Molecules involved in mammalian sperm-egg interaction

International Review of Cytology

Volumn 177, Issue , 1997, Pages 57-113

  McLeskey, S B ^a   Dowds, C ^a   Carballada, R ^b   White, R R ^b   Saling, P M ^a  

^a DUKE UNIVERSITY   (United States)

^b AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Acrosome reaction; Cell adhesion; Egg; Exocytosis; Fertilization; Gamete; Mammals; Membrane fusion; Spermatozoa; Zona pellucida

Indexed keywords

ADHESIN; GALACTOSYLTRANSFERASE; GLYCOPROTEIN; INTEGRIN; PHOSPHOTRANSFERASE;

ACROSOME REACTION; CELL INTERACTION; EXOCYTOSIS; EXTRACELLULAR MATRIX; FERTILIZATION; GAMETE; HUMAN; MEMBRANE FUSION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; REVIEW; SPERM; SPERMATOZOON; ZONA PELLUCIDA;

MAMMALIA;

EID: 0030732361     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0074-7696(08)62231-7     Document Type: Article

References (288)

1. Aarons, D. J., Boettger-Tong, H. L., Holt, G., and Poirier, G. R. (1991). Acrosome reaction induced by immunoaggregation of a proteinase inhibitor bound to the murine sperm head. Mol. Reprod. Dcv. 30, 258-264.
2. Aitken, R. J., Ross, A., and Lees, M. M. (1983). Analysis of sperm function in Kartagener's syndrome. Fertil. Steril. 40, 696-698.
3. Alien, C. A., and Green, D. P. (1995). Monoclonal antibodies which recognize equatorial segment epitopcs presented de novo following the A23187-induccd acrosome reaction of guinea pig sperm. J. Cell Sci. 108, 767-777.
4. 1, show preferential binding to laminin or sperm. Mol. Biol. Cell 6, 8a.
5. 1 functions as a sperm receptor. Cell 81, 1095-1104.
6. Alvcs, M. S., Martins, M. S., and Pcna, S. D. (1995). Monoclonal antibody against a 52 K sperm surface protein inhibits sperm-zona pellucida interactions in the rat. J. Exp. Zool. 272, 123-133.
7. Arts, E. G. J. M., Kuiken, J., Jagcr, S., and Hoekstra, D. (1993). Fusion of artificial membranes with mammalian spermatozoa-Specific involvement of the equatorial segment after aerosome reaction. Eur. J. Biocheni. 217, 1001-1009.
8. Austin, C. R. (1951). Observations on the penetration of the sperm into the mammalian egg. A list. J. Sci. Res. Ser. B 4, 581.
9. Austin, C. R. (1961). "The Mammalian Egg." Thomas, Springfield, IL.
10. Austin, C. R., and Braden, A.W.H. (1956). Early reaction of the rodent egg to sperm penetration. J. Exp. Biol. 33, 358-365.
11. Baba, T., Kashiwabara, S., Watanabc, K., Itoh, H., Michikawa, Y., Kimura, K., Takada, M., Fukamizu, A..and Arai, Y. (1989a). Activation and maturation mechanisms of boar acrosin zymogen based on the deduced primary structure. J. Biol. Client. 26-1, 11920-11927.
12. Baba, T., Watanabc, K., Kashiwabara, S., and Arai, Y. (1989b). Primary structure of human proacrosin deduced from its cDNA sequence. FEBS Lett. 244, 296-300.
13. Baba, T., Azuma, S., Kashiwabara, S., and Toyoda, Y. (1994). Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization. J. Biol. Chem. 269, 31845-31849.
14. Bagavant, H., Yurewicz, E. C, Sacco, A. G., Talwar, G. P., and Gupta, S. K. (1993a). Delineation of cpitopes on porcine zona pellucida relevant for binding of sperm to oocyte using monoclonal antibodies. J. Reprocl. Immunol. 23, 265-279.
15. Bagavant, H., Yurewicz, E. C. Sacco, A. G., Talwar, G. P., and Gupta, S. K. (1993b). Block in porcine gamete interaction by polyclonal antibodies to a pig ZP3/3 fragment having partial sequence homology to human ZP3. J. Reprod. Iinimmol. 25, 277-283.
16. Bairoch, A. (1991). PROSITE: A dictionary of sites and patterns in proteins. Nucleic Acids Res. 19(Suppl.), 2241-2245.
17. Baldi, E., Krausz, C., Luconi, M., Bonaccorsi, L., Maggi, M., and Forti, G. (1995). Actions of progesterone on human sperm: A model of non-genomic effects of steroids. J. Steroid Biochem. Mol. Biol. 53, 199-203.
18. Barrait, C. L. R., and Hornby, D. P. (1995). Induction of the human acrosome reaction by rhuZP3. In "The Human Sperm Acrosome Reaction" (P. Fcnichel and J. Parinaud. eds.), pp. 105-122. John Libbey Eurotext, Montrouge, France.
19. Barros. C., and Yanagimachi, R. (1971). Induction of zona reaction in golden hamster eggs by cortical granule material. Nature 233, 268-269.
20. Barros, C, and Yanagimachi, R. (1972). Polyspermy-preventing mechanisms in the golden hamster egg. JExp. ZooJ. 180, 251-265.
21. Bedford, J. M. (1983). Significance of the need for sperm capacitation before fertilization in eulherian mammals. Biol. Reprod. 28, 108-120.
22. Bedford, J. M. (1994). The contraceptive potential of fertilization: A physiological perspective. Hum. Reprod. 9, 842-858.
23. Bedford, J. M.. Moore, H. D. M., and Franklin, L. E. (1979). Significance of the equatorial segment of the acrosome of the spermatozoon in eutherian mammals. Exp. Cell Res. 119, 119-126.
24. Bcebe, S. J., Lcyton, L., Burks, D., Ishikawa, M., Fuerst, T., Dean, J., and Saling, P. (1992). Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction. Dev. Biol. 151, 48-54.
25. Benoff, S. (1993). Preliminaries to fertilization. The role of cholesterol during capacitation of human spermatozoa. Hum. Reprod. 8, 2001-2006.
26. Berruti, G. (1991). Evidence for Ca2t-mediated F-actin/phospholipid binding of human sperm calpactin II. Cell Biol. Int. Rep. 15, 917-927.
27. Bleil, J. D., and Wassarman, P. M. (199O). Mammalian sperm-egg interaction: Identification of a glycoprotein in mouse egg zonae pellucidae possessing receptor activity for sperm. Cell 20, 873-882.
28. Bleil, J. D., and Wassarman, P. M. (1983). Sperm-egg interactions in the mouse: Sequence of events and induction of the acrosome reaction by a zona pellucida glycoprotein. Dev. Biol. 95,317-324.
29. Bleil, J. D., and Wassarman, P. M. (1986). Autoradiographic visualization of the mouse egg's sperm receptor bound to sperm. J. Cell Biol. 102, 1363-1371.
30. Bleil, J. D., and Wassarman, P. M. (1988). Galactose at the nonreducing terminus of Chunked oligosaccharides of mouse egg zona pellucida glycoprotein ZP3 is essential for the glycoprotein's sperm receptor activity. Proc. Natl. Acad. Sci. USA 85, 6778-6782.
31. Bleil, J. D., and Wassarman, P. M. (1990). Identification of a ZP3-binding protein on acrosomc-intact mouse sperm by photoaffinity crosslinking. Proc. Natl. Acad. Sci. USA 87,5563-5567.
32. Bleil, J. D., Greve, J. M., and Wassarman, P. M. (1988). Identification of a secondary sperm receptor in the mouse egg zona pellucida: Role in maintenance of binding of acrosome-reacted sperm to eggs. Dev. Biol. 128, 376-385.
33. Blobel, C. P., and White, J. M. (1992). Structure, function and evolutionary relationship of proteins containing a disintegrin domain. Curr. Opin. Cell Biol. 4, 760-765.
34. Blobel, C. P., Mylcs, D. G., Primakoff, P., and White, J. M. (1990). Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence. J. Cell Biol. III, 69-78.
35. Blobel, C. P., Wolfsberg, T. G., Turck, C. W., Myles, D. G., Primakoff, P., and White, J. M. (1992). A potential fusion pcptide and an integrin ligand domain in a protein active in sperm-egg fusion. Nature 356, 248-252.
