A switch in distinct IκBα degradation mechanisms mediates constitutive NF-κB activation in mature B cells

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4762-4767

  Fields, Erika R ^a   Seufzer, Bradley J ^a   Oltz, Eugene M ^b   Miyamoto, Shigeki ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; PROTEIN INHIBITOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; LYMPHOCYTE TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM;

EID: 0034194260     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4762     Document Type: Article

References (45)

1. Gorman, J. R., and F. W. Alt. 1998. Regulation of immunoglobulin light chain isotype expression. Adv. Immunol. 69:113.
2. Verma, I. M., J. K. Stevenson, E. M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723.
3. Baldwin, A. S. J. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
4. Miyamoto, S., M. J. Schmitt, and I. M. Verma. 1994. Qualitative changes in the subunit composition of κB-binding complexes during murine B-cell differentiation. Proc. Natl. Acad. Sci. USA 91:5056.
5. Liou, H. C., W. C. Sha, M. L. Scott, and D. Baltimore. 1994. Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol. Cell. Biol. 14:5349.
6. Grumont, R. J., and S. Gerondakis. 1994. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Difer. 5:1321.
7. Sen, R., and D. Baltimore. 1986. Inducibility of K immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism. Cell 47:921.
8. Scherer, D. C., J. A Brockman, H. H. Bendall, G. M. Zhang, D. W. Ballard, and E. M. Oltz. 1996. Corepression of RelA and c-rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes. Immunity 5:563.
9. Bendall, H. H., D. C. Scherer, C. R. Edson, D. W. Ballard, and E. M. Oltz. 1997. Transcription factor NF-κB regulates inducible Oct-2 gene expression in precursor B lymphocytes. J. Biol. Chem. 272:28826.
10. Grumont, R. J., I. B. Richardson, C. Gaff, and S. Gerondakis. 1993. rel/NF-κB nuclear complexes that bind κB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells. Cell Growth Differ. 4:731.
11. Chiao, P. J., S. Miyamoto, and I. M. Verma. 1994. Autoregulation of IκBα activity. Proc. Natl. Acad. Sci. USA 91:28.
12. Bendall, H. H., M. L. Sikes, D. W. Ballard, and E. M. Oltz. 1999. An intact NF-κB signaling pathway is required for maintenance of mature B cell subsets. Mol. Immunol. 36:187.
13. Wu, M., H. Y. Lee, R. E. Bellas, S. L. Schauer, M. Arsura, D. Katz, M. J. Fitzgerald, T. L. Rothstein, D. H. Sherr, and G. E. Sonenshein. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15:4682.
14. Kontgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
15. Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
16. Miyamoto, S., B. Seufzer, and S. Shumway. 1998. Novel IκBα degradation process in WEHI231 murine immature B cells. Mol. Cell. Biol. 18.19.
17. Yedidia, Y., Y. Ben-Neriah, and S. Jung. 1998. Primary B cells essentially lack constitutive NF-κB activity. Eur. J. Immunol. 28:30.
18. Klug, C. A., S. J. Gerety, P. C. Shah, Y. Y. Chen, N. R. Rice, N. Rosenberg, and H. Singh. 1994. The v-abl tyrosine kinase negatively regulates NF-κB/Rel factors and blocks κ gene transcription in pre-B lymphocytes. Genes Dev. 8:678.
19. Chen, Y. Y., L. C. Wang, M. S. Huang, and N. Rosenberg. 1994. An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev. 8:688.
20. Naumann, M., and C. Scheidereit. 1994. Activation of NF-κB in vivo is regulated by multiple phosphorylations. EMBO J. 13:4597.
21. Phillips, R. J., and S. Ghosh. 1997. Regulation of IκBβ in WEHI231 mature B cells. Mol. Cell. Biol. 17:4390.
22. Sylla, B. S., S. C. Hung, D. M. Davidson, E. Hatzivassiliou, N. L. Malinin, D. Wallach, T. D. Gilmore, E. Kieff, and G. Mosialos. 1998. Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-κB through a pathway that includes the NF-κB-inducing kinase and the IκB kinases IKKα and IKKβ. Proc. Natl. Acad. Sci. USA 95:10106.
23. Suyang, H., R. Phillips, I. Douglas, and S. Ghosh. 1996. Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB. Mol. Cell. Biol. 16:5444.
