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Volumn 37, Issue 2, 1999, Pages 105-125

Clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTEMETHER PLUS BENFLUMETOL; BENFLUMETOL; DIHYDROARTEMISININ; PLASMA PROTEIN;

EID: 0032862673     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-199937020-00002     Document Type: Review
Times cited : (287)

References (58)
  • 1
    • 0031219219 scopus 로고    scopus 로고
    • Phase II trial in China of a new and rapidly-acting and effective antimalarial CGP 56697, for the treatment of Plasmodium falciparum malaria
    • Jiao XQ, Liu GY, Shan CQ, et al. Phase II trial in China of a new and rapidly-acting and effective antimalarial CGP 56697, for the treatment of Plasmodium falciparum malaria. Southeast Asian J Trop Med Public Health 1997; 28: 476-81
    • (1997) Southeast Asian J Trop Med Public Health , vol.28 , pp. 476-481
    • Jiao, X.Q.1    Liu, G.Y.2    Shan, C.Q.3
  • 2
    • 0030812746 scopus 로고    scopus 로고
    • Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697
    • von Seidlein L, Jaffar S, Pinder M, et al. Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697. J Infect Dis 1997; 176: 1113-6
    • (1997) J Infect Dis , vol.176 , pp. 1113-1116
    • Von Seidlein, L.1    Jaffar, S.2    Pinder, M.3
  • 3
    • 0031973150 scopus 로고    scopus 로고
    • Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria
    • van Vugt M, Brockman A, Gemperli B, et al. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria. Antimicrob Agents Chemother 1998; 42: 135-9
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 135-139
    • Van Vugt, M.1    Brockman, A.2    Gemperli, B.3
  • 4
    • 0031777975 scopus 로고    scopus 로고
    • Efficacy and safety of CGP 56697 (artemether and benflumetol) compared wilh chloroquint to treat acute falciparum malaria in Tanzanian children aged 1-5 years
    • Hatz C, Abdulla S, Mull R, et al. Efficacy and safety of CGP 56697 (artemether and benflumetol) compared wilh chloroquint to treat acute falciparum malaria in Tanzanian children aged 1-5 years. Trap Med Int Health 1998; 3: 495-504
    • (1998) Trap Med Int Health , vol.3 , pp. 495-504
    • Hatz, C.1    Abdulla, S.2    Mull, R.3
  • 5
    • 15844394627 scopus 로고    scopus 로고
    • A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria
    • Hien TT, Day NPJ, Phu NH, et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med 1996; 335: 76-83
    • (1996) N Engl J Med , vol.335 , pp. 76-83
    • Hien, T.T.1    Day, N.P.J.2    Phu, N.H.3
  • 7
    • 0028884817 scopus 로고
    • Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria
    • Price RN, Nosten F, Luxemburger C, et al. Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria. Trans R Soc Trap Med Hyg 1995; 89: 523-7
    • (1995) Trans R Soc Trap Med Hyg , vol.89 , pp. 523-527
    • Price, R.N.1    Nosten, F.2    Luxemburger, C.3
  • 8
    • 0032525989 scopus 로고    scopus 로고
    • Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa
    • Wernsdorfer WH, Landgraf B, Kilimali VAEB, et al. Activity of benflumetol and its enantiomers in fresh isolates of Plasmodium falciparum from East Africa. Acta Tropica 1998; 70: 9-15
    • (1998) Acta Tropica , vol.70 , pp. 9-15
    • Wernsdorfer, W.H.1    Landgraf, B.2    Kilimali, V.A.E.B.3
  • 9
    • 0027470164 scopus 로고
    • Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: Selective pressure for resistance is a function of long elimination half-life
    • Watkins WM, Mosobo M. Treatment of Plasmodium falciparum malaria with pyrimethamine-sulfadoxine: selective pressure for resistance is a function of long elimination half-life. Trans R Soc Trop Med Hyg 1993; 87: 75-8
