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Volumn 313, Issue 4, 2001, Pages 711-731

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein

Author keywords

Box I; Growth arrest; Mdm2; p53; Transcriptional transactivation

Indexed keywords

PROTEIN MDM2; PROTEIN P53; TRANSCRIPTION FACTOR;

EID: 0035798376     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5082     Document Type: Article
Times cited : (34)

References (101)
  • 3
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 4
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus 5 EIA and accompanies apoptosis
    • (1993) Genes Dev. , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 12
  • 14
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 28
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • (1994) Genes Dev. , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 31
    • 0033602179 scopus 로고    scopus 로고
    • Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells
    • (1999) Oncogene , vol.18 , pp. 1521-1527
    • Abraham, J.1    Spaner, D.2    Benchimol, S.3
  • 43
    • 0033118933 scopus 로고    scopus 로고
    • DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
    • (1999) EMBO J. , vol.18 , pp. 1815-1823
    • Shieh, S.Y.1    Taya, Y.2    Prives, C.3
  • 47
    • 0033572746 scopus 로고    scopus 로고
    • Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2
    • (1999) EMBO J. , vol.18 , pp. 7002-7010
    • Dumaz, N.1    Meek, D.W.2
  • 58
    • 0033521621 scopus 로고    scopus 로고
    • Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
    • (1999) EMBO J. , vol.18 , pp. 22-27
    • Honda, R.1    Yasuda, H.2
  • 76
    • 0032516219 scopus 로고    scopus 로고
    • Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay
    • (1998) Oncogene , vol.16 , pp. 2527-2539
    • Di Como, C.J.1    Prives, C.2
  • 78
    • 0027994037 scopus 로고
    • Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation
    • (1994) EMBO J. , vol.13 , pp. 3496-3504
    • Ory, K.1    Legros, Y.2    Auguin, C.3    Soussi, T.4
  • 87
    • 0032516802 scopus 로고    scopus 로고
    • P22 tailspike folding mutants revisited: Effects on the thermodynamic stability of the isolated beta-helix domain
    • (1998) J. Mol. Biol. , vol.281 , pp. 227-234
    • Schuler, B.1    Seckler, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.