Dual inhibition of human type 4 phosphodiesterase isostates by (R*,R*)-(±)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate

Biochemistry

Volumn 37, Issue 19, 1998, Pages 6894-6904

  Tian, Gaochao ^a   Rocque, Warren J ^a   Wiseman, Jeffrey S ^a,b   Thompson, Irene Z ^a,c   Holmes, William D ^a   Domanico, Paul L ^a   Stafford, Jeffrey A ^a   Feldman, Paul L ^a   Luther, Michael A ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYL 3 ACETYL 4 [3 (CYCLOPENTYLOXY) 4 METHYOXYPHENYL] 3 METHYL 1 PYRROLIDENECARBOXYLATE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; GENE MUTATION; HUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; BINDING, COMPETITIVE; HUMANS; ISOENZYMES; MUTAGENESIS, SITE-DIRECTED; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINES; PYRROLIDINONES; ROLIPRAM; SEQUENCE DELETION;

EID: 0032510819     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972700v     Document Type: Article

References (23)

1. Beavo, J. A. (1988) in Advances in Second Messenger and Phosphoprotein Research (Greengard, P., and Robison, G. A., Eds.) Vol. 22, pp 1-38, Raven Press, New York.
2. Beavo, J. A., and Reifsnyder, D. H. (1990) Trends Pharmacol. Sci. 11, 150-155.
3. Michaeli, T., Bloom, T. J., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J. A., and Wigler, M. (1993) J. Biol. Chem. 268, 12925-12932.
4. Farber, D. B., Bowes, C., and Danciger, M. (1991) Prog. Clin. Biol. Res. 362, 67-89.
5. Pittler, S. J., and Baehr, W. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 8322-8326.
6. Lee, H. R., Hershberger, R. E., Port, J. D., Rasmussen, R., Renlund, D. G., O'Connell, J. B., Gilbert, E. M., Mealey, P. C., Volkman, K., and Menlove, R. (1991) J. Thorac. Cardiovasc. Surg. 102, 246-258.
7. O'Connell, J. B., Gilbert, E. M., Renlund, D. G., and Bristow, M. R. (1991) J. Heart Lung Transplant. 10, 477-481.
8. Torphy, T. J. (1988) Agents Actions 23 (Suppl), S37-53.
9. Torphy, T. J., and Hay, D. W. P. (1990) in Airway smooth muscle: modulation of receptors and response (Townley, R. G., and Agrawal, D. K., Eds.) pp 39-68, CRC Press, Boca Raton.
10. Bourne, H. R., Lichtenstein, L. M., Melmon, K. L., Henney, C. S., Weinstein, Y., and Shearer, G. M. (1974) Science 184, 19-28.
11. Plaut, M., Marone, G., Thomas, L. L., and Lichtenstein, L. M. (1980) Adv. Cyclic Nucleotide Res. 12, 161-172.
12. Kaehl, F. A., Zannetti, M. E., Soderman, D. D., Miller, K. D., and Ham, E. A. (1987) Am. Rev. Respir. Dis. 136, 210-213.
13. Schneider, H. H., Schmiechen, R., Brezinski, M., and Seidler, J. (1986) Eur. J. Pharmacol. 127, 105-115.
14. Saccomano, N. A., Vinick, F. J., Koe, B. K., Nielsen, J. A., Whalen, W. M., Moletz, M., Philips, D., Thadieo, P. F., Jung, S., Chapin, D. S., Lebel, L. A., Russo, L. L., Heleveg, D. A., Johnson, J. L., Ives, J. F., and Williams, I. H. (1991) J. Med. Chem. 34, 291-298.
15. Nemoz, G., Moueqqit, M., Prigent, A.-F., and Pacheco, H. (1989) Eur. J. Biochem. 184, 511-520.
16. Torphy, T. J., Stadel, J. M., Burman, M., Cieslinski, L. B., McLaughlin, M. M., White, J. R., and Livi, G. P. (1992) J. Biol. Chem. 267, 1798-1804.
17. Lenhard, J. M., Kassel, D. B., Rocque, W. J., Hamacher, L., Holmes, W. D., Patel, I., Hoffman, C., and Luther, M. A. (1996) Biochem. J. 316, 751-758.
18. Rocque, W. J., Holmes, W. D., Patel, I. R., Dougherty, R. W., Ittoop, O., Overton, L., Hoffman, C. R., Wisely, G. B., Willard, D. H., and Luther, M. A. (1997) Protein Expression Purif. 9, 191-202.
19. Rocque, W. J., Tian, G., Wiseman, J. S., Holmes, W. D., Thompson, I. Z., Willard, D. H., Patel, I. R., Wisely, G. B., Clay, W. C., Kadwell, S. H., Hoffman, C. R., and Luther, M. A. (1997) Biochemistry 36, 14250-14261.
20. Stafford, J. A., Veal, J. M., Feldman, P. L., Valvano, N. L., Baer, P. G., Brackeen, M. F., Brawley, E. S., Connolly, K. M., Domanico, P. L., Han, B., Rose, D. A., Rutkowske, R. D., Sekut, L., Stimpson, S. A., Strickland, A. B., and Verghese, M. W. (1995) J. Med. Chem. 38, 4972-4975.
21. Felsenfeld, G., and Miles, H. T. (1957) Annu. Rev. Biochem. 36, 407-649.
22. Cantor, C. R., and Schimmel, P. R. (1980) Biophysical Chemistry Part III: The Behavior of Biological Macromolecules, W. H. Freeman and Co., New York.
23. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. Relat. Areas Mol. Biol. 61, 201-301.