36. Boldt, J., Howe, A. M., and Preble, J. (1988). Enzymatic alteration of the ability of mouse egg plasma membrane to interact with sperm. Biol. Reprod. 39, 19-27.
37. Boldt, J., Gunter, L. E., and Howe, A. M. (1989a). Characterization of cell surface polypeptides of unfertilized, fertilized, and protease-treated zona-free mouse eggs. Gamete Res. 23, 91-101.
38. Boldt, J., Howe, A. M., Parkerson, J. B., Gunter, L. E., and Kuehn, E. (1989b). Carbohydrate involvement in sperm-egg fusion in mice. Biol. Reprod. 40, 887-896.
39. Bookbinder, L. H., Cheng, A., and Bleil, J. D. (1995). Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein. Science 269, 86-89.
40. Bork, P., and Sander, C. (1992). A large domain common to sperm receptors (Zp2 and Zp3) and TGF-/3 type III receptor. FEBS Lett. 300, 237-240.
41. Bronson, R. A., and Fusi, F. (1990). Evidence that an Arg-GIy-Asp adhesion sequence plays a role in mammalian fertilization. Biol. Reprod. 43, 1019-1025.
42. Brooks, D. E. (1987). Developmental expression and androgenic regulation of the mRNA for major secretory proteins of the rat epididymis. Mol. Cell. Endocrinol. 53, 59-66.
43. Brooks, D. E., Means, A. R., Wright, E. J., Singh, S. P., and Tiver, K. K. (1986). Molecular cloning of the cDNA for androgen-dependent sperm-coating glycoproteins secreted by the rat epididymis. Eur. J. Biochem. 161, 13-18.
44. Brucker, C, Sandow, B. A., Blackmore, P. F., Lipford, G. B., and Hodgen, G. D. (1992). Monoclonal antibody AG7 inhibits fertilization post sperm-zona binding. Mol. Reprod. Dev. 33,451-462.
45. Burkman, L. J., Coddington, C. C., Franken, D. R., Krügen, T. F., Rosenwaks, Z., and Hodgen, G. D. (1988). The hemizona assay (HZA): Development of a diagnostic test for the binding of human spermatozoa to the human hemizona pellucida to predict fertilization potential. Fertil. Steril. 49, 688-697.
46. Burks, D. J., Carballada, M. R., Moore, H. D. M., and Saling, P, M. (1995). Interaction of a tyrosine kinase from human sperm with the zona pellucida at fertilization. Science 269,83-86.
47. Burridge, K., and Chrzanowska-Wodnicka, M. (1996). Focal adhesions, contractility and signaling. Anna. Rev. Cell Dev. Biol. 12, 463-518.
48. Calvete, J. J., Sanz, L., Dostàlovà, Z., and Töpfer-Petersen, E. (1993a). Characterization of AWN-1 glycosylated isoforms helps define the zona pellucida and serine proteinase inhibitor-binding region on boar spermadhesins. FEBS Lett. 334, 37-40.
49. Calvete, J. J., Soli's, D., Sanz, L., Díaz-Maurino, T., Schäfer, W., Mann, K., and Töpfer-Petersen, E. (1993b). Characterization of two glycosylated boar spermadhesins. Eur. J. Biochem. 218, 719-725.
50. Calvete, J. J., Solis, D., Sanz, L., Diaz-Maurino, T., and Topfer-Petersen, E. (1994). Glycosylated boar spermadhesin AWN-1 isoforms. Biological origin, structural characterization by lectin mapping, localization of O-glycosylation sites, and effect of glycosylation on ligand binding. Biol. Cliein. Hoppe-Seyler 375, 667-673.
51. Camaioni, A., Salustri, A., Yanagishita, M., and Hascall, V. C. (1996). Proteoglycans and proteins in the extracellular matrix of mouse cumulus cell-oocytc complexes. A rch. Biochem. Biophys. 325, 190-198.
52. Cardullo, R. A., and Wolf, D. E. (1995). Distribution and dynamics of mouse sperm surface galactosyltransferase: Implications for mammalian fertilization. Biochemistry 3-1, 10027-10035.
53. Chamberlin, M. E., and Dean, J. (1990). Human homolog of the mouse sperm receptor. Proc. Natl. Acatl. Sci. USA 87, 6014-6018.
54. Chang, M. C. (1951). Fertilizing capacity of spermatozoa deposited into fallopian tubes. Nature 168, 697-698.
55. Chang, Y. S., Wang, S. C, Tsao, C. C, and Huang, F. L. (1996). Molecular cloning, structural analysis, and expression of carp Zp3 gene. Mol. Reprod. Dev. 44, 295-304.
56. Cheng, A., Le, T., Palacios, M., Bookbinder, L. H., Wassarman, P. M., Suzuki, F., and Bleil, J. D. (1994). Sperm-egg recognition in the mouse: Characterization of sp56, a sperm protein having specific affinity for ZP3. J. Cell Biol. 125, 867-878.
57. Cho, C. H., Primakoff, P., White, J. M., and Myles, D. G. (1996). Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. Genomics 34, 413-417.
58. Cohen, D. J., Munuce, M. J., and Cuasnicu, P. S. (1996). Mammalian sperm-egg fusion-The development of rat oolemma fusibility during oogenesis involves the appearance of binding sites for sperm protein DE. Biol. Reprod. 55, 200-206.
59. Cornwall, G. A., Tulsiani, D. R., and Orgebin-Crist, M. C. (1991). Inhibition of the mouse sperm surface alpha-D-mannosidase inhibits sperm-egg binding in vitro. Biol. Reprod. 44, 913-921.
60. Cuasnicú, P. S., Echeverria, F. G., Piazza, A., Pineiro, L., and Blaquier, J. A. (1984a). Epididy-mal proteins mimic the androgenic effect on zona pellucida recognition by immature hamster spermatozoa.J. Reprod. Fertit. 71,427-431.
61. Cuasnicú, P. S., Gonzalez Echeverria, F., Piazza, A. D., Cameo, M. S., and Blaquier, J. A. (1984b). Antibodies against epididymal glycoproteins block fertilizing ability in rat. J. Reprod. Fenil. 72,467-471.
62. Cuasnicú, P. S., Conesa, D., and Rochwerger, L. (1990). Potential contraceptive use of an epididymal protein that participates in fertilization. In "Gamete Interaction: Prospects for Immunocontraception" (N. J. Alexander, D. Griffin, J. M. Speiler, and G. M. H. Waites, eds.), pp. 143-153. Wiley-Liss, New York.
63. Cuasnicú, P. S., Cohen, D. J., Ellerman, D. A., and Rochwerger, L. (1996). Relationship between the association of an epididymal protein to the sperm surface and its behavior and function. Biol. Reprod. 54, 140.
64. De, A., Brown, D. G., Gorman, M. A., Carr, M., Sanderson, M. R., and Freemont, P. S. (1994). Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors. Proc. Natl. Acad. Sci. USA 91, 1084-1088.
65. Díaz-Pérez, E., and Meizel, S. (1992). Importance of mammalian sperm metalloendoprotcase activity during the acrosomc reaction to subsequent sperm-egg fusion: Inhibitor studies with human sperm and zona-free hamster eggs. Mol. Reprod. Dev. 31, 122-130.
66. Dostálová, Z., Calvete, J. J., Sanz, L., and Töpfer-Petersen, E. (1995). Boar spermadhesin AWN-1. Oligosaccharidc and zona pcllucida binding characteristics. Eur. J. Biochem. 230, 329-336.
67. Drickamer, K., and Taylor, M. E. (1993). Biology of animal lectins. Annii. Rev. Cell Biol. 9, 237-264.
68. Dunbar, B. S., and Wolgemuth, D. J. (1984). Structure and function of the mammalian zona pcllucida, a unique extracellular matrix. Mod. Cell Biol. 3, 77-111.
69. Dyson, A. L., and Orgcbin-Crist, M. C. (1973). Effect of hypophysectomy, castration and androgen replacement upon the fertilizing ability of rat epididymal spermatozoa. Endocrinology 93, 391-402.
