Glycohistochemistry: The why and how of detection and localization of endogenous lectins

Anatomia, Histologia, Embryologia

Volumn 30, Issue 1, 2001, Pages 3-31

  Gabius, H J ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GLYCOCONJUGATE; LECTIN; LIGAND;

APOPTOSIS; CARBOHYDRATE ANALYSIS; CELL DIVISION; CHEMISTRY; CLASSIFICATION; CYTOCHEMISTRY; PHYSIOLOGY; REVIEW; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; BIOLOGICAL MARKERS; CARBOHYDRATE SEQUENCE; CELL DIVISION; GLYCOCONJUGATES; HISTOCYTOCHEMISTRY; LECTINS; LIGANDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035725755     PISSN: 03402096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1439-0264.2001.00305.x     Document Type: Review

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94. 4 binding
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114. Chemical and biochemical strategies for the preparation of glycohistochemical probes and their application in lectinology
115. Special volume on glycosciences
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117. Pattern of endogenous lectins in a human epithelial tumor
118. Localization of endogenous lectins in normal human breast, benign breast lesions and mammary carcinomas
119. Characterization of membrane lectins in human colon carcinoma cells by flow cytofluorometry, drug targeting and affinity chromatography
120. Identification of a cell cycle-dependent gene product as sialic acid-binding protein
121. Binding of T-antigen-bearing neoglycoprotein and peanut agglutinin to cultured tumor cells and breast carcinomas
122. Endogenous lectins with specificity to β-galactosides and α- or β-N-acetylgalactosaminides in human breast cancer
123. Lectin localization in human nerve by biochemically defined lectin-binding glycoproteins, neoglycoprotein and lectin-specific antibody
124. Heparin-binding lectin of human placenta as a tool for histochemical ligand localization and ligand isolation
125. Reverse lectin histochemistry: Design and application of glycoligands for detection of cell and tissue lectins
126. Detection and quantification of carbohydrate-binding sites on cell surfaces and in tissue sections by neoglycoproteins
127. Beyond plant lectin histochemistry: Preparation and application of markers to visualize the cellular capacity for protein-carbohydrate recognition
128. Sugar receptors of the stromal cell layer in human long-term bone marrow cultures: Their presence, modulatory responses to changes in the microenvironment and potential role in cellular adhesion
129. Neoglycoenzymes: A versatile tool for lectin detection in solid-phase assays and glycohistochemistry
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131. Establishment, characterization and determination of cell surface sugar receptor (lectin) expression by neoglycoenzymes of a human myeloid marker-expressing B-lymphoblastoid cell line
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152. Factors mediating cell-cell recognition and adhesion. Galaptins, a recently discovered class of bridging molecules
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156. Lectins and traffic in the secretory pathway
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164. A general comparison of two major families of animal lectins
165. Glycomics, coming of age!
166. Galectins from the nematode Caenorhabditis elegans and the genome project
167. The involvement of the oligosaccharide chains of glycoproteins in gamete interactions at fertilization
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169. Conformation and dynamics of oligosaccharides in solution
170. 3D structure. 2. Three-dimensional structures of oligosaccharides explored by NMR and computer calculations
171. The biology of sulfated oligosaccharides
172. Methods of glycoconjugate analysis
173. O-Linked protein glycosylation structure and function
174. Oligosaccharide structures: Theory versus experiment
175. Oligosaccharide conformation in protein-carbohydrate complexes
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180. Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge or the combination of these features?
181. On the nature of molecular conformations inferred from high-resolution NMR
182. Free and protein-bound carbohydrate structures
183. Animal lectins as cell adhesion molecules
184. Quantitation and histochemical localization of galectin-1 and galectin-1-reactive glycoconjugates in fetal development of bovine organs
185. Lectins and neoglycoproteins in histopathology
186. Conserved domains of glycosyltransferases
187. Synthetic neoglycoproteins
188. Graph theory and the entropy concept in histochemistry. Theoretical considerations, application in histopathology and the combination with receptor-specific approaches
189. The application of thermodynamic principles to histochemical and morphometric tissue research: Principles and practical outline with focus on glycosciences
