Interaction of qinghaosu (artemisinin) with cysteine sulfhydryl mediated by traces of non-heme iron

Angewandte Chemie - International Edition

Volumn 38, Issue 17, 1999, Pages 2580-2582

  Wu, Yikang ^a   Yue, Zheng Yu ^a,b   Wu, Yu Lin ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b HEILONGJIANG UNIVERSITY   (China)

Author keywords

Alkylations; Antimalarial agents; Chelates; Radicals; S ligands

Indexed keywords

ARTEMISININ; CYSTEINE; HEME; IRON;

ALKYLATION; ANTIMALARIAL ACTIVITY; ARTICLE; COMPLEX FORMATION; DRUG CYTOTOXICITY; DRUG DECOMPOSITION; DRUG STRUCTURE; ERYTHROCYTE METABOLISM; HYDROGEN BOND; LIGAND BINDING; MALARIA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0033520282     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19990903)38:17<2580::AID-ANIE2580>3.0.CO;2-J     Document Type: Article

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32. See for example a) A. C. Beekman, H. J. Woerdenbag, W. van Uden, N. Pras, A. W. T. Konings, H. V. Wikstrom, J. Pharm. Pharmacol. 1997, 49, 1254-1258; b) Q. Y. Zheng, L. G. Darbie (Hauser Chemical Research), WO-A 9701548 A1, 1997 [Chem. Abstr. 1997, 126, 157663]; c) H. C.-Y. Lai, N. P. Singh (University of Washington), WO- A 9634602 A1, 1996 [Chem. Abstr. 1997, 126, 26821]; d) S. O. Duke, F. E. Dayan, A. Hernandez, M. V. Duke, H. K. Abbas, Brighton Crop Prot. Conf. Weeds 1997, 2, 579-586 [Chem. Abstr. 1998, 128, 98854]; e) M. Jung, R. F. Schinazi, Bioorg. Med. Chem. Lett. 1994, 4, 931-4; f) R. L. Berens, E. C. Krug, P. B. Nash, T. J. Curiel, J. Infect. Dis. 1998, 177, 1128-1131.
33. See for example a) A. C. Beekman, H. J. Woerdenbag, W. van Uden, N. Pras, A. W. T. Konings, H. V. Wikstrom, J. Pharm. Pharmacol. 1997, 49, 1254-1258; b) Q. Y. Zheng, L. G. Darbie (Hauser Chemical Research), WO-A 9701548 A1, 1997 [Chem. Abstr. 1997, 126, 157663]; c) H. C.-Y. Lai, N. P. Singh (University of Washington), WO- A 9634602 A1, 1996 [Chem. Abstr. 1997, 126, 26821]; d) S. O. Duke, F. E. Dayan, A. Hernandez, M. V. Duke, H. K. Abbas, Brighton Crop Prot. Conf. Weeds 1997, 2, 579-586 [Chem. Abstr. 1998, 128, 98854]; e) M. Jung, R. F. Schinazi, Bioorg. Med. Chem. Lett. 1994, 4, 931-4; f) R. L. Berens, E. C. Krug, P. B. Nash, T. J. Curiel, J. Infect. Dis. 1998, 177, 1128-1131.
34. See for example a) A. C. Beekman, H. J. Woerdenbag, W. van Uden, N. Pras, A. W. T. Konings, H. V. Wikstrom, J. Pharm. Pharmacol. 1997, 49, 1254-1258; b) Q. Y. Zheng, L. G. Darbie (Hauser Chemical Research), WO-A 9701548 A1, 1997 [Chem. Abstr. 1997, 126, 157663]; c) H. C.-Y. Lai, N. P. Singh (University of Washington), WO- A 9634602 A1, 1996 [Chem. Abstr. 1997, 126, 26821]; d) S. O. Duke, F. E. Dayan, A. Hernandez, M. V. Duke, H. K. Abbas, Brighton Crop Prot. Conf. Weeds 1997, 2, 579-586 [Chem. Abstr. 1998, 128, 98854]; e) M. Jung, R. F. Schinazi, Bioorg. Med. Chem. Lett. 1994, 4, 931-4; f) R. L. Berens, E. C. Krug, P. B. Nash, T. J. Curiel, J. Infect. Dis. 1998, 177, 1128-1131.
35. See for example a) A. C. Beekman, H. J. Woerdenbag, W. van Uden, N. Pras, A. W. T. Konings, H. V. Wikstrom, J. Pharm. Pharmacol. 1997, 49, 1254-1258; b) Q. Y. Zheng, L. G. Darbie (Hauser Chemical Research), WO-A 9701548 A1, 1997 [Chem. Abstr. 1997, 126, 157663]; c) H. C.-Y. Lai, N. P. Singh (University of Washington), WO- A 9634602 A1, 1996 [Chem. Abstr. 1997, 126, 26821]; d) S. O. Duke, F. E. Dayan, A. Hernandez, M. V. Duke, H. K. Abbas, Brighton Crop Prot. Conf. Weeds 1997, 2, 579-586 [Chem. Abstr. 1998, 128, 98854]; e) M. Jung, R. F. Schinazi, Bioorg. Med. Chem. Lett. 1994, 4, 931-4; f) R. L. Berens, E. C. Krug, P. B. Nash, T. J. Curiel, J. Infect. Dis. 1998, 177, 1128-1131.
36. 3S: 256.1133; found: 256.1132.