Mutations in serines 15 and 20 of human p53 impair its apoptotic activity

Oncogene

Volumn 18, Issue 21, 1999, Pages 3205-3212

  Unger, Tamar ^a   Vogt Sionov, Ronit ^b   Moallem, Eli ^b   Yee, Carole L ^c   Howley, Peter M ^d   Oren, Moshe ^a   Haupt, Ygal ^b  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; p53; Phosphorylation; Serine; Transactivation

Indexed keywords

ALANINE; MUTANT PROTEIN; PROTEIN P53; SERINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL TRANSFORMATION; DNA BINDING; EMBRYO; FIBROBLAST CULTURE; GROWTH INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION;

ALANINE; ANIMALS; APOPTOSIS; BINDING SITES; CELL TRANSFORMATION, NEOPLASTIC; DNA; GENE EXPRESSION; HUMANS; MICE; MUTAGENESIS, SITE-DIRECTED; SERINE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033609306     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202656     Document Type: Article

References (57)

1. Addison C, Jenkins JR and Sturzbecher HW. (1990). Oncogene, 5, 423-426.
2. Bunin S, Moyal L, Shich S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y and Ziv Y. (1998). Science, 281, 1674-1677.
3. Bates S and Vousden KH. (1996). Curr. Opin. Genet. Dev., 6, 12-18.
4. Bischoff JR, Friedman PN, Marshak DR, Prives C and Beach D. (1990). Proc. Natl. Acad. Sci. USA, 87, 4766-4770.
5. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella F, Kastan MB and Siliciano JD. (1998). Science, 281, 1677-1679.
6. Crook T, Marston NJ, Sara EA and Vousden KH. (1994). Cell, 79, 817-827.
7. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P and Traganos F. (1992). Cytometry, 13, 795-808.
8. Fiscella M, Ullrich SJ, Zambrano N, Shields MT, Lin D, Lees Miller SP, Anderson CW, Mercer WE and Appella E. (1993). Oncogene, 8, 1519-1528.
9. Fiscella M, Zambrano N, Ullrich SJ, Unger T, Lin D, Cho B, Mercer WE, Anderson CW and Appella E. (1994). Oncogene, 9, 3249-3257.
10. Fuchs B, O'connor D, Fallis L, Sheidtmann KH and Lu X. (1995). Oncogene, 10, 789-793.
11. Fuchs SY, Dolan L, Davis RJ and Ronai Z. (1996). Oncogene, 13, 1531-1535.
12. Funk WD, Pak DT, Karas RH, Wright WE and Shay JW. (1992). Mol. Cell. Biol., 12, 2866-2871.
13. Gonzalez GA and Montminy MR. (1989). Cell, 59, 675-680.
14. Gottleib TM and Oren M. (1996). Biochim. Biophys. Acta, 1287, 77-102.
15. Hall SR, Campbell LE and Meek DW. (1996). Nucl. Acids Res., 24, 1119-1126.
16. Hao MM, Lowy AM, Kapoor M, Deffie A, Liu G and Lozano G. (1996). J. Biol. Chem., 271, 29380-29385.
17. Haupt Y, Barak Y and Oren M. (1996). EMBO, J., 15, 1596-1606.
18. Haupt Y, Maya R, Kazaz A and Oren M. (1997). Nature, 387, 296-299.
19. Haupt Y and Oren M. (1996). Behring. Inst. Mitt., 97, 32-59.
20. Haupt Y, Rowan S, Shaulian E, Vousden KH and Oren M. (1995). Genes Dev., 9, 2170-2183.
21. Hupp TR, Meek DW, Midgley CA and Lane DP. (1992). Cell, 71, 875-886.
22. Ko LJ, Shieh SY, Chen X, Jayaraman L., Tamai K, Taya Y, Prives C and Pan ZQ. (1997). Mol. Cell Biol., 17, 7220-7229.
23. Kubbutat MH, Jones SN and Vousden KH. (1997). Nature, 387, 299-303.
24. Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ and Pavletich NP. (1996). Science, 274, 948-953.
25. Lees Miller SP, Sakaguchi K, Ullrich SJ, Appella E and Anderson CW. (1992). Mol. Cell. Biol., 12, 5041-5049.
26. Levine AJ. (1997). Cell, 88, 323-331.
27. Lin R, Beauparlant P, Makris C, Meloche S and Hiscott J. (1996). Mol. Cell. Biol., 16, 1401-1409.
28. Lohrum M and Scheidtmann KH. (1996). Oncogene, 13, 2527-2539.
29. Lu H, Fisher RP, Bailey P and Levine AJ. (1997). Mol. Cell. Biol., 17, 5923-5934.
30. Lu H and Levine AJ. (1995). Proc. Natl. Acad. Sci. USA, 92, 5154-5158.
31. Mayr GA, Reed M, Wang P, Wang Y, Schweds JF and Tegtmeyer P. (1995). Cancer Res., 55, 2410-2417.
32. Meek DW. (1998). Cell Signal, 10, 159-166.
33. Meek DW, Simon S, Kikkawa U and Eckhart W. (1990). EMBO J., 9, 3253-3260.
34. Mictz JA, Unger T, Huibregtse JM and Howley PM. (1992). EMBO. J., 11, 5013-5020.
35. Milczarek GJ, Martinez J and Bowden GT. (1997). Life Sci., 60, 1-11.
36. Milne DM, Palmer RH and Meek DW. (1992). Nucleic Acids Research, 20, 5565-5570.
37. Miyashita T, Harigai M, Hanada M and Reed JC. (1994). Cancer Res., 54, 3131-3135.
38. Miyashita T and Reed JC. (1995). Cell, 80, 293-299.
39. Momand J and Zambetti GP. (1997). J. Cell Biochem., 64, 343-352.
40. Murphy M, Hinman A and Levine AJ. (1996). Genes Dev., 10, 2971-2980.
41. Naumovski L and Cleary ML. (1996). Mol. Cell. Biol., 16, 3884-3892.
42. Polyak K, Xia Y, Zweier JL, Kinzler KW and Vogelstein B. (1997). Nuture, 389, 300-305.
43. Prisco M, Hongo A, Rizzo MG, Sacchi A and Baserga R. (1997). Mol. Cell. Biol., 17, 1084-1092.
44. Prives C. (1998). Cell, 95, 5-8.
45. Shieh SY, Ikeda M, Taya Y and Prives C. (1997). Cell, 91, 325-334.
46. Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E and Kastan MB. (1997). Genes Dev., 11, 3471-3481.
47. Smeal T, Binetruy B, Mercola DA, Birrer M and Karin M. (1991). Nature, 354, 494-496.
48. Steegenga WT, van der Eb Aj and Jochemsen AG. (1996). J. Mol. Biol., 263, 103-131.
49. Takenaka I, Morin F, Seizinger BR and Kley N. (1995). J. Biol. Chem., 270, 5405-5411.
50. Trautwein C, Caelles C, van der Geer P, Hunter T, Karin M and Chojkier M. (1993). Nature, 364, 544-547.
51. Unger T, Mietz JA, Scheffner M, Yee CL and Howley PM. (1993). Mol. Cell. Biol., 13, 5186-5194.
52. Unger T, Nau MM, Segal S and Minna JD. (1992). EMBO J., 11, 1383-1390.
53. Velculescu VE and El Deiry WS. (1996). Clin. Chem., 42, 858-868.
54. Vogt Sionov R and Haupt Y. (1998). Springer Semin. Immunopathol., 19, 345-362.
55. Wang Y and Prives C. (1995). Nature, 376, 88-91.
56. Wyllie A. (1997). Nature, 389, 237-238.
57. Zauberman A, Lupo A and Oren M. (1995). Oncogene, 10, 2361-2366.