    • (1993) Trans R Soc Trop Med Hyg , vol.87 , pp. 75-78
    • Watkins, W.M.1    Mosobo, M.2
  • 10
    • 0030858470 scopus 로고    scopus 로고
    • Assessment of the pharmacodynamic properties of antimalarial drugs in vivo
    • White NJ. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agents Chemothor 1997; 41: 1413-22
    • (1997) Antimicrob Agents Chemothor , vol.41 , pp. 1413-1422
    • White, N.J.1
  • 11
    • 77949810315 scopus 로고    scopus 로고
    • Preventing antimalarial drug resistance through combinations
    • White NJ. Preventing antimalarial drug resistance through combinations. Drug Resistance Updates 1998; 1: 3-9
    • (1998) Drug Resistance Updates , vol.1 , pp. 3-9
    • White, N.J.1
  • 12
    • 85069121022 scopus 로고    scopus 로고
    • The use of independently acting drug combinations to reduce the rate of resistance acquisition in Plasmodium falciparum malaria: Studies with lumefantrine, artemether, and co-artemether
    • [abstract] Sep 14-18; Liverpool
    • Atkinson JD, Ward SA. The use of independently acting drug combinations to reduce the rate of resistance acquisition in Plasmodium falciparum malaria: studies with lumefantrine, artemether, and co-artemether [abstract]. European Congress on Tropical Medicine; 1998 Sep 14-18; Liverpool
    • (1998) European Congress on Tropical Medicine
    • Atkinson, J.D.1    Ward, S.A.2
  • 13
    • 0031753648 scopus 로고    scopus 로고
    • Population pharmacokinetics and therapeutic response or CGP 56697 (artemether + benflumetol) in malaria patients
    • Ezzet F, Mull R, Karbwang J. Population pharmacokinetics and therapeutic response or CGP 56697 (artemether + benflumetol) in malaria patients. Br J Clin Pharmacol 1998; 46: 553-62
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 553-562
    • Ezzet, F.1    Mull, R.2    Karbwang, J.3
  • 14
    • 0033048031 scopus 로고    scopus 로고
    • A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment or acute Plasmodium falciparum malaria in Thailand
    • Looareesuwan S, Wilairatana P, Chokejindachai W, et al. A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment or acute Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 1999; 60: 238-43
    • (1999) Am J Trop Med Hyg , vol.60 , pp. 238-243
    • Looareesuwan, S.1    Wilairatana, P.2    Chokejindachai, W.3
  • 15
    • 85069125681 scopus 로고    scopus 로고
    • Efficacy of six doses of artemether-lumefantrine in the treatment of multi drug resistant falciparum malaria
    • In press
    • van Vugt M, Wilairatana P, Gemperli B, et al. Efficacy of six doses of artemether-lumefantrine in the treatment of multi drug resistant falciparum malaria. Am J Trop Med Hyg. In press
    • Am J Trop Med Hyg
    • Van Vugt, M.1    Wilairatana, P.2    Gemperli, B.3
  • 16
    • 0027536966 scopus 로고
    • Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo
    • Shmuklarsky MJ, Klayman DL, Milhous WK, et al. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. Am J Trop Med Hyg 1993; 48: 377-84
    • (1993) Am J Trop Med Hyg , vol.48 , pp. 377-384
    • Shmuklarsky, M.J.1    Klayman, D.L.2    Milhous, W.K.3
  • 17
    • 0027491870 scopus 로고
    • In vitro activity or artemisinin derivatives against African isolates and clones of Plasmodium falciparum
    • Basco LK, Le Bras J. In vitro activity or artemisinin derivatives against African isolates and clones of Plasmodium falciparum. Am Journal Trop Med Hyg 1993; 49: 301-7
    • (1993) Am Journal Trop Med Hyg , vol.49 , pp. 301-307
    • Basco, L.K.1    Le Bras, J.2
  • 18
    • 0029852334 scopus 로고    scopus 로고
