Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors

Biological Chemistry

Volumn 381, Issue 9-10, 2000, Pages 827-838

  Malumbres, M ^a   Ortega, S ^a   Barbacid, M ^a  

^a Molecular Oncology Program   (Spain)

Author keywords

Cip; Cyclin; Cyclin dependent kinase; Gene targeting; INK4 inhibitors; Kip inhibitors

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BIOCHEMISTRY; CANCER CONTROL; CATALYSIS; CELL CYCLE; CELL CYCLE G1 PHASE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MAMMAL CELL; MITOGENICITY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REGULATORY MECHANISM; REVIEW;

ANIMALIA; MAMMALIA;

EID: 0033790450     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2000.105     Document Type: Review

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3. Induction of mammary gland hyperplasia and carcinoma in transgenic mice expressing human cyclin E
4. Retinoblastoma protein meets chromatin
5. Radiation-induced cell cycle arrest compromised by p21 deficiency
6. P21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells
7. Expression and amplification of cyclin genes in human breast cancer
8. 2 arrest after DNA damage
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11. Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations
12. Mice lacking p21(CIP1/WAF1) undergo normal development, but are defective in G1 checkpoint control
13. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
14. A syndrome of multi-organ hyperplasia with features of gigantism, tumorigenesis and female sterility in p27Kip1-deficien mice
15. The murine gene p27(Kip1) is haplo-insufficient for tumour suppression
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17. Rescue of cyclin D1 deficiency by knockin cyclin E
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21. Functions of the retinoblastoma protein
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26. New functional activities for the p21 family of CDK inhibitors
27. Limited overlapping roles of p15INK4b and p18INK4c cell cycle inhibitors in proliferation and tumorigenesis
28. E2F target genes and cell cycle checkpoint control
29. Cyclin A1 is required for meiosis in the male mouse
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31. PRb and E2f-1 in mouse development and tumorigenesis
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33. Principles of Cdk regulation
34. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
35. Mice lacking p27Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
36. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of Cdk4
37. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
38. Mechanisms of cyclin-dependent kinase regulation: Structures of cdks, their cyclin activators, and Cip and INK4 inhibitors
39. The D-type cyclins and their role in tumorigenesis
40. Tumor suppression by p27(Kip1) and p21(Cip1) during chemically induced skin carcinogenesis
41. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
42. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
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46. The INK4A/ARF locus and its two gene products
47. Cancer cell cycles
48. Inhibitors of mammalian G1 cyclin-dependent kinases
49. CDK inhibitors: Positive and negative regulators of G1-phase progression
50. The ARF/p53 pathway
51. Cyclin D1 provides a link between development and oncogenesis in the retina and breast
52. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
53. Deregulated cyclin E induces chromosome instability
54. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
55. Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors
56. The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer
57. Targeted disruption of Cdk4 delays cell cycle entry with enhanced p27Kip1 activity
58. Developmental defects and tumor predisposition in Rb mutant mice
59. Uncouplig of S phase and mitosis induced by anticancer agents in cells lacking p21
60. Regulated chromosomal DNA replication in the absence of a nucleus
61. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
62. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
63. The retinoblastoma protein and cell cycle control
64. Ap16INK4a-insensitive Cdk4 mutant targeted by cytilytic lymphocytes in a human melanoma
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66. The cell cycle and development: Redundant roles of cell cycle regulators
67. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome
68. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development
69. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
70. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
71. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
72. Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases
73. INK4d-deficient mice are fertile despite testicular atrophy
74. Germline mutations in the p16INK4a binding domain of Cdk4 in familial melanoma
75. Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1