Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: No alteration of soluble gp130

Neuroscience Letters

Volumn 259, Issue 3, 1999, Pages 145-148

  Stübner, Susanne ^a   Schön, Tanja ^a   Padberg, Frank ^a   Teipel, Stefan J ^a   Schwarz, Markus J ^a   Haslinger, Andreas ^a   Buch, Katharina ^a   Dukoff, Ruth ^b   Lasser, Robert ^b   Müller, Norbert ^a   Sunderland, Trey ^b   Rapoport, Stanley I ^c   Möller, Hans Jürgen ^a   Hampel, Harald ^a  

^a Geriatric Psychiat Br   (Germany)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Cerebrospinal fluid; gp130; Healthy controls; Interleukin 6; Major depression; Soluble Interleukin 6 receptor

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; PSYCHOTROPIC AGENT;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEPRESSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GERIATRIC PATIENT; HUMAN; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS;

EID: 0345130090     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00916-1     Document Type: Article

References (26)

1. Blum-Degen D., Müller T., Kuhn W., Gerlach M., Przuntek H., Riederer P. Interleukin-1β and Interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 202:1995;111-114.
2. Connor T.J., Leonard B.E. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci. 62:1998;583-606.
3. Daynes R.A., Araneo B.A., Ershler W.B., Maloney C., Li G.H.-Z., Ryu S.-Y. Altered regulation of IL-6 production with normal aging. J. Immunol. 150:1993;5219-5230.
4. Emery O., Oxman T.E. Update on the dementia spectrum of depression. Am. J. Psychiatry. 149(3):1992;305-317.
5. Ershler W.B. Interleukin-6: a cytokine for gerontologists. Geriatric Biosci. 41:1993;176-181.
6. Frommberger U.H., Bauer J., Haselbauer P., Fräulin A., Riemann D., Berger M. Interleukin-6 (IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission. Eur. Arch. Psychiatry Clin. Neurosci. 247:1997;228-233.
7. Hampel H., Schoen D., Schwarz M.J., Kötter H.U., Schneider C., Sunderland T., Dukoff R., Levy J., Padberg F., Stübner S., Buch K., Müller N., Möller H.-J. Interleukin-6 is not altered in cerebrospinal fluid of first-degree relatives and patients with Alzheimer's disease. Neurosci. Lett. 228:1997;143-146.
8. Hampel H., Sunderland T., Kötter H.U., Schneider C., Teipel S.J., Padberg F., Dukoff R., Levy J., Möller H.-J. Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease. Brain Res. 780:1998;356-359.
9. Hibi M., Nakajima K., Hirano T. IL-6 cytokine family and signal transduction: a model of the cytokine system. J. Mol. Med. 74:1996;1-12.
10. Huell M., Strauss S., Volk B., Berger M., Bauer J. Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimeŕs disease patients. Acta Neuropathol. 89:1995;544-551.
11. Katila H., Appelberg B., Hume M., Rimón R. Plasma levels of interleukin-1β and interleukin-6 in schizophrenia, other psychosis, and affective disorders. Schizophrenia Res. 12:1994;29-34.
12. Kral V., Emery O. Long term follow-up of depressive pseudodementia. Can. J. Psychiatry. 34:1989;445-447.
13. Lee S.C., Liu W., Dickson D.W., Brosnan C.F., Berman J.W. Cytokine production by human fetal microglia and astrocytes. J. Immunol. 150:1993;2659-2667.
14. März P., Heese K., Hock C., Golombowski S., Müller-Spahn F., Rose-John S., Otten U. Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients. Neurosci. Lett. 239(1):1997;29-32.
15. Maes M., Scharpé S., Meltzer H.Y., Bosmans E., Suy E., Calabrese J., Cosyns P. Relationships between interleukin-6 activity, acute phase proteins, and functions of the hypothalamic-pituary-adrenal axis in severe depression. Psychiatry Res. 49:1993;11-27.
16. Maes M., Meltzer H.Y., Bosmans E., Bergmans R., Vandoolaeghe E., Ranjan R., Desnyder R. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J. Aff. Dis. 34:1995;301-309.
17. Maier S.F., Watkins L.R., Fleshner M. Psychoneuroimmunology. The interface between behavior, brain and immunity. Am. Psychologist. 49:1994;1004-1017.
18. Maimone D., Guazzi G.C., Annunziata P. IL-6 detection in multiple sclerosis brain. J. Neurol. Sci. 146:1997;59-65.
19. Navikas V., Link H. Review: cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 45:1996;322-333.
20. Rose-John S., Heinrich P.C. Soluble receptors for cytokines and growth factors: generation and biological functions. Biochem. J. 300:1994;281-290.
21. Saito M., Yoshida K., Hibi K., Taga T., Kishimoto T. Molecular cloning of a murine IL-6 receptor-associated signal tranducer, gp130, and its regulated expression in vivo. J. Immunol. 148:1992;4066-4071.
22. Seidel A., Arolt V., Hunstinger M., Rink L., Behnisch A., Kirchner H. Cytokine production and serum proteins in depression. Scand. J. Immunol. 41:1995;534-538.
23. Sluzewska A., Rybakowski J.K., Bosmans E., Sobieska M., Berghmans R., Maes M., Wiktorowicz K. Indicators of immune activation in major depression. Psychiatry Res. 64:1996;161-167.
24. Somers W., Stahl M., Seehra J.S. 1,9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. Embo. J. 16:1997;989-997.
25. Vandenabeele P., Fiers W. Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated 'acute phase response' in the brain? Immunol. Today. 12:1991;217-219.
26. Yamada K., Kono K., Umegaki H., Yamada K., Iguchi A., Fukatsu T., Nakashima N., Nishiwaki H., Shimada H., Sugita Y., Yamamoto T., Hasegawa T., Nabeshima T. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Neurosci. Lett. 186:1995;219-221.