    • Comparative bio-availability of oral, rectal and intramuscular artemether in healthy subjects - Use of simultaneous measurement by high performance liquid chromatography with electrochemical detection and bioassay
    • Teja-Isavadharm P, Nosten F, Kyle DE, et al. Comparative bio-availability of oral, rectal and intramuscular artemether in healthy subjects - use of simultaneous measurement by high performance liquid chromatography with electrochemical detection and bioassay. Br J Clin Pharmacol 1996; 42: 599-604
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 599-604
    • Teja-Isavadharm, P.1    Nosten, F.2    Kyle, D.E.3
  • 19
    • 0027280310 scopus 로고
    • Plasmodium falciparum: In-vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria
    • ter Kuile F, White NJ, Holloway P, et al. Plasmodium falciparum: in-vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Exp Parasitol 1993; 76: 86-95
    • (1993) Exp Parasitol , vol.76 , pp. 86-95
    • Ter Kuile, F.1    White, N.J.2    Holloway, P.3
  • 20
    • 0033023732 scopus 로고    scopus 로고
    • In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs
    • Pradines B, Tall A, Fusai T, et al. In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs. Antimicrob Agents Chemother 1999; 43: 418-20
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 418-420
    • Pradines, B.1    Tall, A.2    Fusai, T.3
  • 21
    • 0031711884 scopus 로고    scopus 로고
    • In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaoundc, Cameroon
    • Basco LK, Bickii J, Ringwald P. In vitro activity of lumefantrine (benflumetol) against clinical isolates of Plasmodium falciparum in Yaoundc, Cameroon. Antimicrob Agents Chemother 1998; 42: 2347-51
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2347-2351
    • Basco, L.K.1    Bickii, J.2    Ringwald, P.3
  • 22
    • 0030176425 scopus 로고    scopus 로고
    • The mode of action of the antimalarial artemisinin and its derivatives
    • Kamchonwongpaisan S, Meshnick SR. The mode of action of the antimalarial artemisinin and its derivatives. Gen Pharmacol 1996; 27: 587-92
    • (1996) Gen Pharmacol , vol.27 , pp. 587-592
    • Kamchonwongpaisan, S.1    Meshnick, S.R.2
  • 23
    • 0028228429 scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives
    • White NJ. Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: 41-3
    • (1994) Trans R Soc Trop Med Hyg , vol.88 , Issue.SUPPL. 1 , pp. 41-43
    • White, N.J.1
  • 24
    • 0026079169 scopus 로고
    • Determination or the antimalarial arteether and its dethylated metabolite dihydroartemisinin in plasma by high performance liquid chromatography with reductive electrochemical detection
    • Melendez V, Peggins JO, Brewer TG, et al. Determination or the antimalarial arteether and its dethylated metabolite dihydroartemisinin in plasma by high performance liquid chromatography with reductive electrochemical detection. J Pharm Sci 1991; 80: 132-8
    • (1991) J Pharm Sci , vol.80 , pp. 132-138
    • Melendez, V.1    Peggins, J.O.2    Brewer, T.G.3
  • 25
    • 0029146165 scopus 로고
    • Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies
    • Navaratnam V, Mansor SM, Chin LK, et al. Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J Chromatogr (B) Biomed Appl 1995; 669: 289-94
    • (1995) J Chromatogr (B) Biomed Appl , vol.669 , pp. 289-294
    • Navaratnam, V.1    Mansor, S.M.2    Chin, L.K.3
  • 26
    • 0028241457 scopus 로고
    • Measurement of artemisinin and its derivatives in biological fluids
    • Edwards G. Measurement of artemisinin and its derivatives in biological fluids. Trans R Soc Trop Med Hyg 1994; 88 Suppl. I: 37-9
    • (1994) Trans R Soc Trop Med Hyg , vol.88 , Issue.SUPPL. I , pp. 37-39