70. Eberspaechcr, U., Roosterman, D., Kratzschmar, J., Haendler, B., Habenicht, U. F., Becker, A., Qucnsel, C, Pétri, T., Schleuning, W. D., and Donner, P. (1995). Mouse androgen-dependent epididymal glycoprotein CRISP-I (DE/AEG): Isolation, biochemical characterization, and expression in recombinant form. Mol. Reprod. Dev. 42, 157-172.
71. Eddy, E. M., and O'Bricn, D. A. (1994). The spermatozoon. In "The Physiology of Reproduction" (E. Knobil and J. D. Neill, eds.), 2nd Ed., pp. 29-77. Raven Press, New York.
72. Epifano, O., and Dean, J. (1994). Biology and structure of the zona pcllucida: A target for immunocontraccption. Reprod. Fertil. Dev. 6, 319-330.
73. Epifano, O., Liang, L. F., and Dean, J. (1995a). Mouse Zpl encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish. J. Biol. Clicm. 270, 27254-27258.
74. Epifano, O., Liang. L. F., Familari, M., Moos, M. C, Jr., and Dean, J. (1995b). Coordinate expression of the three zona pellucida genes during mouse oogenesis. Development 121, 1947-1956.
75. Eppig, J. J., Obrien, M., and Wigglesworth, K. (1996). Mammalian oocyte growth, and development in vitro. Mol. Reprod. Dev. 44, 260-273.
76. Evans, J. P., Schultz, R. M., and Kopf, G. S. (1995a). Mouse sperm-egg plasma membrane interactions: Analysis of roles of egg integrins and the mouse sperm homologue of PH-30 (fertilin) beta. J. Cell Sci. 108, 3267-3278.
77. Evans, S. C., Youakim, A., and Shur, B. D. (1995b). Biological consequences of targeting beta 1,4-galactosyltransferase to two different subcellular compartments. BioEssays 17, 261-268.
78. Faye, J. C, Duguet, L., Mazzuca, M., and Bayard, F. (1980). Purification, radioimmunoassay, and immunohistochemical localization of a glycoprotein produced by the rat epididymis. Biol. Reprod. 23, 423-432.
79. Florman, H. M., and Babcock, D. F. (1991). Progress toward understanding the molecular basis of capacitation. In "Elements of Mammalian Fertilization" (P. M. Wassarman, ed.), Vol. 1, pp. 105-132. CRC Press, Boca Raton, FL.
80. Florman, H. M., and First, N. L. (1988). The regulation of acrosomal cxocytosis. I. Sperm capacitation is required for the induction of acrosome reactions by the bovine zona pellucida in vitro. Dev. Bio!. 128, 453-463.
81. Florman, H. M., and Wassarman, P. M. (1985). O-linkcd oligosaccharides of mouse egg ZP3 account for its sperm receptor activity. Cell 41, 313-324.
82. Florman, H. M., Bechtol, K. B., and Wassarman, P. M. (1984). Enzymatic dissection of the functions of the mouse egg's receptor for sperm. Dev. Biol. 106, 243-255.
83. Foster, J. A., and Gerton, G. L. (1996). Autoantigen l of the guinea pig sperm acrosome is the homologue of mouse Tpx-1 and human Tpxl and is a member of the cysteine-rich secretory protein (CRISP) family. Mol. Reprod. Dev. 44, 221-229.
84. Fraser, L. R. (1995). Cellular biology of capacitation and the acrosome reaction. Hum. Reprod. 10, 22-30.
85. Fusi, F. M.. Vignali, M., Busacca, M., and Bronson, R. A. (1992). Evidence for the presence of an inlegrin cell adhesion receptor on the oolemma of unfertilized human oocytes. Mol. Rcprod. Dev. 31, 215-222.
86. Fusi, F. M., Vignali, M., Gailit, J., and Bronson, R. A. (1993). Mammalian oocytes exhibit specific recognition of the ROD (Arg-Gly-Asp) tripeptide and express oolemmal integrins. A/oJ. Rcprod. Dev. 36, 212-219.
87. Gajhede, M., Petersen. T. N., Hcnriksen, A., Peterscn, J. F. W., Dautcr, Z., Wilson, K. S., and Thim, L. (1993). Pancreatic spasmolytic polypcptidc: First three-dimensional structure of a member of the mammalian trefoil family of proteins. Structure 1, 253-262.
88. Garbcri, J. C., Kohanc, A. C, Cameo, M. S.. and Blaquicr, J. A. (1979). Isolation and characterization of specific rat epididymal proteins. Mol. Cell. Emlocrinol. 13, 73-82.
89. Gong. X. H.. Dubois. D. H.. Miller, D. J.. and Shur, B. D. (1995). Activation of a G protein complex by aggregation of /3-1,4-galactosyltransferase on the surface of sperm. Science 269, 1718-1721.
90. Graham, D. K., Dawson, T. L., Mullaney, D. L., Snodgrass, H. R., and Earp, H. S. (1994). Cloning and mRNA expression analysis of a novel human prolooncogene, c-mer. Cell Growth Differ. 5, 647-657.
91. Greve, J. M., and Wassarman, P. M. (1985). Mouse egg extracellular coat is a matrix of interconnected filaments possessing a structural repeat. J. Mol. Dial. 181, 253-264.
92. Grootenhuis, A. J.. Philipsen, H. L. A., de Brccl-Grijsbach. J. T. M., and Van Duin, M. (1996). Immunocytochcmical localization of ZP3 in primordial follicles of rabbit, marmoset, rhesus monkey and human ovaries using antibodies against human ZP3. J. Rcprod. Ferrit. Suppl. 50, 43-54.
93. Gupta, S. K.. Alvcs, K., Palladino, L. O., Mark, G. E., and Mollis, G. F. (1996a). Molecular cloning of the human fertilin β subunit. Biocliem. Biophys. Res. Commun. 224, 318-326.
94. Gupta, S. K., Chadha, K., Harris, J. D., Yurewicz, E. C., Sacco, A. G., Kolluri, S. K., and Afzalpurkar, A. ( 1996b). Mapping of epitopes on porcine zona pelIucida-3-alpha by monoclonal antibodies inhibiting oocyte-sperm interaction. Biol. Rcprod. 55, 410-415.
95. Haendlcr, B., Kratzschmar. J., Theuring, F., and Schleuning, W.-D. (1993). Transcripts for cysteine-rich secretory protein-1 (CRISP-1; DE/AEG) and the novel related CRISP-3 are expressed under androgen control in the mouse salivary gland. Endocrinology 133,192-198.
96. Hardy, D. M., and Garbers, D. L. (1995). A sperm membrane protein that binds in a speciesspecific manner to the egg extracellular matrix is homologous to von Willcbrand factor. J. Biol. Chem. 270, 26025-26028.
97. Harris. J. D., Hibler, D. W., Fontenot, G. K., Hsu, K. T., Yurewicz, E. C, and Sacco, A. G. (1994). Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: The ZPA, ZPB and ZPC gene families. DNA Seq. 4, 361-393.
98. Hatanaka, Y., Nagai, T., Tobita, T., and Nakano, M. (1992). Changes in the properties and composition of zona pellucida of pigs during fertilization in vitro. J. Reprod. Fertil. 95,431-440.
99. Hayashi, M., Fujimoto. S., Takano, H., Ushiki, T., Abc, K., Ishikura, H., Yoshida, M. C, Kirchhoff, C., Ishibashi.T., and Kasahara, M. (1996). Characterization of a human glycoprotein with a potential role in sperm-egg fusion-cDNA cloning, immunohistochcmical localization, and chromosomal assignment of the gene (AEGL1). Genomics 32, 367-374.
100. Hedrick, J. L., Wardrip, N. J., and Berger, T. (1987). Differences in the macromolecular composition of the zona pellucida isolated from pig oocytes, eggs, and zygotes. J. Exp. Zool. 241, 257-262.
101. Heinlein, U. A. O., Wallat, S., Senftlebcn, A., and Lemaire, L. (1994). Male germ cell-expressed mouse gene TAZ83 encodes a putative, cysteine-rich transmembrane protein (cyritestin) sharing homologics with snake toxins and sperm-egg fusion proteins. Dev. Growth Differ. 36, 49-58.
102. Messing, M. (1991). The interaction between complement component C4b-binding protein and the vitamin K-dependent protein S forms a link between blood coagulation and the complement system. Biochem. J. 277, 581-592.
