Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer

Clinical Cancer Research

Volumn 5, Issue 6, 1999, Pages 1369-1379

  Chen, Zhong ^a   Malhotra, Pramit S ^a   Thomas, Giovana R ^a   Ondrey, Frank G ^a   Duffey, Dianne C ^a   Smith, Conrad W ^a   Enamorado, Ileana ^a   Yeh, Ning T ^a   Kroog, Glenn S ^a   Rudy, Susan ^a   McCullagh, Linda ^b   Mousa, Shaker ^c   Quezado, Matha ^d   Herscher, Laurie L ^d   Van Waes, Carter ^a,b  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c DUPONT COMPANY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1 DERIVATIVE; INTERLEUKIN 6; INTERLEUKIN 8; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HEAD CANCER; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; INFLAMMATION; MALE; NECK CANCER; PRIORITY JOURNAL; REGULATORY MECHANISM; SQUAMOUS CELL CARCINOMA; TUMOR CELL; TUMOR VOLUME;

ACUTE-PHASE REACTION; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CYTOKINES; ENDOTHELIAL GROWTH FACTORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST GROWTH FACTOR 2; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-6; INTERLEUKIN-8; LYMPHOKINES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033017066     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Wolf, F., Hudson, J., Peterson, K., Miller, H., and McClatchey, K. Lymphocyte subpopulations infiltrating squamous carcinomas of the head and neck: correlations with extent of tumor and prognosis. Otolaryngol. Head Neck Surg., 95: 142-152, 1986.
2. Young, M. R. I., Wright, M. A., Lozano, Y., Prechel, M. M., Benefield, J., Leonetti, J. P., Collins, S. L., and Petruzelli, G. J. Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony stimulating factor and contained CD34+ natural suppressor cells. Int. J. Cancer, 74: 69-74, 1997.
3. Gleich, L. L., Biddinger, P. W., Duperier, F. D., and Gluckman, J. L. Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma: a clinical-pathologic correlation. Head Neck, 19: 276-280, 1997.
4. Pak, A. S., Wright, M. A., Matthews, J. P., Collins, S. L., Petruzelli, G. J., and Young, M. R. I. Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34+ cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor. Clin. Cancer Res., 1: 95-103, 1995.
5. Smith, D. R., Polverini, P. J., Kunkel, S. L., Orringer, M. B., Whyte, R. I., Burdick, M. D., Wilke, C. A., and Strieter, R. M. Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. J. Exp. Med., 179: 1409-1415, 1994.
6. Norton, J. A., Peacock, J. L., and Morrison, S. D. Cancer cachexia. Crit. Rev. Oncol. Hematol., 7: 289-327, 1987.
7. Vlock, D. R., Arnold, B., Humpierres, J., Schwartz, D. R., Baker, S. R., Krause, C. J., Swanson, N., and Carey, T. E. Serial studies of autologous antibody reactivity to squamous cell carcinoma of the head and neck. Cancer Immunol. Immunother., 34: 329-336, 1992.
8. Veltri, R., Rodman, S., Maxim, P., Baseler, M., and Sprinkle, P. Immune complexes, serum proteins, cell-mediated immunity, and immune regulation in patients with squamous cell carcinoma of the head and neck. Cancer (Phila.), 57: 2295-2308, 1986.
9. Mandel, M., and Kiehn, C. The prognostic significance of delayed cutaneous reactivity in head and neck cancer patients. J. Plast. Reconstr. Surg., 53: 72-76, 1974.
10. Burdick, J., Wells, S., and Herberman, R. Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions. Surg. Gynecol. Obstet., 141: 779-794, 1975.
11. Das, S., and Khanna, N. In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis. Cancer Invest., 4: 207-216, 1986.
12. Mickel, R., Kessler, D., Taylor, J., and Lichtenstein, A. Natural killer cell cytotoxicity in the peripheral blood, cervical lymph nodes, and tumor of head and neck cancer patients. Cancer Res., 48: 5017-5022, 1998.
13. Yoneda, T., Aufdemorte, T., Nishimura, R., Nishikawa, N., Sakuda, M., Alsina, M., Chavez, J., and Mundy, G. Occurrence of hypercalcemia and leukocytosis with cachexia in a human squamous cell carcinoma of the maxilla in athymic nude mice. A novel experimental model of three concomitant paraneoplastic syndromes. J. Clin. Oncol., 9: 468-477, 1991.
