Involvement of α-synuclein in Parkinson's disease and other neurodegenerative disorders

Journal of Neural Transmission

Volumn 107, Issue 1, 2000, Pages 31-40

  Kruger R ^a   Muller T ^a   Riess, O ^b  

^a ST JOSEF HOSPITAL   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Alzheimer's disease; Disease; Neurodegeneration; Parkinson's; synuclein

Indexed keywords

ALPHA SYNUCLEIN;

AMYOTROPHIC LATERAL SCLEROSIS; BRAIN REGION; DEGENERATIVE DISEASE; DEMENTIA; GENE MUTATION; HUMAN; LEWY BODY; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SHY DRAGER SYNDROME;

EID: 0033969730     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050002     Document Type: Review

References (57)

1. Arai H, Lee VMY, Hill WD, Greenberg BD, Trojanowski JQ (1992) Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Res 585: 386-390
2. Ashkenas J, Byers P (1997) The final step of gene expression: chaperones and the regulation of protein fate. J Hum Genet 61: 267-272
3. 18F-Dopa and positron emission tomography. Neurology 42: 1894-1900
4. Campion D, Martin C, Heilig R, Charbonnier F, Moreau V, Flaman JM, Petit JL, Hannequin D, Brice A, Frebourg T (1995) The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease. Genomics 26: 254-257
5. Chan P, Tanner CM, Jiang X, Langston JW (1998) Failure to find the (-synuclein gene missense mutation (G209A) in 100 patients with younger onset Parkinson's disease. Neurology 50: 513-514
6. Chen X, de Silva HA, Pettenati MJ, Rao PN, St. George-Hyslop P, Roses AD, Xia Y, Horsburgh K, Ueda K, Saitoh T (1995) The human NACP/α-synuclein gene: chromosome assignement to 4q21.3-q22 and TaqI RFLP analysis. Genomics 26: 425-427
7. Davidson WS, Jonas A, Clayton DF, George F (1998) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol Chem 273: 9443-9449
8. Duvoisin RC (1986) On heredity, twins, and Parkinson's disease. Ann Neurol 19: 409-411
9. Duvoisin RC, Eldridge R, Williams A, Nutt J, Calne D (1981) Twin study of Parkinson's disease. Neurology 31: 77-80
10. El-Agnaf OM, Jakes R, Curran MD, Wallace A (1998) Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease. FEBS Lett 440: 67-70
11. Engelender S, Guo X, Hoffman BE, Lee MK, Sharp AH, Zhang C, Cooper JK, Herring WJ, Troncoso JC, Price DL, Lanahan A, Worley P, Dawson VL, Dawson TM, Ross CA (1998) Alpha-synuclein interacts in vivo with a novel protein (synphilin1). Mov Disord 13: 87(Abstract)
12. Farrer M, Wavrant-De Vrieze F, Crook R, Boles L, Perez-Tur J, Hardy J, Johnson WG, Steele J, Maraganore D, Gwinn K, Lynch T (1998) Low frequency of α-synuclein mutations in familial Parkinson's disease. Ann Neurol 43: 394-397
13. Farrer M, Gwinn-Hardy K, Muenter M DeVrieze FW, Crook R, Perez-Tur J, Lincoln S, Maraganore D, Adler C, Newman S, MacElwee K, McCarthy P, Miller C, Waters C, Hardy J (1999) A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor. Hum Mol Genet 8: 81-85
14. Finley D, Chau V (1991) Ubiquitination. Ann Rev Cell Biol 7: 25-69
15. Gasser T, Muller-Myhsok B, Wszolek ZK, Oehlmann R, Calne DB, Bonifati V, Bereznai B, Fabrizio E, Vieregge P, Horstmann RD (1998) A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nature Genet 18: 262-265
16. George JM, Jin H, Woods WS, Clayton DF (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15: 361-372
17. Goedert M (1997) The awakening of α-synuclein. Nature 388: 232-233
18. Han H, Weinreb PH, Lansbury PT (1995) The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disorders? Chem Biol 2: 163-169
19. Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A, Saitoh T (1995) The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14: 467-475
20. Iwai A, Yoshimoto M, Masliah E, Saitoh T (1995) Non-Aβ component of Alzheimer's disease amyloid (NAC) is amyloidogenic. Biochemistry 34: 10139-10145
21. 2+-calmodulin-dependent protein kinase-II immunoreactivity in Lewy bodies. Acta Neuropathol 82: 159-163
22. Jakes R, Spillantini MG, Goedert M (1994) Identification of two distinct synucleins form human brain. FEBS Lett 345: 27-32
23. Jenko JM, Rawlingson A, Daniels B, Morris AJ (1998) Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by α-and β-synucleins. Biochemistry 37: 4901-4909
24. Jensen PH, Sorensen ES, Petersen TE, Gliemann J, Rasmussen LK (1995) Residues in the synuclein consensus motif of the α-synuclein fragment, NAC, participate in transglutaminase-catalysed cross-linking to Alzheimer-disease amyloid bA4 peptide. Biochem J 310: 91-94
25. Jensen PH, Hojrup P, Hager H, Nielsen MS, Jacobsen L, Olesen OF, Gliemann J, Jakes R (1997) Binding of Abeta to alpha-and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC. Biochem J 323: 539-546
26. Jensen PH, Nielsen MS, Jakes R, Dotti CG, Goedert M (1998) Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. J Biol Chem 273: 26292-26294
27. Ji H, Liu YE, Liu J, Shi YE (1999) Stimulation of breast cancer invasion and metastasis by synuclein gamma. Cancer Res 59: 742-747
28. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392: 605-608