103. Hirao, Y., and Yanagimachi, R. (1978). Temperature dependence of sperm-egg fusion and post-fusion events in hamster fertilization. J. Exp. ZooJ. 205, 433-437.
104. Huffman, W., and Hauser, F. (1996). The P-domain or trefoil motif: A role in renewal and pathology of mucous epithelia. Trends Biochem. Sci. 18, 239-243.
105. Hogervorst, F., Kuikman, L, von dem Borne, A. E., and Sonnenberg, A. (1990). Cloning and sequence analysis of -4 cDNA: An integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J. 9, 765-770.
106. Horan, A. H., and Bedford, J. M. (1972). Development of the fertilizing ability of spermatozoa in the epididymis of the Syrian hamster. J. Reprod. Fertil. 30, 417-423.
107. Horvath, P. M., Kellom, T., Caulfield, J., and Boldt, J. (1993). Mechanistic studies of the plasma membrane block to polyspermy in mouse eggs. Mol. Reprod. Dev. 34, 65-72.
108. Hunnicutt, G. R., Primakoff, P., and Myles, D. G. (1996). Sperm surface protein PH-20 is bifunctional-One activity is a hyaluronidase and a second, distinct activity is required in secondary sperm-zona binding. Biol. Reprod. 55, 80-86.
109. Hynes, R. O. (1991). The complexity of platelet adhesion to extracellular matrices. Thromb. Haemostasis 66, 40-43.
110. Hynes, R. O. (1992). Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
111. Jansen, S., Quigley, M., Reik, W., and Jones, R. (1995). Analysis of polysulfate-binding domains in porcine proacrosin, a putative zona adhesion protein from mammalian spermatozoa. Int. J. Dev. Biol. 39, 501-510.
112. Johnson, M. H., Eager, D., Muggleton-Harris, A., and Grave, H. M. (1975). Mosaicism in organisation concanavalin A receptors on surface membrane of mouse egg. Nature 257, 321-322.
113. Jones, R. (1990). Identification and functions of mammalian sperm-egg recognition molecules during fertilization. J. Reprod. Fertil. Suppl. 42, 89-105.
114. Jones, R., and Brown, C. R. (1987). Identification of a zona-binding protein from boar spermatozoa as proacrosin. Exp. Cell Res. 171, 503-508.
115. Kadam, A. L., Fateh, M., and Naz, R. K. (1995). Fertilization antigen (FA-1) completely blocks human sperm binding to human zona pellucida: FA-1 antigen may be a sperm receptor for zona pellucida in humans. J. Reprod. Immimol. 29, 19-30.
116. Kalab, P., Visconti, P., Leclerc, P., and Kopf, G. S. (1994). p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties. J. Biol. Chem. 269, 3810-3817.
117. Kasahara, M., Gutknecht, J., Brew, K., Spurr, N., and Goodfellow, P. N. (1989). Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene. Genomics 5, 527-534.
118. Kaul, R., Afzalpurkar, A., and Gupta, S. K. (1996). Strategies for designing an immunocontraceptive vaccine based on zona pellucida synthetic peptides and recombinant antigen. J. Reprod. Fertil. Suppl. 50, 127-134.
119. Kellom, T., Vick, A., and Boldt, J. (1992). Recovery of penetration ability in protease-treated zona-free mouse eggs occurs coincident with recovery of a cell surface 94 kD protein. Mol. Reprod. Dev. 33, 46-52.
120. Kinloch, R. A., Ruiz-Seiler, B., and Wassarman, P. M. (1990). Genomic organization and polypeptide primary structure of zona pellucida glycoprotein hZP3, the hamster sperm receptor. Dev. Biol. 142, 414-421.
121. Kinloch, R. A., Mortillo, S., Stewart, C. L., and Wassarman, P. M. (1991). Embryonal carcinoma cells transfected with ZP3 genes differentially glycosylate similar polypeptides and secrete active mouse sperm receptor. J. Cell Biol. 115, 655-664.
122. Kinloch, R. A., Sakai, Y., and Wassarman, P. M. (1995). Mapping the mouse ZP3 combining site for sperm by exon swapping and site-directed mutagenesis. Proc. Natl. Acad. Sci. USA 92, 263-267.
123. Kipersztok, S., Osawa, G. A., Liang, L. F., Modi, W. S., and Dean, J. (1995). POM-ZP3, a bipartite transcript derived from human ZP3 and a POM121 homologue. Genomics 25, 354-359.
124. Kohane, A. C, Gonzalez Echeverria, F., Pineiro, L., and Blaquier, J. A. (1980). Interaction of proteins of epididymal origin with spermatozoa. Biol. Reprod. 23, 737-742.
125. Kölle, S., Sinowatz, F., Boie, G., Totzauer, I., Amselgruber, W., and Plendl, J. (1996). Localization of the mRNA encoding the zona protein ZP3a in the porcine ovary, oocyte and embryo by non-radioactive in situ hybridization. Histochem. J. 28, 441-447.
126. Kolluri, S. K., Kaul, R., Banerjee, K., and Gupta, S. K. (1995). Nucleotide sequence of cdna encoding bonnet monkey (macaca radiata) zona pellucida glycoprotein-zp3. Reprod. Fertil. Dev. 7, 1209-1212, 2232.
127. Kong, M., Richardson, R. T., Widgren, E. E., and O'Rand, M. G. (1995). Sequence and localization of the mouse sperm autoantigenic protein, Spl7. Biol. Reprod. 53, 579-590.
128. Kratzschmar, J., Haendler, B., Eberspaecher, U., Roosterman, D., Donner, P., and Schleuning, W. D. (1996). The human cysteine-rich secretory protein (CRISP) family primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. Ear. J. Biocliem. 236, 827-836.
129. Lathrop, W. F., Carmichael, E. P., Myles, D. G., and Primakoff, P. (1990). cDNA cloning reveals the structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals. J. Cell Biol. 111, 2939-2949.
130. Lea, O. A., and French, F. S. (1981). Characterization of an acidic glycoprotein secreted by principal cells of the rat epididymis. Biochim. Biophys. Acta 668, 370-376.
131. Lea, I. A., Richardson, R. T., Widgren, E. E., and O'Rand, M. G. (1996). Cloning and sequencing of cDNAs encoding the human sperm protein, Spl7. Biochim. Biophys. Ada Gene Struct. Expression 1307, 263-266.
132. Lee, V. H., and Dunbar, B. S. (1993). Developmental expression of the rabbit 55-kDa zona pellucida protein and messenger RNA in ovarian follicles. Dev. Biol. 155,371-382.
133. Lee, V. H., Schwoebel, E., Prasad, S., Cheung, P., Timmons, T. M., Cook, R., and Dunbar, B. S. (1993). Identification and structural characterization of the 75-kDa rabbit zona pellucida protein. J. Biol. Chem. 268, 12412-12417.
134. Leyton, L., and Saling, P. (1989a). Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction. J. Cell Biol. 108, 2163-2168.
135. Leyton, L., and Saling, P. (1989b). 95 kd Sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Cell 57, 1123-1130.
136. Leyton, L., LeGuen, P., Bunch, D., and Saling, P. M. (1992). Regulation of mouse gamete interaction by a sperm tyrosine kinase. Proc. Natl. Acad. Sci. USA 89, 11692-11695.
137. Leyton, L., Tomes, C. N., and Saling, P. M. (1995). LL95 monoclonal antibody mimics functional effects of ZP3 on mouse sperm: Evidence that the antigen recognized is not hexokinase. Mol. Reprod. Dev. 42, 347-358.
138. Liang, L.-F., and Dean, J. (1993). Conservation of mammalian secondary sperm receptor genes enables the promoter of the human gene to function in mouse oocytes. Dev. Biol. 156, 399-408.
139. Liang, L. F., Chamow, S. M., and Dean, J. (1990). Oocyte-specific expression of mouse Zp- 2: Developmental regulation of the zona pellucida genes. Mol. Cell. Biol. 10, 1507-1515.
140. Lin, Y., Kimmel, L. H., Myles, D. G., and Primakoff, P. (1993). Molecular cloning of the human and monkey sperm surface protein PH-20. Proc. Natl. Acad. Sci. USA 90, 10071-10075.