24. Dobrzanski, P., R. P. Ryseck, and R. Bravo. 1994. Differential interactions of Rel-NF-κB complexes with IκBα determine pools of constitutive and inducible NF-κB activity. EMBO J. 13:4608.
25. Lernbecher, T., B. Kistler, and T. Wirth. 1994. Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells. EMBO J. 13:4060.
26. Kistler, B., A. Rolink, R. Marienfeld, M. Neumann, and T. Wirth. 1998. Induction of nuclear factor-κB during primary B cell differentiation. J. Immunol. 160: 2308.
27. Feuillard, J., M. Korner, A. Israel, J. Vassy, and M. Raphael. 1996. Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ. Eur. J. Immunol. 26:2547
28. . 28. Pettit, A. R., C. Quinn, K. P. MacDonald, L. L. Cavanagh, G, Thomas, W. Townsend, M. Handel, and R. Thomas. 1997. Nuclear localization of RelB is associated with effective antigen-presenting cell function. J. Immunol. 159:3681.
29. Neumann, M., G. Wohlleben, S. Chuvpilo, B. Kistler, T. Wirth, E. Serfling, and A. Schimpl. 1996. CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB. J. Immunol. 157:4862.
30. Schauer, S. L., R. E. Bellas, and G. E. Sonenshein. 1998. Dominant signals leading to inhibitor κB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis. J. Immunol. 160:4398.
31. Nishikawa, S. I., S. I. Hayashi, M. Ogawa, T. Kunisada, S. Nishikawa, S. T., H. Nakauchi, and T. Suda. 1989. Control of cell growth and differentiation during early B-cell development by stromal cell molecules. Cold Spring Harbor Symp. Quant. Biol. 54:171.
32. Quesenberry, P. J., I. K. McNiece, B. E. Robinson, T. A. Woodward, G. B. Baber, H. E. McGrath, and P. C. Isakson. 1987. Stromal cell regulation of lymphoid and myeloid differentiation. Blood Cells 13:137.
33. Snapper, C. M., P. Zelazowski, F. R. Rosas, M. R. Kehry, M. Tian, D. Baltimore, and W. C. Sha. 1996. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching. J. Immunol. 156:183.
34. Lam, K. P., R. Kuhn, and K. Rajewsky. 1997. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073.
35. Chen, F., Y. Lu, D. C. Kuhn, M. Maki, X. Shi, S. C. Sun, and L. M. Demers. 1997. Calpain contributes to silica-induced IκBα degradation and nuclear factor-κB activation. Arch. Biochem. Biophys. 342:383.
36. Han, Y., S. Weinman, I. Boldogh, R. K. Walker, and A. R. Brasier. 1999. Tumor necrosis factor-α-inducible IκBα proteolysis mediated by cytosolic μ-calpain. J. Biol. Chem. 274:787.
37. Baghdiguian, S., M. Martin, I. Richard, F. Pons, C. Astier, N. Bourg, R. T. Hay, R. Chemaly, G. Halaby, J. Loiselet, et al. 1999. Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBa/NF-κB pathway in limb-girdle muscular dystrophy type 2A. Nat. Med. 5:503.
38. Shumway, S. D., M. Maki, and S. Miyamoto. 1999. The PEST domain of IκBα is necessary and sufficient for in vitro degradation by μ-calpain. J. Biol. Chem. 274:30874.
39. Chen, F., V. Castranova, X. Shi, and L. M. Demers. 1999. New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem. 45:7.
40. Barnes, P. J., and M. Karin. 1997. Nuclear faclor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066.
41. Grilli, M., and M. Memo. 1999. Nuclear factor-κB/Rel proteins: a point of convergence of signaling pathways relevant in neuronal function and dysfunction. Biochem. Pharmacol. 57:1.
42. O'Neill, L. A., and C. Kaltschmidt. 1997. NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 20:252.
43. Bours, V., E. Dejardin, F. Goujon-Letawe, M. P. Merville, and V. Castronovo. 1994. The NF-κB transcription factor and cancer: high expression of NF-κB-and IκB-related proteins in tumor cell lines. Biochem. Pharmacol. 47:145.
44. Nakshatri, H., P. Bhat-Nakshatri, D. A. Martin, R. J. J. Goulet, and G. W. J. Sledge. 1997. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 17:3629.
45. Finco, T. S., J. K. Westwick, J. L. Norris, A. A. Beg, C. J. Der, and A. S. J. Baldwin. 1997. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272:24113.