Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter

International Immunology

Volumn 11, Issue 12, 1999, Pages 1945-1955

  Shang, Catherine ^a   Attema, Joanne ^b   Cakouros, Dimitrios ^b   Cockerill, Peter N ^c   Shannon, M Frances ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

Author keywords

Co stimulatory molecules; Cytokines; Gene regulation; T cell; Transcription factors

Indexed keywords

ADAPTOR PROTEIN; CD28 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; BINDING SITE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T LYMPHOCYTE;

EID: 0033405971     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/11.12.1945     Document Type: Article

References (48)

1. Bluestone, J. A. 1995. New perspectives of CD28-B7-mediated T cell co-stimulation. Immunity 2:555.
2. Rudd, C. E. 1996. Upstream-downstream: CD28 co-signaling pathways and T cell function. Immunity 4:527.
3. Jenkins, M. K. 1994. The ups and downs of T cell co-stimulation. Immunity 1:443.
4. Fraser, J. D., Irving, B. A., Crabtree, G. R. and Weiss, A. 1991. Regulation of Interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
5. Metcalf, D. 1991. Control of granulocytes and macrophages: molecular, cellular and clinical aspects. Science 254:529.
6. Himes, S. R., Coles, L. S., Reeves, R. and Shannon, M. F. 1996. High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. Immunity 5:479.
7. Fraser, J. D. and Weiss, A. 1992. Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Mol. Cell. Biol. 12:4357.
8. Serfling, E., Avots, A. and Neumann, M. 1995. The architecture of the Interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim. Biophys. Acta 1263:181.
9. Jain, J., Loh, C. and Rao, A. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
10. Shannon, M. F., Coles, L. S., Vadas, M. A. and Cockerill, P. N. 1997. Signals for activation of the GM-CSF promoter and enhancer in T cells. Crit. Rev. Immunol. 17:301.
11. Verweij, C. L., Geerts, M. and Aarden, L. A. 1991. Activation of Interleukin-2 gene transcription via the T cell surface molecule CD28 is mediated through an NFκB-like response element. J. Biol. Chem. 266:14179.
12. Ghosh, P., Tan, T.-H., Rice, N. R., Sica, A. and Young, H. A. 1993. The interleukin 2 CD28-responsive complex contains at least three members of the NFκB family: c-Rel, p50, and p65. Proc. Natl Acad. Sci. USA 90:1696.
13. Bryan, R. G., Li, Y., Lai, J.-H., Van, M., Rice, N. R., Rich, R. R. and Tan, T.-H. 1994. Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells. Mol. Cell. Biol. 14:7933.
14. Rincon, M. and Flavell, R. A. 1994. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 13:4370.
15. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M. and Ben-Neriah, Y. 1994. JNK is involved in signal integration during co-stimulation of T lymphocytes. Cell 77:727.
16. Shannon, M. F., Gamble, J. R. and Vadas, M. A. 1988. Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene. Proc. Natl Acad. Sci. USA 85:674.
17. Dunn, S. M., Coles, L. S., Lang, R. K., Gerondakis, S., Vadas, M. A. and Shannon, M. F. 1994. Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter. Blood 83:2469.
18. Molitor, J. A., Walker, W. H., Doerre, S., Ballard, D. W. and Greene, W. C. 1990. NF kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc. Natl Acad. Sci. USA 87:10028.
19. Kalli K., Huntoon, C., Bell, M. and McKean, D. J. 1998. Mechanism responsible for T-cell antigen receptor-and CD28-or interleukin 1 (IL-1) receptor-initiated regulation of IL-2 gene expression by NFκB. Mol. Cell. Biol. 18:3140.
20. Shannon, M. F., Himes, S. R. and Coles, L. S. 1995. GM-CSF and IL-2 share common control mechanisms in response to co-stimulatory signals in T cells. J. Leuk. Biol. 57:767.
21. Gerondakis, S., Strasser, A., Metcalf, D., Grigoriadis, G., Scheerlinck, J. Y. and Grumont, R. J. 1996. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc. Natl Acad. Sci. USA 93:3405.
22. Shapiro, V. S., Truitt, K. E., Imboden, J. B. and Weiss, A. 1997. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NFIL-2B AP-1 sites. Mol. Cell. Biol. 17:4051.
23. Butscher, W. G., Powers, C., Olive, M., Vinson, C. and Gardner, K. 1998. Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF/CREB2. J. Biol. Chem. 273:552.