190. Is the profile of binding of a panel of neoglycoproteins useful as diagnostic marker in human lung cancer?
191. Cell type-dependent alterations of binding of synthetic blood group antigen-related oligosaccharides in lung cancer
192. Correlation of expression of binding sites for synthetic blood group A-, B-, and H-trisaccharides and for sarcolectin with survival of patients with bronchial carcinoma
193. Preneoplasia-associated expression of calcyclin and of binding sites for synthetic blood group A/H-trisaccharide-exposing neoglycoconjugates in human lung
194. Pulmonary metastases of breast carcinoma: Ligandohistochemical, nuclear and structural analysis of primary and metastatic tumors with emphasis on period of occurrence of metastases and survival
195. Glyco- and immunohistochemical refinement of the differential diagnosis between mesothelioma and metastatic carcinoma and survival analysis of patients
196. Carbohydrate-deficient glycoprotein syndromes: Inborn errors of protein glycosylation
197. Lectins, versatile proteins of recognition: A review
198. Role of galectin-1 in the olfactory nervous system
199. Peptide mimotopes of carbohydrate antigens
200. Functions of plant lectins
201. Lectins as blood typing reagents
202. Modular organization of carbohydrate recognition domains in animal lectins
203. Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands
204. Immobilized lectin columns: Useful tools for the fractionation and structural analysis of oligosaccharides
205. Historical background
206. Heparin-binding lectin from human placenta: Purification, partial molecular characterization and its relationship to basic fibroblast growth factors
207. Heparin-binding lectin from human placenta: Further characterization of ligand binding and structural properties and its relationship to histones and heparin-binding growth factors
208. GalNAc/Gal-specific rat liver lectins: Their role in cellular recognition
209. Increased expression of S100A6 (calcyclin), a calcium-binding protein of the S100 family, in human colorectal adenocarcinoma
210. Glycolipids: Structure and function
211. Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture
212. Attachment of thioglycosides to proteins: Enhancement of liver membrane binding
213. Proteoglycans: Structure and functions
214. Detection of binding sites for biotinylated neoglycoproteins and heparin (endogenous lectins) during cerebellar ontogenesis in the rat
215. Detection of binding sites for biotinylated neoglycoproteins and heparin (endogenous lectins) during cerebellar ontogenesis in the rat: An ultrastructural study
216. Analysis of growth of lectin literature: 1983-86
217. The information-storing potential of the sugar code
218. Synthetic ligands for lectins
219. Enhanced biochemical affinities of multivalent neoglycoconjugates
220. Neoglycoconjugates
221. Ligand-binding characteristics of the major mistletoe lectin
222. Neoglycoproteins as probes for binding and cellular uptake of glycoconjugates
223. 2-Imino-2-methoxyethyl 1-thioglycosides: New reagents for attaching sugars to proteins
224. Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin
225. Specificity of binding of soluble rat lung lectins to substituted and unsubstituted mammalian β-galactosides
226. The origin of the specificity in the recognition of oligosaccharides by proteins
227. How water provides the impetus for molecular recognition in aqueous solution
228. x types in addition to the sulfated N-glycans of lutropin
229. Protein-ligand interactions: Exchange processes and determination of ligand conformation and protein-ligand contacts
230. Preface
231. The mechanism of fertilization
232. Affinity chromatography for the purification of lectins
233. Lectins: Carbohydrate-specific proteins that mediate cellular recognition
234. Role of galectin-3 in inflammation
235. Crystal structure of the cysteine-rich domain of mannose receptor complexed with a sulfated carbohydrate ligand
236. Legume lectin structure
237. Purification of cell membrane glycoproteins by lectin affinity chromatography
238. Bio-specific sequences and domains in heparan sulphate and the regulation of cell growth and adhesion
239. Synthesis of neoglycoconjugates
240. Rat olfactory neurons can utilize the endogenous lectin, L-14, in a novel adhesion mechanism
241. Neoganglioproteins: Probes for endogenous ganglioside receptors
242. Classics in total synthesis of oligosaccharides and glycoconjugates
243. Polyvalente wechselwirkungen in biologischen systemen: Auswirkungen auf das design und die verwendung multivalenter liganden und inhibitoren
244. Lectin-glycoconjugate cross-linking interactions
245. Glycocoding as an information management system in embryonic development
246. Cell surface oligosaccharide modulation during differentiation. III. Lectin affinity class distributions
247. P-Type lectins and lysosomal enzyme trafficking
248. Glycoproteins
