CDK4 gene amplification in osteosarcoma: Reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

International Journal of Cancer

Volumn 80, Issue 2, 1999, Pages 199-204

  Wei, Guo ^a   Lonardo, Fulvio ^a   Ueda, Takafumi ^a,b   Kim, Tonia ^a,c   Huvos, Andrew G ^a   Healey, John H ^a   Ladanyi, Marc ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Osaka Medical Center for Cancer   (Japan)

^c ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHROMOSOME 12Q; GENE AMPLIFICATION; GENE MAPPING; HUMAN; HUMAN TISSUE; OSTEOSARCOMA; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BONE NEOPLASMS; CHILD; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 12; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; DNA METHYLATION; FEMALE; GENE AMPLIFICATION; HUMANS; MALE; OSTEOSARCOMA; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS;

EID: 0033579870     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990118)80:2<199::AID-IJC7>3.0.CO;2-4     Document Type: Article

References (40)

1. BELCHIS, D.A., MEECE, C.A., BENKO, F.A., ROGAN, P.K., WILLIAMS, R.A. and GOCKE, C.D., Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas. Diagn. mol. Pathol., 5, 214-219 (1996).
2. BERNER, J.-M., FORUS, A., ELKAHLOUN, A., MELTZER, P.S., FODSTAD, O. and MYKLEBOST, O., Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas. Genes Chromosomes Cancer, 17, 254-259 (1996).
3. BERNER, J.M., MEZA-ZEPEDA, L.A., KOOLS, P.F., FORUS, A., SCHOENMAKERS, E.F., VAN DE VEN, W.J., FODSTAD, O. and MYKLEBOST, O., HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas. Oncogene, 14, 2935-2941 (1997).
4. CORDON-CARDO, C., Mutation of cell cycle regulators. Biological and clinical implications for human neoplasia. Amer. J. Pathol., 147, 545-560 (1995).
5. CROZAT, A., AMAN, P., MANDAHL, N. and RON, D., Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature (Lond.), 363, 640-644 (1993).
6. ELKAHLOUN, A.G., BITTNER, M., HOSKINS, K., GEMMILL, R. and MELTZER, P., Molecular cytogenetic characterization and physical mapping of 12q13-15 amplification in human cancers. Genes Chromosomes Cancer, 17, 205-214 (1996).
7. FEUGEAS, O. and 12 OTHERS, Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J. clin. Oncol., 14, 467-472 (1996).
8. ARF encoding exons in T-cell acute lymphoblastic leukemia. Blood, 91, 1016-1020 (1998).
9. HALL, M. and PETERS, G., Genetic alterations of cyclins, cyclin-dependent kinases, and cdk inhibitors in human cancer. Adv. Cancer Res., 68, 67-107 (1996).
10. HE, J., ALLEN, J.R., COLLINS, V.P., ALLALUNIS-TURNER, M.J., GODBOUT, R., DAY, R.S., III and JAMES, C.D., CDK4 amplification is an alternative mechanism to P16 gene homozygous deletion in glioma cell lines. Cancer Res., 54, 5804-5807 (1994).
11. HERMAN, J.G., MERLO, A., MAO, L., LAPIDUS, R.G., ISSA, J.P., DAVIDSON, N.E., SIDRANSKY, D. and BAYLIN, S.B., Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55, 4525-4530 (1995).
12. KAMB, A., GRUIS, N.A., WEAVER-FELDHAUS, J., LIU, Q., HARSHMAN, K., TAVTIGIAN, S.V., STOCKERT, E., DAY, R.S., III. JOHNSON, B.E. and SKOLNICK, M.H., A cell cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436-440 (1994).
13. KHATIB, Z.A., MATSUSHIME, H., VALENTINE, M., SHAPIRO, D.N., SHERR, C.J. and LOOK, A.T., Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res., 53, 5535-5541 (1993).
14. KINZLER, K.W., BIGNER, S.H., BIGNER, D.D., TRENT, J.M., LAW, M.L., O'BRIEN, S.J., WONG, A.J. and VOGELSTEIN, B., Identification of an amplified, highly expressed gene in a human glioma. Science, 236, 70-73 (1987).
15. KOH, J., ENDERS, G.H., DYNLACHT, B.D. and HARLOW, E., Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature (Lond.), 375, 506-510 (1995).
16. LADANYI, M., CHA, C., LEWIS, R., JHANWAR, S.C., HUVOS, A.C. and HEALEY, J.H., MDM2 gene amplification in metastatic osteosarcoma. Cancer Res., 53, 16-18 (1993).
17. LADANYI, M., LEWIS, R., JHANWAR, S.C., GERALD, W., HUVOS, A.G. and HEALEY, J.H., MDM2 and CDK4 gene amplification in Ewing's sarcoma. J. Pathol., 175, 211-217 (1995).
18. INK4a: a gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression. Oncogene, 12, 2041-2044 (1996).
