The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram

Journal of Biological Chemistry

Volumn 271, Issue 49, 1996, Pages 31334-31344

  Huston, Elaine ^a   Pooley, Linda ^a   Julien, Pascale ^a,c   Scotland, Grant ^a   McPhee, Ian ^a   Sullivan, Michael ^a,d   Bolger, Graeme ^b   Houslay, Miles D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; CYCLIC AMP PHOSPHODIESTERASE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; ROLIPRAM; SODIUM CHLORIDE; TRITON X 100;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RABBIT;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; COS CELLS; CYCLIC AMP; CYTOSOL; HUMANS; KINETICS; MICROSCOPY, CONFOCAL; PHOSPHODIESTERASE INHIBITORS; PYRROLIDINONES; ROLIPRAM; SOLUBILITY; TRANSFECTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0029857245     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.49.31334     Document Type: Article

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