    • Edwards, G.1
  • 27
    • 0030013737 scopus 로고    scopus 로고
    • Determination of benflumctol in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection
    • Zeng MY, Lu ZL, Yang SC, et al. Determination of benflumctol in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Appl 1996; 681: 299-306
    • (1996) J Chromatogr B Biomed Appl , vol.681 , pp. 299-306
    • Zeng, M.Y.1    Lu, Z.L.2    Yang, S.C.3
  • 28
    • 0030581186 scopus 로고    scopus 로고
    • Determination of a new antimalarial drug, benflurnectol, in blood plasma by high-performance liquid chromatography
    • Mansor SM, Navaratnam V, Yahaya N, et al. Determination of a new antimalarial drug, benflurnectol, in blood plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl 1996; 682: 321-5
    • (1996) J Chromatogr B Biomed Appl , vol.682 , pp. 321-325
    • Mansor, S.M.1    Navaratnam, V.2    Yahaya, N.3
  • 29
    • 0031764316 scopus 로고    scopus 로고
    • The relationship between capillary and venous concentrations of lumefantrine (benflumetol)
    • van Vugt M, Ezzet F, Phaipun L, et al. The relationship between capillary and venous concentrations of lumefantrine (benflumetol). Trans R Soc Trop Med Hyg 1998; 92: 564-5
    • (1998) Trans R Soc Trop Med Hyg , vol.92 , pp. 564-565
    • Van Vugt, M.1    Ezzet, F.2    Phaipun, L.3
  • 30
    • 0031953576 scopus 로고    scopus 로고
    • Metabolism of β-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P-450
    • Grace JM, Aguilar AJ, Trotman KM, et al. Metabolism of β-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P-450. Drug Metab Dispos 1998; 26: 313-17
    • (1998) Drug Metab Dispos , vol.26 , pp. 313-317
    • Grace, J.M.1    Aguilar, A.J.2    Trotman, K.M.3
  • 31
    • 85069121080 scopus 로고    scopus 로고
    • The contribution of the enzymes CYP2D6-and CYP2C19 in the demethylation of artemether in healthy subjects
    • van Agtmael MA, Van Der Graaf CA, Dien TK, et al. The contribution of the enzymes CYP2D6-and CYP2C19 in the demethylation of artemether in healthy subjects. Br J Pharmacol 1998; 125: 159-67
    • (1998) Br J Pharmacol , vol.125 , pp. 159-167
    • Van Agtmael, M.A.1    Van Der Graaf, C.A.2    Dien, T.K.3
  • 32
    • 0030740220 scopus 로고    scopus 로고
    • Effects of Plasmodium berghei infection on arteether metabolism and disposition
    • Leo KU, Grace JM, Li Q, et al. Effects of Plasmodium berghei infection on arteether metabolism and disposition. Pharmacology 1997; 54: 276-84
    • (1997) Pharmacology , vol.54 , pp. 276-284
    • Leo, K.U.1    Grace, J.M.2    Li, Q.3
  • 33
    • 0031679973 scopus 로고    scopus 로고
    • Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisnin using rat liver perfusions and microsomes
    • Batty KT, Hett KF, Edwards G, et al. Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisnin using rat liver perfusions and microsomes. Br J Pharmacol 1998; 125: 159-67
    • (1998) Br J Pharmacol , vol.125 , pp. 159-167
    • Batty, K.T.1    Hett, K.F.2    Edwards, G.3
  • 34
    • 85069122264 scopus 로고
    • Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver
    • Murdoch RT, Ghabrial H, Mihaly GW, et al. Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver. Xenobiotica 1991; 15: 71-82
    • (1991) Xenobiotica , vol.15 , pp. 71-82
    • Murdoch, R.T.1    Ghabrial, H.2    Mihaly, G.W.3
  • 36
    • 85069125402 scopus 로고    scopus 로고
    • 14C-dihydroartemisinin to plasma proteins and red blood cells of human and animal species in-vivo and in-vitro
    • [abstract PpA 144]; San Francisco