249. The mannose receptor and its role in antigen presentation
250. Cell-specific glycoforms of sialoadhesin and CD45 are counterreceptors for the cysteine-rich domain of the mannose receptor
251. Characterization of membrane homing receptors in two cloned murine hemopoietic progenitor cell lines
252. Requirement of divalent galactoside-binding activity of ecalectin/galectin-9 for eosinophil chemoattraction
253. Über die ablagerung des galaktogens im warmblüterorganismus
254. Carbohydrate antigens: Coupling of carbohydrates to proteins by diazonium and phenylisothiocyanate reactions
255. Contemporary laboratory applications of lectins
256. Inherited disorders of glycoprotein synthesis: Cell biological insights
257. Hepatic clearance of serum glycoproteins
258. Molecules involved in mammalian sperm-egg interaction
259. Targeting of drugs to the liver
260. Lectin affinity chromatography of glycopeptides
261. Transmembrane signaling: The joy of aggregation
262. Normal and pathologic catabolism of glycoproteins. Catabolic pathways
263. Quantitation of binding, uptake, and degradation of fluoresceinylated neoglycoproteins by flow cytometry
264. Researches upon the venom of the rattlesnake
265. Researches upon the venoms of poisonous serpents
266. CAP-50, a newly identified annexin, localizes in nuclei of cultured fibroblast 3Y1 cells
267. Uptake of neoglycoproteins via membrane lectin (s) of L1210 cells evidenced by quantitative flow cytofluorometry and drug targeting
268. Endogenous lectins of myeloid and tumor cells: Characterization and biological implications
269. The history of glycoprotein research, a personal view
270. Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo
271. Annexins
272. Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting
273. Crystal structures of human pancreatic α-amylase in complex with carbohydrate and proteinaceous inhibitors
274. Recent developments in transferred NOE methods
275. Lectin-carbohydrate interaction in the immune system
276. The CH/π interaction: Significance in molecular recognition
277. Galectins in tumor cells
278. Carcinoembryonic antigen and other glycoconjugates act as ligands for galectin-3 in human colon carcinoma cells
279. 2+-dependent insulin release from the pancreatic β cell
280. Carbohydrate moieties of glycoproteins. A re-evaluation of their function
281. Divergent evolution of fucosyltransferase genes from vertebrates, invertebrates and bacteria
282. Fractionation and structural assessment of oligosaccharides and glycopeptides by use of immobilized lectins
283. Biocatalytic synthesis of oligosaccharides
284. Comparing the glycosylation patterns of recombinant glycoproteins
285. Glycoproteins: What are the sugar chains for?
286. Topology of glycosylation - A histochemist's view
287. Affinity chromatography of macromolecular substances on adsorbents bearing carbohydrate ligands
288. How is an NMR structure best defined? An analysis of molecular dynamics distance-based approaches
289. Galectins: Versatile modulators of cell adhesion, cell proliferation and cell death
290. Specificities of heparan sulphate proteoglycans in developmental processes
291. Transfer NOE experiments for the study of carbohydrate-protein interactions
292. Plant lectins: Specific tools for the identification, isolation and characterization of O-linked glycans
293. Higher plants developed structurally different motifs to recognize foreign glycans
294. Comparison of the carbohydrate-binding specificities of seven N-acetylgalactosamine-recognizing lectins
295. Glycobiology of the olfactory system
296. Endogenous lectins (galectins-1 and -3) as probes to detect differentiation-dependent alterations in human squamous cell carcinomas of oropharynx and larynx
297. x tetrasaccharide, free in solution and bound to E-, P-, and L-selectin
298. Biotinylated hyaluronic acid: A new tool for probing hyaluronate-receptor interaction
299. NMR studies of carbohydrate-protein interaction in solution
300. I-type lectins
301. Role of galectin-1 in the developing mouse olfactory system
302. Involvement of sugars in protein-protein interactions
303. Protein-carbohydrate interactions: Basic molecular features
304. Galectins: An evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy
305. Glycobiology
306. Analysis of differentiation and transformation of cells by lectins
307. Cell surface carbohydrates and cell adhesion
308. Preferred conformation of C-lactose at the free and peanut lectin bound states
309. Annexins: The problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins
310. Monoclonal antibodies to endogenous galactose-specific tumor cell lectins
311. Coupling of carbohydrates to proteins by diazonium and phenylisothiocyanate reactions
312. Carbohydrate histochemistry of epithelial glycoproteins
313. Histochemical localization of a β-galactoside-binding lectin and its binding sites in developing and adult rat cochlea