24. Parra, E., McGuire, K., Hedlund, G. and Dohlsten, M. 1998. Overexpression of p65 and c-Jun substitutes for B7-1 co-stimulation by targeting the CD28RE within the IL-2 promoter. J. Immunol. 160:5374.
25. McGuire, K. L. and Iacobelli, M. 1997. Involvement of Rel, Fos and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J. Immunol. 159:1319.
26. Himes, S. R., Katsikeros, R. and Shannon, M. F. 1996. Co-stimulation of cytokine gene expression in T cells by the human T leukemia/lymphotropic virus type 1 trans activation Tax. J. Virol. 70:4001.
27. Wolfe, S. A., Zhou, P., Dotsch, V., Chen, L., You, A., Ho, S. N., Crabtree, G. R., Wagner, G. and Verdine, G. L. 1997. Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. Nature 385:172.
28. Chen, L., Glover, J. N., Hogan, P. G., Rao, A. and Harrison, S. C. 1998. Structure of the DNA-binding domains of NFAT, Fos and Jun bound specifically to DNA. Nature 392:42.
29. McCaffrey, P. G., Jain, J., Jamieson, C., Sen, R. and Rao, A. 1992. A T cell nuclear factor resembling NFAT binds to an NFκB site and to the conserved lymphokine promoter 'cytokine-1'. J. Biol. Chem. 267:1864.
30. Luo, C., Burgeon, E., Carew, J. A., McCaffrey, P. G., Badalian, T. M., Lane, W. S., Hogan, P. G. and Rao, A. 1996. Recombinant NFATI (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol. Cell. Biol. 16:3955.
31. McCaffrey, P. G., Luo, C., Kerppola, T. K., Jain, J., Badalian, T. M., Ho, A. M., Burgeon, E., Lane, W. S., Lambert, J. N., Curran, T., et al. 1993. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science 262:750.
32. Grumont, R. J. and Gerondakis, S. 1994. The subunit composition of NFκB complexes changes during B-cell development. Cell Growth Different. 5:1321.
33. Cockerill, P. N., Bert, A. G., Jenkins, F., Ryan, G. R., Shannon, M. F. and Vadas, M. A. 1995. Human granulocyte-macrophage colony-stimulating factor enhancer function is associated with cooperative interactions between AP-1 and NFATp/c. Mol. Cell. Biol. 15:2071.
34. Kunsch, C., Ruben S. M. and Rosen, C. A. 1992. Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF kappa B with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412.
35. Ng, K. W., Ridgway, P., Cohen, D. R. and Tremethick, D. J. 1997. The binding of a Fos/Jun heterodimer can completely disrupt the structure of a nucleosome. EMBO J. 16:2072.
36. Schreiber, E., Matthias, P., Muller, M. M. and Schaffner, W. 1989. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
37. Jenkins, F., Cockerill, P. N., Bohmann, D. and Shannon, M. F. 1995. Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells. J. Immunol. 155:1240.
38. Cockerill, P. N., Shannon, M. F., Bert, A. G., Ryan, G. R. and Vadas, M. A 1993. The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc. Natl Acad. Sci USA 90:2466.
39. Cockerill, G. W, Bert, A. G., Ryan, G. R., Gamble, J. R., Vadas, M. A. and Cockerill, P. N. 1995. Regulation of GM-CSF and E-selectin expression in endothelial cells by cyclosporin A and the T cell transcription factor NFAT. Blood 86:2689.
40. Rao, A. 1994. NFATp: a transcription factor required for the coordinate induction of several cytokine genes. Immunol. Today 15:274.
41. Shaw, K. T., Ho, A. M., Raghavan, A., Kim, J., Jain, J., Park, J., Sharma, S., Rao, A. and Hogan, P. G. 1995. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc. Natl Acad. Sci. USA 92:11205.
42. Rao, A., Luo, C. and Hogan, P. G. 1997. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15:707.
43. Siebenlist, U., Franzoso, G. and Brown, K. 1994. Structure, regulation and function of NFκB. Annu. Rev. Cell Biol. 10:405.
44. McCaffrey, P. G., Goldfeld, A. E. and Rao, A. 1994. The role of NFATp in cyclosporin A-sensitive TNFα gene transcription. J. Biol. Chem. 269:30445.
45. Maggirwar, S. B., Harhaj, E. W. and Sun, S.-C. 1997. Regulation of the interleukin-2 CD28-responsive element by NFATp and various NFκB/Rel transcription factors. Mol. Cell. Biol. 17:2605.
46. Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi Y. and Collins, T. 1997. CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl Acad. Sci. USA 94:2927.
47. Garcia-Rodriguez C. and Rao, A. 1998. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J. Exp. Med. 187:2031.
48. Rooney, J. W., Sun, Y. L., Glimcher, L. H. and Hoey, T. 1995. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell. Biol. 15:6299.