S.-Y., Mayer, J. P., Zamborelli, T., Nathenson, S. G. and Ohashi, P. S. 1996. Mature T cell reactivity altered by peptide agonist that induces positive selection. J. Exp. Med. 183:1093.
15. Husbands, S. D., Schonrich, G., Arnold, B., Chandler, P. R., Simpson, E., Philpott, K. L., Tomlinson, P., O'Reilly, L. and Mellor, A. L. 1992. Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non-deletional mechanism. Eur. J. Immunol. 22:2655.
16. Auphan, N., Curnow, J., Guimezanes, A., Langlet, C., Malissen, B., Mellor, A. L. and Schmitt-Verhulst, A.-M. 1994. The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR-transgenic mice. Eur. J. Immunol. 24:1572.
17. Jameson., S. C., Hogquist, K. A. and Bevan, M. J. 1994. Specificity and flexibility in thymic selection. Nature 369:750.
18. Posselt, A. M., Barker, C. F., Tomaszewski, J. E., Markmann, J. F., Choti, M. A. and Naji, A. 1990. Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science 49:1293.
19. Staples, P. J., Gery, I. and Waksman, B. H. 1966. Role of the thymus in tolerance: III Tolerance to bovine gamma globulin after direct injection of antigen into the shielded thymus of irradiated rats. J. Exp. Med. 124:127.
20. Vbjtiskova, M. and Lengerova, A. 1968. Thymus-mediated tolerance to cellular alloantigens. Transplantation 6:13.
21. Posselt, A. M., Barker, C. F., Friedman, A. L. and Naji, A. 1992. Prevention of autoimmune diabetes in the BB Rat by intrathymic islet transplantation at birth. Science 256:1321.
22. Posselt, A. M., Barker, C. F., Friedman, A. L., Koeberlein, B., Tomaszewski, J. E. and Naji, A. 1993. Intrathymic inoculation of islets at birth prevents autoimmune diabetes and pancreatic insulitis in the BB rat. Transplant. Proc. 25:301.
23. Nomura, Y., Stein, E. and Mullen, Y. 1993. Prevention of overt diabetes and insulitis by intrathymic injection of syngeneic islets in newborn non-obese diabetic (NOD) mice. Transplantation 56:638.
24. Sponaas, A.-M., Tomlinson, P. D., Schultz, R., Antoniou, J., Ize-lyamu, P., Schmitt-Verhulst, A.-M. and Mellor, A. L. 1994. Tolerance induction by elimination of subsets of self-reactive thymocytes. Int. Immunol. 6:1593.
25. Sponaas, A.-M., Tomlinson, P. D., Antoniou, J., Auphan, N., Langlet, C., Malissen, B., Schmitt-Verhulst, A.-M. and Mellor, A. L. 1994. Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or β-globin gene promoters. Int. Immunol. 6:277.
26. Corry, R. J., Winn, H. J. and Russel, P. S. 1973. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation 16:343.
27. Superina, R. A., Peugh, W. M., Wood, K. J. and Morris, P. J. 1986. Assessment of primary vascularized cardiac allografts in mice. Transplantation 42:225.
28. Cobbold, S. P., Jayasuriya, A., Nash, A., Prospero, T. D. and Waldmann, H. 1984. Therapy by monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312:548.
29. Buferne, M., Luton, F., Letourneur, F., Hoeveler, A., Couez, D., Barad, M., Malissen, B., Schmitt-Verhulst, A.-M. and Boyer, C. 1992. Role of CD3 delta in surface expression of the TCR/CD3 complex and in activation for killing analyzed with a CD3 delta-negative cytotoxic T lymphocyte variant. J. Immunol. 148:657.
30. Pearson, T. C., Hamano, K., Morris, P. J. and Wood, K. J. 1993. Anti-CD4 monoclonal antibody-induced allograft survival is associated with a defect in interleukin-2-dependent T-cell activation. Transplant. Proc. 25:786.
31. b antibody. Immune System 2:202.
32. Steinman, R. M., Nogueira, N., Witmer, M. D., Tydings, J. D. and Mellman, I. S. 1980. Lymphokine enhances the expression and synthesis of la antigens on cultured mouse peritoneal macrophages. J. Exp. Med. 152:1248.
33. Adams, T. E., Alpert, S. and Hanahan, D. 1987. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 325:223.
34. Lo, D., Freedman, J., Hesse, S., Brinster, R. L. and Sherman, L. 1991. Peripheral tolerance in transgenic mice: tolerance to Class II MHC and non-MHC transgene antigen. Immunol. Rev. 122:87.
35. Arnold, B., Schonrich, G. and Hammerling, G. J. 1992. Extrathymic T-cell selection. Curr. Opin. Immunol. 4:166.
36. Arnold, B., Schonrich, G. and Hammerling, G. J. 1993. Multiple levels of peripheral tolerance. Immunol. Today 14:12.
37. Ridge, J. P., Fuchs, E. J. and Matzinger, P. 1996. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 271:1723.
38. Sarzotti, M., Robbins, D. S. and Huffman, P. M. 1996. Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271:1726.
39. h2 immunity in neonatal mice. Science 271:1728.
40. Coulombe, M. and Gill, R. G. 1996. T lymphocyte indifference to extrathymic islet allografts. J. Immunol. 156:1998.