314. Studies on the nature of hemagglutinins present in seeds of some representatives of the family of leguminosae
315. Eukaryotic glycosylation - Whim of nature or multipurpose tool?
316. Glycoconjugate-mediated drug targeting
317. Lectin structure
318. New animal lectin structures
319. Studies on the molecular recognition of synthetic methyl β-lactoside analogs by ricin, a cytotoxic plant lectin
320. Endogenous lectins from cultured cells. Isolation and characterization of carbohydrate-binding proteins from 3T3 fibroblasts
321. Identification of carbohydrate-binding proteins from mouse and human fibroblasts
322. The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion
323. Carbohydrate sulfotransferases
324. Protein glycosylation in the endoplasmic reticulum and the Golgi apparatus and cell-type specificity of cell surface glycoconjugate expression: Analysis by protein A-gold and lectin-gold techniques
325. A molecular model for cell interactions
326. Blue-prints, synthesis and applications of glycopolymers
327. Synthesis and some applications of chemically defined multivalent glycoconjugates
328. Sialoside mimetics and conjugates as anti-inflammatory agents and inhibitors of flu virus infections
329. Isolation of plant lectins
330. Structure and function of plant lectins
331. Plant lectins - More than just tools for glycoscientists: Occurrence, structure and possible functions of plant lectins
332. Medicinal chemistry based on the sugar code: Fundamentals of lectinology and experimental strategies with lectins as targets
333. Lectin-digoxigenin conjugates: A new hapten system for glycoconjugate histochemistry
334. Reactivity of five N-acetylgalactosamine-recognizing lectins with preimplantation embryos, early postimplantation embryos, and teratocarcinoma cells of the mouse
335. Quantitative glycohistochemistry defines new prognostic markers in cancers of the oral cavity
336. Molecular basis of glycoconjugate disease
337. Strategies for chemical synthesis of carbohydrate structures
338. Cytochemistry of cell glycoconjugates
339. Galectin fingerprinting in tumor diagnosis. Differential expression of galectin-3 and galectin-3-binding sites, but not of galectin-1, in benign versus malignant uterine smooth muscle tumors
340. Enzyme action in glycoprotein synthesis
341. Kohlenhydratmimetika: Ein neuer Lösungsansatz für das Problem der kohlenhydratvermittelten biologischen Erkennung
342. Proteoglycans and pattern formation: Sugar biochemistry meets developmental genetics
343. The role of carbohydrate residues in mammalian fertilization
344. The galactosyltransferases
345. Glycoproteins
346. Glycoproteins now and then: A personal account
347. Lectins: From obscurity into the limelight
348. Glycoproteins: Structure and function
349. NMR-based, molecular dynamics- and random walk molecular mechanics-supported study of conformational aspects of a carbohydrate ligand (Galβ1-2Galβ1-R) for an animal galectin in the free and in the bound state
350. Carbohydrate-protein interaction
351. Involvement of laser photo CIDNP (chemically induced dynamic nuclear polarization)-reactive amino acid side-chains in ligand binding by galactoside-specific lectins in solution
352. A new combined computational and NMR-spectroscopical strategy for the identification of additional conformational constraints of the bound ligand in an aprotic solvent
353. Selectin-carbohydrate interactions: From natural ligands to designed mimics
354. Surface sugar-binding components of bovine spermatozoa as evidenced by fluorescent neoglycoproteins
355. Cytochemical analysis of mammalian sperm membranes
356. Glycobiology of fertilization
357. Protein-carbohydrate interactions during fertilization
358. The missing link in lysosomal enzyme targeting
359. The generation of carbohydrate-based combinatorial libraries for drug discovery
360. Analysis of protein-carbohydrate interaction by engineered ligands
361. Hydrogen-bonding pattern of methyl β-lactoside binding to the Ricinus communis lectins
362. Probing hydrogen-bonding interactions of bovine heart galectin-1 and methyl β-lactoside by use of engineered ligands
363. Different architecture of the combining sites of two chicken galectins revealed by chemical-mapping studies with synthetic ligand derivatives
364. Multiple soluble β-galactoside-binding lectins from human lung
365. Detection and differentiation of glycoconjugates in various cell types by lectin histochemistry
366. Diversity of cell glycoconjugates shown histochemically: A perspective
367. Glycopeptid- und Oligosaccharidbibliotheken
368. The mannose receptor is a pattern recognition molecule involved in host defense
369. The asialoglycoprotein receptor: Relationship between structure, function and expression
370. Endocytosis of asialoglycoprotein-enzyme conjugates by hepatocytes
371. Neoglycoproteins: The preparation and application of synthetic glycoproteins
372. Cytochemical detection of mannose-specific receptors for glycoproteins with horseradish peroxidase as a ligand
373. Mannose-specific binding sites for horseradish peroxidase in various cells of the rat
