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Volumn 12, Issue 3, 2000, Pages 256-266

Adapter proteins in lymphocyte antigen-receptor signaling

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 0034008281     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00085-6     Document Type: Review
Times cited : (95)

References (96)
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    • 3 generation. These defects can be overcome by transfection of either wild-type BLNK or a membrane-bound form of PLCγ2. In addition BCR-stimulated JNK and p38 activation were abrogated in this mutant cell line and could not be restored by expression of a membrane-bound form of PLCγ2, suggesting that BLNK is also involved in the Rac1/JNK pathway.
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    • ••] provide in vivo evidence that supports a required role for SLP-65 in B cell development at the pro-B cell to pre-B cell transition, indicating an important function for SLP-65 in pre-BCR signaling. Additionally, impaired signaling through the IgM BCR is also suggested in these studies.
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    • •], this study also describes the independent cloning and characterization of Gads/Grf40/GrpL as a novel Grb2 homologue. The authors isolated Gads from a mouse embryo expression library through its association with a biotinylated Shc phosphopeptide.
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    • ••] demonstrate a role for c-Cbl in the attenuation and desensitization of receptor-tyrosine-kinase-mediated responses by promoting receptor polyubiquitination. In vitro and in vivo cellular approaches were taken to demonstrate the requirement for the RING domain of c-Cbl in mediating receptor ubiquitination and its ability to bind the ubiquitin-conjugating enzyme, UbcH7. In addition, mutations of c-Cbl in its RING domain were shown to provide a dominant inhibitory effect; this gives a plausible explanation for the oncogenic effects of c-Cbl mutants, which lack a functional RING domain.
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    • The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
    • In this study, SAP is identified by the yeast two-hybrid method as a novel SLAM-associated adapter molecule. Furthermore, SAP was found to be encoded by the gene for X-linked lymphoproliferative disease (XLP) by characterization of three XLP patients who carry mutations in the SAP gene. A possible mechanism for SAP function was demonstrated by its ability to act as a natural inhibitor of SHP-2 binding to phosphorylated SLAM and its ability to augment SLAM costimulatory effects on IL-2 promoter activity in Jurkat T cells.
    • Sayos J., Wu C., Morra M., Wang N., Zhang X., Allen D., van Schaik S., Notarangelo L., Geha R., Roncarolo M.G.et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 395:1998;462-469. In this study, SAP is identified by the yeast two-hybrid method as a novel SLAM-associated adapter molecule. Furthermore, SAP was found to be encoded by the gene for X-linked lymphoproliferative disease (XLP) by characterization of three XLP patients who carry mutations in the SAP gene. A possible mechanism for SAP function was demonstrated by its ability to act as a natural inhibitor of SHP-2 binding to phosphorylated SLAM and its ability to augment SLAM costimulatory effects on IL-2 promoter activity in Jurkat T cells.
    • (1998) Nature , vol.395 , pp. 462-469
    • Sayos, J.1    Wu, C.2    Morra, M.3    Wang, N.4    Zhang, X.5    Allen, D.6    Van Schaik, S.7    Notarangelo, L.8    Geha, R.9    Roncarolo, M.G.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.