141. Lin, Y., Mahan, K., Lathrop, W. F., Myles, D. G., and Primakoff, P. (1994). A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg. J. Cell Biol. 125,1157-1163.
142. Litscher, E. S., and Wassarman, P. M. (1996). Characterization of a mouse ZP3-derived glycopcptide, gp55, that exhibits sperm receptor and acrosome reaction-inducing activity in vitro. Biochemistry 35, 3980-3985.
143. Litscher, E. S., Juntunen, K., Seppo, A., Penttila, L., Niemela, R., Renkonen, O., and Wassarman, P. M. (1995). Oligosaccharide constructs with defined structures that inhibit binding of mouse sperm to unfertilized eggs in vitro. Biochemistry 34, 4662-4669.
144. Liu, C. Y., Litscher, E. S., Mortillo, S., Sakai, Y., Kinloch, R. A., Stewart, C. L., and Wassarman, P. M. (1996). Targeted disruption of the mzp3 gene results in production of eggs lacking a zona pellucida and infertility in female mice. Proc. Natl. Acad. Sci. USA 93, 5431-5436.
145. Longo, F. J., and Yanagimachi, R. (1993). Detection of sperm-egg fusion. Methods Enzymol. 221, 249-260.
146. Lopata, A., and Leung, P. C. (1988). The fertilizability of human oocytes at different stages of meiotic maturation. Ann. NY Acad. Sci. 541, 324-336.
147. Lopez, L. C, and Shur, B. D. (1987). Redistribution of mouse sperm surface galactosyltransferase after the acrosome reaction. J. Cell Biol. 105, 1663-1670.
148. Lyons, C. E., Payette, K. L., Price, J. L., and Huang, R. C. C. (1993). Expression and structural analysis of a teleost homolog of a mammalian zona pellucida gene. J. Biol. Chem. 268,21351-21358.
149. Macek, M. B., Lopez, L. C, and Shur, B. D. (1991). Aggregation of β-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction. Dev. Biol. 147, 440-444.
150. Mahi, C. A., and Yanagimachi, R. (1976). Maturation and sperm penetration of canine ovarian oocytes in vitro. J. Exp. ZooJ. 196, 189-196.
151. Martinez, M. L., Fontenot, G. K., and Harris, J. D. (1996). The expression and localization of the zona pellucida glycoproteins and mRNA in cynomolgus monkeys (Macaca fascicularis). J. Reprod. Fertil. Suppl. 50, 35-41.
152. Miller, D. J., Macck, M. B., and Shur, B. D. (1992). Complementarity between sperm surface /3-1,4-galactosyl-transferase and egg-coat ZP3 mediates sperm-egg binding. Nature 357, 589-593.
153. Miller, D. J., Gong, X., Decker, G., and Shur, B. D. (1993). Egg cortical granule N-acetylgluco-saminidase is required for the mouse zona block to polyspermy. J. Cell Biol. 123,1431-1440.
154. Mintz, B. (1962). Experimental study of the developing egg after removal of the zona pellucida. Science 135, 594-595.
155. Mizuki, N., and Kasahara, M. (1992). Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule. Mol. Cell. Endocrinol. 89, 25-32.
156. Mizuki, N., Sarapata, D. E., Garcia-Sanz, J. A., and Kasahara, M. (1992). The mouse male germ cell-specific gene Tpx-1: Molecular structure, mode of expression in spermatogenesis, and sequence similarity to two non-mammalian genes. Mamm. Genome 3, 274-280.
157. Modlinski, J. A. (1970). The role of the zona pellucida in the development of mouse eggs in vivo. J. Embryol. Exp. Morphol. 23, 539-547.
158. Moller, C. C., and Wassarman, P. M. (1989). Characterization of a proteinase that cleaves zona pellucida glycoprotein ZP2 following activation of mouse eggs. Dev. Biol. 132,103-112.
159. Moller, C. C, Bleil, J. D., Kinloch, R. A., and Wassarman, P. M. (1990). Structural and functional relationships between mouse and hamster zona pellucida glycoproteins. Dev. Biol. 137, 276-286.
160. Monroy, A. (1985). Processes controlling sperm-egg fusion. Eur. J. Biochem. 152, 51-56.
161. Moore, H. D. M., and Bedford, J. M. (1978). Ultrastructure of the equatorial segment of hamster spermatozoa during penetration of oocytes. J. Ultrastruct. Res. 62, 110-117.
162. Moore, H. D. M., Hartman, T. D., Bye, A. P., Lutjen, P., De Wilt, M., and Trounson, A. O. (1987). Monoclonal antibody against a sperm antigen Mr 95,000 inhibits attachment of human spermatozoa to the zona pellucida. J. Reprod. Immunol. 11, 157-166.
163. Moos, J., Faundes, D., Kopf, G. S., and Schultz, R. M. (1995). Composition of the human zona pellucida and modifications following fertilization. Hum. Reprod. 10, 2467-2471.
164. Mori, E., Kashiwabara, S., Baba, T., Inagaki, Y., and Mori, T. (1995). Amino acid sequences of porcine Sp38 and proacrosin required for binding to the zona pellucida. Dev. Biol. 168, 575-583.
165. Mortillo, S., and Wassarman, P. M. (1991). Differential binding of gold-labeled zona pellucida glycoproteins mZP2 and mZP3 to mouse sperm membrane compartments. Development 113, 141-149.
166. Muga, A., Neugebauer, W., Hirama, T., and Surewicz, W. K. (1994). Membrane interaction and conformational properties of the putative fusion peptide of PH-30, a protein active in sperm-egg fusion. Biochemistry 33, 4444-4448.
167. Murata, K., Sasaki, T., Yasumasu, S., luchi, I., Enami, J., Yasumasu, I., and Yamagami, K. (1995). Cloning of cDNAs for the precursor protein of a low-molecular-weight subunit of the inner layer of the egg envelope (chorion) of the fish Oryzias latipes. Dev. Biol. 167,9-17.
168. Myles, D. G. (1993). Molecular mechanisms of sperm-egg membrane binding and fusion in mammals. Dev. Biol. 158, 35-45.
169. Myles, D. G., Hyatt, H., and Primakoff, P. (1987). Binding of both acrosome-intact and acrosome-reacted guinea pig sperm to the zona pellucida during in vitro fertilization. Dev. Biol. 121, 559-567.
170. Myles, D. G., Kimmel, L. H., Blobel, C. P., White, J. M., and Primakoff, P. (1994). Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion. Proc. Natl. Acad. Sci. USA 91, 4195-4198.
171. Nakano, M., Yonezawa, N., Hatanaka, Y., and Noguchi, S. (1996). Structure and function of the AMinked carbohydrate chains of pig zona pellucida glycoproteins. J. Reprod. Fertil. Suppl. 50, 25-34.
172. Naz, R. K., and Ahmad, K. (1994). Molecular identities of human sperm proteins that bind human zona pellucida: Nature of sperm-zona interaction, tyrosine kinase activity, and involvement of FA-1. Mol. Reprod. Dev. 39, 397-408.
173. Niwa, K., and Chang, M. C. (1975). Fertilization of rat eggs in vitro at various times before and after ovulation with special reference to fertilization of ovarian oocytes matured in culture. J. Reprod. Fertil. 43, 435-451.
174. Okabe, M., Yagasaki, M., Oda, H., Matzno, S., Kohama, Y., and Mimura, T. (1988). Effect of a monoclonal anti-mouse sperm antibody (OBF13) on the interaction of mouse sperm with zona-free mouse and hamster eggs. J. Reprod. Imnnmol. 13, 211-219.
175. Okabe, M., Yagasaki, M., Matzno, S., Nagira, M., Kohama, Y., and Mimura, T. (1989). Glucosamine enhanced sperm-egg binding but inhibited sperm-egg fusion in mouse. Experientia 45, 193-194.
176. Okabe, M., Nagira, M., Kawai, Y., Matzno, S., Mimura, T., and Mayumi, T. (1990). A human sperm antigen possibly involved in binding and/or fusion with zona-free hamster eggs. Fertil. Steril. 54, 1121-1126.
177. O'Rand, M. G. (1988). Sperm-egg recognition and barriers to interspecies fertilization. Gamete Res. 19, 315-328.
178. Oura, C., and Toshimori, K. (1990). Ultrastructural studies on the fertilization of mammalian gametes. Int. Rev. Cytol. 122, 105-151.