14. Saito, K., Kuratomi, Y., and Yamamoto, K., Saito, T., Kuzuya, T., Yoshida, S., Moriyama, S. I., and Takahashi, A. Primary squamous cell carcinoma of the thyroid associated with marked leukocytosis and hypercalcemia. Cancer (Phila.), 48: 2080-2083, 1981.
15. Chen, Z., Smith, C. W., Kiel, D., and Van Waes, C. Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction. Clin. Exp. Metastasis, 15: 527-537, 1997.
16. Dong, G., Loukinova, E., Smith, C. W., Chen, Z., and Van Waes, C. Genes differentially expressed with malignant transformation and metastatic tumor progress on of murine squamous cell carcinoma. J. Cell Biochem. Suppl., 28/29: 90-100, 1997.
17. Smith, C. W., Chen, Z., Dong, G., Loukinova, E., and Van Waes, C. The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1α, IL-6, GM-CSF and KC. Clin. Exp. Metastasis, 16: 655-664, 1998.
18. Chen, Z., Colon, I., Ortiz, N., Callister, M., Dong, G., Pegram, M. Y., Arosarena, O., Strome, S., Nicholson, J. C., and Van Waes, C. Effects of interleukin-1α, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines. Cancer Res., 58: 3668-3676, 1998.
19. Mann, E., Spiro, J., Chen, L., and Kreutzer, D. Cytokine expression by head and neck squamous cell carcinoma. Am. J. Surg., 164: 567-573, 1992.
20. Cohen, R., Contrino, J., Spiro, J., Mann, E., Chen, L., and Kreutzer, D. Interleukin-8 expression by head and neck squamous cell carcinoma. Arch. Otolaryngol. Head Neck Surg., 121: 202-209, 1995.
21. Yamamura, M., Modlin, R., Ohmen, J., and Moy, R. Local expression of antiinflammatory cytokines in cancer. J. Clin. Invest., 91: 1005-1010, 1993.
22. Woods, K. V., El-Nagger, A., dayman, G. L., and Grimm, E. A. Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens. Cancer Res., 58: 3132-3141, 1998.
23. Krause, C., Carey, T., Ott, R., Hurbis, C., McClatchey, K., and Regezi, J. Human squamous cell carcinoma. Establishment and characterization of new permanent cell lines. Arch. Otolaryngol., 107: 703-710, 1981.
24. Bradford, C. R., Kimmel, K. A., Van Dyke, D. L., Worsham, M. J., Tilley, B. J., Burk, D., del Rosario, F., Lutz, S., Tooley, R., Hayashida, D. J. S., and Carey, T. E. 11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody. Genes Chromosomes Cancer, 3: 272-282, 1991.
25. Van Dyke, D. L., Worsham, M. J., Benninger, M. S., Krause, C. J., Baker, S. R., Wolf, G. T., Drumheller, T., Tilley, B. C., and Carey, T. E. Genes Chromosomes Cancer, 9: 192-206, 1994.
26. Van Waes, C., Mi Surh, D., Cheng, Z., Kirby, M., Rhim, J. S., Brager, R., Sessions, R. B., Poore, J., Wolf, G. T., and Carey, T. E. Increase in suprabasilar integrin adhesion molecule expression in human epidermal neoplasms accompanies increased proliferation occurring with immortalization and tumor progression. Cancer Res., 55: 5434-5444, 1995.
27. Ågren, K., Andersson, V., Litton, M., Funa, K., Nordlander, B., and Andersson J. Production of immunoregulatory cytokines is located to the extrafollicular area of human tonsils. Acta Otolaryngol. (Stockh), 116: 477-485, 1996.
28. Van Waes, C., Chen, Z., Callister, M., Colon, I., Ortiz, N., Smith, C. W., Thomas, G. R., and Dong, G. Cytokines in the immune pathogenesis and therapy of head and neck cancer. In: J. E. Veldman, D. Passali, and D. J. Lim (eds.), Immuno- and Molecular Biology in ORL-State of the Art, in press. The Hague, the Netherlands: Kugler Publications, 1999.
29. Berek, J. S., Chung, C., Kaldi, K., Watson, J. M., Knox, R. M., and Martinez-Maza, O. Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer. Am. J. Obstet. Gynecol., 164: 1038-1042, 1991.