374. 2+-binding S100A6 protein in normal, preneoplastic and neoplastic colon mucosa
375. The identification of a hemagglutinin of the jack bean with concanavalin A
376. Hydrophobic surfaces in saccharide chains
377. Structures of sugar chains included in mammalian zona pellucida glycoproteins and their potential roles in sperm-egg interactions
378. Genome sequence of the nematode C. elegans: A platform for investigating biology
379. Applications of enzymes in synthetic carbohydrate chemistry
380. A membrane receptor for gangliosides is associated with central nervous system myelin
381. The gene encoding the calcium binding protein calcyclin is expressed at sites of exocytosis in the mouse
382. Dissection of the impact of various intracellular signaling pathways on rat thymocytes after initial lectin-dependent cell association using a plant lectin as model and target-selective inhibitors
383. Differential potency of two crosslinking plant lectins to induce formation of haptenic sugar-resistant aggregates of rat thymocytes by post-binding signaling
384. Structure and energetics of protein-carbohydrate complexes
385. Enzyme-catalyzed synthesis of carbohydrates
386. An auto-antibody concept of cell structure, growth and differentiation
387. Plant lectins: A composite of several distinct families of structurally and evolutionary related proteins with diverse biological roles
388. Physical and chemical studies on ceruloplasmin. IX. The role of galactosyl residues in the clearance of ceruloplasmin from the circulation
389. O-Linked glycosylation in focus
390. Drug targeting to the liver with lactosylated albumins: Does the glycoprotein target the drug or is the drug targeting the glycoprotein?
391. The 2.15 Å crystal structure of CG-16, the developmentally regulated homodimeric chicken galectin
392. Biological roles of oligosaccharides: All of the theories are correct
393. 'Unusual' modiffications and variations of vertebrate oligosaccharides: Are we missing the flowers for the trees?
394. C-type lectins and galectins mediate innate and adaptive immune functions: Their roles in the complement activation pathway
395. Lectin receptors
396. Plant lectins in immunology, cytology and hematology: A bibliography and projects for development
397. Lectins
398. Signaling pathways for transduction of the initial message of the glycocode into cellular responses
399. Structural glycobiology: How to gain insight into the structure-function relationship
400. Novel forms of protein glycosylation
401. Glycosidase-catalysed oligosaccharide synthesis
402. A (critical) survey of modeling protocols used to explore the conformational space of oligosaccharides
403. Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins
404. Mannose-6-phosphat-rezeptoren: Ihre rolle beim transport lysosomaler proteine
405. Sialic acid analogues as potential antimicrobial agents
406. The use of lectins in histopathology
407. The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes
408. Mammalian fertilization: Molecular aspects of gamete adhesion, exocytosis, and fusion
409. Blood group substances
410. A half century of blood-group antigen research: Some personal recollections
411. Neutralisation of the anti-H agglutinin in eel serum by simple sugars
412. Are matrix-immobilized neoglycoproteins, plant and human lectins and carbohydrate-binding antibodies from human serum mediators of adhesion in vitro for carcinoma and lymphosarcoma cells?
413. Mechanisms and control of glycoconjugate turnover
414. Structural basis of lectin-carbohydrate recognition
415. The problem of specificity in growth and development
416. Lectin affinity chromatography
417. Expression of calcyclin in human melanoma cell lines correlates with metastatic behavior in nude mice
418. The crystal structure of porcine pancreatic α-amylase in complex with the microbial inhibitor tendamistat
419. The significance of glycosylated proteins
420. Sertoli cell expression of galectin-1 and -3 and accessible binding sites in normal testis and sertoli cell onlysyndrome
421. Computational carbohydrate chemistry: What theoretical methods can tell us
422. A table of lectin carbohydrate specificities
423. Intracellular lectins associated with N-linked glycoprotein traffic
424. Endogenous lectins as targets for drug delivery
425. Diverse functions and structures on heparan sulfate proteoglycan
426. Biotinylated hyaluronic acid as a probe identifying hyaluronic acid-binding proteins
427. Functions and properties of animal lectins
428. On the possible role of endogenous lectins in early animal development
429. Lectins and carbohydrates in animal cell adhesion and control of cell proliferation
430. Structure and functions of lectins in the central and peripheral nervous system
431. Lectins and their uses as biotechnological tools
432. Carbohydrate-binding specifficity of calcyclin and its expression in human tissues and leukemic cells
433. Identification of annexin II, annexin VI and glyceraldehyde-3-phosphate dehydrogenase as calcyclin-binding proteins in bovine heart