179. Oyen, O., Myklebust, F., Scott, J. D., Hansson, V., and Jahnsen, T. (1989). Human testis cDNA for the regulatory subunit Rlla of cyclic AMP-dependent protein kinase encodes an alternate amino-terminal region. FEES Lett. 246, 57-64.
180. Pan, Y. C., and Li, S. S. (1982). Structure of secretory protein IV from rat seminal vesicles. Int. J. Pept. Protein Res. 20, 177-187.
181. Parrish, J. J., Susko-Parrish, J. L., Handrow, R. R., Ax, R. L., and First, N. L. (1989). Effect of sulfated glycoconjugates on capacitation and the acrosome reaction of bovine and hamster spermatozoa. Gamete Res. 24, 403-413.
182. Ferez Martinez, S., Conesa, D., and Cuasnicú, P. S. (1995). Potential contraceptive use of epididymal proteins: Evidence for thé participation of specific antibodies against rat epididymal protein DE in male and female fertility inhibition. J. Reprod. Imnmnol. 29, 31-45.
183. Perry, A. C. F., Jones, R., Barker, P. J., and Hall, L. (1992). A mammalian epididymal protein with remarkable sequence similarity to snake venom haemorrhagic peptides. Biochem. J. 286, 671-675.
184. Perry, A. C. F., Gichuhi, P. M., Jones, R., and Hall, L. (1995). Cloning and analysis of monkey fertilin reveals novel a subunit isoforms. Biochem. J. 307, 843-850.
185. Phelps, B. M., Primakoff, P., Koppel, D. E., Low, M. G., and Myles, D. G. (1988). Restricted lateral diffusion of PH-20,a Pi-anchored sperm membrane protein. Science 240,1780-1782.
186. Phillips, D. M., and Shalgi, R. (1980). Surface architecture of the mouse and hamster zona pellucida and oocyte. J. Ultrastritct. Res. 72, 1-12.
187. Phillips, D. M., and Shalgi, R. (1982). Sperm penetration into rat ova fertilized in vivo. J. Exp. Zool. 221, 373-378.
188. Folge, E., and Dziuk, P. J. (1965). Recovery of immature eggs penetrated by spermatozoa following induced ovulation in the pig. J. Reprod. Fertil. 9, 357-358.
189. Prasad, S. V., Mujtaba, S., Lee, V. H., and Dunbar, B. S. (1995). Immunogenicity enhancement of recombinant rabbit 55-kilodalton zona pellucida protein expressed using the baculovirus expression system. BioJ. Reprod. 52, 1167-1178.
190. Prasad, S. V., Wilkins, B., Skinner, S. M., and Dunbar, B. S. (1996). Evaluating zona pellucida structure and function using antibodies to rabbit 55 kda zp protein expressed in baculovirus expression system. Mol. Reprod. Dev. 43, 519-529.
191. Primakoff, P. (1994). Sperm proteins being studied for use in a contraceptive vaccine. Am. J. Reprod. Imnmnol. 31, 208-210.
192. Primakoff, P., Hyatt, H., and Myles, D. G. (1985). A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida. J. Cell Biol. 101,2239-2244.
193. Primakoff, P., Hyatt, H., and Tredick-Kline, J. (1987). Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion. J. Cell Biol. 104, 141-149.
194. Primakoff, P., Lathrop, W., Woolman, L., Cowan, A., and Myles, D. (1988). Fully effective contraception in male and female guinea pigs immunized with the sperm protein. Nature 335, 543-546.
195. Ramarao, C. S., Myles, D. G., White, J. M., and Primakoff, P. (1996). Initial evaluation of fertilin as an immunocontraceptive antigen and molecular cloning of the cynomolgus monkey fertilin subunit. Mol. Reprod. Dev. 43, 70-75.
196. Rankin, T., Familari, M., Lee, E., Ginsberg, A., Dwyer, N., Blanchettemackie, J., Drago, J., Westphal, H., and Dean, J. (1996). Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development 122, 2903-2910.
197. Rankin, T. L., Tsuruta, K. J., Holland, M. K., Griswold, M. D., and Orgebin-Crist, M.-C. (1992). Isolation, immunolocalization, and sperm-association of three proteins of 18, 25, and 29 kilodaltons secreted by the mouse epididymis. Biol. Reprod. 46, 747-766.
198. Reid, K. B. M., and Day, A. J. (1989). Structure-function relationships of the complement components. Imnmnol. Today 10,177-180.
199. Repin, V. S., and Akimova, I. M. (1976). A study of the protein composition of the zona pellucida of mammalian oocytes and zygotes by a method of microelectrophoresis in poly- acrylamide gel. Biokhimiia 41, 50-57.
200. Richardson, R. T., and O'Rand, M. G. (1996). Site-directed mutagenesis of rabbit proacrosin: Identification of residues involved in zona pellucida binding. J. Biol. Client. 271, 24069-24074.
201. Richardson, R. T., Yamasaki, N., and O'Rand, M. G. (1994). Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction. Dev. Biol. 165, 688-701.
202. Ringuette, M. J., Chamberlin, M. E., Baur, A. W., Sobieski, D. A., and Dean, J. (1988). Molecular analysis of cDNA coding for ZP3, a sperm binding protein of the mouse zona pellucida. Dev. Biol. 127, 287-295.
203. Robinson, R., Richardson, R., Hinds, K., Clayton, D., and Poirier, G. R. (1987). Features of a seminal proteinase inhibitor-zona pellucida-binding component on murine spermatozoa. Gamete Res. 16, 217-228.
204. Rochwerger, L., and Cuasnicú, P. S. (1992). Redistribution of a rat sperm epididymal glycopro- tein after in vitro and in vivo capacitation. Mol. Reprod. Dev. 31, 34-41.
205. Rochwerger, L:, Cohen, D. J., and Cuasnicú, P. S. (1992). Mammalian sperm-egg fusion: The rat egg has complementary sites for a sperm protein that mediates gamete fusion. Dev. Biol. 153, 83-90.
206. Resales, C, O'Brien, V., Kornberg, L., and Juliano, R. (1995). Signal transduction by cell adhesion receptors. Biochim. Biophys. Ada 1242, 77-98.
207. Rosière, T. K., and Wassarman, P. M. (1992). Identification of a region of mouse zona pellucida glycoprotein mZP3 that possesses sperm receptor activity. Dev. Biol. 154, 309-317.
208. Ruoslahti, E. (1996a). Integrin signaling and matrix assembly. Tumour Biol. 17, 117-124.
209. Ruoslahti, E. (1996b). ROD and other recognition sequences for integrins. Anna. Rev. Cell Dev. Biol. 12, 697-715.
210. Sacco, A. G., Yurewicz, E. C., Subramanian, M. G., and Matzat, P. D. (1989). Porcine zona pellucida: Association of sperm receptor activity with the a-glycoprotein component of the A/r = 55,000 family. Biol. Reprod. 41, 523-532.
211. Saling, P. M. (1989). Mammalian sperm interaction with extracellular matrices of the egg. Oxf. Rev. Reprod. Biol. 11, 339-388.
212. Saling, P. M. (1996). Gamete interactions leading to fertilization in mammals: Principles, paradigms, and paradoxes. In "Reproductive Endocrinology, Surgery, and Technology"(E. Y. Adashi, J. A. Rock, and Z. Rosenwaks, eds.), pp. 403-421. Raven Press, New York.
213. Saling, P. M., Irons, G., and Waibel, R. (1985). Mouse sperm antigens that participate in fertilization. I. Inhibition of sperm fusion with the egg plasma membrane using monoclonal antibodies. Biol. Reprod. 335, 515-526.
214. Saling, P. M., Burks, D. J., and Tomes, C. N. (1996). Sperm-zona pellucida interaction: A model for ZRK-mediated signalling. In "Signal Transduction in Testicular Cells" (V. Hansson, F. D. Levy, and K. Tasken, eds.), pp. 247-270. Springer-Verlag, Berlin.
215. Sanjurjo, C., Dawidowsky, A. R., Cameo, M. S., Gonzalez Echeverria, F., and Blaquier, J. A. (1990). Participation of human epididymal sperm coating antigens in fertilization. J. Androl. 11, 476-483.