19. LONARDO, F., UEDA, T., HUVOS, A.G., HEALEY, J. and LADANYI, M., p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathological features and proliferative rate. Cancer, 79, 1541-1547 (1997).
20. LUKAS, J., PARRY, D., AAGAARD, L., MANN, D.J., BARTKOVA, J., STRAUSS, M., PETERS, G. and BARTEK, J., Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature (Lond.), 375, 503-506 (1995).
21. MAELANDSMO, G.M., BERNER, J.-M., FLORENES, V.A., FORUS, A., HOVIG, E., FODSTAD, O. and MYKLEBOST, O., Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas - relationship to amplification and MRNA levels of CDK4 and CCND1. Brit. J. Cancer, 72, 393-398 (1995).
22. MERLO, A., HERMAN, J.G., MAO, L., LEE, D.J., GABRIELSON, E., BURGER, P.C., BAYLIN, S.B. and SIDRANSKV, D., 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/ CDKN2/MTS1 in human cancers. Nature (Med.) 1, 686-692 (1995).
23. MILLER, C.W., ASLO, A., CAMPBELL, M.J., KAWAMATA, N., LAMPKIN, B.C. and KOEFFLER, H.P., Alterations of the P15, P16, and P18 genes in osteosarcoma. Cancer Genet. Cytogenet., 86, 136-142 (1996).
24. NIELSEN, G.P., BURNS, K.L., ROSENBERG, A.E. and LOUIS, D.N., CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. Amer. J. Pathol., 153, 159-163 (1998).
25. NOBLE-TOPHAM, S.E., BURROW, S.R., EPPERT, K., KANDEL, R.A., MELTZER, P.S., BELL, R.S. and ANDRULIS, I.L., SAS is amplified predominantly in surface osteosarcoma. J. Orthoped. Res., 14, 700-705 (1996).
26. NOBORI, T., MIURA, K., WU, D.J., LOIS, A., TAKABAYASHI, K. and CARSON, D.A., Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368, 753-756 (1994).
27. PATINO-GARCIA, A. and SIERRASESUMAGA, L., Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients. Cancer Genet. Cytogenet., 98, 50-55 (1997).
28. POLLOCK, P.M., PEARSON, J.V. and HAYWARD, N.K., Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions. Genes Chromosomes Cancer, 15, 77-88 (1996).
29. POMERANTZ, J., SCHREBER-AGUS, N., LIEGEOIS, N.J., SILVERMAN, A., ALLAND, L., CHIN, L., POTES, J., ORLOW, I., LEE, H.-W., CORDON-CARDO, C. and DEPINHO, R.A., The INK4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell, 92, 1-20 (1998).
30. QUELLE, D.E., CHENG, M., ASHMUN, R.A. and SHERR, C.J., Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. Proc. nat. Acad. Sci. (Wash.), 94, 669-673 (1997).
31. QUELLE, D.E., ZINDY, F., ASHMUN, R.A. and SHERR, C.J., Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell, 83, 993-1000 (1995).
32. REIFENBERGER, G., ICHIMURA, K., REIFENBERGER, J., ELKAHLOUN, A.G., MELTZER, P.S. and COLLINS, V.P., Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets. Cancer Res., 56, 5141-5145 (1996).
33. SCHMIDT, E.E., ICHIMURA, K., REIFENBERGER, G. and COLLINS, V.P., CDKN2 (P16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res., 54, 6321-6324 (1994).
34. SERRANO, M., HANNON, G.J. and BEACH, D., A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366, 704-707 (1993).
35. SMITH-SORENSEN, B. and HOVIG, E., CDKN2A (p16INK4A) somatic and germline mutations. Hum. mutation, 7, 294-303 (1996).
36. SONODA, Y., YOSHIMOTO, T. and SEKIYA, T., Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma. Oncogene, 11, 2145-2149 (1995).
37. SZYMANSKA, J., MANDAHL, N., MERTENS, F., TARKKANEN, M., KARAHARJU, E. and KNUUTILA, S., Ring chromosomes in parosteal osteosarcoma contain sequences from 12q13-15: a combined cytogenetic and comparative genomic hybridization study. Genes Chromosomes Cancer, 16, 31-34 (1996).
38. UEKI, K., ONO, Y., HENSON, J.W., EFIRD, J.T., VON DEIMLING, A. and LOUIS, D.N., CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res., 56, 150-153 (1996).
39. WADAYAMA, B., TOGUCHIDA, J., SHIMIZU, T., ISHIZAKI, K., SASAKI, M.S., KOTOURA, Y. and YAMAMURO, T., Mutation spectrum of the retinoblastoma gene in osteosarcoma. Cancer Res., 54, 3042-3048 (1994).
40. ZHANG, S.-Y., KLEIN-SZANTO, A.J.P., SAUTER, E.R., SHAFARENKO, M., MITSUNAGA, S., NOBORI, T., CARSON, D.A., RIDGE, J.A. and GOODROW, T.L., Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res., 54, 5050-5053 (1994).