B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1

Journal of Experimental Medicine

Volumn 194, Issue 4, 2001, Pages 529-539

  Tsuji, S ^a   Okamoto, M ^a   Yamada, K ^a   Okamoto, N ^a   Goitsuka, R ^a   Arnold, R ^a   Kiefer, F ^a   Kitamura, D ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Antigen receptor signaling; BCR; BLNK; I B kinase; SH2 domain

Indexed keywords

B LYMPHOCYTE RECEPTOR; HEMATOPOIETIC PROGENITOR KINASE 1; PROTEIN KINASE LYN; PROTEIN KINASE SYK; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; CATALYSIS; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TYROSINE;

EID: 0035920555     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.4.529     Document Type: Article

References (48)

1. Initiation and processing of signals from the B cell antigen receptor
2. The complexity of signaling pathways activated by the BCR
3. Genetic analysis orb cell antigen receptor signaling
4. Signal transduction from the B cell antigen-receptor
5. 2+ response amplitude and duration
6. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
7. BLNK: A central linker protein in B cell activation
8. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
9. BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius
10. Adapter proteins in lymphocyte antigen-receptor signaling
11. Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cγ Grb2, and Vav after B cell antigen receptor activation
12. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells
13. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK. Functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
14. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
15. Requirement for B cell linker protein (BLNK) in B cell development
16. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
17. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
18. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway
19. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade
20. Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IκB kinases (IKK-α/β) and IKK-β is a developmentally regulated protein kinase
21. SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1
22. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase
23. A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1
24. Activation of hematopoietic progenitor kinase-1 by erythropoietin
25. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1
26. The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR
27. Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate
28. 2+ mobilization through distinct pathways
29. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2
30. Cell-cycle arrest and apoptosis induced by Notch1 in B cells
31. Efficient selection for high-expression transfectants with a novel eukaryotic vector
32. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis
33. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
34. 2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor
35. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
36. SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases
37. Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase
38. Site specificity of p72syk protein tyrosine kinase: Efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family
39. FYN-T-FYB-SLP-76 interactions define a T-cell receptor ζ/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells
40. 651
41. Caspase mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFκB into an inhibitor of NFκB
42. 2-terminal kinase 1, and p38 mitogen-activated protein kinase
43. Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor κB in response to B cell receptor engagement
44. Novel IκBα proteolytic pathway in WEHI231 immature B cells
45. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells
46. A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation
47. Bruton's tyrosine kinase links the B cell receptor to nuclear factor κB activation
48. Phospholipase C-γ2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes