메뉴 건너뛰기




Volumn 80, Issue SUPPL. 1, 1999, Pages 1-5

Exploiting the p53 pathway for cancer diagnosis and therapy

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

EID: 0032813181     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690312     Document Type: Conference Paper
Times cited : (56)

References (25)
  • 1
    • 0027459198 scopus 로고
    • Mdm2 expression is induced by wild-type p53 activity
    • Barak Y, Juven T, Haffner R and Oren M (1993) Mdm2 expression is induced by wild-type p53 activity. Embo J 12: 461-468
    • (1993) Embo J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 3
    • 0030965298 scopus 로고    scopus 로고
    • Tolerance of high levels of wild type p53 in transformed epithelial cells dependant on auto regulation by Mdm2
    • Blaydes JP, Gire V, Rowson JM, Wynford Thomas D (1997) Tolerance of high levels of wild type p53 in transformed epithelial cells dependant on auto regulation by Mdm2, Oncogene 14: 1859-1868.
    • (1997) Oncogene , vol.14 , pp. 1859-1868
    • Blaydes, J.P.1    Gire, V.2    Rowson, J.M.3    Wynford Thomas, D.4
  • 6
    • 0031282325 scopus 로고    scopus 로고
    • Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
    • Bottger A, Bottger V, Sparks. A, Liu WL, Howard SF and Lane DP (1997b) Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo, Curr Biol 7: 860-869
    • (1997) Curr Biol , vol.7 , pp. 860-869
    • Bottger, A.1    Bottger, V.2    Sparks, A.3    Liu, W.L.4    Howard, S.F.5    Lane, D.P.6
  • 8
    • 0027528673 scopus 로고
    • High levels of p53 protein in UV-irradiated normal human skin
    • Hall PA, McKee PH, Menage HD, Dover R and Lane DP (1993) High levels of p53 protein in UV-irradiated normal human skin. Oncogene 8: 203-207
    • (1993) Oncogene , vol.8 , pp. 203-207
    • Hall, P.A.1    McKee, P.H.2    Menage, H.D.3    Dover, R.4    Lane, D.P.5
  • 9
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A and Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 10
    • 0028845158 scopus 로고
    • Small peptides activate the latent sequence-specific DNA binding function of p53
    • Hupp TR, Sparks A and Lane DP (1995) Small peptides activate the latent sequence-specific DNA binding function of p53. Cell 83: 237-245
    • (1995) Cell , vol.83 , pp. 237-245
    • Hupp, T.R.1    Sparks, A.2    Lane, D.P.3
  • 11
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat MH, Jones SN and Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387: 299-303
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 12
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP (1992) Cancer. p53, guardian of the genome, Nuture 358; 15-16
    • (1992) Nuture , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 13
    • 0030612360 scopus 로고    scopus 로고
    • Mdm2; arbiter of p53's destruction
    • Lane DP and Hall PA (1997) Mdm2; arbiter of p53's destruction. Trends Biochem Sci 22: 372-374
    • (1997) Trends Biochem Sci , vol.22 , pp. 372-374
    • Lane, D.P.1    Hall, P.A.2
  • 14
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 15
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • Lu X and Lane DP (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell 75: 765-778
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 16
    • 0029944241 scopus 로고
    • A functionally inactive p53 protein in teralocarcinoma cells is activated by either DNA damage or cellular differentiation
    • Lutzker SG and Levine AJ (1990) A functionally inactive p53 protein in teralocarcinoma cells is activated by either DNA damage or cellular differentiation. Nat Med 2: 804-810
    • (1990) Nat Med , vol.2 , pp. 804-810
    • Lutzker, S.G.1    Levine, A.J.2
  • 18
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP and Hall PA (1994) The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 54: 614-617
    • (1994) Cancer Res , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 19
    • 0030825813 scopus 로고    scopus 로고
    • p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
    • Midgley CA and Lane DP (1997) p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15: 1179-1189
    • (1997) Oncogene , vol.15 , pp. 1179-1189
    • Midgley, C.A.1    Lane, D.P.2
  • 20
    • 0026569616 scopus 로고
    • Analysis of p53 expression in human tumours: An antibody raised against human p53 expressed in Escherichia coli
    • Midgley CA, Fisher CJ, Bartek J, Vojtesek B, Lane D and Barnes DM (1992) Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli. J Cell Sci 101: 183-189
    • (1992) J Cell Sci , vol.101 , pp. 183-189
    • Midgley, C.A.1    Fisher, C.J.2    Bartek, J.3    Vojtesek, B.4    Lane, D.5    Barnes, D.M.6
  • 21
    • 0026649648 scopus 로고
    • The Mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D and Levine AJ (1992) The Mdm2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237-1245
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 22
    • 0027964904 scopus 로고
    • Immunochemical analysis of the interaction of p53 with MDM2 - Fine mapping of the Mdm2 binding site on p53 using synthetic peptides
    • Picksley SM, Vojtesek B, Sparks A and Lane DP (1994) Immunochemical analysis of the interaction of p53 with MDM2 - fine mapping of the Mdm2 binding site on p53 using synthetic peptides. Oncogene 9: 2523-2529
    • (1994) Oncogene , vol.9 , pp. 2523-2529
    • Picksley, S.M.1    Vojtesek, B.2    Sparks, A.3    Lane, D.P.4
  • 24
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ and Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 25
    • 0030961889 scopus 로고    scopus 로고
    • Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
    • Selivanova G, Iotsova V, Okan I, Fritsche M, Strom M, Groner B, Grafstrom RC and Wiman KG (1997) Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat Med 3: 632-638
    • (1997) Nat Med , vol.3 , pp. 632-638
    • Selivanova, G.1    Iotsova, V.2    Okan, I.3    Fritsche, M.4    Strom, M.5    Groner, B.6    Grafstrom, R.C.7    Wiman, K.G.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.