216. Santella, L., Alikani, M., Talansky, B. E., Cohen, J., and Dale, B. (1992). Is the human oocyte plasma membrane polarized? Hum. Reprod. 7, 999-1003.
217. Sanz, L., Calvete, J. J., Mann, K., Schäfer, W., Schmid, E. R., and Topfer-Petersen, E. (1991). The amino acid sequence of AQN-3, a carbohydrate-binding protein isolated from boar sperm. Location of disulphide bridges. FEES Lett. 291, 33-36.
218. Sanz, L., Calvete, J. J., Mann, K., Scháfer, W., Schmid, E. R., Amselgruber, W., Sinowatz, F., Ehrhard, M., and Topfer-Petersen, E. (1992a). The complete primary structure of the spermadhesin AWN, a zona pellucida-binding protein isolated from boar spermatozoa, FEES Lett. 300, 213-218.
219. Sanz, L., Calvete, J. J., Mann, K., Scháfer, W., Schmid, E. R., and Topfer-Petersen, E. (1992b). The complete primary structure of the boar spermadhesin AQN-1, a carbohydrate-binding protein involved in fertilization. Eur. J. Biochem. 205, 645-652.
220. Schollmeyer, J. E. (1986). Identification of calpain II in porcine sperm. Biol. Reprod. 34, 721-731.
221. Schwartz, M. A., Ingber, D. E., Lawrence, M., Springer, T. A., and Lechene, C. (1991). Multiple integrins share the ability to induce elevation of intracellular pH. Exp. Cell Res. 195, 533-535.
222. Schwoebel, E., Prasad, S., Timmons, T. M., Cook, R., Kimura, H., Niu, E., Cheung, P., Skinner, S., Avery, S., Wilkins, B., and Dunbar, B. S. (1991). Isolation and characterization of a full length cDNA encoding the 55 kDa rabbit zona pellucida protein. J. Dial. Cliein. 266,7214-7219.
223. Sengoku, K., Tamate, K., Horikawa, M., Takaoka, Y., Ishikawa, M., and Dukelow, W. R. (1995). Plasma membrane block to polyspcrmy in human oocytes and preimplantation embryos. J. Reprod. Fertil. 105, 85-90.
224. Shabanowitz, R. B., and O'Rand, M. O. (1988). Characterization of the human zona pellucida from fertilized and unfertilized eggs. J. Reprod. Fertil. 82, 151-161.
225. Shalgi, R., and Phillips, D. (1980a). Mechanics of in vitro fertilization in the hamster. Biol. Reprod. 23, 433-444.
226. Shalgi, R., and Phillips, D. (1980b). Mechanics of sperm entry in cycling hamsters. J. Ultrastrnct. Res. 71, 154-161.
227. Shaper, N. L., Hollis, G. F., Douglas, J. G., Kirsch, I. R., and Shaper, J. H. (1988). Characterization of the full length cDNA for murine β-1,4-galactosyltransferase. J. Biol. Client. 263, 10420-10428.
228. Shaper, N. L., Wright, W. W., and Shaper, J. H. (1990). Murine 01,4-galactosyltransferase: Both the amount and the structure of the mRNA are regulated during spermatogenesis. Proc. Natl. Acad. Sci. USA 87, 791-795.
229. Shur, B. D., and Bennett, D. (1979). A specific defect in galactosyltransferase regulation on sperm bearing mutant alleles of the T/t locus. Dev. Biol. 71, 243-259.
230. Shur, B. D., and Hall, N. G. (1982). A role for mouse sperm surface galactosyltransferase in sperm binding to the egg zona pellucida. J. Cell Biol. 95, 574-579.
231. Shur, B. D., and Neely, C. A. (1988). Plasma membrane association, purification, and partial characterization of mouse sperm /31,4-galactosyltransferase. J. Biol. Client. 263, 17706-17714.
232. Songyang, Z., Shoelson, S. E., McGlade, J., Olivier, P., Pawson, T., Bustelo, X. R., Barbacid, M., Sabe, H., Hanafusa, H., Yi, T., Ren, R., Baltimore, D., Ratnofsky, S., Feldman, R. A., and Cantley, L. C. (1994). Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol. Cell. Biol. 14, 2777-2785.
233. Stauss, C. R., Votta, T. J., and Suarez, S. S. (1995). Sperm motility hyperactivation facilitates penetration of the hamster zona pellucida. Biol. Reprod. 53, 1280-1285.
234. Stephens, L. R., Jackson, T. R., and Hawkins, P. T. (1993). Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: A new intracellular signalling system. Biochim. Biophys. Ada. 1179, 27-75.
235. Sutherland, A. E., Calarco, P. G., and Damsky, C. H. (1993). Developmental regulation of integrin expression at the time of implantation in the mouse embryo. Development 119, 1175-1186.
236. Suzuki, S., and Naitoh, Y. (1990). Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. EMBO J. 9, 757-763.
237. Talansky, B. E., Malter, H. E., and Cohen, J. (1991). A preferential site for sperm-egg fusion in mammals. Mol. Reprod. Dev. 28, 183-188.
238. Taya, T., Yamasaki, N., Tsubamoto, H., Hasegawa, A., and Koyama, K. (1995). Cloning of a cDNA coding for porcine zona pellucida glycoprotein ZP1 and its genomic organization. Biochem. Biophys. Res. Commun. 207, 790-799.
239. Taylor, S., Buechler, J. A., and Yonemoto, W. (1990). cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes. Annu. Rev. Biocliem. 59,971-1005.
240. Tesarik, J., Drahorad, J., Testart, J., and Mendoza, C. (1990). Acrosin activation follows its surface exposure and precedes membrane fusion in human sperm acrosome reaction. Development 110, 391-400.
241. Tezon, J. G., Ramella, E., Cameo, M. S., Vazquez, M. H., and Blaquier, J. A. (1985). Immuno-chemical localization of secretory antigens in the human epididymis and their association with spermatozoa. Biol. Reprod. 32, 591-597.
242. Thaler, C. D., and Cardullo, R. A. (1996). The initial molecular interaction between mouse sperm and the zona pellucida is a complex binding event. J. Biol. Cliem. 271,23289-23297.
243. Thillai-Koothan, P., Van Duin, M., and Aitken, R. J. (1993). Cloning, sequencing and oocyte-specific expression of the marmoset sperm receptor protein, ZP3. Zygote I, 93-101.
244. Thim, L. (1989). A new family of growth factor-like peptides. "Trefoil" disulphide loop structures as a common feature in breast cancer-associated peptide (p52), pancreatic spasmolytic peptide (PSP), and frog skin peptides (spasmolysins). FEES Lett. 250, 85-90.
245. Tomes, C. N., McMaster, C, and Saling, P. M. (1996). Activation of mouse P1P2-PLC by zona pellucida is modulated by tyrosine phosphorylation. Mol. Reprod. Dev. 43, 196-204.
246. Töpfer-Petersen, E. (1996). Molecular mechanism of fertilization in the pig. Reprod. Dornest. Anim. 31, 93-100.
247. Töpfer-Petersen, E., and Calvete, J. J. (1995). Molecular mechanisms of the interaction between sperm and the zona pellucida in mammals-Studies on the pig. Int. J. Androl. 18 (2), 20-26, 1275.
248. Töpfer-Petersen, E., and Cechova, D. (1990). Zona pellucida induces conversion of proacrosin to acrosin. Int. J. Androl. 13, 190-196.
249. Töpfer-Petersen, E., and Menschen, A. (1987). Acrosin shows zona and fucose binding, novel properties for a serine proteinase. FEBS Lett. 226, 38-42.
250. Topfer-Petersen, E., and Menschen, A. (1988). Zona pellucida-binding and fucose-binding of boar sperm acrosin is not correlated with proteolytic activity. Biol. Chem. Hoppe-Seyler 369, 69-76.
251. Töpfer-Petersen, E., Stcinberger, M., von Eschenbach, C. E., and Zucker, A. (1990). Zona pellucida-binding of boar sperm acrosin is associated with the N-terminal peptide of the acrosin B-chain (heavy chain). FEBS Lett. 265, 51-54.