    • 14C-dihydroartemisinin to plasma proteins and red blood cells of human and animal species in-vivo and in-vitro [abstract PpA 144]. 21st Annual Meeting Experimental Biology; 1998; San Francisco
    • (1998) 21st Annual Meeting Experimental Biology
    • Li, Q.-G.1    Peggins, J.O.2    Fleckenstein, L.3
  • 37
    • 0025646009 scopus 로고
    • Metabolism of antimalarial sesquiterpene lactones
    • Lee IS, Hufford CD. Metabolism of antimalarial sesquiterpene lactones. Pharmacol Ther 1990; 48: 345-55
    • (1990) Pharmacol Ther , vol.48 , pp. 345-355
    • Lee, I.S.1    Hufford, C.D.2
  • 38
    • 0026239217 scopus 로고
    • Identification of the in-vivo metabolites of the antimalarial arteether by thermospray high performance liquid chromatography/mass spectrometry
    • Chi HT, Ramu K, Baker JK, et al. Identification of the in-vivo metabolites of the antimalarial arteether by thermospray high performance liquid chromatography/mass spectrometry. Biol Mass Spectrum 1991; 20: 609-28
    • (1991) Biol Mass Spectrum , vol.20 , pp. 609-628
    • Chi, H.T.1    Ramu, K.2    Baker, J.K.3
  • 40
    • 0028357240 scopus 로고
    • Pharmacokinetics of artemether after oral administration to healthy Thai males and patients with acute, uncomplicated falciparum malaria
    • Na Bangchang K, Karbwang J, Thomas CG, et al. Pharmacokinetics of artemether after oral administration to healthy Thai males and patients with acute, uncomplicated falciparum malaria. Br J Clin Pharmacol 1994; 37: 249-53
    • (1994) Br J Clin Pharmacol , vol.37 , pp. 249-253
    • Na Bangchang, K.1    Karbwang, J.2    Thomas, C.G.3
  • 41
    • 0030941625 scopus 로고    scopus 로고
    • Single dose pharmacokinetics of oral artemether in healthy Malaysian volunteers
    • Mordi MN, Mansor SM, Navaratnam V, et al. Single dose pharmacokinetics of oral artemether in healthy Malaysian volunteers. Br J Clin Pharmacol 1998; 43: 363-5
    • (1998) Br J Clin Pharmacol , vol.43 , pp. 363-365
    • Mordi, M.N.1    Mansor, S.M.2    Navaratnam, V.3
  • 42
    • 0003257143 scopus 로고    scopus 로고
    • Comparative bioavailability of benflurnetol after administration of single oral doses of co-artemether under fed and fasted conditions to healthy subjects
    • [abstract] Nov 17-22; Nagasaki
    • Bindschedler M, Degen P, Lu ZL, et al. Comparative bioavailability of benflurnetol after administration of single oral doses of co-artemether under fed and fasted conditions to healthy subjects [abstract]. XIVth International Congress for Tropical Medicine and Malaria; 1996 Nov 17-22; Nagasaki
    • (1996) XIVth International Congress for Tropical Medicine and Malaria
    • Bindschedler, M.1    Degen, P.2    Lu, Z.L.3
  • 43
    • 0026659564 scopus 로고
    • Antimatarial pharmacokinetics
    • White NJ. Antimatarial pharmacokinetics. Br J Clin Pharmacol 1992; 34: 1-10
    • (1992) Br J Clin Pharmacol , vol.34 , pp. 1-10
    • White, N.J.1
  • 44
    • 0025170004 scopus 로고
    • Nonlinear mixed effects models for repeated measures data
    • Lindstrom MJ, Bates DM. Nonlinear mixed effects models for repeated measures data. Biometrics 1990; 46: 673-87
    • (1990) Biometrics , vol.46 , pp. 673-687
    • Lindstrom, M.J.1    Bates, D.M.2
  • 46
    • 0002680428 scopus 로고
    • Blood examination and prognosis in acute falciparum malaria
    • Field JW. Blood examination and prognosis in acute falciparum malaria. Trans R Soc Trop Med Hyg 1949; 43: 33-48
    • (1949) Trans R Soc Trop Med Hyg , vol.43 , pp. 33-48
    • Field, J.W.1
  • 47
    • 0028338629 scopus 로고
    • Neurotoxicity in animals due to arteether and artemether
    • Brewer TG, Peggins JO, Grate SJ, et al. Neurotoxicity in animals due to arteether and artemether. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: 33-6