30. Watson, J. M., Sensintaffar, J. L., Berek, J. S., and Martinez-Maza, O. Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures. Cancer Res., 50: 6959-6965, 1990.
31. Blay, J. Y., Rossi, J. F., Wijdenes, J., Menetrier-Caux, C., Scheman, S., Negrier, S., Philip, T., and Favrot, M. Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma. Int. J. Cancer, 72: 424-430, 1997.
32. Ueda, T., Shimada, E., and Urakawa, T. Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J. Gastroenterol., 29: 423-429, 1994.
33. Oka, M., Yamamoto, K., Takahashi, M., Hakozaki, M., Abe, T., Iizka, N., Hazama, S., Hirazawa, K., Hayashi, H., Tangoku, A., Hirose, K., Ishihara, T., and Suzuki, T. Relationship between serum levels of interleukin 6, various disease parameters, and malnutrition in patients with esophageal squamous cell carcinoma. Cancer Res., 56: 2776-2780, 1996.
34. Chopra, V., Dinh, T. V., and Hannigan, E. V. Circulating serum levels of cytokines and angiogenic factors in patients with cervical cancer. Cancer Invest., 16: 152-159, 1998.
35. Sakamoto, K., Masuda, T., Mita, S., Ishiko, T., Nakashima, Y., Arakawa, H., Egami, H., Harada, S., Matsushima, K., and Ogawa, M. Interleukin-8 is constitutively and commonly produced by various human carcinoma cell lines. Int. J. Clin. Lab. Res., 22: 216-219, 1992.
36. Scheibenbogen, C., Mohler, T., Haefele, J., Hunstein, W., and Keilholz, U. Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load. Melanoma Res., 5: 179-181, 1995.
37. Chopra, V., Dinh, T. V., and Hannigan, E. V. Serum levels of interleukins, growth factors and angiogenin in patients with endometrial cancer. J. Cancer Res. Clin. Oncol., 123: 167-172, 1997.
38. Obermair, A., Kucera, E., Mayerhofer, K., Speiser, P., Seifert, M., Czerwenka, K., Kaider, A., Leodolter, S., Kainz, C., and Zeillinger, R. Vascular endothelial growth factor (VEGF) in human breast cancer: correlation with disease-free survival. Int. J. Cancer, 74: 455-458, 1997.
39. Salven, P., Ruotsalainen, T., Mattson, K., and Joensuu, H. High pre-treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer. Int. J. Cancer, 79: 144-146, 1998.
40. Lissoni, P., Rovelli, F., Tisi, E., Brivio, F., Ardizzoia, A., Barni, S., Tancini, G., Saudelli, M., Cesana, E., and Vigano, M. G. Relationship between macrophage and T helper-2 lymphocyte functions in human neoplasms: neopterin, interleukin-10 and interleukin-6 blood levels in early or advanced solid tumors. J. Biol. Regul. Homeostatic Agents, 9: 146-149, 1995.
41. Dvorak, H. F., Sioussat, T. M., Brown, L. F., Berse, B., Nagy, J. A., Sotrel, A., Manseau, E. J., Van De Water, L., and Senger, D. R. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. Exp. Med., 174: 1275-1278, 1991.
42. Kolch, W., Martiny-Baron, G., Kieser, A., and Marme, D. Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis. Breast Cancer Res. Treat., 36: 139-155, 1995.
43. Weidner, N., and Folkman, J. Tumoral vascularity as a prognostic factor in cancer. Important Adv. Oncol., 1996: 167-190, 1996.
44. Folkman, J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N. Engl. J. Med., 333: 1757-1763, 1995.
45. Paul, W. Fundamental Immunology, Ed. 3. pp 801-836. New York: Raven Press, Ltd., 1993.
46. Duffey, D., Ondrey, F. G., Chen, Z., Dong, G., and Van Waes, C. Activation of immediate-early transcription factor NF-κB in human head neck squamous carcinoma cell Lines that are resistant to TNF α. Proc. Am. Assoc. Cancer Res., 39: 451, 1998.
47. Ondrey, F. G., Dong, G., and Van Waes, C. Constitutive expression of AP-1 and NF IL-6 in squamous carcinoma of the head and neck. Proc. Am. Assoc. Cancer Res., 39: 453, 1998.