29. Klein J, Chalifa V, Liscovitch M, Loffelholz K (1995) Role of phospholipase D activation in nervous system physiology and pathophysiology. J Neurochem 65: 1445-1455
30. Krüger R, Kuhn W, Müller Th, Woitalla D, Graeber M, Kösel S, Przuntek H, Epplen JT, Schöls L, Riess O (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat Genet 18: 106-108
31. Krüger R, Kuhn W, Müller T, Kühnl N, Fuchs GA, Berg D, Storch A, Hungs M, Woitalla D, Przuntek H, Epplen JT, Schöls L, Riess O (1998) Increased susceptibility to sporadic Parkinson's disease by a certain combined α-synuclein/apolipoprotein E genotype. Ann Neurol 45: 611-617
32. Lantos PL, Papp MI (1994) Cellular pathology of multiple system atrophy: a review. J Neurol Neurosurg Psychiatry 57: 129-133
33. Lavedan C, Leroy E, Dehejia A, Buchholtz S, Dutra A, Nussbaum RL, Polymeropoulos MH (1998) Identification, localization and characterization of the human γ-synuclein gene. Hum Genet 103: 106-112
34. Lazzarini AM, Myers RH, Zimmerman TR, Mark MH, Golbe LI, Sage JI, Johnson WG, Duvoisin RC (1994) A clinical genetic study of Parkinson's disease: evidence for dominant transmission. Neurology 44: 499-506
35. Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, Dehejia A, Lavedan C, Gasser T, Steinbach PJ, Wilkinson KD, Polymeropoulos MH (1998) The ubiquitin pathway in Parkinson's disease. Nature 395: 451-452
36. Maroteaux L, Campanelli JT, Scheller RH (1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminals. J Neurosci 8: 2804-2815
37. Marttila RJ, Kaprio J, Koskenvuo M, Rinne UK (1988) Parkison's disease in a nationwide twin cohort. Neurology 38: 1217-1219
38. Matsumine H, Saito M, Shimoda-Matsubayashi S, Tanaka H, Ishikawa A (1997) Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27. Am J Hum Genet 60: 588-596
39. Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ (1998) Alpha synuclein in neurodegenerative disorders: murderer or accomplice? Nat Med 4: 755-756
40. Nakajo S, Tsukada K, Omata K, Nakamura Y, Nakaya, K (1993) A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation. Eur J Biochem 217: 1057-1063
41. Olanow CW (1993) A radical hypothesis for neurodegeneration. Trends Neurosci 16: 439-444
42. Paik SR, Lee JH, Kim DH, Chang CS, Kim YS (1998) Self-oligomerization of NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer's disease amyloid, observed in the presence of a C-terminal Aβ fragment (residues 25-35). FEBS Lett 421: 73-76
43. Papadimitriou A, Veletza V, Hadjigeorgiou GM, Patrikiou A, Hirano M, Anastasopoulos I (1999) Mutated α-synuclein gene in two Greek kindreds with familial PD: incomplete penetrance? Neurology 52: 651-654
44. Polymeropoulos MH, Higgins JJ, Golbe LI, Johnson WG, Ide SE, Di Iorio G, Sanges G, Stenroos ES, Pho LT, Schafffer AA, Lazzarini AM, Nussbaum RL, Duvoisin RC (1997) Mapping of a gene for Parkinson's disease to chromosome 4q12-q23. Science 274: 1197-1199
45. Polymeropoulos MH, Laavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047
46. Spillantini MG, Divane A, Goedert M (1995) Assignement of human α-synuclein (SNCA) and β-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. Genomics 27: 379-381
47. Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95: 6469-6473
48. Tamaoka A, Mizusawa H, Mori H, Shoji S (1995) Ubiquitinated alpha B-crystallin in glial cytoplasmic inclusions from the brain of a patient with multiple system atrophy. J Neurol Sci 129: 192-198
49. Trojanowski JQ, Lee VMY (1998) Aggregation of neurofilament and α-synuclein proteins in Lewy bodies. Arch Neurol 55: 151-152
50. Tu P-H, Galvin JE, Baba M, et al. (1998) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 44: 415-422
51. Ueda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci USA 90: 11282-11286
52. Vaughan JR, Farrer MJ, Wszolek ZK, Gasser T, Durr A, Agid Y, Bonifati V, DeMichele G, Volpe G, Lincoln S, Breteler M, Meco G, Brice A, Marsden CD, Hardy J, Wood NW (1998) Sequencing of the α-synuclein gene in a large series of cases of familial Parkinson's disease fails to reveal any further mutations. Hum Mol Genet 7: 751-753
53. Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H (1998) Alpha synuclein immunorectivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 249: 180-182
54. Weinreb PH, Zhen W, Poon AW, Conway KA, Landsbury PT (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35: 13709-13715
55. Welch WJ, Gambetti P (1998) Chaperoning brain diseases. Nature 392: 23-24
56. Xia Y, Rohan de Silva HA, Rosi BL, Yamaoka LH, Rimmler JB, Pericak-Vance MA, Roses AD, Chen X, Masliah E, DeTeresa R, Iwai A, Sundsmo M, Thomas RG, Hofstetter CR, Gregory E, Hansen LA, Katzman R, Thal LJ, Saitoh T (1996) Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism. Ann Neurol 40: 207-215
57. Zareparsi S, Kaye J, Camicioli R, Kramer P, Nutt J, Bird T, Litt M, Payami H (1998) Analysis of the α-synuclein G209A mutation in familial Parkinson's disease. Lancet 351: 37-38