    • (1994) Trans R Soc Trop Med Hyg , vol.88 , Issue.SUPPL. 1 , pp. 33-36
    • Brewer, T.G.1    Peggins, J.O.2    Grate, S.J.3
  • 48
  • 49
    • 0032960336 scopus 로고    scopus 로고
    • Adverse effects in patients with acute uncomplicated falciparum malaria treated with artemisinin derivatives
    • Price RN, van Vugt M, Phaipun L, et al. Adverse effects in patients with acute uncomplicated falciparum malaria treated with artemisinin derivatives. Am J Trap Med Hyg 1999; 60: 547-55
    • (1999) Am J Trap Med Hyg , vol.60 , pp. 547-555
    • Price, R.N.1    Van Vugt, M.2    Phaipun, L.3
  • 50
    • 0027404778 scopus 로고
    • Cardiac effects of antimalarial treatment with halofantrine
    • Nosten I, ter Kuile FO, Luxemburger C, et al. Cardiac effects of antimalarial treatment with halofantrine. Lancet 1993; 341: 1054-6
    • (1993) Lancet , vol.341 , pp. 1054-1056
    • Nosten, I.1    Ter Kuile, F.O.2    Luxemburger, C.3
  • 51
    • 0032186040 scopus 로고    scopus 로고
    • c interval in African children treated for Falciparum malaria
    • c interval in African children treated for Falciparum malaria. Am J Trop Med Hyg 1998; 59: 503
    • (1998) Am J Trop Med Hyg , vol.59 , pp. 503
    • Price, R.1    Nosten, F.2    White, N.J.3
  • 52
    • 0030428256 scopus 로고    scopus 로고
    • Cytochrome P4503A (CYP3A) metabolism: Prediction of in vivo activity in humans
    • Wilkinson GR. Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans. J Pharmacokinet Biopharm 1996; 24: 474-90
    • (1996) J Pharmacokinet Biopharm , vol.24 , pp. 474-490
    • Wilkinson, G.R.1
  • 53
    • 0024334387 scopus 로고
    • Reduced hepatic blood flow and intestinal malabsorption in severe falciparum malaria
    • Molyneux ME, Looareesuwan S, Menzies IS, et al. Reduced hepatic blood flow and intestinal malabsorption in severe falciparum malaria. Am J Trop Med Hyg 1989; 40: 470-76
    • (1989) Am J Trop Med Hyg , vol.40 , pp. 470-476
    • Molyneux, M.E.1    Looareesuwan, S.2    Menzies, I.S.3
  • 55
    • 0028106706 scopus 로고
    • Treatment of multi-drug resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination
    • Nosten F, Luxemburger C, ter Kuile FO, et al. Treatment of multi-drug resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination. J Infect Dis 1994; 170: 971-7
    • (1994) J Infect Dis , vol.170 , pp. 971-977
    • Nosten, F.1    Luxemburger, C.2    Ter Kuile, F.O.3
  • 56
    • 0024335624 scopus 로고
    • Pharmacokinetics of halofantrine in man: Effects of food and dose size
    • Milton KA, Edwards G, Ward SA, et al. Pharmacokinetics of halofantrine in man: effects of food and dose size. Br J Clin Pharmacol 1989; 28: 71-7
    • (1989) Br J Clin Pharmacol , vol.28 , pp. 71-77
    • Milton, K.A.1    Edwards, G.2    Ward, S.A.3
  • 57
    • 0030909429 scopus 로고    scopus 로고
    • Population pharmacokinetics of atovaquone in patients with acute malaria caused by Plasmodium falciparum
    • Husscin Z, Eaves J, Hutchinson DB, et al. Population pharmacokinetics of atovaquone in patients with acute malaria caused by Plasmodium falciparum. Clin Pharmacol Ther 1997; 61: 518-30
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 518-530
    • Husscin, Z.1    Eaves, J.2    Hutchinson, D.B.3
  • 58
    • 0001981684 scopus 로고
    • Observations on malaria made during treatment of general paralysis
    • Yorke W, Macfie JWS. Observations on malaria made during treatment of general paralysis. Trans R Soc Trap Med Hyg 1924; 18: 33
    • (1924) Trans R Soc Trap Med Hyg , vol.18 , pp. 33
    • Yorke, W.1    Macfie, J.W.S.2


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