Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors

Biochemistry

Volumn 40, Issue 34, 2001, Pages 10179-10186

  Liu, S ^a   Laliberte F ^a   Bobechko, B ^a   Bartlett, A ^a   Lario, P ^a   Gorseth, E ^a   Van Hamme, J ^a   Gresser, M J ^a   Huang, Z ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIVALENT METAL IONS;

ASSAYS; CATALYSIS; ENZYMES; HYDROLYSIS; STOICHIOMETRY;

BIOCHEMISTRY;

ADENOSINE PHOSPHATE; APOENZYME; CATION; COBALT; CYCLIC AMP; HOLOENZYME; LIGAND; MAGNESIUM; MANGANESE; METAL ION; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL BOND; DOSE RESPONSE; DRUG BINDING; HYDROLYSIS; LIGAND BINDING; PRIORITY JOURNAL; STOICHIOMETRY;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADENOSINE MONOPHOSPHATE; APOENZYMES; BINDING SITES; BINDING, COMPETITIVE; CATIONS, DIVALENT; COBALT; CYCLIC AMP; KINETICS; LIGANDS; MAGNESIUM; MANGANESE; MODELS, CHEMICAL; PEPTIDE FRAGMENTS; PHOSPHODIESTERASE INHIBITORS; RECOMBINANT FUSION PROTEINS; ROLIPRAM; STEREOISOMERISM;

EID: 0035964174     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi010096p     Document Type: Article

References (39)