252. Töpfer-Petersen, E., Mann, K., and Calvete, J. J. (1993). Identification of porcine oocyte 55 kDa α and β proteins within the zona pellucida glycoprotein families indicates that oocyte sperm receptor activity is associated with different zona pellucida proteins in different mammalian species. Biol. Chem. Hoppe-Seyler 374, 411-417.
253. Töpfer-Petersen, E., Calvete, J. J., Sanz, L., and Sinowatz, F. (1995). Carbohydrate- and heparin-binding proteins in mammalian fertilization. Androtogia 27, 303-324.
254. Tsubamoto, H., Hasegawa, A., Inoue, M., Yamasaki, N., and Koyama, K. (1996). Binding of recombinant pig zona pellucida protein 1 (zpl) to acrosome-reacted spermatozoa. J Reprod. Fertil. 50, 63-67.
255. Urch, U. A., and Patel, H. (1991). The interaction of boar sperm proacrosin with its natural substrate, the zona pellucida, and with polysulfated polysaccharides. Development 111,1165-1172.
256. Van Duin, M., Polman, J. E. M., Suikerbuijk, R. F., Geurts van Kessel, A. H. M., and Olijve, W. (1993). The human gene for the zona pellucida glycoprotein ZP3 and a second polymorphic locus are located on chromosome 7. Cytogenet. Cell Genet. 63, 111-113.
257. Van Duin, M., Polman, J. E., De Breet, I. T., van Ginneken, K., Bunschoten, H., Grootenhuis, A., Brindle, J., and Aitken, R. J. (1994). Recombinant human zona pellucida protein ZP3 produced by Chinese hamster ovary cells induces the human sperm acrosome reaction and promotes sperm-egg fusion, Biol. Reprod. 51, 607-617.
258. Varticovski, L., Harrison-Findik, D., Keeler, M. L., and Susa, M. (1994). Role of PI 3-kinase in mitogenesis. Biochim. Biophys. Acta 1226, 1-11.
259. Vigil, P. (1989). Gamete membrane fusion in hamster spermatozoa with reacted equatorial segment. Gamete Res. 23, 203-213.
260. Wassarman, P. M. (1988). Zona pellucida glycoproteins. Annii. Rev. Biochem. 57, 415-442.
261. Wassarman, P. M., and Albertini, D. F. (1994). The mammalian ovum. In "The Physiology of Reproduction" (E. Knobil and J. D. Neill, eds.), 2nd Ed., pp. 79-122. Raven Press, New York.
262. Wassarman, P. M., and Litscher, E. S. (1995). Sperm-egg recognition mechanisms in mammals. Curr. Top. Dev. Biol. 30, 1-19.
263. While, J. M. (1992). Membrane fusion. Science 258, 917-924.
264. Wolf, D. E., and Ziomek, C. A. (1983). Regionalization and lateral diffusion of membrane proteins in unfertilized and fertilized mouse eggs. J. Cell Biol. 96, 1786-1790.
265. Wolf, D. P. (1977). Involvement of a trypsin-like activity in sperm penetration of zona-free mouse ova. J. Exp. ZooJ. 199, 149-156.
266. Wolf, D. P. (1978). The block to sperm penetration in zonal-free mouse eggs. Dev. Biol. 64,1-10.
267. Wolfsberg, T. G., Bazan, J. F., Blobel, C. P., Myles, D. G., Primakoff, P., and White, J. M. (1993). The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: Structural, functional, and evolutionary implications. Proc. Natl. Acad. Sci. USA 90, 10783-10787.
268. Wolfsberg, T. G., Primakoff, P., Myles, D. G., and White, J. M. (1995a). ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain- Multipotential functions in cell-cell and cell-matrix interactions. J. Cell Biol. 131, 275-278.
269. Wolfsberg, T. G., Straight, P. D., Gerena, R. L., Huovila, A. P., Primakoff, P., Myles, D. G., and White, J. M. (1995b). ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev. Biol. 169, 378-383.
270. Wong, P. Y., and Tsang, A. Y. (1982). Studies on the binding of a 32K rat epididymal protein to rat epididymal spermatozoa. Biol. Reprod. 27, 1239-1246.
271. Yagami-Hiromasa, T., Sato, T., Kurisaki, T., Kamijo, K., Nabeshima, Y., and Fujisawa-Sehara, A. (1995). A metalloprotease-disintegrin participating in myoblast fusion. Nature 377, 652-656.
272. Yamada, K. M., and Miyamoto, S. (1995). Integrin transmembrane signaling and cytoskeletal control. Curr. Opin. Cell Biol. 7, 681-689.
273. Yamasaki, N., Richardson, R. T., and O'Rand, M. G. (1995). Expression of the rabbit sperm protein Spl7 in COS cells and interaction of recombinant Spl7 with the rabbit zona pellucida. Mol. Reprod. Dev. 40, 48-55.
274. Yamasaki, N., Tsubamoto, H., Hasegawa, A., Inoue, M., and Koyama, K. (1996). Genomic organization of the gene for pig zona pellucida glycoprotein zpl and its expression in mammalian cells. J. Reprod. Fertil. 50, 19-23.
275. Yanagimachi, R. (1978). Calcium requirement for sperm-egg fusion in mammals. Biol. Reprod. 19, 949-958.
276. Yanagimachi, R. (1981). Mechanisms of fertilization in mammals. In "Fertilization and Embryonic Development m Vitro" (L. Mastroianni and J. D. Biggers, eds.), pp. 81-187. Plenum, New York.
277. Yanagimachi, R. (1994). Mammalian fertilization. In "The Physiology of Reproduction" (E. Knobil and J. D. Neill, eds.), 2nd Ed., pp. 189-317. Raven Press, New York.
278. Yanagimachi, R., and Noda, Y. D. (1970). Physiological changes in the post-nuclear cap region of mammalian spermatozoa: A necessary preliminary to the membrane fusion between sperm and egg cells. J. Ultrastruct. Res. 31, 486-493.
279. Yanagimachi, R., Miyashiro, L. R., and Yanagimachi, H. (1980). Reversible inhibition of sperm-egg fusion in the hamster by low pH. Dev. Growth Differ. 22, 281-288.
280. Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y., and Matsuda, Y. (1993). Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268, 25846-25856.
281. Yonezawa, N., Aoki, H., Hatanaka, Y., and Nakano, M. (1995). Involvement of N-linked carbohydrate chains of pig zona pellucida in sperm-egg binding. Eur. J. Biochem. 233,35-41.
282. Youakim, A., Hathaway, H. J., Miller, D. J., Gong, X. H., and Shur, B. D. (1994). Overexpressing sperm surface /31,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interaction. J. Cell Biol. 126, 1573-1583.
283. Yurewicz, E. C., Sacco, A. G., and Subramanian, M. G. (1983). Isolation and preliminary characterization of a purified pig zona antigen (PPZA) from porcine oocytes. Biol. Reprod. 29,511-523.
284. Yurewicz, E. C, Sacco, A. C., and Subramanian, M. G. (1987). Structural characterization of the Mr = 55 000 antigen (ZP3) of porcine oocyte zona pellucida:Purification and characterization of α- and β-glycoproteins following digestion of lactosaminoglycan with endo-βgalactosidase. J. Biol. Chem. 262, 564-571.
285. Yurewicz, E. C, Hibler, D., Fontenot, G. K., Sacco, A. G., and Harris, J. (1993a). Nucleotide sequence of cDNA encoding ZP3a, a sperm-binding glycoprotein from zona pellucida of pig oocyte. Biochim. Biophys. Ada 1174, 211-214.
286. Yurewicz, E. C, Pack, B. A., Armant, D. R., and Sacco, A. G. (1993b). Porcine zona pellucida ZP3a glycoprotein mediates binding of the biotin-labeled Mr 55,000 family (ZP3) to boar sperm membrane vesicles. Mol. Reprod. Dev. 36, 382-389.
287. Yurewicz, E. C., Zhang, S., and Sacco, A. G. (1993c). Generation and characterization of site-directed antisera against an ammo-terminal segment of a 55 kDa sperm adhesive glycoprotein from zona pellucida of pig oocytes. J. Reprod. Fertil. 98, 147-152.
288. Zuccotti, M., Yanagimachi, R., and Yanagimachi, H. (1991). The ability of hamster oolemma to fuse with spermatozoa: Its acquisition during oogenesis and loss after fertilization. Development 112, 143-152.